LOCUS       NM_001320912             981 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens FXYD domain containing ion transport regulator 5
            (FXYD5), transcript variant 5, mRNA.
ACCESSION   NM_001320912 XM_006723245
VERSION     NM_001320912.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 981)
  AUTHORS   Lee,C.J., Jang,T.Y., Kim,J.H., Lim,S., Lee,S. and Nam,J.S.
  TITLE     The dysadherin/FAK axis promotes individual cell migration in colon
            cancer
  JOURNAL   Int J Biol Sci 20 (7), 2356-2369 (2024)
   PUBMED   38725858
  REMARK    GeneRIF: The dysadherin/FAK axis promotes individual cell migration
            in colon cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 981)
  AUTHORS   Hostrup,M., Lemminger,A.K., Thomsen,L.B., Schaufuss,A., Alsoe,T.L.,
            Bergen,G.K., Bell,A.B., Bangsbo,J. and Thomassen,M.
  TITLE     High-Intensity Training Represses FXYD5 and Glycosylates
            Na,K-ATPase in Type II Muscle Fibres, Which Are Linked with
            Improved Muscle K+ Handling and Performance
  JOURNAL   Int J Mol Sci 24 (6), 5587 (2023)
   PUBMED   36982661
  REMARK    GeneRIF: High-Intensity Training Represses FXYD5 and Glycosylates
            Na,K-ATPase in Type II Muscle Fibres, Which Are Linked with
            Improved Muscle K[+] Handling and Performance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 981)
  AUTHORS   Tan,X.P., Xiong,B.H., Zhang,Y.X., Wang,S.L., Zuo,Q. and Li,J.
  TITLE     FXYD5 promotes sorafenib resistance through the Akt/mTOR signaling
            pathway in hepatocellular carcinoma
  JOURNAL   Eur J Pharmacol 931, 175186 (2022)
   PUBMED   35977595
  REMARK    GeneRIF: FXYD5 promotes sorafenib resistance through the Akt/mTOR
            signaling pathway in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 981)
  AUTHORS   Park,S.Y., Lee,C.J., Choi,J.H., Kim,J.H., Lee,W.J., Jang,T.Y.,
            Jeon,S.E., Kim,J.H., Cho,S.H., Lee,J.S. and Nam,J.S.
  TITLE     Dysadherin awakens mechanical forces and promotes colorectal cancer
            progression
  JOURNAL   Theranostics 12 (9), 4399-4414 (2022)
   PUBMED   35673579
  REMARK    GeneRIF: Dysadherin awakens mechanical forces and promotes
            colorectal cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 981)
  AUTHORS   Bai,Y., Li,L.D., Li,J., Chen,R.F., Yu,H.L., Sun,H.F., Wang,J.Y. and
            Lu,X.
  TITLE     A FXYD5/TGF-beta/SMAD positive feedback loop drives
            epithelial-to-mesenchymal transition and promotes tumor growth and
            metastasis in ovarian cancer
  JOURNAL   Int J Oncol 56 (1), 301-314 (2020)
   PUBMED   31746425
  REMARK    GeneRIF: A FXYD5/TGFbeta/SMAD positive feedback loop drives
            epithelialtomesenchymal transition and promotes tumor growth and
            metastasis in ovarian cancer.
REFERENCE   6  (bases 1 to 981)
  AUTHORS   Shimada,Y., Yamasaki,S., Hashimoto,Y., Ito,T., Kawamura,J.,
            Soma,T., Ino,Y., Nakanishi,Y., Sakamoto,M., Hirohashi,S. and
            Imamura,M.
  TITLE     Clinical significance of dysadherin expression in gastric cancer
            patients
  JOURNAL   Clin Cancer Res 10 (8), 2818-2823 (2004)
   PUBMED   15102690
  REMARK    GeneRIF: dysadherin has a role in hematogenous metastasis of
            gastric cancer
            Erratum:[Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4198]
REFERENCE   7  (bases 1 to 981)
  AUTHORS   Sato,H., Ino,Y., Miura,A., Abe,Y., Sakai,H., Ito,K. and
            Hirohashi,S.
  TITLE     Dysadherin: expression and clinical significance in thyroid
            carcinoma
  JOURNAL   J Clin Endocrinol Metab 88 (9), 4407-4412 (2003)
   PUBMED   12970317
  REMARK    GeneRIF: dysadherin expression was significantly associated with
            the prognosis, occurrence of secondary undifferentiated carcinomas,
            size of the primary tumor, and metastasis to the regional lymph
            nodes and lungs
REFERENCE   8  (bases 1 to 981)
  AUTHORS   Ino,Y., Gotoh,M., Sakamoto,M., Tsukagoshi,K. and Hirohashi,S.
  TITLE     Dysadherin, a cancer-associated cell membrane glycoprotein,
            down-regulates E-cadherin and promotes metastasis
  JOURNAL   Proc Natl Acad Sci U S A 99 (1), 365-370 (2002)
   PUBMED   11756660
  REMARK    GeneRIF: We report the cloning and characterization of a
            cancer-associated cell membrane glycoprotein recognized by mAb
            NCC-3G10.
REFERENCE   9  (bases 1 to 981)
  AUTHORS   Omasa,T., Chen,Y.G., Mantalaris,A. and Wu,J.H.
  TITLE     A cDNA from human bone marrow encoding a protein exhibiting
            homology to the ATP1gamma1/PLM/MAT8 family of transmembrane
            proteins
  JOURNAL   Biochim Biophys Acta 1517 (2), 307-310 (2001)
   PUBMED   11342114
REFERENCE   10 (bases 1 to 981)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG025158.1, BM550889.1,
            AC002390.1 and AI424071.1.
            
