LOCUS       NM_181425               6986 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens frataxin (FXN), transcript variant 2, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_181425
VERSION     NM_181425.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6986)
  AUTHORS   Guo,Y., Cheng,X., Huang,C., Gao,J. and Shen,W.
  TITLE     Frataxin Loss Promotes Angiotensin II-Induced
            Endothelial-to-Mesenchymal Transition
  JOURNAL   J Am Heart Assoc 13 (15), e034316 (2024)
   PUBMED   39023059
  REMARK    GeneRIF: Frataxin Loss Promotes Angiotensin II-Induced
            Endothelial-to-Mesenchymal Transition.
REFERENCE   2  (bases 1 to 6986)
  AUTHORS   Dong,Y.N., Mercado-Ayon,E., Coulman,J., Flatley,L., Ngaba,L.V.,
            Adeshina,M.W. and Lynch,D.R.
  TITLE     The Regulation of the Disease-Causing Gene FXN
  JOURNAL   Cells 13 (12), 1040 (2024)
   PUBMED   38920668
  REMARK    GeneRIF: The Regulation of the Disease-Causing Gene FXN.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6986)
  AUTHORS   Da Conceicao,L.M.A., Cabral,L.M., Pereira,G.R.C. and De
            Mesquita,J.F.
  TITLE     An In Silico Analysis of Genetic Variants and Structural Modeling
            of the Human Frataxin Protein in Friedreich's Ataxia
  JOURNAL   Int J Mol Sci 25 (11), 5796 (2024)
   PUBMED   38891993
  REMARK    GeneRIF: An In Silico Analysis of Genetic Variants and Structural
            Modeling of the Human Frataxin Protein in Friedreich's Ataxia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6986)
  AUTHORS   Pietrangeli,P., Marcocci,L., Pennacchietti,V., Diop,A., Di
            Felice,M., Pagano,L., Malagrino,F., Toto,A., Brunori,M. and
            Gianni,S.
  TITLE     The Mechanism of Folding of Human Frataxin in Comparison to the
            Yeast Homologue - Broad Energy Barriers and the General Properties
            of the Transition State
  JOURNAL   J Mol Biol 436 (10), 168555 (2024)
   PUBMED   38552947
  REMARK    GeneRIF: The Mechanism of Folding of Human Frataxin in Comparison
            to the Yeast Homologue - Broad Energy Barriers and the General
            Properties of the Transition State.
REFERENCE   5  (bases 1 to 6986)
  AUTHORS   Bidichandani,S.I., Ashizawa,T. and Patel,P.I.
  TITLE     Atypical Friedreich ataxia caused by compound heterozygosity for a
            novel missense mutation and the GAA triplet-repeat expansion
  JOURNAL   Am J Hum Genet 60 (5), 1251-1256 (1997)
   PUBMED   9150176
REFERENCE   6  (bases 1 to 6986)
  AUTHORS   Carvajal,J.J., Pook,M.A., dos Santos,M., Doudney,K., Hillermann,R.,
            Minogue,S., Williamson,R., Hsuan,J.J. and Chamberlain,S.
  TITLE     The Friedreich's ataxia gene encodes a novel
            phosphatidylinositol-4- phosphate 5-kinase
  JOURNAL   Nat Genet 14 (2), 157-162 (1996)
   PUBMED   8841185
REFERENCE   7  (bases 1 to 6986)
  AUTHORS   Campuzano,V., Montermini,L., Molto,M.D., Pianese,L., Cossee,M.,
            Cavalcanti,F., Monros,E., Rodius,F., Duclos,F., Monticelli,A.,
            Zara,F., Canizares,J., Koutnikova,H., Bidichandani,S.I.,
            Gellera,C., Brice,A., Trouillas,P., De Michele,G., Filla,A., De
            Frutos,R., Palau,F., Patel,P.I., Di Donato,S., Mandel,J.L.,
            Cocozza,S., Koenig,M. and Pandolfo,M.
