LOCUS       NM_000144               6978 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens frataxin (FXN), transcript variant 1, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_000144
VERSION     NM_000144.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6978)
  AUTHORS   Guo,Y., Cheng,X., Huang,C., Gao,J. and Shen,W.
  TITLE     Frataxin Loss Promotes Angiotensin II-Induced
            Endothelial-to-Mesenchymal Transition
  JOURNAL   J Am Heart Assoc 13 (15), e034316 (2024)
   PUBMED   39023059
  REMARK    GeneRIF: Frataxin Loss Promotes Angiotensin II-Induced
            Endothelial-to-Mesenchymal Transition.
REFERENCE   2  (bases 1 to 6978)
  AUTHORS   Dong,Y.N., Mercado-Ayon,E., Coulman,J., Flatley,L., Ngaba,L.V.,
            Adeshina,M.W. and Lynch,D.R.
  TITLE     The Regulation of the Disease-Causing Gene FXN
  JOURNAL   Cells 13 (12), 1040 (2024)
   PUBMED   38920668
  REMARK    GeneRIF: The Regulation of the Disease-Causing Gene FXN.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6978)
  AUTHORS   Da Conceicao,L.M.A., Cabral,L.M., Pereira,G.R.C. and De
            Mesquita,J.F.
  TITLE     An In Silico Analysis of Genetic Variants and Structural Modeling
            of the Human Frataxin Protein in Friedreich's Ataxia
  JOURNAL   Int J Mol Sci 25 (11), 5796 (2024)
   PUBMED   38891993
  REMARK    GeneRIF: An In Silico Analysis of Genetic Variants and Structural
            Modeling of the Human Frataxin Protein in Friedreich's Ataxia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6978)
  AUTHORS   Pietrangeli,P., Marcocci,L., Pennacchietti,V., Diop,A., Di
            Felice,M., Pagano,L., Malagrino,F., Toto,A., Brunori,M. and
            Gianni,S.
  TITLE     The Mechanism of Folding of Human Frataxin in Comparison to the
            Yeast Homologue - Broad Energy Barriers and the General Properties
            of the Transition State
  JOURNAL   J Mol Biol 436 (10), 168555 (2024)
   PUBMED   38552947
  REMARK    GeneRIF: The Mechanism of Folding of Human Frataxin in Comparison
            to the Yeast Homologue - Broad Energy Barriers and the General
            Properties of the Transition State.
REFERENCE   5  (bases 1 to 6978)
  AUTHORS   Bidichandani,S.I., Ashizawa,T. and Patel,P.I.
  TITLE     Atypical Friedreich ataxia caused by compound heterozygosity for a
            novel missense mutation and the GAA triplet-repeat expansion
  JOURNAL   Am J Hum Genet 60 (5), 1251-1256 (1997)
   PUBMED   9150176
REFERENCE   6  (bases 1 to 6978)
  AUTHORS   Carvajal,J.J., Pook,M.A., dos Santos,M., Doudney,K., Hillermann,R.,
            Minogue,S., Williamson,R., Hsuan,J.J. and Chamberlain,S.
  TITLE     The Friedreich's ataxia gene encodes a novel
            phosphatidylinositol-4- phosphate 5-kinase
  JOURNAL   Nat Genet 14 (2), 157-162 (1996)
   PUBMED   8841185
REFERENCE   7  (bases 1 to 6978)
  AUTHORS   Campuzano,V., Montermini,L., Molto,M.D., Pianese,L., Cossee,M.,
            Cavalcanti,F., Monros,E., Rodius,F., Duclos,F., Monticelli,A.,
            Zara,F., Canizares,J., Koutnikova,H., Bidichandani,S.I.,
            Gellera,C., Brice,A., Trouillas,P., De Michele,G., Filla,A., De
            Frutos,R., Palau,F., Patel,P.I., Di Donato,S., Mandel,J.L.,
            Cocozza,S., Koenig,M. and Pandolfo,M.
