LOCUS       NM_002033               5975 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens fucosyltransferase 4 (FUT4), mRNA.
ACCESSION   NM_002033
VERSION     NM_002033.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5975)
  AUTHORS   Yang,Y., Yan,X., Chen,Y., Liu,J., Xue,J., Sheng,X., Qin,J., Xue,Q.
            and Liu,X.
  TITLE     Silencing FUT4 Inhibits the Progression of Osteosarcoma through
            Activation of FOXO1
  JOURNAL   Curr Pharm Des 30 (6), 440-447 (2024)
   PUBMED   38343056
  REMARK    GeneRIF: Silencing FUT4 Inhibits the Progression of Osteosarcoma
            through Activation of FOXO1.
REFERENCE   2  (bases 1 to 5975)
  AUTHORS   Stenzel,P.J., Schindeldecker,M., Seidmann,L., Herpel,E.,
            Hohenfellner,M., Hatiboglu,G., Foersch,S., Porubsky,S.,
            Macher-Goeppinger,S., Roth,W. and Tagscherer,K.E.
  TITLE     CD15 Is a Risk Predictor and a Novel Target in Clear Cell Renal
            Cell Carcinoma
  JOURNAL   Pathobiology 91 (3), 219-229 (2024)
   PUBMED   37963432
  REMARK    GeneRIF: CD15 Is a Risk Predictor and a Novel Target in Clear Cell
            Renal Cell Carcinoma.
REFERENCE   3  (bases 1 to 5975)
  AUTHORS   Costa,A.F., Senra,E., Faria-Ramos,I., Teixeira,A., Morais,J.,
            Pacheco,M., Reis,C.A. and Gomes,C.
  TITLE     ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells
            and associates with cancer cell motility
  JOURNAL   Glycoconj J 40 (4), 421-433 (2023)
   PUBMED   37074623
  REMARK    GeneRIF: ST3GalIV drives SLeX biosynthesis in gastrointestinal
            cancer cells and associates with cancer cell motility.
REFERENCE   4  (bases 1 to 5975)
  AUTHORS   Liang,J.X., Gao,W., Wei,W.T., Yang,X. and Liu,J.S.
  TITLE     X-ray inhibits FUT4-mediated proliferation in A549 cells by
            downregulating SP1 expression
  JOURNAL   J Pak Med Assoc 73 (3), 494-499 (2023)
   PUBMED   36932748
  REMARK    GeneRIF: X-ray inhibits FUT4-mediated proliferation in A549 cells
            by downregulating SP1 expression.
REFERENCE   5  (bases 1 to 5975)
  AUTHORS   Miyoshi,K., Sato,E., Katsumata,K., Fukushima,G., Udo,R.,
            Nishimura,E., Tago,T., Kasahara,K., Mazaki,J., Enomoto,M.,
            Ishizaki,T., Nagakawa,Y. and Tsuchida,A.
  TITLE     CD15+ Bone Marrow-derived Cells Are Regulators of Immune Response
            in ARG1-producing Colorectal Cancer Cells
  JOURNAL   Anticancer Res 42 (1), 459-470 (2022)
   PUBMED   34969756
  REMARK    GeneRIF: CD15(+) Bone Marrow-derived Cells Are Regulators of Immune
            Response in ARG1-producing Colorectal Cancer Cells.
REFERENCE   6  (bases 1 to 5975)
  AUTHORS   Weston,B.W., Nair,R.P., Larsen,R.D. and Lowe,J.B.
  TITLE     Isolation of a novel human alpha (1,3)fucosyltransferase gene and
            molecular comparison to the human Lewis blood group alpha
            (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic
            genes encoding enzymes with distinct acceptor substrate
            specificities
  JOURNAL   J Biol Chem 267 (6), 4152-4160 (1992)
   PUBMED   1740457
REFERENCE   7  (bases 1 to 5975)
  AUTHORS   Kumar,R., Potvin,B., Muller,W.A. and Stanley,P.
  TITLE     Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes
            ELFT but does not confer ELAM-1 recognition on Chinese hamster
            ovary cell transfectants
  JOURNAL   J Biol Chem 266 (32), 21777-21783 (1991)
   PUBMED   1718983
REFERENCE   8  (bases 1 to 5975)
  AUTHORS   Lowe,J.B., Kukowska-Latallo,J.F., Nair,R.P., Larsen,R.D.,
            Marks,R.M., Macher,B.A., Kelly,R.J. and Ernst,L.K.
