LOCUS       NM_023934               6297 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FUN14 domain containing 2 (FUNDC2), mRNA.
ACCESSION   NM_023934
VERSION     NM_023934.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6297)
  AUTHORS   Yin,L., Cao,R., Liu,Z., Luo,G., Li,Y., Zhou,X., Chen,X., Wu,Y.,
            He,J., Zu,X. and Shen,Y.
  TITLE     FUNDC2, a mitochondrial outer membrane protein, mediates
            triple-negative breast cancer progression via the AKT/GSK3beta/GLI1
            pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (11), 1770-1783 (2023)
   PUBMED   37700593
  REMARK    GeneRIF: FUNDC2, a mitochondrial outer membrane protein, mediates
            triple-negative breast cancer progression via the AKT/GSK3beta/GLI1
            pathway.
REFERENCE   2  (bases 1 to 6297)
  AUTHORS   Gao,L., Zhang,Y., Gao,X., Xu,L. and Duan,X.
  TITLE     Methylation of the HCBP6 promoter is associated with primary
            biliary cholangitis pathogenesis
  JOURNAL   Biochem Biophys Res Commun 610, 176-181 (2022)
   PUBMED   35468421
  REMARK    GeneRIF: Methylation of the HCBP6 promoter is associated with
            primary biliary cholangitis pathogenesis.
REFERENCE   3  (bases 1 to 6297)
  AUTHORS   Li,S., Han,S., Zhang,Q., Zhu,Y., Zhang,H., Wang,J., Zhao,Y.,
            Zhao,J., Su,L., Li,L., Zhou,D., Ye,C., Feng,X.H., Liang,T. and
            Zhao,B.
  TITLE     FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated
            mitochondrial fusion
  JOURNAL   Nat Commun 13 (1), 3486 (2022)
   PUBMED   35710796
  REMARK    GeneRIF: FUNDC2 promotes liver tumorigenesis by inhibiting
            MFN1-mediated mitochondrial fusion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6297)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 6297)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6297)
  AUTHORS   Gao,L.L., Li,M., Wang,Q., Liu,S.A., Zhang,J.Q. and Cheng,J.
  TITLE     HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the
            SREBP1c/FASN Pathway
  JOURNAL   J Cell Biochem 116 (10), 2375-2384 (2015)
   PUBMED   25855506
  REMARK    GeneRIF: our results provide new evidence that miR-122-regulated
            HCBP6 functions as a sensor protein to maintain intrahepatocyte
            Triglyceride levels.
REFERENCE   7  (bases 1 to 6297)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   8  (bases 1 to 6297)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   9  (bases 1 to 6297)
  AUTHORS   Li,K., Wang,L., Cheng,J., Zhang,L., Duan,H., Lu,Y., Yang,J.,
            Liu,Y., Xia,X., Wang,G., Dong,J., Li,L., Zhong,Y., Hong,Y. and
            Chen,J.
  TITLE     [Screening and cloning gene of hepatocyte protein interacting with
            hepatitis C virus core protein]
  JOURNAL   Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16 (4), 351-353
            (2002)
   PUBMED   12665903
REFERENCE   10 (bases 1 to 6297)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI463291.1, AF320778.1, CN306694.1, AI886036.1, BM713884.1,
            BU738737.1 and BX470111.4.