  TITLE     Friedreich's ataxia: autosomal recessive disease caused by an
            intronic GAA triplet repeat expansion
  JOURNAL   Science 271 (5254), 1423-1427 (1996)
   PUBMED   8596916
REFERENCE   8  (bases 1 to 6986)
  AUTHORS   Montermini,L., Rodius,F., Pianese,L., Molto,M.D., Cossee,M.,
            Campuzano,V., Cavalcanti,F., Monticelli,A., Palau,F., Gyapay,G. et
            al.
  TITLE     The Friedreich ataxia critical region spans a 150-kb interval on
            chromosome 9q13
  JOURNAL   Am J Hum Genet 57 (5), 1061-1067 (1995)
   PUBMED   7485155
  REMARK    Erratum:[Am J Hum Genet 1995 Dec;57(6):1520]
REFERENCE   9  (bases 1 to 6986)
  AUTHORS   Bidichandani,S.I., Delatycki,M.B., Napierala,M. and Duquette,A.
  TITLE     Friedreich Ataxia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301458
REFERENCE   10 (bases 1 to 6986)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162730.26, BF058880.1,
            BC023633.2 and AA232366.1.
            
            On May 31, 2019 this sequence version replaced NM_181425.2.
            
            Summary: This nuclear gene encodes a mitochondrial protein which
            belongs to the FRATAXIN family. The protein functions in regulating
            mitochondrial iron transport and respiration. The expansion of
            intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats
            results in Friedreich ataxia. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, that results in a
            frameshift. It encodes isoform 2, which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.270376.1,
                                           SRR1163657.196832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL162730.26        84488-84627
            141-641             BF058880.1         1-501
            642-1469            BC023633.2         631-1458
            1470-6771           AL162730.26        122296-127597
            6772-6986           AA232366.1         3-217               c
FEATURES             Location/Qualifiers
     source          1..6986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..6986
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="frataxin"
                     /db_xref="GeneID:2395"
                     /db_xref="HGNC:HGNC:3951"
                     /db_xref="MIM:606829"
     exon            1..196
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..622
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /EC_number="1.16.3.1"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; frataxin, mitochondrial; Friedreich ataxia
                     protein"
                     /codon_start=1
                     /product="frataxin, mitochondrial isoform 2 preproprotein"
                     /protein_id="NP_852090.1"
                     /db_xref="CCDS:CCDS43834.1"
                     /db_xref="GeneID:2395"
                     /db_xref="HGNC:HGNC:3951"
                     /db_xref="MIM:606829"
                     /translation="MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRT
                     DIDATCTPRRASSNQRGLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEET
                     LDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPS
                     RYVVDLSVMTGLGKTGCTPTTACPSMSCWPQSSLKP"
