LOCUS       NM_003902               6714 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens far upstream element binding protein 1 (FUBP1),
            transcript variant 2, mRNA.
ACCESSION   NM_003902
VERSION     NM_003902.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6714)
  AUTHORS   Shi,W., Chen,M., Pan,T., Chen,M., Cheng,Y., Hao,Y., Chen,S. and
            Tang,Y.
  TITLE     Integration of risk variants from GWAS with SARS-CoV-2 RNA
            interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19
  JOURNAL   Sci Rep 13 (1), 19194 (2023)
   PUBMED   37932299
  REMARK    GeneRIF: Integration of risk variants from GWAS with SARS-CoV-2 RNA
            interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6714)
  AUTHORS   Ebersberger,S., Hipp,C., Mulorz,M.M., Buchbender,A., Hubrich,D.,
            Kang,H.S., Martinez-Lumbreras,S., Kristofori,P., Sutandy,F.X.R.,
            Llacsahuanga Allcca,L., Schonfeld,J., Bakisoglu,C., Busch,A.,
            Hanel,H., Tretow,K., Welzel,M., Di Liddo,A., Mockel,M.M.,
            Zarnack,K., Ebersberger,I., Legewie,S., Luck,K., Sattler,M. and
            Konig,J.
  TITLE     FUBP1 is a general splicing factor facilitating 3' splice site
            recognition and splicing of long introns
  JOURNAL   Mol Cell 83 (15), 2653-2672 (2023)
   PUBMED   37506698
  REMARK    GeneRIF: FUBP1 is a general splicing factor facilitating 3' splice
            site recognition and splicing of long introns.
REFERENCE   3  (bases 1 to 6714)
  AUTHORS   Yu,J., Peng,W., Xue,Y., Li,Y., Yang,L. and Geng,Y.
  TITLE     FUBP1 promotes the proliferation of lung squamous carcinoma cells
            and regulates tumor immunity through PD-L1
  JOURNAL   Allergol Immunopathol (Madr) 50 (5), 68-74 (2022)
   PUBMED   36086966
  REMARK    GeneRIF: FUBP1 promotes the proliferation of lung squamous
            carcinoma cells and regulates tumor immunity through PD-L1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6714)
  AUTHORS   Wang,S., Wang,Y., Li,S., Nian,S., Xu,W. and Liang,F.
  TITLE     Far upstream element -binding protein 1 (FUBP1) participates in the
            malignant process and glycolysis of colon cancer cells by combining
            with c-Myc
  JOURNAL   Bioengineered 13 (5), 12115-12126 (2022)
   PUBMED   35546072
  REMARK    GeneRIF: Far upstream element -binding protein 1 (FUBP1)
            participates in the malignant process and glycolysis of colon
            cancer cells by combining with c-Myc.
REFERENCE   5  (bases 1 to 6714)
  AUTHORS   Zhang,J. and Chen,Q.M.
  TITLE     Far upstream element binding protein 1: a commander of
            transcription, translation and beyond
  JOURNAL   Oncogene 32 (24), 2907-2916 (2013)
   PUBMED   22926519
  REMARK    GeneRIF: biochemical features of FBP1
            Review article
REFERENCE   6  (bases 1 to 6714)
  AUTHORS   He,L., Weber,A. and Levens,D.
  TITLE     Nuclear targeting determinants of the far upstream element binding
            protein, a c-myc transcription factor
  JOURNAL   Nucleic Acids Res 28 (22), 4558-4565 (2000)
   PUBMED   11071946
REFERENCE   7  (bases 1 to 6714)
  AUTHORS   Markovtsov,V., Nikolic,J.M., Goldman,J.A., Turck,C.W., Chou,M.Y.
            and Black,D.L.
  TITLE     Cooperative assembly of an hnRNP complex induced by a
            tissue-specific homolog of polypyrimidine tract binding protein
  JOURNAL   Mol Cell Biol 20 (20), 7463-7479 (2000)
   PUBMED   11003644
REFERENCE   8  (bases 1 to 6714)
  AUTHORS   Williams,B.Y., Hamilton,S.L. and Sarkar,H.K.
