LOCUS       NM_005087               8343 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens FMR1 autosomal homolog 1 (FXR1), transcript variant 1,
            mRNA.
ACCESSION   NM_005087
VERSION     NM_005087.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8343)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8343)
  AUTHORS   Chen,X., Fansler,M.M., Janjos,U., Ule,J. and Mayr,C.
  TITLE     The FXR1 network acts as a signaling scaffold for actomyosin
            remodeling
  JOURNAL   Cell 187 (18), 5048-5063 (2024)
   PUBMED   39106863
  REMARK    GeneRIF: The FXR1 network acts as a signaling scaffold for
            actomyosin remodeling.
REFERENCE   3  (bases 1 to 8343)
  AUTHORS   Li,M., Hou,Y., Zhou,Y., Yang,Z., Zhao,H., Jian,T., Yu,Q., Zeng,F.,
            Liu,X., Zhang,Z. and Zhao,Y.G.
  TITLE     LLPS of FXR proteins drives replication organelle clustering for
            beta-coronaviral proliferation
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38587486
  REMARK    GeneRIF: LLPS of FXR proteins drives replication organelle
            clustering for beta-coronaviral proliferation.
REFERENCE   4  (bases 1 to 8343)
  AUTHORS   Khan,F.A., Fang,N., Zhang,W. and Ji,S.
  TITLE     The multifaceted role of Fragile X-Related Protein 1 (FXR1) in
            cellular processes: an updated review on cancer and clinical
            applications
  JOURNAL   Cell Death Dis 15 (1), 72 (2024)
   PUBMED   38238286
  REMARK    GeneRIF: The multifaceted role of Fragile X-Related Protein 1
            (FXR1) in cellular processes: an updated review on cancer and
            clinical applications.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8343)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8343)
  AUTHORS   Tamanini,F., Willemsen,R., van Unen,L., Bontekoe,C., Galjaard,H.,
            Oostra,B.A. and Hoogeveen,A.T.
  TITLE     Differential expression of FMR1, FXR1 and FXR2 proteins in human
            brain and testis
  JOURNAL   Hum Mol Genet 6 (8), 1315-1322 (1997)
   PUBMED   9259278
REFERENCE   7  (bases 1 to 8343)
  AUTHORS   Siomi,M.C., Zhang,Y., Siomi,H. and Dreyfuss,G.
  TITLE     Specific sequences in the fragile X syndrome protein FMR1 and the
            FXR proteins mediate their binding to 60S ribosomal subunits and
            the interactions among them
  JOURNAL   Mol Cell Biol 16 (7), 3825-3832 (1996)
   PUBMED   8668200
REFERENCE   8  (bases 1 to 8343)
  AUTHORS   Coy,J.F., Sedlacek,Z., Bachner,D., Hameister,H., Joos,S.,
            Lichter,P., Delius,H. and Poustka,A.
  TITLE     Highly conserved 3' UTR and expression pattern of FXR1 points to a
            divergent gene regulation of FXR1 and FMR1
  JOURNAL   Hum Mol Genet 4 (12), 2209-2218 (1995)
   PUBMED   8634689
REFERENCE   9  (bases 1 to 8343)
  AUTHORS   Zhang,Y., O'Connor,J.P., Siomi,M.C., Srinivasan,S., Dutra,A.,
            Nussbaum,R.L. and Dreyfuss,G.
  TITLE     The fragile X mental retardation syndrome protein interacts with
            novel homologs FXR1 and FXR2
  JOURNAL   EMBO J 14 (21), 5358-5366 (1995)
   PUBMED   7489725
REFERENCE   10 (bases 1 to 8343)
  AUTHORS   Siomi,M.C., Siomi,H., Sauer,W.H., Srinivasan,S., Nussbaum,R.L. and
            Dreyfuss,G.
  TITLE     FXR1, an autosomal homolog of the fragile X mental retardation gene
  JOURNAL   EMBO J 14 (11), 2401-2408 (1995)
   PUBMED   7781595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC352767.1, AK292633.1 and
            AC008009.5.
            
            On Nov 22, 2018 this sequence version replaced NM_005087.3.
