LOCUS       NM_000150               3326 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens fucosyltransferase 6 (FUT6), transcript variant 1,
            mRNA.
ACCESSION   NM_000150
VERSION     NM_000150.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3326)
  AUTHORS   Zhou,S., Zheng,Z., Wang,L., Song,W., Xia,Y., Shao,L. and Liang,X.
  TITLE     Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter
            pylori Infection
  JOURNAL   Helicobacter 29 (4), e13122 (2024)
   PUBMED   39108208
  REMARK    GeneRIF: Correlation of FUT3 and FUT6 Gene Polymorphisms With
            Helicobacter pylori Infection.
REFERENCE   2  (bases 1 to 3326)
  AUTHORS   Lao,J., Pang,Y., Chen,H., Tang,X., Li,R., Tong,D., Qiu,P. and
            Tang,Q.
  TITLE     FUT6 Suppresses the Proliferation, Migration, Invasion, and
            Epithelial-Mesenchymal Transition of Esophageal Carcinoma Cells via
            the Epidermal Growth Factor Receptor/Extracellular Signal-Regulated
            Kinase Signaling Pathway
  JOURNAL   Turk J Gastroenterol 35 (9), 699-708 (2024)
   PUBMED   39375968
  REMARK    GeneRIF: FUT6 Suppresses the Proliferation, Migration, Invasion,
            and Epithelial-Mesenchymal Transition of Esophageal Carcinoma Cells
            via the Epidermal Growth Factor Receptor/Extracellular
            Signal-Regulated Kinase Signaling Pathway.
REFERENCE   3  (bases 1 to 3326)
  AUTHORS   Wang,Q., Liao,C., Tan,Z., Li,X., Guan,X., Li,H., Tian,Z., Liu,J.
            and An,J.
  TITLE     FUT6 inhibits the proliferation, migration, invasion, and
            EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by
            regulating EGFR/ERK/STAT signaling pathway
  JOURNAL   Cancer Gene Ther 30 (1), 182-191 (2023)
   PUBMED   36151332
  REMARK    GeneRIF: FUT6 inhibits the proliferation, migration, invasion, and
            EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by
            regulating EGFR/ERK/STAT signaling pathway.
REFERENCE   4  (bases 1 to 3326)
  AUTHORS   Puan,K.J., San Luis,B., Yusof,N., Kumar,D., Andiappan,A.K., Lee,W.,
            Cajic,S., Vuckovic,D., Chan,J., Dollner,T., Hou,H.W., Jiang,Y.,
            Tian,C., Rapp,E., Poidinger,M., Wang,Y., Soranzo,N., Lee,B. and
            Rotzschke,O.
  CONSRTM   23andMe Research Team
  TITLE     FUT6 deficiency compromises basophil function by selectively
            abrogating their sialyl-Lewis x expression
  JOURNAL   Commun Biol 4 (1), 832 (2021)
   PUBMED   34215830
  REMARK    GeneRIF: FUT6 deficiency compromises basophil function by
            selectively abrogating their sialyl-Lewis x expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3326)
  AUTHORS   Al-Amoodi,A.S., Sakashita,K., Ali,A.J., Zhou,R., Lee,J.M.,
            Tehseen,M., Li,M., Belmonte,J.C.I., Kusakabe,T. and Merzaban,J.S.
  TITLE     Using Eukaryotic Expression Systems to Generate Human
            alpha1,3-Fucosyltransferases That Effectively Create
            Selectin-Binding Glycans on Stem Cells
  JOURNAL   Biochemistry 59 (39), 3757-3771 (2020)
   PUBMED   32901486
  REMARK    GeneRIF: Using Eukaryotic Expression Systems to Generate Human
            alpha1,3-Fucosyltransferases That Effectively Create
            Selectin-Binding Glycans on Stem Cells.
REFERENCE   6  (bases 1 to 3326)
  AUTHORS   Cameron,H.S., Szczepaniak,D. and Weston,B.W.
  TITLE     Expression of human chromosome 19p alpha(1,3)-fucosyltransferase
            genes in normal tissues. Alternative splicing, polyadenylation, and
            isoforms
  JOURNAL   J Biol Chem 270 (34), 20112-20122 (1995)
   PUBMED   7650030
REFERENCE   7  (bases 1 to 3326)
  AUTHORS   McCurley,R.S., Recinos,A. 3rd, Olsen,A.S., Gingrich,J.C.,
            Szczepaniak,D., Cameron,H.S., Krauss,R. and Weston,B.W.
  TITLE     Physical maps of human alpha (1,3)fucosyltransferase genes
            FUT3-FUT6 on chromosomes 19p13.3 and 11q21
  JOURNAL   Genomics 26 (1), 142-146 (1995)
   PUBMED   7782074
REFERENCE   8  (bases 1 to 3326)
  AUTHORS   Reguigne-Arnould,I., Couillin,P., Mollicone,R., Faure,S.,
            Fletcher,A., Kelly,R.J., Lowe,J.B. and Oriol,R.