  TITLE     The survival motor neuron protein interacts with the transactivator
            FUSE binding protein from human fetal brain
  JOURNAL   FEBS Lett 470 (2), 207-210 (2000)
   PUBMED   10734235
REFERENCE   9  (bases 1 to 6714)
  AUTHORS   Liu,J., He,L., Collins,I., Ge,H., Libutti,D., Li,J., Egly,J.M. and
            Levens,D.
  TITLE     The FBP interacting repressor targets TFIIH to inhibit activated
            transcription
  JOURNAL   Mol Cell 5 (2), 331-341 (2000)
   PUBMED   10882074
REFERENCE   10 (bases 1 to 6714)
  AUTHORS   Duncan,R., Bazar,L., Michelotti,G., Tomonaga,T., Krutzsch,H.,
            Avigan,M. and Levens,D.
  TITLE     A sequence-specific, single-strand binding protein activates the
            far upstream element of c-myc and defines a new DNA-binding motif
  JOURNAL   Genes Dev 8 (4), 465-480 (1994)
   PUBMED   8125259
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA113820.1, U05040.2,
            CB133133.1 and AC096948.2.
            
            On Feb 27, 2020 this sequence version replaced NM_003902.4.
            
            Summary: The protein encoded by this gene is a single stranded
            DNA-binding protein that binds to multiple DNA elements, including
            the far upstream element (FUSE) located upstream of c-myc. Binding
            to FUSE occurs on the non-coding strand, and is important to the
            regulation of c-myc in undifferentiated cells. This protein
            contains three domains, an amphipathic helix N-terminal domain, a
            DNA-binding central domain, and a C-terminal transactivation domain
            that contains three tyrosine-rich motifs. The N-terminal domain is
            thought to repress the activity of the C-terminal domain. This
            protein is also thought to bind RNA, and contains 3'-5' helicase
            activity with in vitro activity on both DNA-DNA and RNA-RNA
            duplexes. Aberrant expression of this gene has been found in
            malignant tissues, and this gene is important to neural system and
            lung development. Binding of this protein to viral RNA is thought
            to play a role in several viral diseases, including hepatitis C and
            hand, foot and mouth disease. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.1286.1,
                                           SRR11853559.1628.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370768.7/ ENSP00000359804.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               DA113820.1         134-301
            169-2143            U05040.2           127-2101
            2144-2367           CB133133.1         75-298
            2368-6714           AC096948.2         78811-83157         c
FEATURES             Location/Qualifiers
     source          1..6714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..6714
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /note="far upstream element binding protein 1"
                     /db_xref="GeneID:8880"
                     /db_xref="HGNC:HGNC:4004"
                     /db_xref="MIM:603444"
     exon            1..188
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2003
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /note="isoform 2 is encoded by transcript variant 2; DNA
                     helicase V; far upstream element (FUSE) binding protein 1;
                     FUSE binding protein 1; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="far upstream element-binding protein 1 isoform
                     2"
                     /protein_id="NP_003893.2"
                     /db_xref="CCDS:CCDS683.1"
                     /db_xref="GeneID:8880"
                     /db_xref="HGNC:HGNC:4004"