  TITLE     Molecular cloning of a human fucosyltransferase gene that
            determines expression of the Lewis x and VIM-2 epitopes but not
            ELAM-1-dependent cell adhesion
  JOURNAL   J Biol Chem 266 (26), 17467-17477 (1991)
   PUBMED   1716630
REFERENCE   9  (bases 1 to 5975)
  AUTHORS   Goelz,S.E., Hession,C., Goff,D., Griffiths,B., Tizard,R.,
            Newman,B., Chi-Rosso,G. and Lobb,R.
  TITLE     ELFT: a gene that directs the expression of an ELAM-1 ligand
  JOURNAL   Cell 63 (6), 1349-1356 (1990)
   PUBMED   1702034
REFERENCE   10 (bases 1 to 5975)
  AUTHORS   Skubitz,K.M. and Snook,R.W. 2nd.
  TITLE     Monoclonal antibodies that recognize lacto-N-fucopentaose III
            (CD15) react with the adhesion-promoting glycoprotein family
            (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils
  JOURNAL   J Immunol 139 (5), 1631-1639 (1987)
   PUBMED   3305706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000943.5.
            
            On Oct 23, 2020 this sequence version replaced NM_002033.3.
            
            Summary: The product of this gene transfers fucose to
            N-acetyllactosamine polysaccharides to generate fucosylated
            carbohydrate structures. It catalyzes the synthesis of the
            non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M58597.1, BC136373.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358752.4/ ENSP00000351602.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5975              AP000943.5         47184-53158
FEATURES             Location/Qualifiers
     source          1..5975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..5975
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /note="fucosyltransferase 4"
                     /db_xref="GeneID:2526"
                     /db_xref="HGNC:HGNC:4015"
                     /db_xref="MIM:104230"
     exon            1..5975
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1806
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /EC_number="2.4.1.152"
                     /note="ELAM ligand fucosyltransferase; galactoside
                     3-L-fucosyltransferase; stage-specific embryonic antigen
                     1; Lewis X; fucosyltransferase IV; fucT-IV; ELAM-1 ligand
                     fucosyltransferase; alpha (1,3) fucosyltransferase,
                     myeloid-specific; 4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 4"
                     /protein_id="NP_002024.1"
                     /db_xref="CCDS:CCDS8301.1"
                     /db_xref="GeneID:2526"
                     /db_xref="HGNC:HGNC:4015"
                     /db_xref="MIM:104230"
                     /translation="MRRLWGAARKPSGAGWEKEWAEAPQEAPGAWSGRLGPGRSGRKG
                     RAVPGWASWPAHLALAARPARHLGGAGQGPRPLHSGTAPFHSRASGERQRRLEPQLQH
                     ESRCRSSTPADAWRAEAALPVRAMGAPWGSPTAAAGGRRGWRRGRGLPWTVCVLAAAG
                     LTCTALITYACWGQLPPLPWASPTPSRPVGVLLWWEPFGGRDSAPRPPPDCRLRFNIS
                     GCRLLTDRASYGEAQAVLFHHRDLVKGPPDWPPPWGIQAHTAEEVDLRVLDYEEAAAA
                     AEALATSSPRPPGQRWVWMNFESPSHSPGLRSLASNLFNWTLSYRADSDVFVPYGYLY
                     PRSHPGDPPSGLAPPLSRKQGLVAWVVSHWDERQARVRYYHQLSQHVTVDVFGRGGPG
                     QPVPEIGLLHTVARYKFYLAFENSQHLDYITEKLWRNALLAGAVPVVLGPDRANYERF
                     VPRGAFIHVDDFPSASSLASYLLFLDRNPAVYRRYFHWRRSYAVHITSFWDEPWCRVC
                     QAVQRAGDRPKSIRNLASWFER"
     regulatory      2660..2665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /note="hexamer: ATTAAA"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /note="hexamer: ATTACA"
     polyA_site      2681
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /note="major polyA site"
     polyA_site      2685
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /note="major polyA site"
     regulatory      5959..5964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /note="hexamer: AATAAT"
