LOCUS       NM_002034               1988 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens fucosyltransferase 5 (FUT5), mRNA.
ACCESSION   NM_002034
VERSION     NM_002034.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Gao,H.F., Wang,Q.Y., Zhang,K., Chen,L.Y., Cheng,C.S., Chen,H.,
            Meng,Z.Q., Zhou,S.M. and Chen,Z.
  TITLE     Overexpressed N-fucosylation on the cell surface driven by FUT3, 5,
            and 6 promotes cell motilities in metastatic pancreatic cancer cell
            lines
  JOURNAL   Biochem Biophys Res Commun 511 (2), 482-489 (2019)
   PUBMED   30808544
  REMARK    GeneRIF: Overexpressed N-fucosylation on cell surface promotes the
            migration and invasion of metastatic pancreatic cancer cells.
            Overexpressed N-fucosylation is driven by gene FUT3, 5, and 6 in
            metastatic pancreatic cancer cells.
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Mondal,N., Dykstra,B., Lee,J., Ashline,D.J., Reinhold,V.N.,
            Rossi,D.J. and Sackstein,R.
  TITLE     Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl
            Lewis-X assembly in human cells
  JOURNAL   J Biol Chem 293 (19), 7300-7314 (2018)
   PUBMED   29593094
REFERENCE   3  (bases 1 to 1988)
  AUTHORS   Liang,L., Gao,C., Li,Y., Sun,M., Xu,J., Li,H., Jia,L. and Zhao,Y.
  TITLE     miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell
            proliferation, migration, invasion and pathological angiogenesis
            via PI3K-Akt pathway
  JOURNAL   Cell Death Dis 8 (8), e2968 (2017)
   PUBMED   28771224
  REMARK    GeneRIF: data suggest that both FUT5 and FUT6 can promote the
            development of colorectal cancer (CRC) via the PI3K/Akt signalling
            pathway, which is regulated by miR-125a-3p. miR-125a-3p may serve
            as a predictive biomarker and a potential therapeutic target in CRC
            treatment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1988)
  AUTHORS   Li,F.R., Zhou,Y.S., Zhu,L.H., Cui,H.G., Wang,B.J., Ding,M. and
            Pang,H.
  TITLE     [Distribution specificity of human fucosyltransferase 5 and its
            expression and localization in spermatids]
  JOURNAL   Fa Yi Xue Za Zhi 28 (2), 112-114 (2012)
   PUBMED   22619806
  REMARK    GeneRIF: FUT5 was expressed on spermatid membranes and in serum,
            but not in seminal plasma, vaginal fluid and saliva. Expression was
            localized on head of spermatids.
REFERENCE   5  (bases 1 to 1988)
  AUTHORS   Padro,M., Cobler,L., Garrido,M. and de Bolos,C.
  TITLE     Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens
            expression and reduces the adhesion capacities of gastric cancer
            cells
  JOURNAL   Biochim Biophys Acta 1810 (12), 1141-1149 (2011)
   PUBMED   21978830
  REMARK    GeneRIF: down-regulation of FUT3 and FUT5 reduces the expression of
            sialyl-Lewis antigens and the adhesion capacities of gastric cancer
            cells and allows to identify the specific alpha1-3,4
            fucosyltransferases implicated in the Lewis antigens synthesis
REFERENCE   6  (bases 1 to 1988)
  AUTHORS   Cameron,H.S., Szczepaniak,D. and Weston,B.W.
  TITLE     Expression of human chromosome 19p alpha(1,3)-fucosyltransferase
            genes in normal tissues. Alternative splicing, polyadenylation, and
            isoforms
  JOURNAL   J Biol Chem 270 (34), 20112-20122 (1995)
   PUBMED   7650030
REFERENCE   7  (bases 1 to 1988)
  AUTHORS   de Vries,T., Srnka,C.A., Palcic,M.M., Swiedler,S.J., van den
            Eijnden,D.H. and Macher,B.A.
