LOCUS       NM_032664               3549 bp    mRNA    linear   PRI 02-FEB-2024
DEFINITION  Homo sapiens fucosyltransferase 10 (FUT10), mRNA.
ACCESSION   NM_032664
VERSION     NM_032664.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Mollicone,R., Moore,S.E., Bovin,N., Garcia-Rosasco,M.,
            Candelier,J.J., Martinez-Duncker,I. and Oriol,R.
  TITLE     Activity, splice variants, conserved peptide motifs, and phylogeny
            of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11)
  JOURNAL   J Biol Chem 284 (7), 4723-4738 (2009)
   PUBMED   19088067
  REMARK    GeneRIF: Activity, splice variants, conserved peptide motifs, and
            phylogeny of two new alpha1,3-fucosyltransferase families (FUT10
            and FUT11).
REFERENCE   2  (bases 1 to 3549)
  AUTHORS   Baboval,T. and Smith,F.I.
  TITLE     Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and
            expression studies in the mouse
  JOURNAL   Mamm Genome 13 (9), 538-541 (2002)
   PUBMED   12370785
  REMARK    GeneRIF: Comparison of human and mouse Fuc-TX and Fuc-TXI genes,
            and expression studies in the mouse.
REFERENCE   3  (bases 1 to 3549)
  AUTHORS   Roos,C., Kolmer,M., Mattila,P. and Renkonen,R.
  TITLE     Composition of Drosophila melanogaster proteome involved in
            fucosylated glycan metabolism
  JOURNAL   J Biol Chem 277 (5), 3168-3175 (2002)
   PUBMED   11698403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ582015.1 and BC063462.1.
            
            On Jan 13, 2004 this sequence version replaced NM_032664.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ582015.1, SRR1660803.3619.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327671.10/ ENSP00000332757.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2254              AJ582015.1         1-2254
            2255-3549           BC063462.1         2295-3589
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..3549
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /note="fucosyltransferase 10"
                     /db_xref="GeneID:84750"
                     /db_xref="HGNC:HGNC:19234"
                     /db_xref="MIM:616931"
     exon            1..83
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /inference="alignment:Splign:2.1.0"
     exon            84..437
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1796
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /EC_number="2.4.1.69"
                     /note="alpha 1,3-fucosyl transferase; fuc-TX; fucT-X;
                     fucosyltransferase X; galactoside 3-L-fucosyltransferase
                     10; alpha (1,3) fucosyltransferase"
                     /codon_start=1
                     /product="alpha-(1,3)-fucosyltransferase 10"
                     /protein_id="NP_116053.3"
                     /db_xref="CCDS:CCDS6088.1"
                     /db_xref="GeneID:84750"
                     /db_xref="HGNC:HGNC:19234"
                     /db_xref="MIM:616931"
                     /translation="MVRIQRRKLLASCLCVTATVFLLVTLQVMVELGKFERKEFKSSS
                     LQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGA
                     DACFFTINRTYLHHHMTKAFLFYGTDFNIDSLPLPRKAHHDWAVFHEESPKNNYKLFH
                     KPVITLFNYTATFSRHSHLPLTTQYLESIEVLKSLRYLVPLQSKNKLRKRLAPLVYVQ
                     SDCDPPSDRDSYVRELMTYIEVDSYGECLRNKDLPQQLKNPASMDADGFYRIIAQYKF
                     ILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPSITDWLPSNKSAILVSEFSHPRELA
                     SYIRRLDSDDRLYEAYVEWKLKGEISNQRLLTALRERKWGVQDVNQDNYIDAFECMVC
                     TKVWANIRLQEKGLPPKRWEAEDTHLSCPEPTVFAFSPLRTPPLSSLREMWISSFEQS
                     KKEAQALRWLVDRNQNFSSQEFWGLVFKD"
     exon            438..732
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1568
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..3549
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /note="hexamer: AATAAA"
     polyA_site      2294
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /note="major polyA site"
     polyA_site      2323
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
     regulatory      3345..3350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /note="hexamer: ACTAAA"
     polyA_site      3365
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
     regulatory      3491..3496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
                     /note="hexamer: AATAAA"
     polyA_site      3511
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
     polyA_site      3549
                     /gene="FUT10"
