LOCUS       NM_000511               3116 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens fucosyltransferase 2 (H blood group) (FUT2),
            transcript variant 1, mRNA.
ACCESSION   NM_000511
VERSION     NM_000511.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Dong,C., Zhang,Y., Zeng,J., Chong,S., Liu,Y., Bian,Z., Fan,S. and
            Chen,X.
  TITLE     FUT2 promotes colorectal cancer metastasis by reprogramming fatty
            acid metabolism via YAP/TAZ signaling and SREBP-1
  JOURNAL   Commun Biol 7 (1), 1297 (2024)
   PUBMED   39390072
  REMARK    GeneRIF: FUT2 promotes colorectal cancer metastasis by
            reprogramming fatty acid metabolism via YAP/TAZ signaling and
            SREBP-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Abdulrida,F.M. and Diajil,A.R.
  TITLE     Chemo-sensory loss and FUT2 gene in COVID-19 infected Iraqi
            dentists
  JOURNAL   Wiad Lek 77 (7), 1377-1386 (2024)
   PUBMED   39241136
  REMARK    GeneRIF: Chemo-sensory loss and FUT2 gene in COVID-19 infected
            Iraqi dentists.
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Jiang,F., Boakye,D., Sun,J., Wang,L., Yu,L., Zhou,X., Zhao,J.,
            Bian,Z., Song,P., He,Y., Zhu,Y., Chen,J., Yuan,S., Song,M.,
            Larsson,S.C., Giovannucci,E.L., Theodoratou,E., Ding,K. and Li,X.
  TITLE     Association between antibiotic use during early life and
            early-onset colorectal cancer risk overall and according to
            polygenic risk and FUT2 genotypes
  JOURNAL   Int J Cancer 153 (9), 1602-1611 (2023)
   PUBMED   37504220
  REMARK    GeneRIF: Association between antibiotic use during early life and
            early-onset colorectal cancer risk overall and according to
            polygenic risk and FUT2 genotypes.
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Kim,J., Yuan,C., Amundadottir,L.T., Wolpin,B.M., Klein,A.P.,
            Risch,H.A. and Kraft,P.
  CONSRTM   Pancreatic Cancer Cohort Consortium (PanScan); Pancreatic Cancer
            Case-Control Consortium (PanC4)
  TITLE     Relationship between ABO Blood Group Alleles and Pancreatic Cancer
            Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen
            (FUT3) Genotype
  JOURNAL   Cancer Epidemiol Biomarkers Prev 32 (9), 1242-1248 (2023)
   PUBMED   37342060
  REMARK    GeneRIF: Relationship between ABO Blood Group Alleles and
            Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not
            Lewis Antigen (FUT3) Genotype.
REFERENCE   5  (bases 1 to 3116)
  AUTHORS   Fernandez-Mateos,P., Cailleau,A., Henry,S., Costache,M.,
            Elmgren,A., Svensson,L., Larson,G., Samuelsson,B.E., Oriol,R. and
            Mollicone,R.
  TITLE     Point mutations and deletion responsible for the Bombay H null and
            the Reunion H weak blood groups
  JOURNAL   Vox Sang 75 (1), 37-46 (1998)
   PUBMED   9745152
REFERENCE   6  (bases 1 to 3116)
  AUTHORS   Kudo,T., Iwasaki,H., Nishihara,S., Shinya,N., Ando,T., Narimatsu,I.
            and Narimatsu,H.
  TITLE     Molecular genetic analysis of the human Lewis histo-blood group
            system. II. Secretor gene inactivation by a novel single missense
            mutation A385T in Japanese nonsecretor individuals
  JOURNAL   J Biol Chem 271 (16), 9830-9837 (1996)
   PUBMED   8621666
REFERENCE   7  (bases 1 to 3116)
  AUTHORS   Kelly,R.J., Rouquier,S., Giorgi,D., Lennon,G.G. and Lowe,J.B.
  TITLE     Sequence and expression of a candidate for the human Secretor blood
            group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an
            enzyme-inactivating nonsense mutation commonly correlates with the
            non-secretor phenotype
  JOURNAL   J Biol Chem 270 (9), 4640-4649 (1995)
   PUBMED   7876235
REFERENCE   8  (bases 1 to 3116)
  AUTHORS   Rouquier,S., Lowe,J.B., Kelly,R.J., Fertitta,A.L., Lennon,G.G. and
            Giorgi,D.
  TITLE     Molecular cloning of a human genomic region containing the H blood
            group alpha(1,2)fucosyltransferase gene and two H locus-related DNA
            restriction fragments. Isolation of a candidate for the human
            Secretor blood group locus
  JOURNAL   J Biol Chem 270 (9), 4632-4639 (1995)
   PUBMED   7876234
REFERENCE   9  (bases 1 to 3116)
  AUTHORS   Reguigne-Arnould,I., Couillin,P., Mollicone,R., Faure,S.,
            Fletcher,A., Kelly,R.J., Lowe,J.B. and Oriol,R.