            
            Summary: The protein encoded by this gene is an RNA binding protein
            that interacts with the functionally-similar proteins FMR1 and
            FXR2. These proteins shuttle between the nucleus and cytoplasm and
            associate with polyribosomes, predominantly with the 60S ribosomal
            subunit. Three transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.24403.1,
                                           SRR1803617.183754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357559.9/ ENSP00000350170.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                DC352767.1         225-319
            96-1994             AK292633.1         96-1994
            1995-8343           AC008009.5         72297-78645
FEATURES             Location/Qualifiers
     source          1..8343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..8343
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="FMR1 autosomal homolog 1"
                     /db_xref="GeneID:8087"
                     /db_xref="HGNC:HGNC:4023"
                     /db_xref="MIM:600819"
     exon            1..67
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1882
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="isoform a is encoded by transcript variant 1;
                     RNA-binding protein FXR1; FMR1 autosomal protein-like
                     protein 1"
                     /codon_start=1
                     /product="RNA-binding protein FXR1 isoform a"
                     /protein_id="NP_005078.2"
                     /db_xref="CCDS:CCDS3238.1"
                     /db_xref="GeneID:8087"
                     /db_xref="HGNC:HGNC:4023"
                     /db_xref="MIM:600819"
                     /translation="MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPF
                     NEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDAT
                     YNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIF
                     YHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAA
                     FHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKAR
                     GFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVP
                     FVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRG
                     PNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVS
                     GGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRR
                     RRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMA
                     KDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS"
     exon            68..120
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            121..214
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            215..286
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            287..435
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            436..529
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            530..646
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            647..817
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            818..896
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1006
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1093
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1151
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1214
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1418
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1619
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1711
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..8343
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="hexamer: ATTAAA"
     polyA_site      2136
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="major polyA site"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="hexamer: AATAAA"
