LOCUS       NM_173794               1054 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FUN14 domain containing 1 (FUNDC1), mRNA.
ACCESSION   NM_173794
VERSION     NM_173794.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1054)
  AUTHORS   Zhang,W., Guo,C., Li,Y., Wang,H., Wang,H., Wang,Y., Wu,T., Wang,H.,
            Cheng,G., Man,J., Chen,S., Fu,S. and Yang,L.
  TITLE     Mitophagy mediated by HIF-1alpha/FUNDC1 signaling in tubular cells
            protects against renal ischemia/reperfusion injury
  JOURNAL   Ren Fail 46 (1), 2332492 (2024)
   PUBMED   38584135
  REMARK    GeneRIF: Mitophagy mediated by HIF-1alpha/FUNDC1 signaling in
            tubular cells protects against renal ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 1054)
  AUTHORS   Laplace,J. and Bonneau,B.
  TITLE     [FUNDC1 promotes the formation of MAMs involved in angiogenesis]
  JOURNAL   Med Sci (Paris) 40 (2), 206-208 (2024)
   PUBMED   38411432
  REMARK    GeneRIF: [FUNDC1 promotes the formation of MAMs involved in
            angiogenesis].
REFERENCE   3  (bases 1 to 1054)
  AUTHORS   Chu,C., Wang,X., Chen,F., Yang,C., Shi,L., Xu,W., Wang,K., Liu,B.,
            Wang,C., Sun,D., Li,J. and Ding,W.
  TITLE     Neutrophil extracellular traps aggravate intestinal epithelial
            necroptosis in ischaemia-reperfusion by regulating
            TLR4/RIPK3/FUNDC1-required mitophagy
  JOURNAL   Cell Prolif 57 (1), e13538 (2024)
   PUBMED   37691112
  REMARK    GeneRIF: Neutrophil extracellular traps aggravate intestinal
            epithelial necroptosis in ischaemia-reperfusion by regulating
            TLR4/RIPK3/FUNDC1-required mitophagy.
REFERENCE   4  (bases 1 to 1054)
  AUTHORS   Xu,J., Deng,Z., Shang,S., Wang,C. and Han,H.
  TITLE     FUNDC1 collaborates with PINK1 in regulating mitochondrial Fission
            and compensating for PINK1 deficiency
  JOURNAL   Biochem Biophys Res Commun 687, 149210 (2023)
   PUBMED   37931419
REFERENCE   5  (bases 1 to 1054)
  AUTHORS   Ma,J., Liu,L., Song,L., Liu,J., Yang,L., Chen,Q., Wu,J.Y. and
            Zhu,L.
  TITLE     Integration of FUNDC1-associated mitochondrial protein import and
            mitochondrial quality control contributes to TDP-43 degradation
  JOURNAL   Cell Death Dis 14 (11), 735 (2023)
   PUBMED   37951930
  REMARK    GeneRIF: Integration of FUNDC1-associated mitochondrial protein
            import and mitochondrial quality control contributes to TDP-43
            degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1054)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 1054)
  AUTHORS   Terracciano,A., Sanna,S., Uda,M., Deiana,B., Usala,G., Busonero,F.,
            Maschio,A., Scally,M., Patriciu,N., Chen,W.M., Distel,M.A.,
            Slagboom,E.P., Boomsma,D.I., Villafuerte,S., Sliwerska,E.,
            Burmeister,M., Amin,N., Janssens,A.C., van Duijn,C.M.,
            Schlessinger,D., Abecasis,G.R. and Costa,P.T. Jr.
  TITLE     Genome-wide association scan for five major dimensions of
            personality
  JOURNAL   Mol Psychiatry 15 (6), 647-656 (2010)
   PUBMED   18957941
REFERENCE   8  (bases 1 to 1054)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 1054)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   10 (bases 1 to 1054)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM837991.1, BG213042.1 and
            BC035015.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_173794.3.
            
            Summary: This gene encodes a protein with a FUN14 superfamily
            domain. The function of the encoded protein is not known. [provided
            by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035015.2, CD389571.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378045.5/ ENSP00000367284.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               BM837991.1         143-608
            467-1036            BG213042.1         51-620
            1037-1054           BC035015.2         1036-1053
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..1054
                     /gene="FUNDC1"
                     /note="FUN14 domain containing 1"
                     /db_xref="GeneID:139341"
                     /db_xref="HGNC:HGNC:28746"
                     /db_xref="MIM:300871"
     exon            1..55
                     /gene="FUNDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..495
                     /gene="FUNDC1"
                     /codon_start=1
                     /product="FUN14 domain-containing protein 1"
                     /protein_id="NP_776155.1"
                     /db_xref="CCDS:CCDS14263.1"
                     /db_xref="GeneID:139341"
                     /db_xref="HGNC:HGNC:28746"
                     /db_xref="MIM:300871"
                     /translation="MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPM
                     VEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWKRV
                     EKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFLLGLAS"
     exon            56..212
                     /gene="FUNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..288
                     /gene="FUNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..417
                     /gene="FUNDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..1054
                     /gene="FUNDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      857..862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUNDC1"
                     /note="hexamer: AATAAA"
     polyA_site      877
                     /gene="FUNDC1"
                     /note="major polyA site"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUNDC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1054
                     /gene="FUNDC1"
                     /note="major polyA site"
ORIGIN      
        1 actccagaat tggccgctgg cggtatcatg gcgacccgga acccccctcc ccaagactat
       61 gaaagtgatg acgactctta tgaagtgttg gatttaactg agtatgcaag aagacaccag
      121 tggtggaatc gagtgtttgg ccacagttcg ggacctatgg tagaaaaata ctcagtagct
      181 acccagattg taatgggtgg cgttactggc tggtgtgcag gatttctgtt ccagaaagtt
      241 ggaaaacttg cagcaactgc agtaggtggt ggctttcttc ttcttcagat tgctagtcat
      301 agtggctatg tgcagattga ctggaagaga gttgaaaaag atgtaaataa agcaaaaaga
      361 cagattaaga aacgagcgaa caaagcagca cctgaaatca acaatttaat tgaagaagca
      421 acagaattta tcaagcagaa cattgtgata tccagtggat ttgtgggagg ctttttgctc
      481 ggacttgcat cttaaggaca tgaatattct cccataacgg attcaactat gagaagagaa
      541 gtggcagcaa taaggcagtc tctcaaaagt catactgcca gagtctctag ggcaaggaga
      601 aacaactagc tggacaatac tcaattcaca acttagcatt ttgccatctg aagcttggca
      661 aactagtatc tgctgtaaaa caacctatat ggtatgtgaa ccgtagtatt cctgagcaaa
      721 acgtggcttt catcgctttg taaaaatttg catctgttta gaaactagcc tataaaatat
      781 caccattgga tgtagatatg gagagaaaag aaatatgttg ggtttattgc ttagcgaaat
      841 attctctttt tatttaaata aaatgttctt cattgtgttt tatggtatgt gtccataatt
      901 taaaattcat gttatagttt cagtattaag gctgactttt tttttttaag atatgtttgc
      961 aataagttaa aaaactgtaa tacccttttg tggaaagctt tagaaatgat ataattatta
     1021 aagatattaa acagactctg ctgatgtaat atga
//