  TITLE     Relative positions of two clusters of human
            alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p
            (FUT6-FUT3-FUT5) within the microsatellite genetic map of
            chromosome 19
  JOURNAL   Cytogenet Cell Genet 71 (2), 158-162 (1995)
   PUBMED   7656588
REFERENCE   9  (bases 1 to 3326)
  AUTHORS   Weston,B.W., Smith,P.L., Kelly,R.J. and Lowe,J.B.
  TITLE     Molecular cloning of a fourth member of a human alpha
            (1,3)fucosyltransferase gene family. Multiple homologous sequences
            that determine expression of the Lewis x, sialyl Lewis x, and
            difucosyl sialyl Lewis x epitopes
  JOURNAL   J Biol Chem 267 (34), 24575-24584 (1992)
   PUBMED   1339443
  REMARK    Erratum:[J Biol Chem 1993 Aug 25;268(24):18398]
REFERENCE   10 (bases 1 to 3326)
  AUTHORS   Koszdin,K.L. and Bowen,B.R.
  TITLE     The cloning and expression of a human alpha-1,3 fucosyltransferase
            capable of forming the E-selectin ligand
  JOURNAL   Biochem Biophys Res Commun 187 (1), 152-157 (1992)
   PUBMED   1520296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024592.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 17, 2020 this sequence version replaced NM_000150.3.
            
            Summary: The protein encoded by this gene is a Golgi stack membrane
            protein that is involved in the creation of sialyl-Lewis X, an
            E-selectin ligand. Mutations in this gene are a cause of
            fucosyltransferase-6 deficiency. Two transcript variants encoding
            the same protein have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2317998.1,
                                           SRR14038194.3442150.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156266 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318336.10/ ENSP00000313398.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1026              AC024592.5         18291-19316         c
            1027-1154           AC024592.5         14564-14691         c
            1155-3326           AC024592.5         10022-12193         c
FEATURES             Location/Qualifiers
     source          1..3326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3326
                     /gene="FUT6"
                     /gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
                     /note="fucosyltransferase 6"
                     /db_xref="GeneID:2528"
                     /db_xref="HGNC:HGNC:4017"
                     /db_xref="MIM:136836"
     exon            1..1026
                     /gene="FUT6"
                     /gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1154
                     /gene="FUT6"
                     /gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..3326
                     /gene="FUT6"
                     /gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
                     /inference="alignment:Splign:2.1.0"
     CDS             1167..2246
                     /gene="FUT6"
                     /gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
                     /EC_number="2.4.1.152"
                     /note="isoform 1 is encoded by transcript variant 1;
                     galactoside 3-L-fucosyltransferase; fucosyltransferase VI;
                     alpha-(1,3)-fucosyltransferase 6; fucosyltransferase 6
                     (alpha (1,3) fucosyltransferase);
                     4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase FUT6"
                     /codon_start=1
                     /product="4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase FUT6 isoform 1"
                     /protein_id="NP_000141.1"
                     /db_xref="CCDS:CCDS12152.1"
                     /db_xref="GeneID:2528"
                     /db_xref="HGNC:HGNC:4017"
                     /db_xref="MIM:136836"
                     /translation="MDPLGPAKPQWSWRCCLTTLLFQLLMAVCFFSYLRVSQDDPTVY
                     PNGSRFPDSTGTPAHSIPLILLWTWPFNKPIALPRCSEMVPGTADCNITADRKVYPQA
                     DAVIVHHREVMYNPSAQLPRSPRRQGQRWIWFSMESPSHCWQLKAMDGYFNLTMSYRS
                     DSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWGPNSARVRYYQSLQAHLKV
                     DVYGRSHKPLPQGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPS
                     RSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWAL
                     AFCKACWKLQEESRYQTRGIAAWFT"
     regulatory      3282..3287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT6"