     polyA_site      2752
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="major polyA site"
     regulatory      5255..5260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="hexamer: AATAAA"
     polyA_site      5282
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
     regulatory      8031..8036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="hexamer: AATAAA"
     polyA_site      8060
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
     regulatory      8321..8326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
                     /note="hexamer: AATAAA"
     polyA_site      8343
                     /gene="FXR1"
                     /gene_synonym="CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1P;
                     MYOPMIL; MYORIBF"
ORIGIN      
        1 cctttgcggt tccaacatgg cggagctgac ggtggaggtt cgcggctcta acggggcttt
       61 ctacaaggga tttatcaaag atgttcatga agactccctt acagttgttt ttgaaaataa
      121 ttggcaacca gaacgccagg ttccatttaa tgaagttaga ttaccaccac cacctgatat
      181 aaaaaaagaa attagtgaag gagatgaagt agaggtatat tcaagagcaa atgaccaaga
      241 gccatgtggg tggtggttgg ctaaagttcg gatgatgaaa ggagaatttt atgtcattga
      301 atatgctgct tgtgacgcta cttacaatga aatagtcaca tttgaacgac ttcggcctgt
      361 caatcaaaat aaaactgtca aaaaaaatac cttctttaaa tgcacagtgg atgttcctga
      421 ggatttgaga gaggcgtgtg ctaatgaaaa tgcacataaa gattttaaga aagcagtagg
      481 agcatgcaga attttttacc atccagaaac aacacagcta atgatactgt ctgccagtga
      541 agcaactgtg aagagagtaa acatcttaag tgacatgcat ttgcgaagta ttcgtacgaa
      601 gttgatgctt atgtccagaa atgaagaggc cactaagcat ttagaatgca caaaacaact
      661 tgcagcagct tttcatgagg aatttgttgt gagagaagat ttaatgggcc tggcaatagg
      721 aacacatggt agtaacatcc agcaagctag gaaggttcct ggagttaccg ccattgagct
      781 agatgaagat actggaacat tcagaatcta cggagagagt gctgatgctg taaaaaaggc
      841 tagaggtttc ttggaatttg tggaggattt tattcaggtt cctaggaatc tcgttggaaa
      901 agtaattgga aaaaatggca aagttattca agaaatagtg gacaaatctg gtgtggttcg
      961 agtgagaatt gaaggggaca atgaaaataa attacccaga gaagacggta tggttccatt
     1021 tgtatttgtt ggcactaaag aaagcattgg aaatgtgcag gttcttctag agtatcatat
     1081 tgcctatcta aaggaagtag aacagctaag aatggaacgc ctacagattg atgaacagct
     1141 gcgacagatt ggttctaggt cttatagcgg aagaggcaga ggtcgtcggg gacctaatta
     1201 cacctccggt tatggtacaa attctgagct gtctaacccc tctgaaacgg aatctgagcg
     1261 taaagacgag ctgagtgatt ggtcattggc aggagaagat gatcgagaca gccgacatca
     1321 gcgtgacagc aggagacgcc caggaggaag aggcagaagt gtttcagggg gtcgaggtcg
     1381 tggtggacca cgtggtggca aatcctccat cagttctgtg ctcaaagatc cagacagcaa
     1441 tccatacagc ttacttgata atacagaatc agatcagact gcagacactg atgccagcga
     1501 atctcatcac agtactaacc gtcgtaggcg gtctcgtaga cgaaggactg atgaagatgc
     1561 tgttctgatg gatggaatga ctgaatctga tacagcttca gttaatgaaa atgggctagt
     1621 cacagttgca gattatattt ctagagctga gtctcagagc agacaaagaa acctcccaag
     1681 ggaaactttg gctaaaaaca agaaagaaat ggcaaaagat gtgattgaag agcatggtcc
     1741 ttcagaaaag gcaataaacg gcccaactag tgcttctggc gatgacattt ctaagctaca
     1801 gcgtactcca ggagaagaaa agattaatac cttaaaagaa gaaaacactc aagaagcagc
     1861 agtcctgaat ggtgtttcat aaactgaaga agttcctagt ttacagttct tttacattac
     1921 atttacaata gtgcttgtac aagcttgcca aagatagaat atggatcgcc agtctttaca
     1981 tcgcactttc agttcctcca tttggaattc aaaaagggga gggatcctga agaaatcata
     2041 tgttaaacat actttgacac ctactgtgtt ataaaatata tcatcagatg tgccttgaga
     2101 atagtatatg taacattaaa aaaaagttgc tggctatagg aaatgttatt ttgttttcaa
     2161 aatatggcag agatgggggg tggtgggtgg ggtgggatcc ctaacgtaat attctttatg
     2221 aaagcattag ctgcttttgt tacattttta atatgcaacc acttcttcac ctgaggaaaa
     2281 ctagaatgaa atgcagtcta aaatattttg cactgaattg taatttcttc attagtttag