            
            On Nov 23, 2018 this sequence version replaced NM_023934.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.312551.1,
                                           SRR1803615.129394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369498.8/ ENSP00000358510.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BI463291.1         61-63
            4-1082              AF320778.1         22-1100
            1083-1805           CN306694.1         8-730
            1806-1967           AI886036.1         17-178              c
            1968-2599           BM713884.1         26-657
            2600-2909           BU738737.1         18-327              c
            2910-6297           BX470111.4         56865-60252         c
FEATURES             Location/Qualifiers
     source          1..6297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..6297
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /note="FUN14 domain containing 2"
                     /db_xref="GeneID:65991"
                     /db_xref="HGNC:HGNC:24925"
                     /db_xref="MIM:301042"
     exon            1..228
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..665
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /note="hepatitis C virus core-binding protein 6; cervical
                     cancer oncogene 3; HCC-3; cervical cancer proto-oncogene 3
                     protein"
                     /codon_start=1
                     /product="FUN14 domain-containing protein 2"
                     /protein_id="NP_076423.2"
                     /db_xref="CCDS:CCDS14763.1"
                     /db_xref="GeneID:65991"
                     /db_xref="HGNC:HGNC:24925"
                     /db_xref="MIM:301042"
                     /translation="METSAPRAGSQVVATTARHSAAYRADPLRVSSRDKLTEMAASSQ
                     GNFEGNFESLDLAEFAKKQPWWRKLFGQESGPSAEKYSVATQLFIGGVTGWCTGFIFQ
                     KVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVRS
                     KAEEVVSFVKKNVLVTGGFFGGFLLGMAS"
     exon            229..379
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /inference="alignment:Splign:2.1.0"
     exon            380..455
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /inference="alignment:Splign:2.1.0"
     exon            456..587
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /inference="alignment:Splign:2.1.0"
     exon            588..6297
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1078..1083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /note="hexamer: AATACA"
     polyA_site      1104
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /note="major polyA site"
     regulatory      1545..1550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /note="hexamer: AATAAA"
     polyA_site      1566
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /note="hexamer: AATAAA"
     polyA_site      2916
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
     regulatory      6278..6283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
                     /note="hexamer: ATTAAA"
     polyA_site      6297
                     /gene="FUNDC2"
                     /gene_synonym="DC44; HCBP6; HCC3; PD03104"
ORIGIN      
        1 gacaccgcac gctgagctct gtgatgtagc cgcttgcgga gactgcaagc agccgcggcg
       61 cgcccggccc tccctcttcc gctgccgccg tgggaatgga aacatctgcc ccacgtgccg
      121 gaagccaagt ggtggcgaca actgcgcgcc actccgcggc ctaccgcgca gatcctctac
      181 gtgtgtcctc gcgagacaag ctcaccgaaa tggccgcgtc cagtcaagga aactttgagg
      241 gaaattttga gtcactggac cttgcggaat ttgctaagaa gcagccatgg tggcgtaagc
      301 tgttcgggca ggaatctgga ccttcagcag aaaagtatag cgtggcaacc cagctgttca
      361 ttggaggtgt cactggatgg tgcacaggtt tcatattcca gaaggttgga aagttggctg
