LOCUS       NP_004851                673 aa            linear   PRI 28-APR-2025
DEFINITION  RNA-binding protein FXR2 [Homo sapiens].
ACCESSION   NP_004851
VERSION     NP_004851.2
DBSOURCE    REFSEQ: accession NM_004860.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 673)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 673)
  AUTHORS   Li,M., Hou,Y., Zhou,Y., Yang,Z., Zhao,H., Jian,T., Yu,Q., Zeng,F.,
            Liu,X., Zhang,Z. and Zhao,Y.G.
  TITLE     LLPS of FXR proteins drives replication organelle clustering for
            beta-coronaviral proliferation
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38587486
  REMARK    GeneRIF: LLPS of FXR proteins drives replication organelle
            clustering for beta-coronaviral proliferation.
REFERENCE   3  (residues 1 to 673)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (residues 1 to 673)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   5  (residues 1 to 673)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (residues 1 to 673)
  AUTHORS   Tamanini,F., Bontekoe,C., Bakker,C.E., van Unen,L., Anar,B.,
            Willemsen,R., Yoshida,M., Galjaard,H., Oostra,B.A. and
            Hoogeveen,A.T.
  TITLE     Different targets for the fragile X-related proteins revealed by
            their distinct nuclear localizations
  JOURNAL   Hum Mol Genet 8 (5), 863-869 (1999)
   PUBMED   10196376
REFERENCE   7  (residues 1 to 673)
  AUTHORS   Joseph,D.R.
  TITLE     The rat androgen-binding protein (ABP/SHBG) gene contains triplet
            repeats similar to unstable triplets: evidence that the ABP/SHBG
            and the fragile X-related 2 genes overlap
  JOURNAL   Steroids 63 (1), 2-4 (1998)
   PUBMED   9437788
REFERENCE   8  (residues 1 to 673)
  AUTHORS   Tamanini,F., Willemsen,R., van Unen,L., Bontekoe,C., Galjaard,H.,
            Oostra,B.A. and Hoogeveen,A.T.
  TITLE     Differential expression of FMR1, FXR1 and FXR2 proteins in human
            brain and testis
  JOURNAL   Hum Mol Genet 6 (8), 1315-1322 (1997)
   PUBMED   9259278
REFERENCE   9  (residues 1 to 673)
  AUTHORS   Siomi,M.C., Zhang,Y., Siomi,H. and Dreyfuss,G.
  TITLE     Specific sequences in the fragile X syndrome protein FMR1 and the
            FXR proteins mediate their binding to 60S ribosomal subunits and
            the interactions among them
  JOURNAL   Mol Cell Biol 16 (7), 3825-3832 (1996)
   PUBMED   8668200
REFERENCE   10 (residues 1 to 673)
  AUTHORS   Zhang,Y., O'Connor,J.P., Siomi,M.C., Srinivasan,S., Dutra,A.,
            Nussbaum,R.L. and Dreyfuss,G.
  TITLE     The fragile X mental retardation syndrome protein interacts with
            novel homologs FXR1 and FXR2
  JOURNAL   EMBO J 14 (21), 5358-5366 (1995)
   PUBMED   7489725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA114906.1, BC020090.1 and
            AA593676.1.
            
            On Sep 22, 2009 this sequence version replaced NP_004851.1.
            
            Summary: The protein encoded by this gene is a RNA binding protein
            containing two KH domains and one RCG box, which is similar to FMRP
            and FXR1. It associates with polyribosomes, predominantly with 60S
            large ribosomal subunits. This encoded protein may self-associate
            or interact with FMRP and FXR1. It may have a role in the
            development of fragile X cognitive disability syndrome. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067272.1, U31501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250113.12/ ENSP00000250113.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     Protein         1..673
                     /product="RNA-binding protein FXR2"
                     /calculated_mol_wt=74092
     Region          13..67
                     /region_name="Tudor_Agenet_FXR2_rpt1"
                     /note="first Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 2 (FXR2) and
                     similar proteins; cd20473"
                     /db_xref="CDD:410544"
     Site            order(20,24,26,42,46,48)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410544"
     Region          69..136
                     /region_name="Tudor_Agenet_FXR2_rpt2"
                     /note="second Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 2 (FXR2) and
                     similar proteins; cd20476"
                     /db_xref="CDD:410547"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q61584; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            order(79,88,90,106,111,113)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410547"
     Region          133..209
                     /region_name="KH_I_FXR2_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 2 (FXR2) and similar proteins; cd22505"
                     /db_xref="CDD:411933"
     Site            192
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Region          228..290
                     /region_name="KH_I_FXR2_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 2 (FXR2) and similar proteins; cd22508"
                     /db_xref="CDD:411936"
     Site            order(238,240..242,244..248,251..252,255..256,262..265)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411936"
     Region          291..368
                     /region_name="KH_I_FXR2_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 2 (FXR2) and similar proteins; cd22511"
                     /db_xref="CDD:411939"
     Site            order(301,303..305,307..311,314..315,318..319,325..328)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411939"
     Region          364..478
                     /region_name="FXMRP1_C_core"
                     /note="Fragile X-related 1 protein core C terminal;
                     pfam12235"
                     /db_xref="CDD:463501"
     Region          389..673
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51116.2)"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            411
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            450
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61584; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            453
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Region          502..577
                     /region_name="FXR_C1"
                     /note="Fragile X-related 1 protein C-terminal region 2;
                     pfam16096"
                     /db_xref="CDD:465019"
     Site            533
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            566
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (P51116.2)"
     Site            580
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            598
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18220336,
                     ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            601
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P51116.2)"
     Site            603
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (P51116.2)"
     CDS             1..673
                     /gene="FXR2"
                     /gene_synonym="FMR1L2; FXR2P"
                     /coded_by="NM_004860.4:366..2387"
                     /db_xref="CCDS:CCDS45604.1"
                     /db_xref="GeneID:9513"
                     /db_xref="HGNC:HGNC:4024"
                     /db_xref="MIM:605339"
ORIGIN      
        1 mgglasggdv epglpvevrg sngafykgfv kdvhedsvti ffennwqser qipfgdvrlp
       61 ppadynkeit egdevevysr aneqepcgww larvrmmkgd fyvieyaacd atyneivtle
      121 rlrpvnpnpl atkgsffkvt mavpedlrea csnenvhkef kkalgancif lnitnselfi
      181 lstteapvkr asllgdmhfr slrtklllms rneeatkhle tskqlaaafq eeftvredlm
      241 glaigthgan iqqarkvpgv taielgeetc tfriygetpe acrqarsyle fsedsvqvpr
      301 nlvgkvigkn gkviqeivdk sgvvrvrveg dndkknpree gmvpfifvgt renisnaqal
      361 leyhlsylqe veqlrlerlq ideqlrqigl gfrppgsgrg sggsdkagys tdessssslh
      421 atrtyggsyg grgrgrrtgg paygpssdvs tasetesekr eepnragpgd rdpptrgees
      481 rrrptggrgr gpppaprpts rynsssissv lkdpdsnpys lldtsepepp vdsepgeppp
      541 asarrrrsrr rrtdedrtvm dgglesdgpn mtengledes rpqrrnrsrr rrnrgnrtdg
      601 sisgdrqpvt vadyisraes qsrqrppler tkpsedslsg qkgdsvsklp kgpsengels
      661 aplelgsmvn gvs
//
