LOCUS       NM_005971               1378 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens FXYD domain containing ion transport regulator 3
            (FXYD3), transcript variant 1, mRNA.
ACCESSION   NM_005971 XM_005258997
VERSION     NM_005971.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Li,M., Nishimura,T., Takeuchi,Y., Hongu,T., Wang,Y., Shiokawa,D.,
            Wang,K., Hirose,H., Sasahara,A., Yano,M., Ishikawa,S., Inokuchi,M.,
            Ota,T., Tanabe,M., Tada,K.I., Akiyama,T., Cheng,X., Liu,C.C.,
            Yamashita,T., Sugano,S., Uchida,Y., Chiba,T., Asahara,H.,
            Nakagawa,M., Sato,S., Miyagi,Y., Shimamura,T., Nagai,L.A.E.,
            Kanai,A., Katoh,M., Nomura,S., Nakato,R., Suzuki,Y., Tojo,A.,
            Voon,D.C., Ogawa,S., Okamoto,K., Foukakis,T. and Gotoh,N.
  TITLE     FXYD3 functionally demarcates an ancestral breast cancer stem cell
            subpopulation with features of drug-tolerant persisters
  JOURNAL   J Clin Invest 133 (22), e166666 (2023)
   PUBMED   37966117
  REMARK    GeneRIF: FXYD3 functionally demarcates an ancestral breast cancer
            stem cell subpopulation with features of drug-tolerant persisters.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Yang,W., He,R., Qu,H., Lian,W., Xue,Y., Wang,T., Lin,W., Zhu,P.,
            Xia,M., Lai,L. and Wang,Q.
  TITLE     FXYD3 enhances IL-17A signaling to promote psoriasis by
            competitively binding TRAF3 in keratinocytes
  JOURNAL   Cell Mol Immunol 20 (3), 292-304 (2023)
   PUBMED   36693922
  REMARK    GeneRIF: FXYD3 enhances IL-17A signaling to promote psoriasis by
            competitively binding TRAF3 in keratinocytes.
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   Cano Portillo,C., Villacreses,R., Thurman,A.L., Pezzulo,A.A.,
            Zabner,J. and Thornell,I.M.
  TITLE     FXYD3 facilitates Na+ and liquid absorption across human airway
            epithelia by increasing the transport capacity of the Na/K ATPase
  JOURNAL   Am J Physiol Cell Physiol 323 (4), C1044-C1051 (2022)
   PUBMED   35993520
  REMARK    GeneRIF: FXYD3 facilitates Na(+) and liquid absorption across human
            airway epithelia by increasing the transport capacity of the Na/K
            ATPase.
REFERENCE   4  (bases 1 to 1378)
  AUTHORS   Plain,F., Howie,J., Kennedy,J., Brown,E., Shattock,M.J.,
            Fraser,N.J. and Fuller,W.
  TITLE     Control of protein palmitoylation by regulating substrate
            recruitment to a zDHHC-protein acyltransferase
  JOURNAL   Commun Biol 3 (1), 411 (2020)
   PUBMED   32737405
  REMARK    GeneRIF: Control of protein palmitoylation by regulating substrate
            recruitment to a zDHHC-protein acyltransferase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1378)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1378)
  AUTHORS   Crowell,K.J., Franzin,C.M., Koltay,A., Lee,S., Lucchese,A.M.,
            Snyder,B.C. and Marassi,F.M.
  TITLE     Expression and characterization of the FXYD ion transport
            regulators for NMR structural studies in lipid micelles and lipid
            bilayers
  JOURNAL   Biochim Biophys Acta 1645 (1), 15-21 (2003)
   PUBMED   12535606
  REMARK    GeneRIF: molecular cloning, protein expression, sequencing and NMR
            structure determination
REFERENCE   7  (bases 1 to 1378)
  AUTHORS   Sweadner,K.J. and Rael,E.
  TITLE     The FXYD gene family of small ion transport regulators or channels:
            cDNA sequence, protein signature sequence, and expression
  JOURNAL   Genomics 68 (1), 41-56 (2000)
   PUBMED   10950925
REFERENCE   8  (bases 1 to 1378)
  AUTHORS   van Groningen,J.J., Bloemers,H.P. and Swart,G.W.
  TITLE     Identification of melanoma inhibitory activity and other
            differentially expressed messenger RNAs in human melanoma cell
            lines with different metastatic capacity by messenger RNA
            differential display
  JOURNAL   Cancer Res 55 (24), 6237-6243 (1995)
   PUBMED   8521420
REFERENCE   9  (bases 1 to 1378)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   10 (bases 1 to 1378)
  AUTHORS   Morrison,B.W., Moorman,J.R., Kowdley,G.C., Kobayashi,Y.M.,
            Jones,L.R. and Leder,P.
  TITLE     Mat-8, a novel phospholemman-like protein expressed in human breast
            tumors, induces a chloride conductance in Xenopus oocytes
  JOURNAL   J Biol Chem 270 (5), 2176-2182 (1995)
   PUBMED   7836447
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020907.6, BQ682674.1,
            BC090044.1, BE793135.1, U28249.1 and AW250864.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005971.3.