     polyA_site      5975
                     /gene="FUT4"
                     /gene_synonym="CD15; ELFT; FCT3A; FUC-TIV; FUTIV; LeX;
                     SSEA-1"
                     /note="major polyA site"
ORIGIN      
        1 gttccgcggc gccgggtccg ccttccgtct gttctagggc ctgctcctgc gcggcagctg
       61 ctttagaagg tctcgagcct cctgtacctt cccagggatg aaccgggcct tccctctgga
      121 aggcgagggt tcgggccaca gtgagcgagg gccagggcgg tgggcgcgcg cagagggaaa
      181 ccggatcagt tgagagagaa tcaagagtag cggatgaggc gcttgtgggg cgcggcccgg
      241 aagccctcgg gcgcgggctg ggagaaggag tgggcggagg cgccgcagga ggctcccggg
      301 gcctggtcgg gccggctggg ccccgggcgc agtggaagaa agggacgggc ggtgcccggt
      361 tgggcgtcct ggccagctca ccttgccctg gcggctcgcc ccgcccggca cttgggagga
      421 gcagggcagg gcccgcggcc tttgcattct gggaccgccc ccttccattc ccgggccagc
      481 ggcgagcggc agcgacggct ggagccgcag ctacagcatg agagccggtg ccgctcctcc
      541 acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg
      601 tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg
      661 ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac
      721 gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg
      781 ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct
      841 gactgccggc tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac
      901 ggagaggctc aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg
      961 cccccgccct ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac
     1021 tacgaggagg cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc
     1081 cagcgctggg tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg
     1141 gcaagtaacc tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct
     1201 tatggctacc tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca
     1261 ctgtccagga aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc
     1321 cgggtccgct actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc
     1381 gggccggggc agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc
     1441 tacctggctt tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac
     1501 gcgttgctcg ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc
     1561 tttgtgcccc gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc
     1621 tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc
     1681 cggagctacg ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag
     1741 gctgtacaga gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag
     1801 cggtgaagcc gcgctcccct ggaagcgacc caggggaggc caagttgtca gctttttgat
     1861 cctctactgt gcatctcctt gactgccgca tcatgggagt aagttcttca aacacccatt
     1921 tttgctctat gggaaaaaaa cgatttacca attaatatta ctcagcacag agatgggggc
     1981 ccggtttcca tattttttgc acagctagca attgggctcc ctttgctgct gatgggcatc
     2041 attgtttagg ggtgaaggag ggggttcttc ctcaccttgt aaccagtgca gaaatgaaat
     2101 agcttagcgg caagaagccg ttgaggcggt ttcctgaatt tccccatctg ccacaggcca
     2161 tatttgtggc ccgtgcagct tccaaatctc atacacaact gttcccgatt cacgtttttc
     2221 tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc ttgttggtgg agagtggaag
     2281 gactgtggct gcaggtggga ctttgttgtt tggattcctc acagccttgg ctcctgagaa
     2341 aggtgaggag ggcagtccaa gaggggccgc tgacttcttt cacaagtact atctgttccc
     2401 ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg aggaaactta agatgaatac
     2461 atgcgtgtac ctcactttac ataagaaatg tattcctgaa aagctgcatt taaatcaagt
     2521 cccaaattca ttgacttagg ggagttcagt atttaatgaa accctatgga gaatttatcc
     2581 ctttacaatg tgaatagtca tctcctaatt tgtttcttct gtctttatgt ttttctataa
     2641 cctggatttt ttaaatcata ttaaaattac agatgtgaaa ataaagcaga agcaaccttt
     2701 ttccctcttc ccagaaaacc agtctgtgtt tacagacaga agagaaggaa gccatagtgt
     2761 cacttccaca caattattta tttcatgtct ttactggacc tgaaatttaa actgcaatgc
     2821 cagtcctgca ggagtgctgg cattaccctc tgcagaacag tgaaaggtat tgcactacat
