LOCUS       NM_003934               3153 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens far upstream element binding protein 3 (FUBP3), mRNA.
ACCESSION   NM_003934 XM_928316 XM_932771 XM_932775 XM_932778 XM_942317
            XM_945904 XM_945906 XM_945907
VERSION     NM_003934.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3153)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3153)
  AUTHORS   Sharma,M., Anandram,S., Ross,C. and Srivastava,S.
  TITLE     FUBP3 regulates chronic myeloid leukaemia progression through PRC2
            complex regulated PAK1-ERK signalling
  JOURNAL   J Cell Mol Med 27 (1), 15-29 (2023)
   PUBMED   36478132
  REMARK    GeneRIF: FUBP3 regulates chronic myeloid leukaemia progression
            through PRC2 complex regulated PAK1-ERK signalling.
REFERENCE   3  (bases 1 to 3153)
  AUTHORS   Gao,Q., Zhou,R., Meng,Y., Duan,R., Wu,L., Li,R., Deng,F., Lin,C.
            and Zhao,L.
  TITLE     Long noncoding RNA CMPK2 promotes colorectal cancer progression by
            activating the FUBP3-c-Myc axis
  JOURNAL   Oncogene 39 (19), 3926-3938 (2020)
   PUBMED   32203166
  REMARK    GeneRIF: Long noncoding RNA CMPK2 promotes colorectal cancer
            progression by activating the FUBP3-c-Myc axis.
REFERENCE   4  (bases 1 to 3153)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3153)
  AUTHORS   Huang,H.I., Chang,Y.Y., Lin,J.Y., Kuo,R.L., Liu,H.P., Shih,S.R. and
            Wu,C.C.
  TITLE     Interactome analysis of the EV71 5' untranslated region in
            differentiated neuronal cells SH-SY5Y and regulatory role of FBP3
            in viral replication
  JOURNAL   Proteomics 16 (17), 2351-2362 (2016)
   PUBMED   27291656
  REMARK    GeneRIF: The redistribution of FBP3 in subcellular compartments was
            observed after Enterovirus 71 (EV71) infection, and the decreased
            expression of FBP3 in host neuronal cells markedly inhibited viral
            replication. The results reveal various host proteins that
            potentially interact with the EV71 5'UTR in neuronal cells, and
            study found that FBP3 could serve as a positive regulator in host
            cells.
REFERENCE   6  (bases 1 to 3153)
  AUTHORS   Lettre,G., Jackson,A.U., Gieger,C., Schumacher,F.R., Berndt,S.I.,
            Sanna,S., Eyheramendy,S., Voight,B.F., Butler,J.L., Guiducci,C.,
            Illig,T., Hackett,R., Heid,I.M., Jacobs,K.B., Lyssenko,V., Uda,M.,
            Boehnke,M., Chanock,S.J., Groop,L.C., Hu,F.B., Isomaa,B., Kraft,P.,
            Peltonen,L., Salomaa,V., Schlessinger,D., Hunter,D.J., Hayes,R.B.,
            Abecasis,G.R., Wichmann,H.E., Mohlke,K.L. and Hirschhorn,J.N.
  CONSRTM   Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung
            Colorectal and Ovarian Cancer Screening Trial; Nurses' Health
            Study; SardiNIA
  TITLE     Identification of ten loci associated with height highlights new
            biological pathways in human growth
  JOURNAL   Nat Genet 40 (5), 584-591 (2008)
   PUBMED   18391950
REFERENCE   7  (bases 1 to 3153)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   8  (bases 1 to 3153)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 3153)
  AUTHORS   Davis-Smyth,T., Duncan,R.C., Zheng,T., Michelotti,G. and Levens,D.
  TITLE     The far upstream element-binding proteins comprise an ancient
            family of single-strand DNA-binding transactivators
  JOURNAL   J Biol Chem 271 (49), 31679-31687 (1996)
   PUBMED   8940189
REFERENCE   10 (bases 1 to 3153)
  AUTHORS   Wu,C., Narayan,P. and Puett,D.