     exon            197..294
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     exon            295..415
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     exon            416..521
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     exon            522..6986
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      982..987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: AATAAG"
     polyA_site      1011
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="major polyA site"
     regulatory      1112..1117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: ATTAAA"
     polyA_site      1131
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
     regulatory      2783..2788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: AATAAA"
     polyA_site      2804
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
     regulatory      6965..6970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: AATAAA"
     polyA_site      6986
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
ORIGIN      
        1 agggcggagc gggcggcaga cccggagcag catgtggact ctcgggcgcc gcgcagtagc
       61 cggcctcctg gcgtcaccca gcccagccca ggcccagacc ctcacccggg tcccgcggcc
      121 ggcagagttg gccccactct gcggccgccg tggcctgcgc accgacatcg atgcgacctg
      181 cacgccccgc cgcgcaagtt cgaaccaacg tggcctcaac cagatttgga atgtcaaaaa
      241 gcagagtgtc tatttgatga atttgaggaa atctggaact ttgggccacc caggctctct
      301 agatgagacc acctatgaaa gactagcaga ggaaacgctg gactctttag cagagttttt
      361 tgaagacctt gcagacaagc catacacgtt tgaggactat gatgtctcct ttgggagtgg
      421 tgtcttaact gtcaaactgg gtggagatct aggaacctat gtgatcaaca agcagacgcc
      481 aaacaagcaa atctggctat cttctccatc caggtatgta gtggacctaa gcgttatgac
      541 tggactggga aaaactgggt gtactcccac gacggcgtgt ccctccatga gctgctggcc
      601 gcagagctca ctaaagcctt aaaaaccaaa ctggacttgt cttccttggc ctattccgga
      661 aaagatgctt gatgcccagc cccgttttaa ggacattaaa agctatcagg ccaagacccc
      721 agcttcatta tgcagctgag gtctgttttt tgttgttgtt gttgtttatt ttttttattc
      781 ctgcttttga ggacagttgg gctatgtgtc acagctctgt agaaagaatg tgttgcctcc
      841 taccttgccc ccaagttctg atttttaatt tctatggaag attttttgga ttgtcggatt
      901 tcctccctca catgataccc cttatctttt ataatgtctt atgcctatac ctgaatataa
      961 caacctttaa aaaagcaaaa taataagaag gaaaaattcc aggagggaaa atgaattgtc
     1021 ttcactcttc attctttgaa ggatttactg caagaagtac atgaagagca gctggtcaac
     1081 ctgctcactg ttctatctcc aaatgagaca cattaaaggg tagcctacaa atgttttcag
     1141 gcttctttca aagtgtaagc acttctgagc tctttagcat tgaagtgtcg aaagcaactc
     1201 acacgggaag atcatttctt atttgtgctc tgtgactgcc aaggtgtggc ctgcactggg
     1261 ttgtccaggg agacctagtg ctgtttctcc cacatattca catacgtgtc tgtgtgtata
     1321 tatatttttt caatttaaag gttagtatgg aatcagctgc tacaagaatg caaaaaatct
     1381 tccaaagaca agaaaagagg aaaaaaagcc gttttcatga gctgagtgat gtagcgtaac
     1441 aaacaaaatc atggagctga ggaggtgcct tgtaaacatg aaggggcaga taaaggaagg
     1501 agatactcat gttgataaag agagccctgg tcctagacat agttcagcca caaagtagtt
     1561 gtccctttgt ggacaagttt cccaaattcc ctggacctct gcttccccat ctgttaaatg
     1621 agagaataga gtatggttga ttcccagcat tcagtggtcc tgtcaagcaa cctaacaggc
     1681 tagttctaat tccctattgg gtagatgagg ggatgacaaa gaacagtttt taagctatat
     1741 aggaaacatt gttattggtg ttgccctatc gtgatttcag ttgaattcat gtgaaaataa