                     /gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
                     /note="hexamer: AAGAAA"
     polyA_site      3326
                     /gene="FUT6"
                     /gene_synonym="FCT3A; FT1A; Fuc-TVI; FucT-VI"
                     /note="major polyA site"
ORIGIN      
        1 attccaggaa gtttgcatag ctccctggac ttctgctttg cactgccctg caggagtggg
       61 tggggaaagg aagtggcttt gaggcacaca gaggggcttg ttgaggccac cggaggaagc
      121 ttctgccacc aatatgggac ctgtgcccag cctaccagaa gagagcatct gaaaacatgt
      181 atcgacatgg taacccctct gcttgaagcc tcacatggct ccctattgcc ttggtgctga
      241 acaccctatg gctgaccgtg gcccagcctc tgcaacagct ctgcctcctc tccagtggtg
      301 aagacccagc ctgctgagac tcctcctgca gttcctcaac atgcctgcat ttctgctgcc
      361 tcagggcctt tgcgaaggtt gttccttgta actggaatgc ccttccatcc cttttttatt
      421 caaaaggctg caattttaat tgaagaaagt tcccttccaa ggttcatgag ttgcctgact
      481 tgcccaccgg tttcctgcaa gatcccttgg cctggcactt agtgctcagg aaatatttgg
      541 tgatgggcca actgagtgag aaggtgggat ctggtgggaa ggaaagcgga aaggtagaaa
      601 ttctgctcac ttcctcattc ccacctccca aggaacccct ggtgtccctg tggaacccgc
      661 tttgggaacc ggtggttcag gtcagccttt tcactttgta ctcaaagcca catcgcattg
      721 aagccacagg tggggcaagg tcatgcatga cctgagtctc caaatccctt caccctgttt
      781 ggttctgcaa cggggattag gggagcccca cgatttgttt tcaaaggatg tccgggctcc
      841 aggacaggat gccctgggtc acctgatgac aggtgtggtg gttggaaagg gcctggtttc
      901 agctccgggt acacttcctc cttccttctg ctgcgtggtg tggcctcttc cacgtcctca
      961 gaatccagct gttactccgt ccgcggcctc tcagctctag ggccctctgc acactggccc
     1021 ccccagtgtc acgggcatcc agacgggatc cagtgcatcc tcttttagaa gaaaggcctg
     1081 tctccagatc cccgagtccc tctagcatct cccagaaggt gtcagacgca gcagtgtcca
     1141 gggagcggca gcagatactc tgacccatgg atcccctggg cccggccaag ccacagtggt
     1201 cgtggcgctg ctgtctgacc acgctgctgt ttcagctgct gatggctgtg tgtttcttct
     1261 cctatctgcg tgtgtctcaa gacgatccca ctgtgtaccc taatgggtcc cgcttcccag
     1321 acagcacagg gacccccgcc cactccatcc ccctgatcct gctgtggacg tggcctttta
     1381 acaaacccat agctctgccc cgctgctcag agatggtgcc tggcacggct gactgcaaca
     1441 tcactgccga ccgcaaggtg tatccacagg cagacgcggt catcgtgcac caccgagagg
     1501 tcatgtacaa ccccagtgcc cagctcccac gctccccgag gcggcagggg cagcgatgga
     1561 tctggttcag catggagtcc ccaagccact gctggcagct gaaagccatg gacggatact
     1621 tcaatctcac catgtcctac cgcagcgact ccgacatctt cacgccctac ggctggctgg
     1681 agccgtggtc cggccagcct gcccacccac cgctcaacct ctcggccaag accgagctgg
     1741 tggcctgggc agtgtccaac tgggggccaa actccgccag ggtgcgctac taccagagcc
     1801 tgcaggccca tctcaaggtg gacgtgtacg gacgctccca caagcccctg ccccagggaa
     1861 ccatgatgga gacgctgtcc cggtacaagt tctatctggc cttcgagaac tccttgcacc
     1921 ccgactacat caccgagaag ctgtggagga acgccctgga ggcctgggcc gtgcccgtgg
     1981 tgctgggccc cagcagaagc aactacgaga ggttcctgcc acccgacgcc ttcatccacg
     2041 tggacgactt ccagagcccc aaggacctgg cccggtacct gcaggagctg gacaaggacc
     2101 acgcccgcta cctgagctac tttcgctggc gggagacgct gcggcctcgc tccttcagct
     2161 gggcactcgc tttctgcaag gcctgctgga aactgcagga ggaatccagg taccagacac
     2221 gcggcatagc ggcttggttc acctgagagg ctggtgtggg gcctgggctg ccaggaacct
     2281 cattttcctg gggcctcacc tgagtggggg cctcatctac ctaaggactc gtttgcctga
     2341 agcttcacct gcctgaggac tcacctgcct gggacggtca cctgttgcag cttcacctgc
     2401 ctggggattc acctacctgg gtcctcactt tcctggggcc tcacctgctg gagtcttcgg
     2461 tggccaggta tgtcccttac ctgggatttc acatgctggc ttccaggagc gtcccctgcg
     2521 gaagcctggc ctgctgggga tgtctcctgg ggactttgcc tactggggac ctcggctgtt
     2581 ggggacttta cctgctggga cctgctccca gagaccttcc acactgaatc tcacctgcta
     2641 ggagcctcac ctgctgggga cctcaccctg gagggcactg ggccctggga actggcaccc
     2701 atggggcccc acccatgagt gatggttctg gctgatttgt ttgtgatgtt gttagccgcc
     2761 tgtgaggggt gcagagagat aatcaccgca ccgtttccag atgtaatact gcaaagaaaa
     2821 ccgatgatga ggccgggtgc ggtggctcac acctgtaatc ccagcacttt gggaggccga
     2881 ggcaggcgga tcacaaggtc aggagatcga gaccatcctg gccaatatgg tgaaacccgt
     2941 ctctactaaa aatacaaaaa tttgccgggc gtggtggtgc atgcctgtaa tcccagctac
     3001 ttgggaagct gaggcaggag aatcgcttga accagagagt cggaggttgc agtaagccga
     3061 gatcgcgcca ctgcactcca gcctggcgac agagcgagac tctgtctcaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaattagct gggtgcggtg gccggtgcct gtaatcccag ctacccaggt
     3181 ggctgagaca caagaatcgc ttgaacccag gaggcagatg ttgtagggag ccatgatcgc
     3241 accactgcac tccaacctgg gcgacacagt gagactgtct caagaaaaaa aaaaaaaggg
     3301 gggagtgtcc ctttctgagt gtgcaa
//