  TITLE     Relative positions of two clusters of human
            alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p
            (FUT6-FUT3-FUT5) within the microsatellite genetic map of
            chromosome 19
  JOURNAL   Cytogenet Cell Genet 71 (2), 158-162 (1995)
   PUBMED   7656588
REFERENCE   10 (bases 1 to 3116)
  AUTHORS   Ball,S.P., Tongue,N., Gibaud,A., Le Pendu,J., Mollicone,R.,
            Gerard,G. and Oriol,R.
  TITLE     The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU,
            PEPD, C3, APOC2, D19S7 and D19S9
  JOURNAL   Ann Hum Genet 55 (3), 225-233 (1991)
   PUBMED   1763885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA918525.1, D87942.1 and
            AC008888.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000511.5.
            
            Summary: This gene is one of two encoding the galactoside
            2-L-fucosyltransferase enzyme. The encoded protein is important for
            the final step in the soluble ABO blood group antigen synthesis
            pathway. It is also involved in cell-cell interaction, cell surface
            expression, and cell proliferation. Mutations in this gene are a
            cause of the H-Bombay blood group where red blood cells lack the H
            antigen. [provided by RefSeq, May 2022].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Sequence Note: This RefSeq record represents the SE*01.01.01
            allele.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY751739.1, SRR1803615.215820.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000425340.3/ ENSP00000387498.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DA918525.1         1-10
            11-538              D87942.1           1-528
            539-3099            AC008888.7         82768-85328
            3100-3116           AC008888.7         85329-85345
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..3116
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
                     /note="fucosyltransferase 2 (H blood group)"
                     /db_xref="GeneID:2524"
                     /db_xref="HGNC:HGNC:4013"
                     /db_xref="MIM:182100"
     exon            1..119
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
                     /inference="alignment:Splign:2.1.0"
     exon            120..3116
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1153
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
                     /EC_number="2.4.1.69"
                     /EC_number="2.4.1.344"
                     /note="galactoside 2-alpha-L-fucosyltransferase 2;
                     GDP-L-fucose:beta-D-galactoside
                     2-alpha-L-fucosyltransferase 2; alpha(1,2)FT2; secretor
                     factor; secretor blood group alpha-2-fucosyltransferase;
                     alpha (1,2) fucosyltransferase; alpha(1,2)FT 2;
                     fucosyltransferase 2 (secretor status included);
                     galactoside 2-L-fucosyltransferase; type 1 galactoside
                     alpha-(1,2)-fucosyltransferase FUT2; type 2 galactoside
                     alpha-(1,2)-fucosyltransferase FUT2"
                     /codon_start=1
                     /product="galactoside alpha-(1,2)-fucosyltransferase 2"
                     /protein_id="NP_000502.4"
                     /db_xref="CCDS:CCDS33069.1"
                     /db_xref="GeneID:2524"
                     /db_xref="HGNC:HGNC:4013"
                     /db_xref="MIM:182100"
                     /translation="MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQ
                     IPVLASTSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHST
                     LAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHL
                     RQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVA
                     DRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFA
                     LLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIA
                     ADLSPLLKH"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
                     /note="hexamer: AATAAA"
     regulatory      3086..3091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