  TITLE     Friedreich's ataxia: autosomal recessive disease caused by an
            intronic GAA triplet repeat expansion
  JOURNAL   Science 271 (5254), 1423-1427 (1996)
   PUBMED   8596916
REFERENCE   8  (bases 1 to 6978)
  AUTHORS   Montermini,L., Rodius,F., Pianese,L., Molto,M.D., Cossee,M.,
            Campuzano,V., Cavalcanti,F., Monticelli,A., Palau,F., Gyapay,G. et
            al.
  TITLE     The Friedreich ataxia critical region spans a 150-kb interval on
            chromosome 9q13
  JOURNAL   Am J Hum Genet 57 (5), 1061-1067 (1995)
   PUBMED   7485155
  REMARK    Erratum:[Am J Hum Genet 1995 Dec;57(6):1520]
REFERENCE   9  (bases 1 to 6978)
  AUTHORS   Bidichandani,S.I., Delatycki,M.B., Napierala,M. and Duquette,A.
  TITLE     Friedreich Ataxia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301458
REFERENCE   10 (bases 1 to 6978)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162730.26, U43747.1 and
            BC023633.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000144.4.
            
            Summary: This nuclear gene encodes a mitochondrial protein which
            belongs to the FRATAXIN family. The protein functions in regulating
            mitochondrial iron transport and respiration. The expansion of
            intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats
            results in Friedreich ataxia. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048097.1, SRR14038196.2249949.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000484259.3/
                                                  ENSP00000419243.2
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL162730.26        84488-84572
            86-554              U43747.1           580-1048
            555-1461            BC023633.2         552-1458
            1462-6978           AL162730.26        122296-127812
FEATURES             Location/Qualifiers
     source          1..6978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..6978
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="frataxin"
                     /db_xref="GeneID:2395"
                     /db_xref="HGNC:HGNC:3951"
                     /db_xref="MIM:606829"
     exon            1..196
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..664
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /EC_number="1.16.3.1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; frataxin, mitochondrial; Friedreich ataxia
                     protein"
                     /codon_start=1
                     /product="frataxin, mitochondrial isoform 1 preproprotein"
                     /protein_id="NP_000135.2"
                     /db_xref="CCDS:CCDS6626.1"
                     /db_xref="GeneID:2395"
                     /db_xref="HGNC:HGNC:3951"
                     /db_xref="MIM:606829"
                     /translation="MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRT
                     DIDATCTPRRASSNQRGLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEET
                     LDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPS
                     SGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGKDA"
     exon            197..294
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     exon            295..415
