LOCUS       NM_004479               1662 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens fucosyltransferase 7 (FUT7), mRNA.
ACCESSION   NM_004479
VERSION     NM_004479.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1662)
  AUTHORS   Qiao,R., Di,F., Wang,J., Wei,Y., Xu,T., Dai,L., Gu,W., Han,B. and
            Yang,R.
  TITLE     Identification of FUT7 hypomethylation as the blood biomarker in
            the prediction of early-stage lung cancer
  JOURNAL   J Genet Genomics 50 (8), 573-581 (2023)
   PUBMED   36898609
  REMARK    GeneRIF: Identification of FUT7 hypomethylation as the blood
            biomarker in the prediction of early-stage lung cancer.
REFERENCE   2  (bases 1 to 1662)
  AUTHORS   Fang,Y., Qu,Y., Ji,L., Sun,H., Li,J., Zhao,Y., Liang,F., Wang,Z.,
            Su,J., Liu,J., Dai,L. and Ouyang,S.
  TITLE     Novel blood-based FUT7 DNA methylation is associated with lung
            cancer: especially for lung squamous cell carcinoma
  JOURNAL   Clin Epigenetics 14 (1), 167 (2022)
   PUBMED   36463240
  REMARK    GeneRIF: Novel blood-based FUT7 DNA methylation is associated with
            lung cancer: especially for lung squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1662)
  AUTHORS   Wu,C.H., Inoue,T., Nakamura,Y., Uni,R., Hasegawa,S., Maekawa,H.,
            Sugahara,M., Wada,Y., Tanaka,T., Nangaku,M. and Inagi,R.
  TITLE     Activation of alpha7 nicotinic acetylcholine receptors attenuates
            monocyte-endothelial adhesion through FUT7 inhibition
  JOURNAL   Biochem Biophys Res Commun 590, 89-96 (2022)
   PUBMED   34973535
  REMARK    GeneRIF: Activation of alpha7 nicotinic acetylcholine receptors
            attenuates monocyte-endothelial adhesion through FUT7 inhibition.
REFERENCE   4  (bases 1 to 1662)
  AUTHORS   Xu,T., Liu,J., Xia,Y., Wang,Z., Li,X. and Gao,Q.
  TITLE     Integrated analysis reveals the participation of IL4I1, ITGB7, and
            FUT7 in reshaping the TNBC immune microenvironment by targeting
            glycolysis
  JOURNAL   Ann Med 53 (1), 916-928 (2021)
   PUBMED   34134578
  REMARK    GeneRIF: Integrated analysis reveals the participation of IL4I1,
            ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by
            targeting glycolysis.
REFERENCE   5  (bases 1 to 1662)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1662)
  AUTHORS   Knibbs,R.N., Craig,R.A., Natsuka,S., Chang,A., Cameron,M.,
            Lowe,J.B. and Stoolman,L.M.
  TITLE     The fucosyltransferase FucT-VII regulates E-selectin ligand
            synthesis in human T cells
  JOURNAL   J Cell Biol 133 (4), 911-920 (1996)
   PUBMED   8666674
REFERENCE   7  (bases 1 to 1662)
  AUTHORS   Smith,P.L., Gersten,K.M., Petryniak,B., Kelly,R.J., Rogers,C.,
            Natsuka,Y., Alford,J.A. 3rd, Scheidegger,E.P., Natsuka,S. and
            Lowe,J.B.
  TITLE     Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid
            aggregate high endothelial venules correlates with expression of
            L-selectin ligands
  JOURNAL   J Biol Chem 271 (14), 8250-8259 (1996)
   PUBMED   8626519
REFERENCE   8  (bases 1 to 1662)
  AUTHORS   Natsuka,S., Gersten,K.M., Zenita,K., Kannagi,R. and Lowe,J.B.
  TITLE     Molecular cloning of a cDNA encoding a novel human leukocyte
            alpha-1,3-fucosyltransferase capable of synthesizing the sialyl
            Lewis x determinant
  JOURNAL   J Biol Chem 269 (32), 20806 (1994)
   PUBMED   8051184
REFERENCE   9  (bases 1 to 1662)
  AUTHORS   Natsuka,S., Gersten,K.M., Zenita,K., Kannagi,R. and Lowe,J.B.
  TITLE     Molecular cloning of a cDNA encoding a novel human leukocyte
            alpha-1,3-fucosyltransferase capable of synthesizing the sialyl
            Lewis x determinant
  JOURNAL   J Biol Chem 269 (24), 16789-16794 (1994)
   PUBMED   8207002
  REMARK    Erratum:[J Biol Chem 1994 Aug 12;269(32):20806]
REFERENCE   10 (bases 1 to 1662)
  AUTHORS   Sasaki,K., Kurata,K., Funayama,K., Nagata,M., Watanabe,E., Ohta,S.,
            Hanai,N. and Nishi,T.
  TITLE     Expression cloning of a novel alpha 1,3-fucosyltransferase that is
            involved in biosynthesis of the sialyl Lewis x carbohydrate
            determinants in leukocytes
  JOURNAL   J Biol Chem 269 (20), 14730-14737 (1994)
   PUBMED   8182079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807752.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 17, 2019 this sequence version replaced NM_004479.3.