     1801 tagccatcct tggcctggcg cggtggctca cacctgtaat cccagcactt ttggaggcca
     1861 aggtgggtgg atcacctgag gtcaggagtt caagaccagc ctggccaaca tgatgaaacc
     1921 ccgtctctac taaaaataca aaaaattagc cgggcatgat ggcaggtgcc tgtaatccca
     1981 gctacttggg aggctgaagc ggaagaatcg cttgaaccca gaggtggagg ttgcagtgag
     2041 ccgagatcgt gccattgcac tgtaacctgg gtgactgagc aaaactctgt ctcaaaataa
     2101 taataacaat ataataataa taatagccat cctttattgt acccttactg ggttaatcgt
     2161 attataccac attacctcat tttaattttt actgacctgc actttataca aagcaacaag
     2221 cctccaggac attaaaattc atgcaaagtt atgctcatgt tatattattt tcttacttaa
     2281 agaaggattt attagtggct gggcatggtg gcgtgcacct gtaatcccag gtactcagga
     2341 ggctgagacg ggagaattgc ttgaccccag gcggaggagg ttacagtgag tcgagatcgt
     2401 acctgagcga cagagcgaga ctccgtctca aaaaaaaaaa aaaggagggt ttattaatga
     2461 gaagtttgta ttaatatgta gcaaaggctt ttccaatggg tgaataaaaa cacattccat
     2521 taagtcaagc tgggagcagt ggcatatacc tatagtccca gctgcacagg aggctgagac
     2581 aggaggattg cttgaagcca ggaattggag atcagcctgg gcaacacagc aagatcctat
     2641 ctcttaaaaa aagaaaaaaa aacctattaa taataaaaca gtataaacaa aagctaaata
     2701 ggtaaaatat tttttctgaa ataaaattat tttttgagtc tgatggaaat gtttaagtgc
     2761 agtaggccag tgccagtgag aaaataaata acatcataca tgtttgtatg tgtttgcatc
     2821 ttgcttctac tgaaagtttc agtgcacccc acttacttag aactcggtga catgatgtac
     2881 tcctttatct gggacacagc acaaaagagg tatgcagtgg ggctgctctg acatgaaagt
     2941 ggaagttaag gaatctgggc tcttatgggg tccttgtggg ccagcccttc aggcctattt
     3001 tactttcatt ttacatatag ctctaattgg tttgattatc tcgttcccaa ggcagtggga
     3061 gatccccatt taaggaaaga aaaggggcct ggcacagtgg ctcatgcctg taatcccagc
     3121 actttgggag gctgaggcaa gtgtatcacc tgaggtcagg agttcaagac cagcctggcc
     3181 aacatggcaa aatcccgtct ctactaaaaa tattaaaaaa ttggctgggc gtggtggttc
     3241 gtgcctataa tttcagctac tcaggaggct gaggcaggag aatcgctgta acctgggggg
     3301 tggaggttgc agtgagacga gatcatgcca cttcactcca gcctggccaa cagagccata
     3361 ctccgtctca aataaataaa taaataaata aagggacttc aaacacatga acagcagcca
     3421 ggggaagaat caaaatcata ttctgtcaag caaactggaa aagtaccact gtgtgtacca
     3481 atagcctccc caccacagac cctgggagca tcgcctcatt tatggtgtgg tccagtcatc
     3541 catgtgaagg atgagtttcc aggaaaaggt tattaaatat tcactgtaac atactggagg
     3601 aggtgaggaa ttgcataata caatcttaga aaactttttt ttcccctttc tattttttga
     3661 gacaggatct cactttggca ctcaggctgg aggacagtgg tacaatcaaa gctcatggca
     3721 gcctcgacct ccctgggctt gggcaatcct cccacaggtg tgcacctcca tagctggcta
     3781 atttgtgtat tttttgtaga gatggggttt caccatgttg cccaggctgg tctctaacac
     3841 ttaggctcaa gtgatccacc tgcctcgtcc tcccaagatg ctgggattac aggtgtgtgc
     3901 cacaggtgtt catcagaaag ctttttctat tatttttacc ttcttgagtg ggtagaacct
     3961 cagccacata gaaaataaaa tgttctggca tgacttattt agctctctgg aattacaaag
     4021 aaggaatgag gtgtgtaaaa gagaacctgg gtttttgaat cacaaattta gaatttaatc
     4081 gaaactctgc ctcttacttg tttgtagaca ctgacagtgg cctcatgttt tttttttttt
     4141 taatctataa aatggagata tctaacatgt tgagcctggg cccacaggca aagcacaatc
     4201 ctgatgtgag aagtactcag ttcatgacaa ctgttgttct cacatgcata gcataatttc
     4261 atattcacat tggaggactt ctcccaaaat atggatgacg ttccctactc aaccttgaac
     4321 ttaatcaaaa tactcagttt acttaacttc gtattagatt ctgattccct ggaaccattt