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     exon            416..513
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     exon            514..6978
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      974..979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: AATAAG"
     polyA_site      1003
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="major polyA site"
     regulatory      1104..1109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: ATTAAA"
     polyA_site      1123
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: AATAAA"
     polyA_site      2796
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
     regulatory      6957..6962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
                     /note="hexamer: AATAAA"
     polyA_site      6978
                     /gene="FXN"
                     /gene_synonym="CyaY; FA; FARR; FRDA; X25"
ORIGIN      
        1 agggcggagc gggcggcaga cccggagcag catgtggact ctcgggcgcc gcgcagtagc
       61 cggcctcctg gcgtcaccca gcccagccca ggcccagacc ctcacccggg tcccgcggcc
      121 ggcagagttg gccccactct gcggccgccg tggcctgcgc accgacatcg atgcgacctg
      181 cacgccccgc cgcgcaagtt cgaaccaacg tggcctcaac cagatttgga atgtcaaaaa
      241 gcagagtgtc tatttgatga atttgaggaa atctggaact ttgggccacc caggctctct
      301 agatgagacc acctatgaaa gactagcaga ggaaacgctg gactctttag cagagttttt
      361 tgaagacctt gcagacaagc catacacgtt tgaggactat gatgtctcct ttgggagtgg
      421 tgtcttaact gtcaaactgg gtggagatct aggaacctat gtgatcaaca agcagacgcc
      481 aaacaagcaa atctggctat cttctccatc cagtggacct aagcgttatg actggactgg
      541 gaaaaactgg gtgtactccc acgacggcgt gtccctccat gagctgctgg ccgcagagct
      601 cactaaagcc ttaaaaacca aactggactt gtcttccttg gcctattccg gaaaagatgc
      661 ttgatgccca gccccgtttt aaggacatta aaagctatca ggccaagacc ccagcttcat
      721 tatgcagctg aggtctgttt tttgttgttg ttgttgttta ttttttttat tcctgctttt
      781 gaggacagtt gggctatgtg tcacagctct gtagaaagaa tgtgttgcct cctaccttgc
      841 ccccaagttc tgatttttaa tttctatgga agattttttg gattgtcgga tttcctccct
      901 cacatgatac cccttatctt ttataatgtc ttatgcctat acctgaatat aacaaccttt
      961 aaaaaagcaa aataataaga aggaaaaatt ccaggaggga aaatgaattg tcttcactct
     1021 tcattctttg aaggatttac tgcaagaagt acatgaagag cagctggtca acctgctcac
     1081 tgttctatct ccaaatgaga cacattaaag ggtagcctac aaatgttttc aggcttcttt
     1141 caaagtgtaa gcacttctga gctctttagc attgaagtgt cgaaagcaac tcacacggga
     1201 agatcatttc ttatttgtgc tctgtgactg ccaaggtgtg gcctgcactg ggttgtccag
     1261 ggagacctag tgctgtttct cccacatatt cacatacgtg tctgtgtgta tatatatttt
     1321 ttcaatttaa aggttagtat ggaatcagct gctacaagaa tgcaaaaaat cttccaaaga
     1381 caagaaaaga ggaaaaaaag ccgttttcat gagctgagtg atgtagcgta acaaacaaaa
     1441 tcatggagct gaggaggtgc cttgtaaaca tgaaggggca gataaaggaa ggagatactc
     1501 atgttgataa agagagccct ggtcctagac atagttcagc cacaaagtag ttgtcccttt
     1561 gtggacaagt ttcccaaatt ccctggacct ctgcttcccc atctgttaaa tgagagaata
     1621 gagtatggtt gattcccagc attcagtggt cctgtcaagc aacctaacag gctagttcta
     1681 attccctatt gggtagatga ggggatgaca aagaacagtt tttaagctat ataggaaaca
     1741 ttgttattgg tgttgcccta tcgtgatttc agttgaattc atgtgaaaat aatagccatc
     1801 cttggcctgg cgcggtggct cacacctgta atcccagcac ttttggaggc caaggtgggt
