LOCUS       NM_004860               2987 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens FMR1 autosomal homolog 2 (FXR2), mRNA.
ACCESSION   NM_004860
VERSION     NM_004860.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2987)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2987)
  AUTHORS   Li,M., Hou,Y., Zhou,Y., Yang,Z., Zhao,H., Jian,T., Yu,Q., Zeng,F.,
            Liu,X., Zhang,Z. and Zhao,Y.G.
  TITLE     LLPS of FXR proteins drives replication organelle clustering for
            beta-coronaviral proliferation
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38587486
  REMARK    GeneRIF: LLPS of FXR proteins drives replication organelle
            clustering for beta-coronaviral proliferation.
REFERENCE   3  (bases 1 to 2987)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (bases 1 to 2987)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   5  (bases 1 to 2987)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2987)
  AUTHORS   Tamanini,F., Bontekoe,C., Bakker,C.E., van Unen,L., Anar,B.,
            Willemsen,R., Yoshida,M., Galjaard,H., Oostra,B.A. and
            Hoogeveen,A.T.
  TITLE     Different targets for the fragile X-related proteins revealed by
            their distinct nuclear localizations
  JOURNAL   Hum Mol Genet 8 (5), 863-869 (1999)
   PUBMED   10196376
REFERENCE   7  (bases 1 to 2987)
  AUTHORS   Joseph,D.R.
  TITLE     The rat androgen-binding protein (ABP/SHBG) gene contains triplet
            repeats similar to unstable triplets: evidence that the ABP/SHBG
            and the fragile X-related 2 genes overlap
  JOURNAL   Steroids 63 (1), 2-4 (1998)
   PUBMED   9437788
REFERENCE   8  (bases 1 to 2987)
  AUTHORS   Tamanini,F., Willemsen,R., van Unen,L., Bontekoe,C., Galjaard,H.,
            Oostra,B.A. and Hoogeveen,A.T.
  TITLE     Differential expression of FMR1, FXR1 and FXR2 proteins in human
            brain and testis
  JOURNAL   Hum Mol Genet 6 (8), 1315-1322 (1997)
   PUBMED   9259278
REFERENCE   9  (bases 1 to 2987)
  AUTHORS   Siomi,M.C., Zhang,Y., Siomi,H. and Dreyfuss,G.
  TITLE     Specific sequences in the fragile X syndrome protein FMR1 and the
            FXR proteins mediate their binding to 60S ribosomal subunits and
            the interactions among them
  JOURNAL   Mol Cell Biol 16 (7), 3825-3832 (1996)
   PUBMED   8668200
REFERENCE   10 (bases 1 to 2987)
  AUTHORS   Zhang,Y., O'Connor,J.P., Siomi,M.C., Srinivasan,S., Dutra,A.,
            Nussbaum,R.L. and Dreyfuss,G.
  TITLE     The fragile X mental retardation syndrome protein interacts with
            novel homologs FXR1 and FXR2
  JOURNAL   EMBO J 14 (21), 5358-5366 (1995)
   PUBMED   7489725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA114906.1, BC020090.1 and
            AA593676.1.
            
            On May 17, 2019 this sequence version replaced NM_004860.3.
            
            Summary: The protein encoded by this gene is a RNA binding protein
            containing two KH domains and one RCG box, which is similar to FMRP
            and FXR1. It associates with polyribosomes, predominantly with 60S
            large ribosomal subunits. This encoded protein may self-associate
            or interact with FMRP and FXR1. It may have a role in the
            development of fragile X cognitive disability syndrome. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067272.1, U31501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250113.12/ ENSP00000250113.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DA114906.1         1-46
            47-2964             BC020090.1         1-2918
            2965-2987           AA593676.1         30-52               c
FEATURES             Location/Qualifiers
     source          1..2987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2987
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /note="FMR1 autosomal homolog 2"
                     /db_xref="GeneID:9513"
                     /db_xref="HGNC:HGNC:4024"
                     /db_xref="MIM:605339"
     exon            1..446
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2387
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /codon_start=1
                     /product="RNA-binding protein FXR2"
                     /protein_id="NP_004851.2"
                     /db_xref="CCDS:CCDS45604.1"
                     /db_xref="GeneID:9513"
                     /db_xref="HGNC:HGNC:4024"
                     /db_xref="MIM:605339"
                     /translation="MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFEN
                     NWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFY
                     VIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEF
                     KKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKH
                     LETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYG
                     ETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDK
                     KNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGF
                     RPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVS
                     TASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSIS
