LOCUS       NM_173540               2071 bp    mRNA    linear   PRI 19-JAN-2025
DEFINITION  Homo sapiens fucosyltransferase 11 (FUT11), transcript variant 1,
            mRNA.
ACCESSION   NM_173540
VERSION     NM_173540.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2071)
  AUTHORS   Zhang,P., Tang,W., Jiang,Y., Lyu,F., Liu,Z., Xiao,Y. and Wang,D.
  TITLE     Dry and wet experiments reveal the significant role of FUT11 in
            clear cell renal cell carcinoma
  JOURNAL   Int Immunopharmacol 113 (Pt B), 109447 (2022)
   PUBMED   36403525
  REMARK    GeneRIF: Dry and wet experiments reveal the significant role of
            FUT11 in clear cell renal cell carcinoma.
REFERENCE   2  (bases 1 to 2071)
  AUTHORS   Ruan,W., Yang,Y., Yu,Q., Huang,T., Wang,Y., Hua,L., Zeng,Z. and
            Pan,R.
  TITLE     FUT11 is a target gene of HIF1alpha that promotes the progression
            of hepatocellular carcinoma
  JOURNAL   Cell Biol Int 45 (11), 2275-2286 (2021)
   PUBMED   34288238
  REMARK    GeneRIF: FUT11 is a target gene of HIF1alpha that promotes the
            progression of hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2071)
  AUTHORS   Zodro,E., Jaroszewski,M., Ida,A., Wrzesinski,T., Kwias,Z.,
            Bluyssen,H. and Wesoly,J.
  TITLE     FUT11 as a potential biomarker of clear cell renal cell carcinoma
            progression based on meta-analysis of gene expression data
  JOURNAL   Tumour Biol 35 (3), 2607-2617 (2014)
   PUBMED   24318988
  REMARK    GeneRIF: FUT11's expression might be potentially used as a
            biomarker of disease progression in clear cell renal cell carcinoma
REFERENCE   4  (bases 1 to 2071)
  AUTHORS   Mollicone,R., Moore,S.E., Bovin,N., Garcia-Rosasco,M.,
            Candelier,J.J., Martinez-Duncker,I. and Oriol,R.
  TITLE     Activity, splice variants, conserved peptide motifs, and phylogeny
            of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11)
  JOURNAL   J Biol Chem 284 (7), 4723-4738 (2009)
   PUBMED   19088067
  REMARK    GeneRIF: Activity, splice variants, conserved peptide motifs, and
            phylogeny of two new alpha1,3-fucosyltransferase families (FUT10
            and FUT11).
REFERENCE   5  (bases 1 to 2071)
  AUTHORS   Roos,C., Kolmer,M., Mattila,P. and Renkonen,R.
  TITLE     Composition of Drosophila melanogaster proteome involved in
            fucosylated glycan metabolism
  JOURNAL   J Biol Chem 277 (5), 3168-3175 (2002)
   PUBMED   11698403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022400.9, BC036037.1 and BC100997.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173540.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036037.1, SRR1803616.157172.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372841.8/ ENSP00000361932.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC022400.9         104987-105001
            16-208              BC036037.1         1-193
            209-1624            BC100997.1         191-1606
            1625-2071           BC036037.1         1610-2056
FEATURES             Location/Qualifiers
     source          1..2071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..2071
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /note="fucosyltransferase 11"
                     /db_xref="GeneID:170384"
                     /db_xref="HGNC:HGNC:19233"
                     /db_xref="MIM:616932"
     exon            1..766
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1537
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /EC_number="2.4.1.65"
                     /EC_number="2.4.1.152"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alpha-(1,3)-fucosyltransferase 11; fuc-TXI;
                     fucT-XI; fucosyltransferase XI; galactoside
                     3-L-fucosyltransferase 11; alpha (1,3) fucosyltransferase"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 11 isoform 1
                     precursor"
                     /protein_id="NP_775811.2"
                     /db_xref="CCDS:CCDS7333.1"
