LOCUS       NM_001204268             829 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens FXYD6-FXYD2 readthrough (FXYD6-FXYD2), transcript
            variant 1, mRNA.
ACCESSION   NM_001204268
VERSION     NM_001204268.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 829)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000757.4, FY214031.1 and
            FY211982.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001204268.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring FXYD domain-containing ion
            transport regulator 6 (GeneID 53826) and
            sodium/potassium-transporting ATPase subunit gamma (GeneID 486)
            genes on chromosome 11. One read-through transcript produces a
            fusion protein that shares sequence identity with each individual
            gene product, while another read-through transcript encodes a
            protein that has a distinct C-terminus and only shares sequence
            identity with the upstream locus (GeneID 53826). [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FY211982.1, FY212491.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 486, 53826
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AP000757.4         121059-121088       c
            31-424              FY214031.1         1-394
            425-576             FY211982.1         395-546
            577-829             AP000757.4         64487-64739         c
FEATURES             Location/Qualifiers
     source          1..829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..829
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /note="FXYD6-FXYD2 readthrough"
                     /db_xref="GeneID:100533181"
                     /db_xref="HGNC:HGNC:39978"
     exon            1..67
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            68..130
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..507
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; FXYD domain-containing ion transport regulator
                     6; Phosphohippolin"
                     /codon_start=1
                     /product="FXYD6-FXYD2 read-through protein isoform 1
                     precursor"
                     /protein_id="NP_001191197.1"
                     /db_xref="GeneID:100533181"
                     /db_xref="HGNC:HGNC:39978"
                     /translation="MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVF
                     AVVLFSVGILLILSRRCKCSFNQKPRNRAPESRELKCSHQVEGGSPKGDVDPFYYDYE
                     TVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP"
     exon            131..169
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            170..244
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            245..281
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            282..331
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            332..370
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            371..445
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            446..482
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            483..513
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     exon            514..829
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      710..715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /note="hexamer: AATAAA"
     polyA_site      746
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /note="major polyA site"
     regulatory      800..805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
                     /note="hexamer: AATACA"
     polyA_site      805
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
     polyA_site      829
                     /gene="FXYD6-FXYD2"
                     /gene_synonym="FXYD6"
ORIGIN      
        1 gccactccca ggctcctcgg gactcggcgg gtcctcctgg gagtctcgga ggggaccggc
       61 tgtgcagacg ccatggagtt ggtgctggtc ttcctctgca gcctgctggc ccccatggtc
      121 ctggccagtg cagctgaaaa ggagaaggaa atggaccctt ttcattatga ttaccagacc
      181 ctgaggattg ggggactggt gttcgctgtg gtcctcttct cggttgggat cctccttatc
      241 ctaagtcgca ggtgcaagtg cagtttcaat cagaagcccc gcaacagagc cccagaaagc
      301 agagaactga agtgcagcca tcaggtggaa ggcggcagcc ccaaggggga cgtggacccg
      361 ttctactatg actatgagac cgttcgcaat gggggcctga tcttcgctgg actggccttc
      421 atcgtggggc tcctcatcct cctcagcaga agattccgct gtgggggcaa taagaagcgc
      481 aggcaaatca atgaagatga gccgtaacag cagcctcggc ggtgccaccc actgcactgg
      541 ggccagctgg gaagccaagc atggccctgc ctctggcgcc tccccttctt ccctgggctt
      601 tagacctttg tccccgtcac tgccagcgct tgggctgaag gaagctccag actcaatgtg
      661 acccccaggt ggcatcgcca actcctgcct cgtgccacct catgcttata ataaagccgg
      721 cgtcagagac cgctgcttcc ctcacctgcc tgcctgtctc cctcctctgt caccaccagc
      781 ctctccaagc tcaagtacaa atacagccgg gtctcatttg ttttttcaa
//