                     /note="hexamer: AATAAA"
     polyA_site      3096
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
                     /note="major polyA site"
     polyA_site      3116
                     /gene="FUT2"
                     /gene_synonym="B12QTL1; SE; Se2; SEC2; sej"
ORIGIN      
        1 agtcaccgat gctggaaggg tttctttggc cctgagtgaa gagagaccca gagggaacac
       61 tgaggtgcct gcccaaccac tctgtcccgg tttccttcag caggaccagg tgagagaagc
      121 catgctggtc gttcagatgc ctttctcctt tcccatggcc cacttcatcc tctttgtctt
      181 tacggtttcc actatatttc acgttcagca gcggctagcg aagattcaag ccatgtggga
      241 gttaccggtg cagataccag tgctagcctc aacatcaaag gcactgggac ccagccagct
      301 cagggggatg tggacgatca atgcaatagg ccgcctgggg aaccagatgg gcgagtacgc
      361 cacactgtac gccctggcca agatgaacgg gcggcccgcc ttcatcccgg cccagatgca
      421 cagcaccctg gcccccatct tcagaatcac cctgccggtg ctgcacagcg ccacggccag
      481 caggatcccc tggcagaact accacctgaa cgactggatg gaggaggaat accgccacat
      541 cccgggggag tacgtccgct tcaccggcta cccctgctcc tggaccttct accaccacct
      601 ccgccaggag atcctccagg agttcaccct gcacgaccac gtgcgggagg aggcccagaa
      661 gttcctgcgg ggcctgcagg tgaacgggag ccggccgggc acctttgtag gggtccatgt
      721 tcgccgaggg gactatgtcc atgtcatgcc aaaagtgtgg aagggggtgg tggccgaccg
      781 gcgataccta cagcaggccc tggactggtt ccgagctcgc tacagctccc tcatcttcgt
      841 ggtcaccagt aatggcatgg cctggtgtcg ggagaacatt gacacctccc acggtgatgt
      901 ggtgtttgct ggcgatggca ttgagggctc acctgccaaa gattttgctc tactcacaca
      961 gtgtaaccac accatcatga ccattgggac gttcgggatc tgggccgcat acctcacggg
     1021 cggagacacc atctacctgg ccaattacac cctccccgac tcccctttcc tcaaaatctt
     1081 taagccagag gcagccttcc tgccggagtg gacagggatt gccgcagacc tgtccccctt
     1141 actcaagcac taatgctggc ccattctttg agaccttttc tccttctctg cctccctcaa
     1201 gatgagtgcc cgggcatgag aagcacatgg ttccatgagc aggacccatc tctcttctgt
     1261 gaagatgcgt tgggctgcaa gtaacagaaa tctcagtgaa cagtggcctg gcgtggtggc
     1321 tcatgcctgt aatgctcgca ctttgtgagg ccagggtggg tggatcactt gaggtcagga
     1381 gttcaagact agcctggcca acatggtgaa accccatctc gactaaaaat acaaaaatta
     1441 gccaggcgtg gtggtgcaca cctgtaatcc cagctactcg ggaggctgag gcaagagaat
     1501 cacttgaacc caggaggcgg aggttgcagt gagccaagat ggtgccgctg cactccagtc
     1561 tgggtgacac agcaagactc catctcaaaa aaaaaaaaaa aaaaaagaaa agaaaaagaa
     1621 atgaatgggt tcaaagacca taatcatgca tatcacataa gaccagaagt ggcccaggtc
     1681 cagggtcagt taatttagcg gctccacaaa gtcatcagtc acctgagctc catccatctt
     1741 cacatgctgt gctaccattt cttagctgta tcatcccatg gtcccaaaag ggctgctaca
     1801 catccagcca tcacatgcag ataattcctt tcaaaaacag cagaaagagg ctcgttcttg
     1861 tcttggtccc ttttgaagaa tgaatgaaac cttcctaagc cttccagcaa tttcccccca
     1921 actccgatgg gtaggaattg tcacataccc atgtgacccg ataggaggca aaagaaatga
     1981 gacttctggg attagtttag cctcagattc tgcagctgag aagttgatca gccacctctg
     2041 aaggacatgc agcttgcaga aaattagggt ggtgttacca aggtgaaaag gggaaatggc
     2101 tttagagtag acaacagaga tgccctgagg ggttgtgtag gttgttcact gcaggaagtc
     2161 ccctggttaa gaaggcaagt ggggtttaaa cagacccaca gtctactcat caaaccaggt
     2221 gtccttggca ttgtgtccac ccagagagct cactgttttc ttttcttttt cttttctttt
     2281 tttttttttt tttgagatgg agtcttgctg catcccccag gctggagtgc agtggcatga
     2341 tcttggctca ctgcagcctc cgcctcccag gttcaagcga ttctcctgcc tcagcctccc
     2401 gagtagctag gattacaggt gcgtgccacc acgcccagct aatttttata tgtttagtgg
     2461 aaatggagtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca tgatccgcct
     2521 tcctcggcct cccaaagtgc tgggattaca ggtgttagcc actgcgcccg gccctagagc
     2581 tcactgtttt ctagttagtc catctggaag tggagccttt ttccagtttg cacaaatgtg
     2641 ccatattggc ttgtagctgg catgcatcca agtccatagg tcctgcctct tcaatcctgg
     2701 ctttctaggg cctgggatga tcattgctag aactgagaga ccagcctggc tcagtgaact
     2761 tcagggcgtt ccgttcattc tttcagtaaa tgtttgcagc acatgtgtta catgtcaggc
     2821 agtgaaaccc cccacagcag ccttccctct cagaggatac atttgtaacc attacacagt
     2881 catcaaagga ataatttttt ttaatcacca gtgtgcatac agtcatggag ttgggtattc
     2941 ccagctacca gggaggctga ggtgggagga ttgcttgatg ccaggagtta gggaatatag
     3001 tgcaccgtga ttggacttgc gaatagccac tgcactgcgg cctggacgac gtagtgatac
     3061 cctgactctt ataaataaat aaatgaataa acacaattat gactttgcgg atggga
//