  TITLE     Protein engineering of a novel constitutively active
            hormone-receptor complex
  JOURNAL   J Biol Chem 271 (49), 31638-31642 (1996)
   PUBMED   8940183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI461266.1, U69127.1, AL537190.3 and BC001325.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003934.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69127.1, SRR1660803.47776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319725.10/ ENSP00000318177.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               BI461266.1         10-197
            189-318             U69127.1           169-298
            319-875             AL537190.3         294-850
            876-2561            U69127.1           856-2541
            2562-3153           BC001325.1         1727-2318
FEATURES             Location/Qualifiers
     source          1..3153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11-q34.12"
     gene            1..3153
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /note="far upstream element binding protein 3"
                     /db_xref="GeneID:8939"
                     /db_xref="HGNC:HGNC:4005"
                     /db_xref="MIM:603536"
     exon            1..188
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1823
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /note="FUSE-binding protein 3; far upstream element (FUSE)
                     binding protein 3"
                     /codon_start=1
                     /product="far upstream element-binding protein 3"
                     /protein_id="NP_003925.1"
                     /db_xref="CCDS:CCDS43893.1"
                     /db_xref="GeneID:8939"
                     /db_xref="HGNC:HGNC:4005"
                     /db_xref="MIM:603536"
                     /translation="MAELVQGQSAPVGMKAEGFVDALHRVRQIAAKIDSIPHLNNSTP
                     LVDPSVYGYGVQKRPLDDGVGNQLGALVHQRTVITEEFKVPDKMVGFIIGRGGEQISR
                     IQAESGCKIQIASESSGIPERPCVLTGTPESIEQAKRLLGQIVDRCRNGPGFHNDIDS
                     NSTIQEILIPASKVGLVIGRGGETIKQLQERTGVKMVMIQDGPLPTGADKPLRITGDA
                     FKVQQAREMVLEIIREKDQADFRGVRGDFNSRMGGGSIEVSVPRFAVGIVIGRNGEMI
                     KKIQNDAGVRIQFKPDDGISPERAAQVMGPPDRCQHAAHIISELILTAQERDGFGGLA
                     AARGRGRGRGDWSVGAPGGVQEITYTVPADKCGLVIGKGGENIKSINQQSGAHVELQR
                     NPPPNSDPNLRRFTIRGVPQQIEVARQLIDEKVGGTNLGAPGAFGQSPFSQPPAPPHQ
                     NTFPPRSSGCFPNMAAKVNGNPHSTPVSGPPAFLTQGWGSTYQAWQQPTQQVPSQQSQ
                     PQSSQPNYSKAWEDYYKKQSHAASAAPQASSPPDYTMAWAEYYRQQVAFYGQTLGQAQ
                     AHSQEQ"
     exon            189..294
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..328
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..378
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..450
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..508
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..671
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..770
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            771..875
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..978
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1079
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1221
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1382
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1456
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1537
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1614
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1686
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1814
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..3153
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3118..3123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /note="hexamer: AATAAA"
     polyA_site      3153
                     /gene="FUBP3"
                     /gene_synonym="FBP3"
                     /note="major polyA site"
ORIGIN      