      421 caacagctgt gggaggtgga ttttttctcc ttcagcttgc aaaccatact gggtacatca
      481 aagttgactg gcaacgagtg gagaaggaca tgaagaaagc caaagagcag ctgaagatcc
      541 gtaagagcaa tcagatacct actgaggtca ggagcaaagc tgaggaggtg gtgtcatttg
      601 tgaagaagaa tgttctagta actgggggat ttttcggagg ctttctgctt ggcatggcat
      661 cctaaggaag atgacctcat gttcattgtt cctggttttt tccagccagc agcctctaca
      721 ctccatcata ggacatcgag tccctcctcc tcttctccca tgccttcttc cctgccatgg
      781 caaatctgag tggcttctct aagcatctgc tggtacaagt caatgtggca ccatgagctt
      841 catggtggca gaagagacaa tagtccttag ctctcctccc agtacacccc ctacttggcc
      901 agtctgtagg ccaacaagaa ggttccttta cccccatgca agacacttat gagaacacat
      961 tacaagatgg ctgaccgtgg aggatgagtg gatcctgaaa ggttgtccca aactgttgat
     1021 ttggaaaaga aataagcaca tagataacct tattgtgtgc tgcatggaaa ggaactgaat
     1081 acatttgcct ttaagcatga aagattttgg tatcttggtg tctactttct tttttagttg
     1141 gttttacatt acagaaagct atttaaatgt gttataatta tgccgacaaa attggcagca
     1201 taattactgt aattgaaaaa tctgatattg tccaggaatg ctttctaccg tacaggataa
     1261 tgtatctcat ggctgtttcc aaagggttta tttattgtaa aacaagtgat ttaggtggga
     1321 aagggaagat tttggatttt tattttgtag aaaaggtttt aagctttgaa atgtgaatga
     1381 aatatcctta tcaaaacatt aggggtggcc ataactcctc tgtgccactt ctactatttt
     1441 tttttttaat ctagttagta tgaaatacaa catttaaacc ggaattttaa agaagtagct
     1501 ttccagggat tcagaattaa gaaagatagt gataggacat gagaaataaa tttccatcaa
     1561 gtgtaatcta ccgtctcatg atgaccacaa ccctgagaat tattctttaa aagcttacac
     1621 acacacacac acacgggcac acacgcacac acagaatctt accacatttt gctgtagtgg
     1681 catgttacca tgtctacagt ccctactaga atatcagtca gctttcagag ggcaagactt
     1741 ctgtcttcac cattatactc acagggccta gcacttaata ggtgctgagt atttgaataa
     1801 tgactttata gaaagaaaac tcactattaa aggttagttt tactcagaat tgttaatctt
     1861 ggagatgatc tcttgtgaaa tatgagtgtg tttctaaggc catacattta aaaatgtttg
     1921 cattttaacc cgtcttgaga atgatgtatt gaatttgaaa atcaaaacta ccagtggatg
     1981 tgtggaactt tacagaaacc acctatttgc gtttttctcc ttacatttaa ggaaacataa
     2041 gccattttgc ttgcaatatg tatgaatcat ctcaaaacca taatggtatg agcctctttg
     2101 ctgcatattt tgctataaga acttattttt tttcactttt tattatggac gctttcagga
     2161 atatataaaa gtagagaata tagtacaata atccccctgt gtatctatca ctcactcaca
     2221 acaatcatca aattatagct ctgctggttt ttaccagtta ttgtgaaaca aatatcaaaa
     2281 tgtcatttta tcatatttca gtatgtatct ctaaaaggta agaattattt ctaaaaatca
     2341 taaatacctc atcatatcag acattaacag taattacata atatccaaaa tctgatcagt
     2401 gttcaaaatt tcctcaagtg ttttatattt agtttgtttg aatcaaaatt catgcaaggt
     2461 tcacatcgta tttgcatgat ttggataagt ctcttaacct tatagatcct cctctatttt
     2521 tttttttttg cttgctatat atttatatct ctatatatat tgatatagac atatgtagtg
     2581 acactgagtc atctgtttcc tgcttcccca cactctgcct ctcctgacat ctgggtctct
     2641 gggttatgcc atatatggtg atagtggctg cagccacttt acctgtgtga cttacccaca
     2701 gcaatgggat ggtaacagca aagctaacca aagtgctctg tgcccctttg ggttgcatgt
     2761 ggggagactg gccacccaat gcctctccag tggggtaggg gttgtctttt ggtgcatctg
     2821 tttttcctgt gattattggt gagggcagca aagattagca ggtggttgta aactaccttg
     2881 agtaggttgt aataaatagt ctggcctcag actgtattct gattgtctga attaagatct
     2941 gtaggtaggt ccctcctgaa gttttttccc agctggctgc ctctacgact gtgagggtca
     3001 tggttgaggt cagtattgca ggttggcctc atcctgctag tatgagaacg gctgtgagtt
     3061 ctgcccacgg tgtgaggcca ctgtgaccac ttgggattgt gcagagctgg catggaggtt
     3121 gaacacgcac agctgcacac cttgttttca gtttagctga accatcggtg aaggaggctc
     3181 aggcatttgg ggttacctgt gaatcaaggc cctattgtgc cagcagtttt gtttcaggtg
     3241 gtgaagtggg agttaaggtt tcccccaaaa gaacagctgc cactcctcca tgcaaaaccg
     3301 agatgattca aggaccaggc agctccacct ttcagtgcac tactttcatt tgactggaga