     2341 tctggaaact ggtctgtttt aatgtgtttt ttaaatgctg tatgtagagg aaaatctgca
     2401 gaccactgga atacatttgt taaactctca tctgcaggga cactgggcga tacttggcag
     2461 tgactgttct accttgaggc tttgtttggt ttatttatta aagtgtacag tatttaaaaa
     2521 tcaaacatag ctttagttaa aacactaagc tgaattagtc atgtccattc agacataacc
     2581 tgaactactg aaaagatcaa tttccagaag gtttattctg tataaactac atgttagtct
     2641 tcagtagagt atcttttttt tttccttttt ttttttttta tttcggttgt ttgatgtgca
     2701 atatgttttt gtatgcaggt agtaaataaa ctttgatctt ccatttgctg aattttttta
     2761 actttctact ttttacacca attgttgcaa aatagttgga gctattaata ggcttaggat
     2821 agtatacttt gctttttaaa aagcatttat acttgctcat aaatagcatt aaaatgtcag
     2881 ttggccattt aatcattttg taatgaatca tctgaaatct ttacacaagt ttaggctgtt
     2941 agatgcatag gtaattaata atacatgtga taattagcaa aaaaacctaa caaaattcta
     3001 atcaaaggca actttggaag acaatggggg atagaaggga tgacaagcaa tttttaaata
     3061 ataggccaat gatttgcttt attcattctc aacttatttt gaaggctctc atatcagtga
     3121 ccaaaaatca gttattaaac tttatgtata tattttagcc agagcttaat ttttatgaag
     3181 ataaagacat gaagtttaac aatggacaac agttagtaca gctaattgtg aggtcaagta
     3241 attgttagac ataggggaag gctttgttcc acaatattat atggaccact gaacaagaat
     3301 gacagccctt tgttatcact tggcatatga aaagtgttgt gtgcatagtt tgtgttaatt
     3361 ttttatgtgc ataaaaatgt gattttaatt tatatgctct gaaggataat tcagggtata
     3421 gttaaaaatg tacaatgtgc cagttcagta tatataaccc tagccctcaa attattctga
     3481 ttaaggttaa aatgtgctgg tattacgtgc tttttcctga ggccttctga ttggttcttg
     3541 gtaacagaat tttaaagtaa ggtgtgagta gtgcaactcc tgtcctttat atataaagat
     3601 atcaagtaat ttcatgtcct gatatttaaa aaaattaccc acaaatgtgt ttttttaaat
     3661 cgatcaaagc tagcaacagg ttaaattgtc tcagttctct tacataattg ggttaaaaat
     3721 tataaggtat tagaagaatt ttaattaatg ccaaattggt aaatatggtg taaaaaaaaa
     3781 aaaaaagact tttcattttc tcccacatag aatagtcaga tatattaaac atcccttttc
     3841 cataaagatg gtttcaatgg gaatggaaga aacaaaatct taaaagagtg agtatagctg
     3901 aaccaattct tcattctagc aataaccaca ctaagttcat tactttacaa atgactaaac
     3961 ccaatgtctt gtcctttaaa aaatataggt agtgcagaat tgtgataaat acgcatttgt
     4021 ttttttagag agccccactc cccaaagggt agccattaat tcaggtagcc ttttaaatgt
     4081 atttgagagg gttccgtctt tttggctgct atcctagtta ggtgagatgt tgctatggga
     4141 agaacttgcc actatacact aaacagacac ttaagcaaaa gatgtattct ggagcctggc
     4201 acagtagctt atgtctttgg ttctagctac tcaggagcct gaggtgggag catcatttga
     4261 actcagttct gggccactga gaccctcttt aaagagaagg aaaaaaaggt attctggaag
     4321 atcttgtgca gttgcaacaa tgtttcagca tatatatgtg aattcatata tgacacctga
     4381 acggaatcat gaagtaacag ctgagattat atggtggcaa aaatgacctg cttttcctga
     4441 agctttggga ggcctaggat tcttgcttta ggcatcacct ttgttaagcc ttaaaggggg
     4501 ctacaacttg tgcaaaatgg tgtctctggt aacacttcag aaataattgg caaaagtgta
     4561 ataggaatac acaaatcttt attttgaaat aatcttgtat tttaatgtgg aattagaagc
     4621 agcacatcaa actggtgagt tcacagaaac ttacctgaga tgatgctggg ttccattgct
     4681 gttgtgctaa gtcacgtatt tttgtagctg ctgttagctg tgtctagcgt tttgtaacct
     4741 aaggagggtc ttatagaagt tggtatgtta actaaatctt ggactgggaa acagcaccat
     4801 ttgtatcctc tgcaaacaga tttacgcttt tgaggctcaa accaactagt gttctcatgg
     4861 gctgttgcct aaggacagat aaacatggaa aacaggctat gtccagggac agatgattgg
     4921 tggttaagaa ttacagtaaa ggaaaattac acctggattt tcttctgtaa agtttcaagg
     4981 aacttggatt tgaactgtga atctactgtt ttggcaaaaa atctcaaaga aaaggatgtt
     5041 tgttactgtc tcagtcttcc tgtctttgct acacgatttg gatcccttac gctttttcgt
     5101 taagaatatc tgtctgctat agtgaatttg ctagcccctt attttttttt ttaattttag
     5161 ttctttatta gaacgtgtac ttgaatggac tgtagttgct cataacccat gttaatctct
     5221 gatagtattt gggttttatt tcaggagctt ttgcaataaa gcagtaactg caatctgcta
     5281 aagtcagact gttagcaagt ggtgttaaaa ctgatttaag tccattacac tgaacagtag