                     SVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLES
                     DGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQ
                     RPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS"
     exon            447..499
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            500..593
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            594..665
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            666..814
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            815..908
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1025
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1196
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1275
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1385
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1472
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1695
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1893
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2094
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2190
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2291
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2987
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /note="hexamer: AATAAA"
     polyA_site      2987
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /note="major polyA site"
ORIGIN      
        1 gcagtaggcg gcggtggcag ggggaggtgg aggctgtgga gcggcagcgg cagcagcggg
       61 tcccgggact gaggcagcag cgggggcggc ggcgggcgga agctgaggtg acgaaggcag
      121 cggcggcggc ggccgtttcc ctcacggtgg cggagaccaa ggcggcggcg gcggacgggg
      181 agcggcccgg ccccggcccc ctgctcgttg gctgtggcag ggccgccgtg gggccggccc
      241 ggctcccgcc ccccgcggct ccccctccgg ctcctcctcc ggggagacgc cgggggcctg
      301 gcccggcccg cactcagact gctgctgcag ccgccgccgg gggagtcgga ggcggtggcg
      361 gcgccatggg cggcctggcc tctggggggg atgtggagcc gggactgccc gtcgaggtgc
      421 gcggctccaa cggggccttc tacaagggct ttgtgaagga tgtccatgaa gactctgtca
      481 ccatcttctt tgaaaacaac tggcagagtg agagacaaat tccttttggg gatgtccggc
      541 taccacctcc agctgactat aataaggaga tcacagaagg ggatgaagtg gaggtttatt
      601 ctcgagccaa tgaacaggaa ccttgtggct ggtggctggc ccgggtgcgg atgatgaagg
      661 gagatttcta tgtcattgaa tatgctgcct gtgatgccac ctacaatgaa attgttaccc
      721 tggagcgact tcggccagtt aatcccaatc cccttgcaac caaaggcagc ttcttcaagg
      781 ttaccatggc tgtgcccgag gatctgagag aagcctgctc caatgaaaac gtccataaag
      841 agttcaagaa agccctggga gccaactgca tctttctcaa catcacaaac agtgagctct
      901 tcattctgtc aaccacagaa gcccctgtga agcgagcatc tctgctgggt gatatgcatt
      961 tccgaagcct gcgcaccaaa ctgctactta tgtcccgcaa tgaagaagct accaagcacc
     1021 tagagacaag caagcagttg gcagcagcct tccaagagga gttcacagtg cgagaggacc
     1081 tgatgggact ggcaattggg actcacggtg ccaacatcca gcaggcccga aaagtacctg
     1141 gggtgaccgc cattgagttg ggtgaagaga cctgcacttt ccgcatctat ggggagactc
     1201 ccgaggcttg ccgacaggcc cgaagctacc ttgagttttc tgaggactca gtgcaagtgc
     1261 ccaggaacct ggttggcaaa gtgattggaa agaacgggaa agtgatccag gagattgtgg
     1321 ataaatctgg tgtggtgagg gttcgagtgg aaggtgataa tgacaagaag aaccccaggg
     1381 aggagggaat ggttcccttc atttttgttg gcacccgaga gaacatcagc aatgcccagg
     1441 ctttgctgga gtatcacctc tcctacctgc aggaggtaga gcagcttcgc ttggagaggc
     1501 tacaaattga tgagcagctt cggcagattg ggctgggctt tcgccctcct gggagtgggc
     1561 ggggcagcgg tggcagcgac aaggctggat atagcactga tgagagctcc tcctcctccc
     1621 tccatgcgac tcgaacctat gggggcagct atgggggccg tggccgtggc cggaggacag
     1681 gcggtcctgc ctatggcccc agctcagatg tgtctacagc ttcagagact gagtcagaga
     1741 agagagagga gcccaaccga gctgggcctg gcgacaggga tcccccaacc cgaggggaag
     1801 aaagccggag gcggccgact gggggccggg gtaggggacc cccacctgcc ccccggccca
     1861 cttcgagata caattcttca tctattagct cagtgctgaa ggatccagac agtaatccct
     1921 acagcctatt ggacacgtct gaaccagagc ccccggttga ttcagaacct ggggaacccc
     1981 ccccagcaag tgccaggcgc cgccgctccc gccgccgccg cactgatgaa gacaggaccg
     2041 tcatggatgg aggcctggaa tcagatgggc ccaacatgac agagaatggc ctggaagatg
     2101 aatcaagacc tcaacgtcgt aatcgcagcc gccgccgccg taaccgtggt aatcggactg
     2161 atggctctat cagtggagac cgccagccag tgactgtggc tgactatatc tcacgagcag
     2221 agtctcagag ccgccagagg ccacccctgg aacgcactaa accctcagaa gactctcttt
     2281 caggacagaa gggtgactct gtcagcaagc ttcctaaggg cccctcggag aatggggagc
     2341 tctccgcccc cttggagttg ggtagtatgg tgaatggggt ttcataaaac ctccaacctg
     2401 cacccctccc ttctccatct cgcttgctgc ccaacaccat ggccctcaca ggcccaactg
     2461 acctgcgctg gagctgctct tatctagggg ggaggggggt ggcacagcag cttgggtacc
     2521 ccccaacctc caggagctag tggaggggtg tgtaacaggg tcataccccc tccctcttgt
     2581 ccaccctacc cccagggtaa ggggagcctc tctccttccc catcagactg gatgtgcctt
     2641 tatcctctaa tgccccaatc tctctctgaa cacccccatt ctccacctgt tggtgggggg
     2701 tgctcctcga cccacccaga tttgaccgtt cagggggcct cccctgctat ccctcctccc
     2761 atcctgtacc ccccatttct ggggcctcat cactgtggaa gacggggata gtaagagata
     2821 agtgggtggg aggcacgggg aaggttttgg agtagaacca ggggtgtgta tgaagggggg
     2881 tgacaaggtc cccctgggga ggggaccaac cttgtctggt ggatgagaag gcgtatttat
     2941 ttttcactgt acagtattta aaaagagaat aaaaaaatcc aaatggc
//
