LOCUS       NM_017647               3551 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens FtsJ RNA 2'-O-methyltransferase 3 (FTSJ3), mRNA.
ACCESSION   NM_017647
VERSION     NM_017647.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3551)
  AUTHORS   Zhuang,Q., Dai,Z., Xu,X., Bai,S., Zhang,Y., Zheng,Y., Xing,X.,
            Hu,E., Wang,Y., Guo,W., Zhao,B., Zeng,Y. and Liu,X.
  TITLE     RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway
            to Promote Hepatocellular Carcinoma Immune Evasion
  JOURNAL   Cancer Res 84 (3), 405-418 (2024)
   PUBMED   37963197
  REMARK    GeneRIF: RNA Methyltransferase FTSJ3 Regulates the Type I
            Interferon Pathway to Promote Hepatocellular Carcinoma Immune
            Evasion.
REFERENCE   2  (bases 1 to 3551)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3551)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 3551)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3551)
  AUTHORS   Manning,M., Jiang,Y., Wang,R., Liu,L., Rode,S., Bonahoom,M., Kim,S.
            and Yang,Z.Q.
  TITLE     Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a
            potential regulator of breast cancer progression
  JOURNAL   RNA Biol 17 (4), 474-486 (2020)
   PUBMED   31957540
  REMARK    GeneRIF: Pan-cancer analysis of RNA methyltransferases identifies
            FTSJ3 as a potential regulator of breast cancer progression.
REFERENCE   6  (bases 1 to 3551)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   7  (bases 1 to 3551)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 3551)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   9  (bases 1 to 3551)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   10 (bases 1 to 3551)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK095861.1, AK315010.1,
            AF147378.1 and BM914774.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017647.3.
            
            Summary: Although the function of this gene is not known, the
            existence of this gene is supported by mRNA and EST data. A
            possible function of the encoded protein can be inferred from amino
            acid sequence similarity to the E.coli FtsJ protein and to a mouse
            protein possibly involved in embryogenesis. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.15384.1,
                                           SRR1660803.125988.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427159.7/ ENSP00000396673.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2879              AK095861.1         9-2887
            2880-3182           AK315010.1         2313-2615
            3183-3529           AF147378.1         200-546
            3530-3551           BM914774.1         309-330
FEATURES             Location/Qualifiers
     source          1..3551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..3551
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /note="FtsJ RNA 2'-O-methyltransferase 3"
                     /db_xref="GeneID:117246"
                     /db_xref="HGNC:HGNC:17136"
                     /db_xref="MIM:618411"
     exon            1..612
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..705
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             639..3182
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /EC_number="2.1.1.-"
                     /note="putative rRNA methyltransferase 3; rRNA
                     (uridine-2'-O-)-methyltransferase 3; protein ftsJ homolog
                     3; SPB1 RNA methyltransferase homolog; pre-rRNA processing
                     protein FTSJ3; FtsJ homolog 3; 2'-O-ribose RNA
                     methyltransferase SPB1 homolog; FtsJ RNA methyltransferase