                     /db_xref="MIM:603444"
                     /translation="MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAK
                     IGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMT
                     EEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSA
                     KRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVK
                     MVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGSRIGGNE
                     GIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQH
                     AAEIITDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLII
                     GKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGGP
                     VNPLGPPVPHGPHGVPGPHGPPGPPGPGTPMGPYNPAPYNPGPPGPAPHGPPAPYAPQ
                     GWGNAYPHWQQQAPPDPAKAGTDPNSAAWAAYYAHYYQQQAQPPPAAPAGAPTTTQTN
                     GQGDQQNPAPAGQVDYTKAWEEYYKKMGQAVPAPTGAPPGGQPDYSAAWAEYYRQQAA
                     YYAQTSPQGMPQHPPAPQGQ"
     exon            189..279
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            280..318
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            319..358
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            359..411
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            412..483
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            484..541
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            542..704
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            705..803
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            804..905
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1008
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1109
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1251
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1412
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1564
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1644
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1773
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1848
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1994
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..6714
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2345..2350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /note="hexamer: AATAAA"
     polyA_site      2365
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /note="major polyA site"
     regulatory      6690..6695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /note="hexamer: AATAAA"
     polyA_site      6714
                     /gene="FUBP1"
                     /gene_synonym="FBP; FUBP; hDH V"
                     /note="major polyA site"
ORIGIN      
        1 ctttctttct tagctgttag ctgagaggaa gtctctgaac aggcggcagc ggctcttata
       61 gtgcaaccat ggcagactat tcaacagtgc ctcccccctc ttctggctca gctggtggcg
      121 gtggtggcgg cggtggtggt ggaggagtta acgacgcttt caaagatgca ctgcagagag
      181 cccggcagat tgcagcaaaa attggaggtg atgcagggac atcactgaat tcaaatgact
      241 atggttatgg gggacaaaaa agacctttag aagatggaga tcaaccagat gctaagaaag
      301 ttgctcctca aaatgactct tttggaacac agttaccacc gatgcatcag cagcaaagca
      361 gatctgtaat gacagaagaa tacaaagttc cagatggaat ggttggattc ataattggca
      421 gaggaggtga acagatctca cgcatacaac aggaatctgg atgcaaaata cagatagctc
      481 ctgacagtgg tggccttcca gaaaggtcct gtatgttaac tggaacacct gaatctgtcc
      541 agtcagcaaa acggttactg gaccagattg ttgaaaaagg aagaccagct cctggcttcc
      601 atcatggcga tggaccggga aatgcagttc aagaaatcat gattccagct agcaaggcag
      661 gattagtcat tggaaaaggg ggagaaacta ttaaacagct tcaggaacgg gctggagtta
      721 aaatggttat gattcaagac gggccgcaga acactggtgc tgacaaacct cttaggatta