     4381 atcgtgtgcc ttaccatgct tatattttac ttgatctttt gcataccttc taaaactatt
     4441 ttagccaatt taaaatttga cagtttgcat taaattatag gtttacaata tgctttatcc
     4501 agctatacct gccccaaatt ctgacagatg cttttgccac ctctaaagga agacccatgt
     4561 tcatagtgat ggagtttgtg tggactaacc atgcaaggtt gccaaggaaa aatcgcttta
     4621 cgcttccaag gtacacacta agatgaaagt aattttagtc cgtgtccagt tggattcttg
     4681 gcacatagtt atcttctgct agaacaaact aaaacagcta catgccagca agggagaaag
     4741 gggaaggagg ggcaaagttt tgaaatttca tgtaaattta tgctgttcaa aacgacgagt
     4801 tcatgacttt gtgtatagag taagaaatgc cttttctttt ttgagacaga gtcttgctct
     4861 gtcacccagg ctggagtgca gtggcacgat ctgggctcac tacaacctcc gcctcctggg
     4921 ttcaagcaat tctctgcctc agcctcccga gtagctggga ttacaggtgc ctgccaccac
     4981 acccggctaa tttttgtatt tttagtagag acggggtttc accatcatgg ccaggctggt
     5041 cttgaactcc tgacctagta atccacctgc ctccgcctcc caaagtgctg ggattacagg
     5101 cgtgagccac tgcacccagc cagaaatgcc ttctaatctt tggtttatct taattagcca
     5161 ggacacttgg agtgcatccc gaagtacctg atcagtggcc cctttggaat gtgtaaaact
     5221 cagctcactt atatccctgc atccgctaca gagacagaat ccaagctcat atgttccatc
     5281 ttctctggct gtatagttta aggaatggaa ggcaccagaa cagatttatt gaaatgttta
     5341 ttagctgaag atttatttag acagttgagg aaaacatcag cacccagcag taaaattggc
     5401 tctcaaagat tttcttctcc tgtggaaagt cagacctctg aggccccatc caggtagaag
     5461 tactagtgca agaagggcct ctgctgtcca cttgtgtttc tgtgatctgt gggaacattg
     5521 ttaacgccac atcttgacct caaattgttt agctcctggc cagacacggt ggctcacacc
     5581 tgtaatccca gcactttgag aggctgaggc aggtggatca cctgaggtta ggagttcgag
     5641 gccagcctgg tcaacatggt aaaaccccgc ctctactaaa aatacaaaaa ttagctggcc
     5701 gtagtggcgc acgcctgtta tcccagctac tcgggaggct gaggcaggag aattgcttga
     5761 acctgggtgg tggaggttgc agtgagccga gattacacca ctgcactcca gcctgggtga
     5821 caagagggaa actccattaa aaaaatgtaa ttcccgtgtc tgccatctta agtgtaaagg
     5881 tggctaaatt atatagaaaa ataagacaat atcatttccc aattacattc ctttcctacc
     5941 gcactctatg atgctagctg agatttttcc aaaagaaaat ggcttaaata aaaccctaag
     6001 agaaagaaaa actttaaatc cctccaaagc tcaaaagtaa tagaaacaga tgagtttgga
     6061 gtcaggattt ctctgtaaga ttgcctaggc tgtgtactgc acatctccag gtgccactgt
     6121 tgacagagat tataactaca atgtgaagtg aatggtgcca ctgacagtta tgcaaaccgt
     6181 ccagagcata gccacctgat cctgctggga ttcctcttgc cagtccatca gcagttcccc
     6241 ttgaaagttt caccaaacat cccttaaatc tgccctctcc tgcccgtccc cagtggaggt
     6301 cctcatcatt tttcacctgc atttttgcag gagctttctt atatccacct tcctcctttt
     6361 ctctcagccc atcatctagc tacacagtct ccagggtaag ctttcagaaa ggcaatctct
     6421 tgtctgtaaa acctaagcag gaccaaggcc aagtttctta gcctgaaaaa tgtgcttttc
     6481 tgactgaact gttcaggcac tgactctaca tataattatg cttttctacc ccctcacact
     6541 caacactttg actccagcaa tcccaaatcc ccagatccct aagtgtgctg tgctattttc
     6601 acgtggctct cagacttggc cagtgctgtt tccattttgg tctttattcc ccacatctct
     6661 gcctgggggg tagattctac cctgaaaaat gttcttggca cagccttgca aactcctcct
     6721 ccactcagcc tctgcctgga tgcccttgat tgttccatgt cctcagcata ccatgtttgt
     6781 ctttcccagc actgacctac catgtgtcac ccctgcttgg ctgtaccttc catgaggcta
     6841 ggactatgtg tctcctttgt tgactgctgt tgccctagca tcttgcacag ttccttgcac
     6901 acaattagag ctctataaat gtcaaataaa tgtgttataa ttatatgttt aagatagttg
     6961 ttcaaataaa ctctaaataa ccccaa
//