                     homolog 3"
                     /codon_start=1
                     /product="pre-rRNA 2'-O-ribose RNA methyltransferase
                     FTSJ3"
                     /protein_id="NP_060117.3"
                     /db_xref="CCDS:CCDS11644.1"
                     /db_xref="GeneID:117246"
                     /db_xref="HGNC:HGNC:17136"
                     /db_xref="MIM:618411"
                     /translation="MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQK
                     ARALLDLCAAPGGWLQVAAKFMPVSSLIVGVDLVPIKPLPNVVTLQQDITTERCRQAL
                     RKELKTWKVDVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARGGSFITKVFR
                     SRDYQPLLWIFQQLFRRVQATKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFK
                     EVEVQAKTVTELVTKKKPKAEGYAEGDLTLYHRTSVTDFLRAANPVDFLSKASEIMVD
                     DEELAQHPATTEDIRVCCQDIRVLGRKELRSLLNWRTKLRRYVAKKLKEQAKALDISL
                     SSGEEDEGDEEDSTAGTTKQPSKEEEEEEEEEQLNQTLAEMKAQEVAELKRKKKKLLR
                     EQRKQRERVELKMDLPGVSIADEGETGMFSLSTIRGHQLLEEVTQGDMSAADTFLSDL
                     PRDDIYVSDVEDDGDDTSLDSDLDPEELAGVRGHQGLRDQKRMRLTEVQDDKEEEEEE
                     NPLLVPLEEKAVLQEEQANLWFSKGSFAGIEDDADEALEISQAQLLFENRRKGRQQQQ
                     KQQLPQTPPSCLKTEIMSPLYQDEAPKGTEASSGTEAATGLEGEEKDGISDSDSSTSS
                     EEEESWEPLRGKKRSRGPKSDDDGFEIVPIEDPAKHRILDPEGLALGAVIASSKKAKR
                     DLIDNSFNRYTFNEDEGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIK
                     KVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRHV
                     TYVVAKKGVGRKVRRPAGVRGHFKVVDSRMKKDQRAQQRKEQKKKHKRK"
     exon            706..811
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..858
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..938
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1038
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1233
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1349
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1454
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1555
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1636
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1792
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1928
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2113
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2234
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2524
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2610
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2710
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2894
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2989
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3551
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /note="hexamer: AATAAA"
     polyA_site      3551
                     /gene="FTSJ3"
                     /gene_synonym="EPCS3; SPB1"
                     /note="major polyA site"
ORIGIN      
        1 agatccggtc gcaggcagcg tccagcatgg actggtccag gcacctccga cccacccgac
       61 gctcctgccc cggcccgctc tccactcaga tcacgctcgc tccgcaccca gccccgtaac
      121 ctgccgggcc gccactgcac ccgccatacc tgctctggtc cgtcaagcgc catcttctct
      181 cttcagcaga gaccgccggc atccgagccg tcttggcgcg caagcgcgga agcggaggat
      241 tgggacctga agaccaggca gagaagaatt ccgggtcaat gggcggggtg tgcggcgaga
      301 ccacactaag ggaaccatga tgggaggggc ggctactcga gttcaggggc tttggaaggg
      361 gatgaggaag gagtagaact cctcctcagt gttgcctcat tgaaactctg tttatagttc
      421 ttgtgatatg ccttcctagt ctcaactttc aacttacaaa acccaaggac agagtattga
      481 gaacaatcta gggccacact caaaatggcg gaaaacctcg agccagggac gcaggggacg
      541 caagcggaag cggaagtagt tagctgcata cttgtgcggt tccaagtgtg gagaaagcgg