     1861 ggatcacctg aggtcaggag ttcaagacca gcctggccaa catgatgaaa ccccgtctct
     1921 actaaaaata caaaaaatta gccgggcatg atggcaggtg cctgtaatcc cagctacttg
     1981 ggaggctgaa gcggaagaat cgcttgaacc cagaggtgga ggttgcagtg agccgagatc
     2041 gtgccattgc actgtaacct gggtgactga gcaaaactct gtctcaaaat aataataaca
     2101 atataataat aataatagcc atcctttatt gtacccttac tgggttaatc gtattatacc
     2161 acattacctc attttaattt ttactgacct gcactttata caaagcaaca agcctccagg
     2221 acattaaaat tcatgcaaag ttatgctcat gttatattat tttcttactt aaagaaggat
     2281 ttattagtgg ctgggcatgg tggcgtgcac ctgtaatccc aggtactcag gaggctgaga
     2341 cgggagaatt gcttgacccc aggcggagga ggttacagtg agtcgagatc gtacctgagc
     2401 gacagagcga gactccgtct caaaaaaaaa aaaaaggagg gtttattaat gagaagtttg
     2461 tattaatatg tagcaaaggc ttttccaatg ggtgaataaa aacacattcc attaagtcaa
     2521 gctgggagca gtggcatata cctatagtcc cagctgcaca ggaggctgag acaggaggat
     2581 tgcttgaagc caggaattgg agatcagcct gggcaacaca gcaagatcct atctcttaaa
     2641 aaaagaaaaa aaaacctatt aataataaaa cagtataaac aaaagctaaa taggtaaaat
     2701 attttttctg aaataaaatt attttttgag tctgatggaa atgtttaagt gcagtaggcc
     2761 agtgccagtg agaaaataaa taacatcata catgtttgta tgtgtttgca tcttgcttct
     2821 actgaaagtt tcagtgcacc ccacttactt agaactcggt gacatgatgt actcctttat
     2881 ctgggacaca gcacaaaaga ggtatgcagt ggggctgctc tgacatgaaa gtggaagtta
     2941 aggaatctgg gctcttatgg ggtccttgtg ggccagccct tcaggcctat tttactttca
     3001 ttttacatat agctctaatt ggtttgatta tctcgttccc aaggcagtgg gagatcccca
     3061 tttaaggaaa gaaaaggggc ctggcacagt ggctcatgcc tgtaatccca gcactttggg
     3121 aggctgaggc aagtgtatca cctgaggtca ggagttcaag accagcctgg ccaacatggc
     3181 aaaatcccgt ctctactaaa aatattaaaa aattggctgg gcgtggtggt tcgtgcctat
     3241 aatttcagct actcaggagg ctgaggcagg agaatcgctg taacctgggg ggtggaggtt
     3301 gcagtgagac gagatcatgc cacttcactc cagcctggcc aacagagcca tactccgtct
     3361 caaataaata aataaataaa taaagggact tcaaacacat gaacagcagc caggggaaga
     3421 atcaaaatca tattctgtca agcaaactgg aaaagtacca ctgtgtgtac caatagcctc
     3481 cccaccacag accctgggag catcgcctca tttatggtgt ggtccagtca tccatgtgaa
     3541 ggatgagttt ccaggaaaag gttattaaat attcactgta acatactgga ggaggtgagg
     3601 aattgcataa tacaatctta gaaaactttt ttttcccctt tctatttttt gagacaggat
     3661 ctcactttgg cactcaggct ggaggacagt ggtacaatca aagctcatgg cagcctcgac
     3721 ctccctgggc ttgggcaatc ctcccacagg tgtgcacctc catagctggc taatttgtgt
     3781 attttttgta gagatggggt ttcaccatgt tgcccaggct ggtctctaac acttaggctc
     3841 aagtgatcca cctgcctcgt cctcccaaga tgctgggatt acaggtgtgt gccacaggtg
     3901 ttcatcagaa agctttttct attattttta ccttcttgag tgggtagaac ctcagccaca
     3961 tagaaaataa aatgttctgg catgacttat ttagctctct ggaattacaa agaaggaatg
     4021 aggtgtgtaa aagagaacct gggtttttga atcacaaatt tagaatttaa tcgaaactct
     4081 gcctcttact tgtttgtaga cactgacagt ggcctcatgt tttttttttt tttaatctat
     4141 aaaatggaga tatctaacat gttgagcctg ggcccacagg caaagcacaa tcctgatgtg
     4201 agaagtactc agttcatgac aactgttgtt ctcacatgca tagcataatt tcatattcac
     4261 attggaggac ttctcccaaa atatggatga cgttccctac tcaaccttga acttaatcaa
     4321 aatactcagt ttacttaact tcgtattaga ttctgattcc ctggaaccat ttatcgtgtg