  TITLE     Acceptor specificity of different length constructs of human
            recombinant alpha 1,3/4-fucosyltransferases. Replacement of the
            stem region and the transmembrane domain of fucosyltransferase V by
            protein A results in an enzyme with GDP-fucose hydrolyzing activity
  JOURNAL   J Biol Chem 270 (15), 8712-8722 (1995)
   PUBMED   7721776
REFERENCE   8  (bases 1 to 1988)
  AUTHORS   McCurley,R.S., Recinos,A. 3rd, Olsen,A.S., Gingrich,J.C.,
            Szczepaniak,D., Cameron,H.S., Krauss,R. and Weston,B.W.
  TITLE     Physical maps of human alpha (1,3)fucosyltransferase genes
            FUT3-FUT6 on chromosomes 19p13.3 and 11q21
  JOURNAL   Genomics 26 (1), 142-146 (1995)
   PUBMED   7782074
REFERENCE   9  (bases 1 to 1988)
  AUTHORS   Weston,B.W., Smith,P.L., Kelly,R.J. and Lowe,J.B.
  TITLE     Molecular cloning of a fourth member of a human alpha
            (1,3)fucosyltransferase gene family. Multiple homologous sequences
            that determine expression of the Lewis x, sialyl Lewis x, and
            difucosyl sialyl Lewis x epitopes
  JOURNAL   J Biol Chem 267 (34), 24575-24584 (1992)
   PUBMED   1339443
  REMARK    Erratum:[J Biol Chem 1993 Aug 25;268(24):18398]
REFERENCE   10 (bases 1 to 1988)
  AUTHORS   Weston,B.W., Nair,R.P., Larsen,R.D. and Lowe,J.B.
  TITLE     Isolation of a novel human alpha (1,3)fucosyltransferase gene and
            molecular comparison to the human Lewis blood group alpha
            (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic
            genes encoding enzymes with distinct acceptor substrate
            specificities
  JOURNAL   J Biol Chem 267 (6), 4152-4160 (1992)
   PUBMED   1740457
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024592.5.
            
            On Sep 22, 2004 this sequence version replaced NM_002034.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U27330.1, U27329.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000588525.1/ ENSP00000466880.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC024592.5         50079-50154         c
            77-1988             AC024592.5         45440-47351         c
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1988
                     /gene="FUT5"
                     /gene_synonym="FUC-TV"
                     /note="fucosyltransferase 5"
                     /db_xref="GeneID:2527"
                     /db_xref="HGNC:HGNC:4016"
                     /db_xref="MIM:136835"
     exon            1..76
                     /gene="FUT5"
                     /gene_synonym="FUC-TV"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1988
                     /gene="FUT5"
                     /gene_synonym="FUC-TV"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1213
                     /gene="FUT5"
                     /gene_synonym="FUC-TV"
                     /EC_number="2.4.1.65"
                     /EC_number="2.4.1.152"
                     /note="alpha (1,3) fucosyltransferase; fucT-V;
                     fucosyltransferase V; galactoside 3-L-fucosyltransferase;
                     alpha-(1,3)-fucosyltransferase 5;
                     3-galactosyl-N-acetylglucosaminide
                     4-alpha-L-fucosyltransferase FUT5"
                     /codon_start=1
                     /product="4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase FUT5"