     2881 tatggaatca tgcaaaagga aaaaaagttt catgatatct gttgttggca gtttttgttt
     2941 atctctgaca gtttttagtt aaatgtttag atcctcagaa ctacattagt gcctactatt
     3001 aacttactct gtctcttgtt aaaggctaaa tctgcgcttc tccctggtgc cagcaggttc
     3061 ccctcacagt caatgcagtg gtatagcata tcctcacatt tctagtgccc ttgagactgt
     3121 gctatggaac caatcttgaa catacatgca ttgacttgac aagttactga gtaagcagca
     3181 tattcagcag gtgccactac atgcctactc tgccagacac tgagcttggg gccctaggga
     3241 agatagagaa ttatacaagg caaagtcctt ctctttaggg ctcttacaat ctatcacttc
     3301 caaaaagtaa atggtgactg ataaaacaat tggcagaacc tgtttgatta ctgtgacagt
     3361 cttaatgata ccataaatca atattagaaa gctagttgac ttaaagcctg aaataatggg
     3421 agttttctcc tccacttatt agaataagga ccctcagtga ctaattattg tgggtagggt
     3481 caagattaac tagttttata cagagttctg ctgtaaatag tcattttgca tttgattagt
     3541 gcagttctct gaatcataaa gcaagtttta cctctctgta catgtttttg cagacatact
     3601 tgaaaagctc acttaaatct aggtgcttca attcactttc ttgagaggac aaatgaaaag
     3661 ctgtggagaa aatgtcctca ttaaagtatt aaagtgtggg cagaattaca attacaaagt
     3721 gccagccacc gaataaagat aaaagttcag ttcttaaaat gagtttttat gagataacag
     3781 tcagtgatct tggtgttacc gggattccac atggggcagt gggaaagagt tcaggttttg
     3841 aaggtaacct agtttagatt tgaattccag ctatgtgaca ttgggtaaat tagtagtagt
     3901 cctgagcctc agcgtcctca tctataaaat gactggcgaa aatacttcac aagctcattt
     3961 tgagcacttt aggaagtaag tgaaagtacc taaaatagca ggcacccaat tgatgatttt
     4021 atatcttcct tctttgcttg cagtgatttc aggatgtcct catatctatt tataggtcta
     4081 aaattatatc ttaaggtatg ttgtagaata aattaaaagg ataatctaaa tcaccattta
     4141 gattaagctt gacttgcaaa ctaggaagaa gcacctaggc tttctttgaa aatatttttt
     4201 tggttcgttt tggtaaagct ctataaattg gtatctatta ttttaccaat ttttttttag
     4261 tattaagtcc atttagaact aaccatatta tttatggaat aattagcatg aggaaggtat
     4321 aattgcattt tttttttttt gagacggagt cttgcactgt agccccagct ggactgcagt
     4381 ggcgtgatct tggctcactg caacctccgc ctcccaggtt caagcgattc tcctgcctca
     4441 gcctcccgag cagctgagac tacaggcgcc tgccaccacg cctggccaat tttttgtatt
     4501 tttagtagag actgcgtttc accatgttgg gcaggctggt cttgaactcc tgaccttgtg
     4561 atccacctgc ctcggcctct cagagagctg ggattacagg tgtgagccgc cgtgcccagc
     4621 cattgcattt ttattcacat acacattgtt aatgtggaac aatttaacac taatctcatc
     4681 agagagcgag atgaatgtgg caattgctca ttttattttg catatattaa attgagtagg
     4741 ttcagctcta acatacctta agaaaaatgc atatcggtgc actgtatgta tttcaaaatg
     4801 cctttcctat gattgtcatg tcctccttta aggcttttcc ctcaaattta ttacaaattt
     4861 agtattttta gtacttgatg actctaatta catgaatgca cctggaatga catttgtaac
     4921 agaagacggt ctgacttgct ttcagtattc acaagttctt tccagtttcc aagtcttttc
     4981 ctagcagtaa tttaggggag acagaggagt ttcatgtaaa gagcatgcag tttggagtca
     5041 gaacctgggt atgactctgt ggccttgatg aagcaagtta cttaaactct tgagttttag
     5101 ctttctcctt tacaatgcat gaatgcctat ccccctacaa aacaaagatt aaatgtgatg
     5161 atgtatgcca aggtgctttg tatattgtaa agtgctatat aattataaga tgttctaaat
     5221 tttcaaggat ctaaaccagg gattggcaaa cgtttttcca gggagtaaat attttacgct
     5281 ttgcatatat aatttatgga ggtgttgaga ggatagatta gacacttgaa gtactcagga
     5341 tagtgcctgg catgtaggaa gcacctggaa aatattcgct gtgattacca tcagtccatt
     5401 ttaccgagga aggagccaag gtccaggccc actgaaggac ttgcataaca ttacaatagc
     5461 agtggcagaa ccagccatgc ttctgcaaat cacaacctct ttgagcctct gtcacctgaa
     5521 ctgcaaaatg agtgggttag acaaaatcat ctgttgggac ctcctagttc cacgtgctat
     5581 cattctacta actggcaccc taaggttgaa agtgcttatc tgctttccaa tgtggcttcc
     5641 ttacagtctg gaactgacaa tatgcaggag cagtaaactg gcagaaaacc aggaatcaga
     5701 gaaagaaaat ataatttaac tttaaagatg taaattatat atatagtata ttatatatat
     5761 ttttaaagct ttatatgcct caaatatcag ggaaaggagc caagtccttg gtatttagtt
     5821 tggtgaatac ttgcattgaa tacatgtcaa gatgtcaagt catttttgaa tgtgtctcag
     5881 ggatttctat gctacacatt cttttaacaa atcaagtatt tatgtacaca tgttcagatt
     5941 ttttgacaaa atgattaaaa taatgagatg gaaaa
//