            
            Summary: This gene belongs to a small family of FXYD-domain
            containing regulators of Na+/K+ ATPases which share a 35-amino acid
            signature sequence domain, beginning with the sequence PFXYD, and
            containing 7 invariant and 6 highly conserved amino acids. This
            gene encodes a cell membrane protein that may regulate the function
            of ion-pumps and ion-channels. This gene may also play a role in
            tumor progression. Alternative splicing results in multiple
            transcript variants encoding distinct isoforms.[provided by RefSeq,
            Oct 2008].
            
            Transcript Variant: This variant (1) lacks multiple exons in the 5'
            coding region, compared to variant 3. These differences result in
            translation initiation from a downstream in-frame ATG and an
            isoform (1) with a shorter N-terminus when compared to isoform 3.
            Variants 1, 7, and 9-12 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090044.1, BQ884244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000604404.6/ ENSP00000474438.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC020907.6         129326-129330
            6-56                BQ682674.1         246-296
            57-683              BC090044.1         1-627
            684-714             BE793135.1         454-484
            715-896             U28249.1           799-980
            897-1378            AW250864.1         10-491              c
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1378
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /note="FXYD domain containing ion transport regulator 3"
                     /db_xref="GeneID:5349"
                     /db_xref="HGNC:HGNC:4027"
                     /db_xref="MIM:604996"
     exon            1..137
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     exon            138..233
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     exon            234..287
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..511
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; phospholemman-like protein;
                     sodium/potassium-transporting ATPase subunit FXYD3;
                     mammary tumor 8 kDa protein; chloride conductance inducer
                     protein Mat-8"
                     /codon_start=1
                     /product="FXYD domain-containing ion transport regulator 3
                     isoform 1 precursor"
                     /protein_id="NP_005962.1"
                     /db_xref="CCDS:CCDS12442.1"
                     /db_xref="GeneID:5349"
                     /db_xref="HGNC:HGNC:4027"
                     /db_xref="MIM:604996"
                     /translation="MQKVTLGLLVFLAGFPVLDANDLEDKNSPFYYDWHSLQVGGLIC
                     AGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS"
     exon            288..320
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     exon            321..344
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     exon            345..419
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     exon            420..456
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     exon            457..494
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     exon            495..1378
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      711
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /note="major polyA site"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
                     /note="hexamer: AATAAA"
     polyA_site      1378
                     /gene="FXYD3"
                     /gene_synonym="MAT8; PLML"
ORIGIN      
        1 ggtcacgcta gcatcttctg ctgatcctga aattgtacca gcggcaagat gtggcctgga
       61 aggggacttt aagttctcca caactgccag caatccttcc accaggcaaa acacatcatc
      121 taaggaaaag aagtgaggtt tgcttagggc gtggcagctt cggataaacg caggactccg
      181 cctggcagcc cgatttctcc cggaacctct gctcagcctg gtgaaccaca caggccagcg
      241 ctctgacatg cagaaggtga ccctgggcct gcttgtgttc ctggcaggct ttcctgtcct
      301 ggacgccaat gacctagaag ataaaaacag tcctttctac tatgactggc acagcctcca
      361 ggttggcggg ctcatctgcg ctggggttct gtgcgccatg ggcatcatca tcgtcatgag
      421 tgcaaaatgc aaatgcaagt ttggccagaa gtccggtcac catccagggg agactccacc
      481 tctcatcacc ccaggctcag cccaaagctg atgaggacag accagctgaa attgggtgga
      541 ggaccgttct ctgtccccag gtcctgtctc tgcacagaaa cttgaactcc aggatggaat
      601 tcttcctcct ctgctgggac tcctttgcat ggcagggcct catctcacct ctcgcaagag
      661 ggtctctttg ttcaattttt tttaatctaa aatgattgtg cctctgccca agcagcctgg
      721 agacttccta tgtgtgcatt ggggtggggc ttggggcacc atgagaaggt tggcgtgccc
      781 tggaggctga cacagaggct ggcactgagc ctgcttgttg ggaaaagccc acaggcctgt
      841 tcccttgtgg cttgggacat ggcacaggcc cgccctctgc ctcctcagcc atgggaacct
      901 catatgcaat ttgggattta ctagtagcca aaaggaatga aagagagctc taaccagatg
      961 gaacactgga acattccagt ggaccctgga ccattccagg aaaactggga cataggatcg
     1021 tcccgctatg atggaagtgt tcagacagtt tataatagta agcccctgtg accctctcac
     1081 ttaccccgag acctcacttt attacaagat ctttccaaat acccaaatgt ccctgcaagc
     1141 ccgttaaata attccctatg ctacccttaa taacatacaa tgaccacata gtgtgagaac
     1201 ttccaacaag cctcaaagtc ccttgagact ccccaatacc taataaggca tgcgaaatgt
     1261 tctcatgaac taccccacaa cacgcctaaa actcaaaaca cccaaaaata tctcctccaa
     1321 tgtcctgaaa catgaaccca aaaagagacc cacaataaac tcgtgacttg tcccctca
//