                     /db_xref="GeneID:170384"
                     /db_xref="HGNC:HGNC:19233"
                     /db_xref="MIM:616932"
                     /translation="MAAGPIRVVLVLLGVLSVCAASGHGSVAEREAGGEAEWAEPWDG
                     AVFRPPSALGAVGVTRSSGTPRPGREEAGDLPVLLWWSPGLFPHFPGDSERIECARGA
                     CVASRNRRALRDSRTRALLFYGTDFRASAAPLPRLAHQSWALLHEESPLNNFLLSHGP
                     GIRLFNLTSTFSRHSDYPLSLQWLPGTAYLRRPVPPPMERAEWRRRGYAPLLYLQSHC
                     DVPADRDRYVRELMRHIPVDSYGKCLQNRELPTARLQDTATATTEDPELLAFLSRYKF
                     HLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLA
                     EFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDSLKHREWGVNDPLLPNYLNGFECFVC
                     DYELARLDAEKAHAASPGDSPVFEPHIAQPSHMDCPVPTPGFGNVEEIPENDSWKEMW
                     LQDYWQGLDQGEALTAMIHNNETEQTKFWDYLHEIFMKRQHL"
     exon            767..1392
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2071
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /note="hexamer: TATAAA"
     polyA_site      2004
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /note="major polyA site"
     regulatory      2051..2056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /note="hexamer: ATTATA"
     polyA_site      2071
                     /gene="FUT11"
                     /gene_synonym="FUCTXI"
                     /note="major polyA site"
ORIGIN      
        1 gactatccgc tgggcggggt cggtgctggc cgagggggcg ccggctgccg gagtggacat
       61 ggcggccggc cccattaggg tggtgttggt ccttctaggg gtgctcagtg tctgtgcagc
      121 cagcggccat gggtccgtag cggagaggga ggccggcggg gaggcggagt gggcggaacc
      181 gtgggatggc gcggttttcc ggccgccctc ggcgctgggc gcagtggggg tgacgcgcag
      241 ctctgggacg ccgcggccag ggagggagga ggcgggggac ttgccggtac tgctgtggtg
      301 gagcccaggg ctattccccc acttcccggg agactcggag cgcatcgagt gtgcgcgcgg
      361 cgcgtgcgtg gcgtcccgga accgccgagc gctgagggac tcgcggacgc gcgcgctgct
      421 cttctacggc acagacttcc gcgcgtcggc cgccccgctg ccgcgcctgg cgcaccagag
      481 ctgggcgctc ctccacgagg agtcgcccct caacaacttc ttgctgagcc acggcccggg
      541 catccgcctc ttcaatctta cctccacctt cagtcgccac tcggattacc cgctgtcgct
      601 gcagtggctg cccgggaccg cctatctgcg ccgcccggtg cctccgccca tggaacgcgc
      661 ggagtggcgc cgccgcggct acgcgccgct gctctatctg cagtcacact gcgacgtgcc
      721 agcggaccgg gaccgctacg tgcgcgagct catgcgccac atcccggtag actcctacgg
      781 gaaatgcctg cagaatcggg agctgcctac cgcgcggcta caggacacag ccacggccac
      841 caccgaggat ccagagctct tggctttctt gtcccgctat aagttccact tggccctgga
      901 aaatgccatc tgtaacgact acatgacaga aaaactgtgg cgtcccatgc acctgggcgc
      961 tgtgcccgtg taccgcggtt ctccctctgt gagggactgg atgccgaaca atcactccgt
     1021 catcctgatt gatgattttg agtctcctca gaagctggca gagtttattg actttctgga
     1081 caagaatgat gaggagtata tgaaatacct ggcatacaag caacctgggg gcatcaccaa
     1141 ccaatttctt ctggatagtc tgaagcatcg ggagtgggga gtgaatgatc ctttgctgcc
     1201 taactacctc aacggcttcg agtgtttcgt ctgtgactac gaactggctc ggctggatgc
     1261 cgagaaagcc cacgcggcct ctcccgggga cagccccgtc tttgagcccc acattgccca
     1321 gccctcacac atggactgcc cagtgcccac acctggcttt ggcaatgtgg aagagattcc
     1381 tgagaatgac agttggaaag agatgtggct gcaagattat tggcaaggtc tggaccaggg
     1441 ggaagctctc actgccatga tccacaacaa tgaaacagag cagacgaaat tttgggatta
     1501 cctacatgaa atcttcatga agaggcaaca tctctaagtg cccttgcaag agcctttaac
     1561 ttggcggagc taaggagatc ttattctacc atgggacata aggagcatcc actgcacaaa
     1621 cccttaatga acactgtctt ttcatggatt caaggaattc cagttttatc tattaagatt
     1681 ttatcttaat gatgagtagc caaggtctaa catagggcct ctcctcaagg agagatggag
     1741 ggatacaatt cttggttcag tgggaaacag aaccctaaaa catccatttg attcaaggtg
     1801 ctggtccaac agagttttta aactactcac ttctttattt catcctttcg actgtacttg
     1861 attaccagtg aagtaagatg ggtcaggtta cgacttacaa cttttgttct attccccaga
     1921 ctcctcatta ttcagtacat ttcccaataa tctctttttc tcatctcttg ctttataaat
     1981 tgttacgttg gtggagaagc aaaacatttg gtgagttgta ttctggtttt ccggagttgg
     2041 atttttttat attatatact ttcatgtcaa a
//