            On May 31, 2019 this sequence version replaced NM_001320912.1.
            
            Summary: This gene encodes a member of a family of small membrane
            proteins that share a 35-amino acid signature sequence domain,
            beginning with the sequence PFXYD and containing 7 invariant and 6
            highly conserved amino acids. The approved human gene nomenclature
            for the family is FXYD-domain containing ion transport regulator.
            Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
            also known as the gamma subunit of the Na,K-ATPase, regulates the
            properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
            FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
            induce channel activity in experimental expression systems.
            Transmembrane topology has been established for two family members
            (FXYD1 and FXYD2), with the N-terminus extracellular and the
            C-terminus on the cytoplasmic side of the membrane. This gene
            product, FXYD5, is a glycoprotein that functions in the
            up-regulation of chemokine production, and it is involved in the
            reduction of cell adhesion via its ability to down-regulate
            E-cadherin. It also promotes metastasis, and has been linked to a
            variety of cancers. Alternative splicing results in multiple
            transcript variants. [RefSeq curation by Kathleen J. Sweadner,
            Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
            
            Transcript Variant: This variant (5) differs in the 5' and 3' UTRs
            and uses an alternate splice site in the penultimate exon, compared
            to variant 1. It encodes isoform 2, which is longer and has a
            distinct C-tetminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM550889.1, BM810965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMEA2162823
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BG025158.1         68-119
            53-704              BM550889.1         1-652
            705-705             AC002390.1         15453-15453
            706-981             AI424071.1         24-299              c
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..981
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /note="FXYD domain containing ion transport regulator 5"
                     /db_xref="GeneID:53827"
                     /db_xref="HGNC:HGNC:4029"
                     /db_xref="MIM:606669"
     exon            1..75
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..660
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 5; keratinocytes associated transmembrane protein
                     1; dysadherin"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 5
                     isoform 2 precursor"
                     /protein_id="NP_001307841.1"
                     /db_xref="CCDS:CCDS82328.1"
                     /db_xref="GeneID:53827"
                     /db_xref="HGNC:HGNC:4029"
                     /db_xref="MIM:606669"
                     /translation="MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPT
                     RAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKAAHPTD
                     DTTTLSERPSPSTDVQTDPQTLKPSGFHEDDPFFYDEHTLRKRGLLVAAVLFITGIII
                     LTSENWGWVGRTPRPGGGLMTEGWVLKGPWAILF"
     exon            76..136
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            137..217
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            218..274
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            275..367
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            368..457
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            458..487
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            488..665
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     exon            666..981
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /note="hexamer: AGTAAA"
     polyA_site      981
                     /gene="FXYD5"
                     /gene_synonym="DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241;
                     RIC"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcctgg acgcagcagc caccgccgcg tccctctctc cacgaggctg ccggcttagg
       61 acccccagct ccgacatgtc gccctctggt cgcctgtgtc ttctcaccat cgttggcctg
      121 attctcccca ccagaggaca gacgttgaaa gataccacgt ccagttcttc agcagactca
      181 actatcatgg acattcaggt cccgacacga gccccagatg cagtctacac agaactccag
      241 cccacctctc caaccccaac ctggcctgct gatgaaacac cacaacccca gacccagacc
      301 cagcaactgg aaggaacgga tgggcctcta gtgacagatc cagagacaca caagagcacc
      361 aaagcagctc atcccactga tgacaccacg acgctctctg agagaccatc cccaagcaca
      421 gacgtccaga cagaccccca gaccctcaag ccatctggtt ttcatgagga tgaccccttc
      481 ttctatgatg aacacaccct ccggaaacgg gggctgttgg tcgcagctgt gctgttcatc
      541 acaggcatca tcatcctcac cagtgagaac tggggttggg tgggaaggac accaagacca
      601 ggagggggac ttatgacgga gggctgggtt ctcaaaggtc cctgggcaat tttgttttaa
      661 atgaggtggc aagtgcaggc agctgtcccg gttatgccgg aatcgttgca ggtgagtcca
      721 tcagaaacag gagctgacaa cctgctgggc acccgaagac caagccccct gccagctcac
      781 cgtgcccagc ctcctgcatc ccctcgaaga gcctggccag agagggaaga cacagatgat
      841 gaagctggag ccagggctgc cggtccgagt ctcctacctc ccccaaccct gcccgcccct
      901 gaaggctacc tggcgccttg ggggctgtcc ctcaagttat ctcctctgct aagacaaaaa
      961 gtaaagcact gtggtctttg c
//