        1 cttttccggc tacgggtccc caagcggagc gggaggccgg accggggagc cgagcggcgg
       61 cgtcggcggc gtcggcggcg gcggcgacgg cggcgggggc ggtaatggcg gagctggtgc
      121 aggggcagag cgctcctgtg gggatgaagg ccgagggctt cgtggatgcc ctgcaccggg
      181 tccggcagat tgctgctaaa attgattcaa ttcctcactt gaataattcc acacctctag
      241 tggacccctc agtatatgga tacggagtac aaaaacggcc cttggatgat ggagtaggta
      301 accagttagg ggccttggta catcaaagga cggtaataac ggaagaattc aaagtgcctg
      361 acaaaatggt tggatttatt atcggcaggg gaggtgagca gatttcacgg attcaagcag
      421 aatctggttg caaaattcag attgcttcag agagttctgg gattccagag aggccctgtg
      481 tacttaccgg aaccccagaa agtattgaac aagccaaacg gctcctggga cagattgtgg
      541 accgctgtcg aaatggacct ggctttcata atgacataga cagcaacagc acaatccagg
      601 agattctcat tcccgcatct aaagtgggtc tggtcatcgg cagaggaggg gaaacaatca
      661 agcagttgca ggagcggaca ggggtgaaga tggtcatgat ccaggatggc ccattgccca
      721 cgggagcaga caagcctctt cgtatcactg gagatgcatt taaagtacag caagcaagag
      781 aaatggtact agagattatc cgagaaaaag accaagctga ctttcggggt gtacgcggcg
      841 atttcaactc tcgaatggga ggaggcagta tagaggtatc tgtgcctagg tttgctgtgg
      901 ggattgtaat aggaagaaac ggggaaatga tcaaaaagat ccagaatgat gctggtgtga
      961 ggattcagtt taaaccagat gatgggatta gtccagaaag agctgcccag gtcatgggcc
     1021 ctccggatcg gtgtcagcat gcagcgcata tcatcagcga gctgattctt acagcccagg
     1081 aaagagacgg ctttggaggc ctggcagcag ccagaggaag aggtcgtggc cgtggcgact
     1141 ggagcgtggg agcccctggt ggcgtccagg agataacata cacggtgcca gccgataagt
     1201 gtggcctcgt cataggcaaa gggggtgaga acatcaaaag catcaaccag cagtcagggg
     1261 cgcacgtgga gcttcagagg aacccccctc ccaacagcga ccccaacctg cggagattca
     1321 ccatcagggg ggttccccag cagatcgagg tggccaggca gctcatagat gagaaagttg
     1381 gcgggaccaa tctcggagca cctggagcct tcggacagag tccattcagc cagccacctg
     1441 ccccacctca tcaaaatacc tttcctccaa ggagctccgg gtgcttccca aacatggctg
     1501 ccaaggtgaa tgggaacccc cacagcaccc ctgtgagtgg tcctccggcc tttctgaccc
     1561 agggctgggg cagcacctac caggcgtggc agcagcccac acagcaggtc ccaagccagc
     1621 agagccagcc gcagagcagc cagcccaact acagcaaggc ctgggaagac tattacaaaa
     1681 aacagagtca cgccgccagc gctgctcctc aggccagctc cccaccggac tacacaatgg
     1741 cctgggcaga atattacaga cagcaggtcg ctttctacgg acagacgtta gggcaggcgc
     1801 aggcccacag ccaggagcag taggacagcg tcctcgtggc caactctccc ctcaaaatca
     1861 ttgtcaaaga aaacctattt gtaacagagg tttttacatt tgcaaacctt ttgatgaaga
     1921 actgttgttt tgttctgtga aacactatat ttagattaac ggaatttttc taaaaatcag
     1981 gaaaattagt tactaaaaat tgctgatcat ttttgtttca ttatttttgt tatttcaaat
     2041 gtataagctc tgggattctt tttggagcaa tacctacaaa gtcaggcacc agaatgtgcc
     2101 tcagagctgt gacatttcaa catgatggtt ttggtttggt ttggttttgt gtccttttta
     2161 tttgcagttt tttctgttgc aacagaaagt ggcttggaag tcttaggtgg tatgtaacaa
     2221 attcttttta aaaattttaa agcagtattt aagtattctt aaatgtgtaa attcatttaa
     2281 tgttttactt ctaatttctt gtatcttggc tgtctggttt tattgcattt ttaaaaaaac
     2341 tgaactatta tgtattgtaa tgaatgatgt gaattctgaa ctgagacaga taattgtatt
     2401 gctgtccaac aggggttggg aggggcattt tgtagggttt gtataatttc tagagttcga
     2461 aaggggtaat ataaaaatgt gctcgtgtgt ttagcctacg tttttctcat gcctccatta
     2521 ccagttgcaa ttgtgtatct aagacctcca agcttgtttt taaaacaaaa caaaaaacct
     2581 ttctctatta tctcagaaat ataaatactg ttatttttaa tattaagaaa ttcaatataa
     2641 cttttaacac acactgtgga acattaaacc gtataaaaat gtagttataa ctatttttaa
     2701 ttccaaggtg ttgtttgctt ttttctttta aatattttct taatattttg tcagattaac
     2761 tagatgaata aataaatcta gtattaaccg cattatgaat taaataattt tgatttaatg
     2821 aaagggataa tatgatttcc agtgtttact gtagtgtatc ttgtacagat aacatgtatt
     2881 tttaaaggaa aaaaaacgga attgaagcta ttttttcttg catttctaat tgacctgagg
     2941 gacattccgt ttgaaatgta ctgaagttac agtttctggt tttttctcct tatttttctt
     3001 ataatgcttg aaatgtctaa ctattaaaaa agacaattgg aaaatgttat gcatggggtt
     3061 tttaagaaaa caaagtgttc tttttatttg actgacaatt cattttacac tctatataat
     3121 aaaatctcca caaggcatct tgtgggcaaa gtc
//