                     /protein_id="NP_002025.2"
                     /db_xref="CCDS:CCDS12154.1"
                     /db_xref="GeneID:2527"
                     /db_xref="HGNC:HGNC:4016"
                     /db_xref="MIM:136835"
                     /translation="MDPLGPAKPQWLWRRCLAGLLFQLLVAVCFFSYLRVSRDDATGS
                     PRPGLMAVEPVTGAPNGSRCQDSMATPAHPTLLILLWTWPFNTPVALPRCSEMVPGAA
                     DCNITADSSVYPQADAVIVHHWDIMYNPSANLPPPTRPQGQRWIWFSMESPSNCRHLE
                     ALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSA
                     RVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRN
                     ALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFH
                     WRETLRPRSFSWALAFCKACWKLQQESRYQTVRSIAAWFT"
ORIGIN      
        1 gattacagac atgagccacc tcgcccagcc ttttcatggc tgagtgatat tccattgtgt
       61 ggatggatca cactagctac tctgacccat ggatcccctg ggcccagcca agccacagtg
      121 gctgtggcgc cgctgtctgg ccgggctgct gtttcagctg ctggtggctg tgtgtttctt
      181 ctcctacctg cgtgtgtccc gagacgatgc cactggatcc cctaggccag ggcttatggc
      241 agtggaacct gtcaccgggg ctcccaatgg gtcccgctgc caggacagca tggcgacccc
      301 tgcccacccc accctactga tcctgctgtg gacgtggcct tttaacacac ccgtggctct
      361 gccccgctgc tcagagatgg tgcccggcgc ggccgactgc aacatcactg ccgactccag
      421 tgtgtaccca caggcagacg cggtcatcgt gcaccactgg gatatcatgt acaaccccag
      481 tgccaacctc ccgcccccca ccaggccgca ggggcagcgc tggatctggt tcagcatgga
      541 gtcccccagc aactgccggc acctggaagc cctggacgga tacttcaatc tcaccatgtc
      601 ctaccgcagc gactccgaca tcttcacgcc ctacggctgg ctggagccgt ggtccggcca
      661 gcctgcccac ccaccgctca acctctcggc caagaccgag ctggtggcct gggcggtgtc
      721 caactggaag ccggactcgg ccagggtgcg ctactaccag agcctgcagg ctcatctcaa
      781 ggtggacgtg tacggacgct cccacaagcc cctgcccaag gggaccatga tggagacgct
      841 gtcccggtac aagttctatc tggccttcga gaactccttg caccccgact acatcaccga
      901 gaagctgtgg aggaacgccc tggaggcctg ggccgtgccc gtggtgctgg gccccagcag
      961 aagcaactac gagaggttcc tgccacccga cgccttcatc cacgtggacg acttccagag
     1021 ccccaaggac ctggcccggt acctgcagga gctggacaag gaccacgccc gctacctgag
     1081 ctactttcac tggcgggaga cgctgcggcc tcgctccttc agctgggcac tggctttctg
     1141 caaggcctgc tggaagctgc agcaggaatc taggtaccag acggtgcgca gcatagcggc
     1201 ttggttcacc tgagaggccg gcatggggcc tgggctgccg ggacctcact ttcccagggc
     1261 ctcacctacc tagggtctca ctagtcgggg gatttaccta cctggggcct cggctgcctg
     1321 gggcctcggc tgcctggggt ctcacctgcc tggggcctca cctgctggag tctttggtgg
     1381 ccaggcatgt gacttacctg ggatttcact tgccgggctt cactgccagg agcctcccct
     1441 gctggggacc ttgccagctg gggctgggga tggtgcctac tggggacctt gctttctgga
     1501 ggctgcacct actgaggatc tcggctgttg gggactttac ctgctgggac ctgctcccag
     1561 agaccttgcc acactgaatg tcacctgcta ggagcctcac ccgctgggag gcacagggcc
     1621 caagggagct ggatgtgttg cccaaggtgt gcagggcagg tcagggaagg gcagggtccc
     1681 ctaaggagga gggcgaaggg tatgtgtgtg accatcagca gtggtgtgca catggctggg
     1741 ggacactcgg tttgaccgcc agcggatggg tgtcacaaat gcatcactat gggtgtgacc
     1801 tcggcgtgac tctgatagtg cctgtggatg tgttgcgatg cctcaccctg gagggcactg
     1861 ggccctgaga acgggtgccc ttgaggccct gcccccgggc gatggtgcag gctggtttgc
     1921 ttgtggtttt attgctgttg ttaaccaccc atgaggggtg caaacagata atgctgttaa
     1981 cattttca
//