                     /gene_synonym="FUCTX"
ORIGIN      
        1 gtcttcccgg cgcccaggct tgggctcata gggagaaagg aagctgcgct gcattctgcg
       61 ggacgaaccc tgctccgcgc gagaattttt ttgattcctt cttatttgga gaaatctcca
      121 gctgctctga tgatagccta agaagactgc atgctgcttc ctctcgatgc caagccagac
      181 cctctcacaa cctcggatct cagtccttca tggagacctg gtcccagcag gaatggcagt
      241 gcaggaaatt ggcgcccaga tggttcttcc atgtgaagtt gtctcgggct ctgggctgac
      301 gagagaacac ctggtaacca ggttagccct ctgtcagtca cccagggcag ggcagcatgg
      361 tgcggattca gaggaggaag cttttggcat cttgcctgtg cgtcacagcc accgtctttc
      421 tgcttgtcac actccaggtc atggttgagc tggggaagtt tgaaaggaag gagtttaaaa
      481 gttccagttt gcaagatgga catacaaaaa tggaggaagc acctacgcat cttaattcat
      541 ttcttaagaa agaaggattg accttcaaca ggaaaagaaa atgggaattg gacagctacc
      601 ccattatgct ctggtggtcc ccgctgacgg gggagactgg gaggttaggc caatgtggag
      661 cagatgcttg tttcttcacc atcaaccgga cctacctcca tcatcacatg accaaagcat
      721 tcctcttcta tggtactgac tttaacatag atagcttacc tctgcctcgg aaagcccatc
      781 atgactgggc tgtttttcat gaagagtccc cgaaaaacaa ttataagctc tttcataaac
      841 cagtgatcac cttgttcaac tacactgcca cgttcagcag gcattcccac ttgccactaa
      901 ctacccaata cttggagagc attgaagtcc tgaagtcact ccgataccta gttcctttgc
      961 agtccaaaaa caagcttaga aaaagacttg ctccgctggt gtatgtacag tcagactgtg
     1021 acccaccatc agacagggac agctatgttc gcgagctgat gacttacatc gaggtcgatt
     1081 cctatggtga atgtttacga aacaaagacc tccctcagca gctgaaaaat ccagcctcta
     1141 tggatgccga tggcttttat aggatcattg cacagtataa gtttatccta gcttttgaga
     1201 atgcagtttg tgatgactac atcactgaga agttctggag gccactgaaa ctgggggtag
     1261 tccctgtata ttacggatcc cccagcatca cagactggct tccaagtaac aaaagtgcta
     1321 ttcttgtatc agaattttct caccccaggg aactggcaag ttacatcaga cgactggatt
     1381 ctgatgacag attgtatgag gcctatgtag aatggaagct gaagggtgag atctctaacc
     1441 agcgacttct gacagctctc agggaacgga aatggggagt gcaagacgtc aaccaggaca
     1501 attacatcga tgcatttgag tgtatggtgt gcaccaaggt gtgggctaat atcaggcttc
     1561 aggaaaaggg cttaccaccc aaaagatggg aggcagaaga tacccacctg agttgcccag
     1621 agcccacagt gtttgctttc tcaccactcc ggactccacc tttgagctct ttgcgagaga
     1681 tgtggatttc cagctttgaa caatccaaga aagaagccca ggcactaagg tggctggttg
     1741 ataggaatca aaacttttca tctcaagagt tttggggcct agtattcaag gactgatttc
     1801 aaaaatgatc agaatgaaac agactagagc cttcttgagg tttattttct aggttgcctt
     1861 aatatttgaa cataatagct attctgttga ctatccatca ggataataat tagttgctgc
     1921 agtactcata atgagccctt tcaaggaata gatgtaaatt acccttaggg gtagccacta
     1981 tattttttat actaaaaaag gaaatatttc ttatggacac tggttatctt ccatgtccgt
     2041 gtctgtggac ccacatactt actgcctttt gtggaaattc acctagagtg agtactttcc
     2101 ttgtgcaatg gagggagacg atctagctat agattcttga tactcacctc actctcaaca
     2161 gcttattggt atttggcaaa cctggtatcc tgcagccgag catgaacatg aaatacatta
     2221 gaacttggca atgagagatc ccatctgttg gtttccaggg atgtaagtga gtaataaaag
     2281 ctgtttcaag tttatccact atccactctt caagtgaaaa gaacttatgt gtgtctacct
     2341 tcttctccat accctgagcc acctctctca ctttctttag ttgtgccttg ccctatcgcc
     2401 tcccattttc ccttcaaagt agaatgtctt gtaaagacac agtaactcct gtgtgttttg
     2461 attagtgaga tgttaccact taccccttct gctgcgcaga ataatattaa gaattgctat
     2521 gcttatgatt caggctggac agcctggaca ttttgagcag cgcgagagta gaagtgaata
     2581 cccccaggaa ctccaattgt gctgaagctg atttgtctgt tcgtaggatg atgtgcagcc
     2641 tgtcacagtg gcagccacag gcattcagtt tgtgggcatt tcctgtcatt tcggatcctg
     2701 ctatagggaa ggttcagctc tcctgtctgg ggcatctact ggagcacctc agaagacaag
     2761 gaggaaaaca ctggctcatg ttttctttcc atgtgaggga ggggaggttt ctagatgata
     2821 ctaaaagcct gttgccactg ttgtgtcatg atttccattc ttcatcatgg aaagccacaa
     2881 gcctcagaag gcagccagag gacaggaaga gtctgtgatg ctcatgtctg tgtcatggca
     2941 tgagggggaa ttgacgagtg cttgcttagc atcagctctc attgtattga aggctgtgcc
     3001 cttggtgtgc ttagcagtga gcagcgtctt cattaggtag ctctggctgg gctttgtcag
     3061 ccagcgtgtg agaaaggaga accaaaacca atacctcctt atagaagcca gaaggatcac
     3121 attggatgag agaaggtgtc tataactggg ttcttcccaa tcccagctct ttcattaact
     3181 aaatatgatc ttggacatat ctcttaacct ccatcggcct tagtttttgc atccaaaaag
     3241 aagtgattgg gctggtcttg gaaggttttt ttcttttttt tcccctgtgt aacattcttc
     3301 attgttcatc aacatttaag aaatttaatt ttgtagatgt ttttactaaa gagggtaaca
     3361 aactattttg gaactgctgt atgttattca agggaagcac gctgtttgga ggaaggagca
     3421 tacttaatgg gtagtattga ggatgaaagg gaatttctct ctctgccatt ttatttgata
     3481 atattaaaga aataaagact ggaaaggggg attccttgtt aaaggtcaga ttttaaattg
     3541 catataaaa
//