      781 caggagaccc atataaagtt caacaagcca aggaaatggt gttagagtta attcgtgatc
      841 aaggcggttt cagagaagtt cggaatgagt atgggtcaag aataggagga aatgaaggga
      901 tagatgtccc cattccaaga tttgctgttg gcattgtaat aggaagaaat ggagagatga
      961 tcaaaaaaat acaaaatgat gctggtgttc gcattcagtt taagccagat gatgggacaa
     1021 cacccgaaag gatagcacaa ataacaggac ctccagaccg atgtcaacat gctgcagaaa
     1081 ttattacaga ccttcttcga agtgttcagg ctggtaatcc tggtggacct ggacctggtg
     1141 gtcgaggaag aggtagaggt caaggcaact ggaacatggg accacctggt ggactacagg
     1201 aatttaattt tattgtgcca actgggaaaa ctggattaat aataggaaaa ggaggtgaaa
     1261 ccataaaaag cataagccag cagtctggtg caagaataga acttcagaga aatcctccac
     1321 caaatgcaga tcctaatatg aagttattta caattcgtgg cactccacaa cagatagact
     1381 atgctcggca actcatagaa gaaaagattg gtggcccagt aaatccttta gggccacctg
     1441 taccccatgg gccccatggt gtcccaggcc cccatggacc tcctgggcct ccagggcctg
     1501 gaactccaat gggaccatac aaccctgcac cttataatcc tggaccacca ggcccggctc
     1561 ctcatggtcc tccagcccca tatgctcccc agggatgggg aaatgcatat ccacactggc
     1621 agcagcaggc tcctcctgat ccagctaagg caggaacgga tccaaattca gcagcttggg
     1681 ctgcttatta cgctcactat tatcaacagc aagcacagcc accaccagca gcccctgcag
     1741 gtgcaccaac tacaactcaa actaatggac aaggagatca gcagaatcca gccccagctg
     1801 gacaggttga ttataccaag gcttgggaag agtactacaa gaaaatgggt caggcagttc
     1861 ctgctccgac tggggctcct ccaggtggtc agccagatta tagtgcagcc tgggctgagt
     1921 attatagaca acaagcagcc tattatgccc agacaagtcc ccagggaatg ccacagcatc
     1981 ctccagcacc tcagggccaa taataagaag tggacaatac agtatttgct tcattgtgtg
     2041 ggggaaaaaa acctttgtta aatatatgga tgcagacgac ttgatgaaga tcttaatttt
     2101 gtttttggtt taaaatagtg tttccttttt tttttttttt tttgaaaatg tacaaaatat
     2161 ctatcactac tgataggagg ttaatatttc tgtgtagaaa tgaaaattgg tttgttttta
     2221 gtatttagtg tagatgtaca cattccagca aatgtatttg caattatgtg gttgatgctt
     2281 tgtgatataa atgtactttt tcaatgtata ctttcacttt taaaatgcct gttttgtgct
     2341 ttacaataaa tgatatgaaa cctcctgtgt cggtaagttg gatatgtggg tatttaaagg
     2401 attcataatt tcttagcaat gataaattaa gatacatata cacaaatata taagctttcc
     2461 ccatgaaata ttgagttttt aaacactggc atgtttttcc ccccttgcag tatagtggta
     2521 gattggagga tcttttccat ttattgtatt ggctctttca gcacaagtaa tcctgatatc
     2581 ttcatttttt ttccttctgt ttgattaaaa actgcatgtg tgtacaatga tcttttggca
     2641 tacttccatt gcattaacag tgaaatttcc ttttatacat gaccactgtt tcagacctgt
     2701 actgctgcta taacagttaa cctttctgtt cttaatttga taatacttga tttccaagac
     2761 tgtttcggca taactaattt taaacagttt tcagatagtg aatatgagta gtctaataag
     2821 aacagttttt ttccatgtga agcaactctt tcaatgtata taatgttagt gtgtttcttt
     2881 ctaaatttag gatagaaaag tgaatagtgt gcaaaaagta tagctacatt gcatctgcca
     2941 ttgaaacata aatggggtat ggaaacgttc aagctttttt tttttcttta tgcagtatag
     3001 ataagctttg ttttgtaaat gcacaagtcc aatcattgaa tcaacttaat ttttttatgt
     3061 acttgaagtc attttattac tctttaacac tcatgctgaa gttctgatat tttgttgaaa
     3121 tccattgttt tactctttgc atatttgttg gctctttgca tattaatata ttagactaca
     3181 tgcaaataca gtctgtcttg ccattgtctg ttgaagtgca ggtttgatcc agccagtata
     3241 gaactagctc tgtaggggtg aggaggactg tgctgtgtat catccttgat tgtgttcctt
     3301 caaggagcat tgcactgtaa gtacatcaga atgacaaatt gatgaactgc aacagtatct
     3361 ttttgtcaat gttccacata atgcaaatgc catacgttgt gtgaatatta tgttggaata
     3421 cagtgctgat atcttggaaa accataactg cctcttaatt taacatagaa taatacatag
     3481 ttctgtattt tttttaaagt gagcttaatg ggtaagtatt ttttatatgc tttagctata
     3541 gctaaagaaa actgatactt aacaaagttg aatagtatta ttcactggtg ctcctaaaat
     3601 attgtttttc agtgtaaaat atgcatatct tctatattta atatgaaagt cttgaaatgt
     3661 atcagacaga aggggatttc agtttgcaaa taatgagcaa tgtagcaatt ttaacacatt
     3721 tcataaatat atattttgtc attggtggag agcaccattt gttgttttga atatacttta