            
            Summary: The protein encoded by this gene is a Golgi stack membrane
            protein that is involved in the creation of sialyl-Lewis X
            antigens. The encoded protein can direct the synthesis of the
            E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086312.1, X78031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314412.7/ ENSP00000318142.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AL807752.10        101941-102050       c
            111-1662            AL807752.10        100136-101687       c
FEATURES             Location/Qualifiers
     source          1..1662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1662
                     /gene="FUT7"
                     /gene_synonym="FucT-VII"
                     /note="fucosyltransferase 7"
                     /db_xref="GeneID:2529"
                     /db_xref="HGNC:HGNC:4018"
                     /db_xref="MIM:602030"
     exon            1..110
                     /gene="FUT7"
                     /gene_synonym="FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1126
                     /gene="FUT7"
                     /gene_synonym="FucT-VII"
                     /EC_number="2.4.1.-"
                     /note="galactoside 3-L-fucosyltransferase; selectin-ligand
                     synthase; fuc-TVII; fucosyltransferase VII;
                     fucosyltransferase 7 (alpha (1,3) fucosyltransferase)"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 7"
                     /protein_id="NP_004470.1"
                     /db_xref="CCDS:CCDS7022.1"
                     /db_xref="GeneID:2529"
                     /db_xref="HGNC:HGNC:4018"
                     /db_xref="MIM:602030"
                     /translation="MNNAGHGPTRRLRGLGVLAGVALLAALWLLWLLGSAPRGTPAPQ
                     PTITILVWHWPFTDQPPELPSDTCTRYGIARCHLSANRSLLASADAVVFHHRELQTRR
                     SHLPLAQRPRGQPWVWASMESPSHTHGLSHLRGIFNWVLSYRRDSDIFVPYGRLEPHW
                     GPSPPLPAKSRVAAWVVSNFQERQLRARLYRQLAPHLRVDVFGRANGRPLCASCLVPT
                     VAQYRFYLSFENSQHRDYITEKFWRNALVAGTVPVVLGPPRATYEAFVPADAFVHVDD
                     FGSARELAAFLTGMNESRYQRFFAWRDRLRVRLFTDWRERFCAICDRYPHLPRSQVYE
                     DLEGWFQA"
     exon            111..1662
                     /gene="FUT7"
                     /gene_synonym="FucT-VII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1644..1649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT7"
                     /gene_synonym="FucT-VII"
                     /note="hexamer: AATAAA"
     polyA_site      1662
                     /gene="FUT7"
                     /gene_synonym="FucT-VII"
                     /note="major polyA site"
ORIGIN      
        1 gagctagggc gtagctgtga tttcaggggc acctctggcg gctgccgtga tttgagaatc
       61 tcgggtctct tggctgactg atcctgggag actgtggatg aataatgctg ggcacggccc
      121 cacccggagg ctgcgaggct tgggggtcct ggccggggtg gctctgctcg ctgccctctg
      181 gctcctgtgg ctgctggggt cagcccctcg gggtaccccg gcaccccagc ccacgatcac
      241 catccttgtc tggcactggc ccttcactga ccagccccca gagctgccca gcgacacctg
      301 cacccgctac ggcatcgccc gctgccacct gagtgccaac cgaagcctgc tggccagcgc
      361 cgacgccgtg gtcttccacc accgcgagct gcagacccgg cggtcccacc tgcccctggc
      421 ccagcggccg cgagggcagc cctgggtgtg ggcctccatg gagtctccta gccacaccca
      481 cggcctcagc cacctccgag gcatcttcaa ctgggtgctg agctaccggc gcgactcgga
      541 catctttgtg ccctatggcc gcctggagcc ccactggggg ccctcgccac cgctgccagc
      601 caagagcagg gtggccgcct gggtggtcag caacttccag gagcggcagc tgcgtgccag
      661 gctgtaccgg cagctggcgc ctcatctgcg ggtggatgtc tttggccgtg ccaatggacg
      721 gccactgtgc gccagctgcc tggtgcccac cgtggcccag taccgcttct acctgtcctt
      781 tgagaactct cagcaccgcg actacattac ggagaaattc tggcgcaacg cactggtggc
      841 tggcactgtg ccagtggtgc tggggccccc acgggccacc tatgaggcct tcgtgccggc
      901 tgacgccttc gtgcatgtgg atgactttgg ctcagcccga gagctggcgg ctttcctcac
      961 tggcatgaat gagagccgat accaacgctt ctttgcctgg cgtgacaggc tccgcgtgcg
     1021 actgttcacc gactggcggg aacgtttctg tgccatctgt gaccgctacc cacacctacc
     1081 ccgcagccaa gtctatgagg accttgaggg ttggtttcag gcctgagatc cgctggccgg
     1141 gggaggtggg tgtgggtgga agggctgggt gtcgaaatca aaccaccagg catccggccc
     1201 ttaccggcaa gcagcgggct aacgggaggc tgggcacaga ggtcaggaag caggggtggg
     1261 gggtgcaggt gggcactgga gcatgcagag gaggtgagag tgggagggag gtaacgggtg
     1321 cctgctgcgg cagacgggag gggaaaggct gccgaggacc ctccccaccc tgaacaaatc
     1381 ttgggtgggt gaaggcctgg ctggaagagg gtgaaaggca gggcccttgg ggctgggggg
     1441 caccccagcc tgaagtttgt gggggccaaa cctgggaccc cgagcttcct cggtagcaga
     1501 ggccctgtgg tccccgagac acaggcacgg gtccctgcca cgtccatagt tctgaggtcc
     1561 ctgtgtgtag gctggggcgg ggcccaggag accacgggga gcaaaccagc ttgttctggg
     1621 ctcagggagg gagggcggtg gacaataaac atctgagcag tg
//
