LOCUS       NM_001098483             689 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fucose mutarotase (FUOM), transcript variant 1, mRNA.
ACCESSION   NM_001098483
VERSION     NM_001098483.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 689)
  AUTHORS   Lee,K.H., Ryu,K.S., Kim,M.S., Suh,H.Y., Ku,B., Song,Y.L., Ko,S.,
            Lee,W. and Oh,B.H.
  TITLE     Crystal structures and enzyme mechanisms of a dual fucose
            mutarotase/ribose pyranase
  JOURNAL   J Mol Biol 391 (1), 178-191 (2009)
   PUBMED   19524593
REFERENCE   2  (bases 1 to 689)
  AUTHORS   Park,D., Ryu,K.S., Choi,D., Kwak,J. and Park,C.
  TITLE     Characterization and role of fucose mutarotase in mammalian cells
  JOURNAL   Glycobiology 17 (9), 955-962 (2007)
   PUBMED   17602138
REFERENCE   3  (bases 1 to 689)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY163253.1 and AI333356.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001098483.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.63774.1,
                                           SRR1163658.388523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278025.9/ ENSP00000278025.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               HY163253.1         2-520
            520-689             AI333356.1         5-174               c
FEATURES             Location/Qualifiers
     source          1..689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..689
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /note="fucose mutarotase"
                     /db_xref="GeneID:282969"
                     /db_xref="HGNC:HGNC:24733"
                     /db_xref="MIM:617725"
     exon            1..97
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..477
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /EC_number="5.1.3.29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein fucU homolog"
                     /codon_start=1
                     /product="fucose mutarotase isoform 1"
                     /protein_id="NP_001091953.1"
                     /db_xref="CCDS:CCDS44499.1"
                     /db_xref="GeneID:282969"
                     /db_xref="HGNC:HGNC:24733"
                     /db_xref="MIM:617725"
                     /translation="MVALKGVPALLSPELLYALARMGHGDEIVLADLNFPASSICQCG
                     PMEIRADGLGIPQLLEAVLKLLPLDTYVESPAAVMELVPSDKERGLQTPVWTEYESIL
                     RRAGCVRALAKIERFEFYERAKKAFAVVATGETALYGNLILRKGVLALNPLL"
     exon            98..166
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /inference="alignment:Splign:2.1.0"
     exon            167..237
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /inference="alignment:Splign:2.1.0"
     exon            238..336
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /inference="alignment:Splign:2.1.0"
     exon            337..410
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /inference="alignment:Splign:2.1.0"
     exon            411..689
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      689
                     /gene="FUOM"
                     /gene_synonym="C10orf125; FucM; FUCU"
                     /note="major polyA site"
ORIGIN      
        1 gtctgccggg ccatggtggc gctgaagggt gtccccgcac tgctgtcccc cgagctgctc
       61 tacgcgctgg cgcggatggg gcacggggac gagatcgttc ttgcggactt gaacttcccg
      121 gcctcctcca tctgccagtg tgggcccatg gagatccgtg cagacggcct gggcatcccg
      181 cagctcctgg aggccgtgct gaagctgctg cccctggaca cctatgtgga gagtccggct
      241 gcagtcatgg agctggtgcc cagcgacaag gagaggggcc tgcagacccc agtgtggacg
      301 gagtacgagt ccatcctacg cagggccggc tgtgtgagag ccctggcaaa gatagagagg
      361 tttgagtttt atgaacgggc taagaaggct tttgctgttg tggcaacggg ggagacggcc
      421 ctctacggaa acctcatcct caggaagggg gtgcttgccc tcaaccccct gctgtaggcc
      481 tggtgaagac cacctgggcc ggaagaggaa ctgggggcac cctgagctcc agtaccacca
      541 ctcacaacag gcctcccagt ggcagctccc agacctgggc cctggccagg gctctagggg
      601 ccggcagtct tggggtgggc cctgccaatt gggacgagta tccctgattt gtgaaaatga
      661 tggaaaaacg ttcagtctca agagtccaa
//