     3781 aaggaagagg tacaaggaca taaatgttga gattacctac aggatggaaa tagcagtaca
     3841 gttcattgta gatattttga aatgtttttg attgttttat ataacctaga gtgacttccc
     3901 ttacccttat ttagatctgc atatatagtt ctagtatgaa gtttaatagt taaggagtta
     3961 gctatttgtt atctttaaga gtagggtatt gacgtgaaca attgcagtat tttgcatgat
     4021 actgttttat agatgacctt ttaggaaagt ggtgcattta ttaattgaac tgaagaagta
     4081 gttcagttga attcagtatc ataattcaca aattggaggc tgttgatttt gattcattta
     4141 aggtttaaaa tctttattaa ttgcaaacag tgcaattatt tatacttcac agtgccttcc
     4201 cagaccttcc accttaggtt ctgctgcaaa aagcaccagg taagcacaac ctaaggacat
     4261 atataaataa atatttcaat acattaatgt tgtccctgtg aggtttttgt ggttgtgtat
     4321 tcaaaggcaa tctgctactg cttccccaaa atgtattttg ttattttatg ctaccatctt
     4381 agtggaaagt ctgtaagttg ttaaagcaac tgtttacatt tctgggtaat gttttttatt
     4441 ttactttttt ttttttatta agacaagaaa atgatgagta gattgctgca gtaattgaac
     4501 tacatccaaa tctttttgta ttttttcccc aaatatagaa gtgttaatat taagaaagga
     4561 caattacaca gttttcaaga tttaggaaat cacttgttta gaaacttcaa cagccttcac
     4621 aatctgtttt atatgatgga cagaaaattt ctttgccctc caaaattata atttctttat
     4681 ttttttctta ttcttaaact ataataattc agtaaggata ttatgggtta gaattttatt
     4741 atgatttttt tcttagacaa aagttatatg ctgaagaagg aaaaagttat aaggcagtat
     4801 gttttgataa aaggcatgtg catcagtgaa atgttaactg tatagcaaat aacctttcat
     4861 aatctgtagc aatcagtatt tttctgattt aataatattt taataactga cgctgcattt
     4921 aatttttttg ccagtttaaa atgtttgtgt gtttttatag atgattttaa ctggtacata
     4981 ttttgagtta agttgaatgt atgaaagcag catcttatca gttttgttta ttcgatttct
     5041 aaaatgtgct gatcctttta aaactcctgc ttatctctgc aacaaagaaa aatattcaaa
     5101 aatactgcct tcattttcac acacagtgct gaagatgctg caagcaccaa atcatagctc
     5161 ataaaatcag gtcctgagat agttacccat aaagaggaat cctttgagtg tatgccattg
     5221 gtgagccgat gagcatggac catagaaggg ctcaatgtag aaggtaaaat tggcaaatca
     5281 taattgagaa atatgaaatg tattcccata cataatatgg tatagggtgt aatgtacctg
     5341 cttttgatca cttttcattt taaagtgcta ttcacttgat cttaaatgtt ccatgaactg
     5401 ttaaatttct taagttacat agttactaca ccacatttat gtgtatgtta tgttttaata
     5461 gtcaatgata ggtatgtaca attgataata taaaggggct cattgaaact tgagagcctg
     5521 ttgagttttg gttagttgta gattgcattt ttataaaaaa aaatacagat agattgatga
     5581 taatagatat tggggcattg tttctgtctc atgagaattc ttttattcat taccataagc
     5641 cttcactgat actataagca ttattttaaa tgacgctgat cttaagtctg aaataaatgg
     5701 aaagcagaaa aggtgagcca gttgatttga atgcattgga tattagtgtt agaaacaatg
     5761 tatagtttag attgaaactg aactgactta tttagcactt aaacaaaaat ttgacaatgt
     5821 ttttagtttt ttttaagaca gcttagtgtg gtgatactta gaattctatg gtttgatgtt
     5881 tcttttagaa atgagaagta tagttttatt ttttaatata aaaaatggtt ttaatactaa
     5941 aactagtaat ttgatactag ttgtttataa acattgtaaa atatatcttt taaacaaatt
     6001 atcttggtag ttaattcata agggtgggtt tgggtaggaa tagcagagta ctttcagagg
     6061 gaaaggggag tcattcagaa gtgatagcat tttatttgtt tgaatactct gccagtaaaa
     6121 tcagctgtac ttagaaagtt atctgttgtg tagaataatg atgtagagtt tactaatcag
     6181 tgaggatgtc ttgtttttat tttctgcaaa ctctgcctca ctttaaaatg cattataaca
     6241 atacctaatt aaagataatt ttggctctga aagttacctt attttttgtt gagttagtga
     6301 cttcattttt cttgccacaa tataagcttt tgagggattt ttttaaattg gtgcttttaa
     6361 taagcaaata aatcccaggg ttttattttc ttcagtgata cccctataga aactcttaaa
     6421 tgtatttgcg catatatata tatatatttt cttatgcatg ctcgatgcat tttcgtcctg
     6481 agaaaaatgt tctctacaga aactacccgt gtgtaaaaag aagattggct taaaatggct
     6541 actgtgatgg gaacagtgtc ttagggagat gcagcttgga cttgaggtaa attgaatact
     6601 ttacaactgt ggtttagagt ttgctttaat gacattgtat gtaaaaggtc acatgattgc
     6661 tgtaattttg tattcattat ggtttcctca ataaatgtac attgatgact atta
//