     5341 gaaattacca cttttgtaag gctcaaaaat gatcaactat taacagtttc ttatggttca
     5401 gtctaattac aaatttttaa aaagtttatc agtgtatcat ttcagattca tctgtatctt
     5461 ctgtaatatt atttccagta ctgaggtaag gtacacaaaa attcccctgg aaaaactata
     5521 ttctagtttt gtaagatgat ttcccacagt ccatttgctt atttcttcct ttgataattc
     5581 aaaaagatgc tttaggtaat ggtacagaat tagaagctgc tattttagct ctattaactt
     5641 tttctctatg gtttcaattt tatccaacca gagagggctg gcctagttgg tatctttaag
     5701 gcccttccag tagtaatttg agtctagtca catgtcagac cctgagcaac acctaaccaa
     5761 atgcccaagt attctcataa ggagtatgct gaatttaagt ggtgtttgtt ttacatatgt
     5821 atccatccca gacattttca actatgctga atgcaatcta taagatattc caaacaagga
     5881 caaagtaatt tttcacaagt cttacagccc cactattaag tatgctacta attagcttct
     5941 tgaatttctt tgtatttcag tgattgggat gttctttttt tttgggaaag tttttttacc
     6001 cctttgtacc ctcttaattg gattaactgt aaaatgtaca tattaatttt ctagttttag
     6061 agaccatttt cattaaaaat attttccaat agtttttcta gataaacaat ttatacttaa
     6121 ttgttgcttg gttgcttaca tttcaacctc taggcttcct ttttcagcta acttggctgt
     6181 cttcaggttg taaagaaaaa tgtaaacata tatttgaaat ttcattaact gaaactgctg
     6241 taaggtgtta gcaaatgtta accataacag attatcccat atcattggac tgttctatta
     6301 ttgggtcagg aataataggt gacacaggat agaagctctt cctatatata tcttgttgct
     6361 aaggcagtag ttggctctaa gctgataaac agcacactgt acagcagtcc aaaaactaaa
     6421 accagagctt aggtcattca agttaactgg tactcaaggt tactcattcc aggatacttt
     6481 acataaccaa aaacctagga gagcattcta cattgtaatt ttttttttac tttgtttaca
     6541 taaaatttac agggttttgt ttttttaagc ttagtctgtt ctttgacatt gttgattcat
     6601 gttctaaatt ttcatcagat ttaacatgtt tggaggttct tgtgcactca atgtgaacct
     6661 actacaagct tctgaactgc aaaacctttt ttttaggtca ctgtcaacag aaagatgcct
     6721 tatagaattt ctcatgattg aaacagaact ctgcattcta acctaaaacc cctctaaccc
     6781 tttaaatgaa gcattatgcc tgcgtgaaat tttattttta gacatttctg atactaggtt
     6841 ttctttacgg gggggcatac atattcagta tactgaattt atacagcttt cagtgtggca
     6901 atatattaag aagctagttc cctaattttt ctcagttctc attggttttc catttaaatg
     6961 tttccgtaag tactctcatc atttggaaaa tacttgatgg caggagaact tgcttaaaac
     7021 taaaggtgga gaaagagtta acttccagga caacccatta tagctcactt cttaccaaca
     7081 aagcagtttt tatacagcac cttaggactc atttctaatg tcaacccaga tggccagtaa
     7141 aggcaaggga agaggctaag tgactcacaa aaatctctga tattgaggtc taatgtgaag
     7201 gctatagata ggaattcccc acaaacttct aatgaggact aatatgaaca gcaaattgga
     7261 gaagacacca aggacctaat tttagtttca ctagccgtgg gaccttagaa aaaagaccat
     7321 ttgctctgga cttttgtttc ccaagccata aaatgtggaa gaatcttcac aatttcaagt
     7381 tggtcatgta tatttccctt ttacagagaa agctgaagcc tcgaggctca gatttacctg
     7441 gcttctgttt acctggcttc tgcagaagtt taacttgtaa cctacctctc attcccaaag
     7501 tgtgtttaat catgccgcct tctttaaaat atatctggaa gcaccaatga gtaaagacaa
     7561 aggccccaag ctagatctgt agagataagt actagactca catctcagta ctatcaagga
     7621 aaacatgctt aggttatcag aattgtgaag gccatagtac aaaaagttaa gagaacggaa
     7681 ctcaggatct gagaaagatc agccattctc agcatgttgc cttggctgct taaccttact
     7741 aaacttccat ttcctcacat gtaaaatgta catcataata actagtctac tgagataagg
     7801 gaagaatact tagcacagtg ctagtacact gtaagtactc aaatgttaca gatccaagta
     7861 ttttgtaaga aaataccagc aaaagataaa agttttttta tggatcgtat ttgtatcaat
     7921 cacctacatg atctagagcc ctcacatgga taacatttaa atgttcagtt tgcctaatag
     7981 ccttcaatga aacacggatt cttctactta aaaaaggtaa gcctggagaa aataaaactg
     8041 attactatgc aagaaaaaaa tgtgctctgc tgtgctcctt ggtattttta agtggtttcc
     8101 attgtcttaa cacctgtctt aaaacgggta tgttgtttgc actgaaccct caaaagtatt
     8161 tatacctatt aagttaaatt tcccttttta gagttaatgc ttcattgcct gtcggcatat
     8221 tatcactatc tgtctttgaa aaattttctt ttaagtctca actatttctt cataaagctc
     8281 ttgttcagag aaacattttt tgatttgtcc aatggactga aataaaaggt tagtaaacca
     8341 aaa
//