     4381 ccttaccatg cttatatttt acttgatctt ttgcatacct tctaaaacta ttttagccaa
     4441 tttaaaattt gacagtttgc attaaattat aggtttacaa tatgctttat ccagctatac
     4501 ctgccccaaa ttctgacaga tgcttttgcc acctctaaag gaagacccat gttcatagtg
     4561 atggagtttg tgtggactaa ccatgcaagg ttgccaagga aaaatcgctt tacgcttcca
     4621 aggtacacac taagatgaaa gtaattttag tccgtgtcca gttggattct tggcacatag
     4681 ttatcttctg ctagaacaaa ctaaaacagc tacatgccag caagggagaa aggggaagga
     4741 ggggcaaagt tttgaaattt catgtaaatt tatgctgttc aaaacgacga gttcatgact
     4801 ttgtgtatag agtaagaaat gccttttctt ttttgagaca gagtcttgct ctgtcaccca
     4861 ggctggagtg cagtggcacg atctgggctc actacaacct ccgcctcctg ggttcaagca
     4921 attctctgcc tcagcctccc gagtagctgg gattacaggt gcctgccacc acacccggct
     4981 aatttttgta tttttagtag agacggggtt tcaccatcat ggccaggctg gtcttgaact
     5041 cctgacctag taatccacct gcctccgcct cccaaagtgc tgggattaca ggcgtgagcc
     5101 actgcaccca gccagaaatg ccttctaatc tttggtttat cttaattagc caggacactt
     5161 ggagtgcatc ccgaagtacc tgatcagtgg cccctttgga atgtgtaaaa ctcagctcac
     5221 ttatatccct gcatccgcta cagagacaga atccaagctc atatgttcca tcttctctgg
     5281 ctgtatagtt taaggaatgg aaggcaccag aacagattta ttgaaatgtt tattagctga
     5341 agatttattt agacagttga ggaaaacatc agcacccagc agtaaaattg gctctcaaag
     5401 attttcttct cctgtggaaa gtcagacctc tgaggcccca tccaggtaga agtactagtg
     5461 caagaagggc ctctgctgtc cacttgtgtt tctgtgatct gtgggaacat tgttaacgcc
     5521 acatcttgac ctcaaattgt ttagctcctg gccagacacg gtggctcaca cctgtaatcc
     5581 cagcactttg agaggctgag gcaggtggat cacctgaggt taggagttcg aggccagcct
     5641 ggtcaacatg gtaaaacccc gcctctacta aaaatacaaa aattagctgg ccgtagtggc
     5701 gcacgcctgt tatcccagct actcgggagg ctgaggcagg agaattgctt gaacctgggt
     5761 ggtggaggtt gcagtgagcc gagattacac cactgcactc cagcctgggt gacaagaggg
     5821 aaactccatt aaaaaaatgt aattcccgtg tctgccatct taagtgtaaa ggtggctaaa
     5881 ttatatagaa aaataagaca atatcatttc ccaattacat tcctttccta ccgcactcta
     5941 tgatgctagc tgagattttt ccaaaagaaa atggcttaaa taaaacccta agagaaagaa
     6001 aaactttaaa tccctccaaa gctcaaaagt aatagaaaca gatgagtttg gagtcaggat
     6061 ttctctgtaa gattgcctag gctgtgtact gcacatctcc aggtgccact gttgacagag
     6121 attataacta caatgtgaag tgaatggtgc cactgacagt tatgcaaacc gtccagagca
     6181 tagccacctg atcctgctgg gattcctctt gccagtccat cagcagttcc ccttgaaagt
     6241 ttcaccaaac atcccttaaa tctgccctct cctgcccgtc cccagtggag gtcctcatca
     6301 tttttcacct gcatttttgc aggagctttc ttatatccac cttcctcctt ttctctcagc
     6361 ccatcatcta gctacacagt ctccagggta agctttcaga aaggcaatct cttgtctgta
     6421 aaacctaagc aggaccaagg ccaagtttct tagcctgaaa aatgtgcttt tctgactgaa
     6481 ctgttcaggc actgactcta catataatta tgcttttcta ccccctcaca ctcaacactt
     6541 tgactccagc aatcccaaat ccccagatcc ctaagtgtgc tgtgctattt tcacgtggct
     6601 ctcagacttg gccagtgctg tttccatttt ggtctttatt ccccacatct ctgcctgggg
     6661 ggtagattct accctgaaaa atgttcttgg cacagccttg caaactcctc ctccactcag
     6721 cctctgcctg gatgcccttg attgttccat gtcctcagca taccatgttt gtctttccca
     6781 gcactgacct accatgtgtc acccctgctt ggctgtacct tccatgaggc taggactatg
     6841 tgtctccttt gttgactgct gttgccctag catcttgcac agttccttgc acacaattag
     6901 agctctataa atgtcaaata aatgtgttat aattatatgt ttaagatagt tgttcaaata
     6961 aactctaaat aaccccaa
//