      601 ctctgggtct agattgaggg atactccccc tttccaccat gggcaagaag ggcaaagttg
      661 gcaagagccg acgagacaag ttttatcact tggcgaagga gacgggttac cgttcccgat
      721 ctgctttcaa gctgatccag ctcaatcgcc gctttcagtt cctgcagaaa gcccgagcct
      781 tgctggacct gtgtgctgcg ccagggggat ggctgcaggt agctgccaag tttatgcctg
      841 tatccagcct tattgtggga gtggacctgg ttccaatcaa gcctctcccc aatgtggtga
      901 ctctccagca ggacatcaca acagaacgtt gtaggcaggc cctgaggaag gagctgaaga
      961 cctggaaggt tgatgttgtg ctcaatgatg gggcccccaa cgttggggct agctgggtcc
     1021 atgatgctta ctcacaagcc catttgacac tgatggctct acgtttggct tgtgactttt
     1081 tggcccgtgg tggcagcttc atcacaaagg ttttccgttc tcgtgactat cagcctctgc
     1141 tatggatctt tcagcagctg ttccgccgtg tccaggccac caagccccaa gcctctcgcc
     1201 atgaatctgc agagatcttt gtagtctgcc aaggattcct ggcccctgac aaggttgaca
     1261 gtaaattctt tgaccccaaa tttgccttta aggaggttga agttcaggct aagaccgtta
     1321 ctgaattggt tactaagaag aagccaaagg ctgaaggcta tgctgagggt gacctcactc
     1381 tctatcaccg tacctcagtc actgacttcc tccgagctgc caaccctgtt gacttcctct
     1441 ccaaggccag cgaaatcatg gtagatgatg aagagttggc acagcatcca gctaccactg
     1501 aggacatacg ggtgtgctgt caggacatca gagtgttggg gcgcaaggag ctcaggtcgc
     1561 tactaaactg gagaacaaaa cttcggcgat atgtggccaa gaagctgaaa gaacaagcaa
     1621 aggcactgga catcagcctc agctctggag aggaagatga aggtgatgag gaggactcaa
     1681 cagctggaac cacaaagcag ccctctaagg aggaggagga agaggaggag gaggaacaac
     1741 tgaaccagac cttggcagaa atgaaggccc aggaggtggc ggaattgaag aggaagaaaa
     1801 agaagctgtt gcgtgagcag agaaagcagc gggagcgtgt ggagctgaag atggatctgc
     1861 ctggggtttc cattgcagac gagggggaga ctggcatgtt ctccttgagc accatccggg
     1921 gtcaccagtt attagaggaa gtaacacaag gggatatgag tgcagcagac acatttctgt
     1981 ccgatctgcc aagggatgat atctatgtgt cagatgttga ggacgacggt gatgacacat
     2041 ctctggatag tgacctggat ccagaggagc tggcaggagt caggggacat cagggtctaa
     2101 gggaccaaaa gcgtatgcga cttactgaag tgcaagatga taaagaggag gaggaggagg
     2161 agaatccact gctggtacca ctggaggaaa aggcagtact gcaggaagaa caagccaacc
     2221 tgtggttctc aaagggcagc tttgctggga tcgaggacga tgccgatgag gccctggaga
     2281 tcagtcaggc ccagctgtta tttgagaacc ggcggaaggg acggcagcag cagcagaagc
     2341 agcagctgcc acagacaccc ccttcctgtt tgaagactga gataatgtct cccctgtacc
     2401 aagatgaagc ccctaaggga acagaggctt cttcggggac agaagctgcc actggccttg
     2461 aaggggaaga aaaggatggc atctcagaca gtgatagcag tactagcagt gaggaagaag
     2521 agagctggga acccctccgt ggtaagaagc gaagccgtgg gcctaagtca gatgatgacg
     2581 ggtttgagat agtgcctatt gaggacccag cgaaacatcg gatactggac cccgaaggcc
     2641 ttgctctagg tgctgttatt gcctcttcca aaaaggccaa gagagacctc atagataact
     2701 ccttcaaccg gtacacattt aatgaggatg agggggagct tccggagtgg tttgtgcaag
     2761 aggaaaagca gcaccggata cgacagttgc ctgttggtaa gaaggaggtg gagcattacc
     2821 ggaaacgctg gcgggaaatc aatgcacgtc ccatcaagaa ggtggctgag gctaaggcta
     2881 gaaagaaaag gaggatgctg aagaggctgg agcagaccag gaagaaggca gaagccgtgg
     2941 tgaacacagt ggacatctca gaacgagaga aagtggcaca gctgcgaagt ctctacaaga
     3001 aggctgggct tggcaaggag aaacgccatg tcacctacgt tgtagccaaa aaaggtgtgg
     3061 gccgcaaagt gcgccggcca gctggagtca gaggtcattt caaggtggtg gactcaagga
     3121 tgaagaagga ccaaagagca cagcaacgta aggaacaaaa gaaaaaacac aaacggaagt
     3181 aagcagagct gccaggctcc caggagagca tggggactag gaggaagggt gtggcatggc
     3241 tcagtctggc ccccttgatt accggcctag cccctgctca catcacagct gtctgaagaa
     3301 cagtgaggtg gagtgcctag aactcccgtg gtggtcctga gcagagagga ggatgtcctc
     3361 ctgcctgcct gaaggtctcc catgaaaaca ctgctgaact gtgttgacac tcatgaccct
     3421 ttttttaaac cgttaaaggg aagttcggtg ttggagcgat actcaatgta gtcagtctac
     3481 acctggacgt gtgggccact taagccctcc ccacccccat cctattcctg aataaaacca
     3541 ggataatgga a
//