     3361 ggcctgctta gctaggcacg tattttctcc agtagcagag tccaatgacg ctctggactt
     3421 cctaattagt ggtggtgggg cggaagtttt tccttgggaa gagcgttgtc gctgtatatg
     3481 gtccgcagaa acttgacttg gaatgtgttc ggggtttcat cgcccccttg tggcggcgac
     3541 gtggtaacac cgcactcaag gcttccaact tgtcaaccaa taggatggca tctacgtagt
     3601 gaaggcttcc cttcccttgt cctgcagcgt gctggacagt gtcccggctc agggacccct
     3661 tctgtcccct tcctggctac tatgggtcgg ccctgcgtcc tcaccacttt gagccaccct
     3721 ttgacccagc gtctctcccg caatgggacc tggtgggatg gggacttgga gcatgctaca
     3781 ggagaggtag aacttttgag tctcttcttc ccaaggttct ccccagagtc ggagagcaga
     3841 gacggatcca ggggcacttt ctggccgctg cctgctcggg ctcaacagat ggagtccaat
     3901 gtttcagtct cccccaagaa tgtgtatcct cattgctgac acgggagctg ggtgcgggga
     3961 gagatgtggt ggtggggacc cttgcctgag cagcccattg tcatgagtgt tattgccatt
     4021 gtgataatat gttagcatga ctctcctccc aaatggccgc ttgtttgttg caatctcccg
     4081 ccactcagcc tccagacatt cattaacagg acagtggggt tcttgactcc cctaccactg
     4141 gggtgacagt ccttgctact ggatctgggc agttactgtc tcatggatgc tggcagaaga
     4201 cgattcaagt tggcggacta gattctacaa ggaatgatct cttgcataat tctagccaac
     4261 atgctcttgg ggtgggtgct tctggttttg gaaagcaaag ttactgtgta gttaacaact
     4321 attgtggtaa gaatagtctc tccatcattc ttttgtttca cggttgtcag aaagatgggc
     4381 ataactaatg gttgggctct tatttggaac ctctactttt gtacagtttg ggaatctctg
     4441 cttgaaaaga tggtatactg atggatttga aatttctgag tatcatcaat gtttcatgat
     4501 gatctcaatt tcttctcaga gggaagctca cagccagttt tggaccccag agaaaaatgt
     4561 ggctgctgcc ctctactccc tctaccaaat tatcagcttc atttctttgt catgaaatct
     4621 agtatgattt ctcagaaatc aggcccagaa ctaaaataca ttttctgccc aattttctaa
     4681 gaggtcacac taacatctga gtaattgggc agaaaaccta ttttagttct gagcctgatt
     4741 tttctagaag tcatatggta tagcttatat ttccgatgct tgcattcttt ttaaggggtc
     4801 atgaatctta atactttttt ttttaaaaga aaagtgtcgc actttttcac atttttataa
     4861 agctttaaag tcagtttact gacttttcaa aagtgtctac ctttttaaat tttaaaatgg
     4921 taagaaatga cattcctgag agcagtggct ttcatccttg cttgcacttg ggaatcacct
     4981 gtgaaatttt aaaaactact aatgcctggc tctcatccta gagattctga tttcactggt
     5041 ctggagtgct gttcaggcat cctgaggttt taaagtgtct tagctttttc taatgagcag
     5101 cagagactga gaaccactga agtacacagt tggaagctgg tgctgaaaaa attaagagtt
     5161 ttgctgttaa ctccttaaga gggctttaaa gccttttata ttaagtgcca tacaacttca
     5221 gatgccttct gaatactgaa cacaagtgta atattatagt tcattaaatg tcttaggaat
     5281 cgtgtggagt gaatgcaagg aaaggagtga caagatatca ccccacaaat gacttaccca
     5341 ttacgaaggg aaaactacct ttctagctaa aaggtctgtc agtcactaac caagtgatta
     5401 aacttagcat cactaatagc caacttaaca aagttttttt ttttttttgg tttctaaaat
     5461 gggagatcat agttttcacc ttcctagagt tctttgctta agactgagat tcagtgttac
     5521 tcttggtccc taacaataag aagcactcag taaatgttaa gccttctatg atggctattt
     5581 tatttttttg tatgtcataa taatacctaa gaataagaag agttaaatta atgtcttcaa
     5641 atggatttgt tgacttaaac tgacacaatc ctttaaaaga aggaactgat ttgaaccttt
     5701 caaaactgaa agaaagtcgt atactgatac agtttggagc caccgaatgt catgttgaac
     5761 cgtattccct aatggaggtg gatcctggtg agaggtgatt ggatcgtggg ggccatcccc
     5821 tcttggtact tcactcatga tagtgagttc tcatgagatc tggcacttca cccctcactc
     5881 tctcttgctc ctgctttggc catgtggagt gctcactccc cttttgcttt ctgccatggc
     5941 tgtaagtttc ctgaggcgtc cccagaagcc catcagatac cagtgccatg cttcctgtac
     6001 agcccatgga actgtgagcc aactaaacct cttttattta taaattaccg agtctcaggc
     6061 actttttata gcaatgcaac aatggactaa tacatatact ttagcataaa aacatttaaa
     6121 agagtctgaa actggagtag ttaactcagt aaaaataact tggcaataaa acacagaaaa
     6181 acaatctatt tgatcatgta gtgattccta atgtaaatcc tagtacaact gtcaactgat
     6241 aattttaaat gtaatttaga tttgtagatg gtgtaacatt aaagttgtat gatgttt
//
