LOCUS       NM_001080432           11573 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens FTO alpha-ketoglutarate dependent dioxygenase (FTO),
            transcript variant 3, mRNA.
ACCESSION   NM_001080432 XM_051200
VERSION     NM_001080432.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11573)
  AUTHORS   Li,B., Wang,L., Du,M. and He,H.
  TITLE     FTO in oral diseases: Functions, mechanisms, and therapeutic
            potential
  JOURNAL   FASEB J 38 (20), e70115 (2024)
   PUBMED   39436191
  REMARK    GeneRIF: FTO in oral diseases: Functions, mechanisms, and
            therapeutic potential.
            Review article
REFERENCE   2  (bases 1 to 11573)
  AUTHORS   Li,Q. and Mu,S.
  TITLE     FTO mediates the diabetic kidney disease progression through
            regulating the m6A modification of NLRP3
  JOURNAL   BMC Nephrol 25 (1), 345 (2024)
   PUBMED   39390397
  REMARK    GeneRIF: FTO mediates the diabetic kidney disease progression
            through regulating the m[6]A modification of NLRP3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11573)
  AUTHORS   Shan,L., Tao,M., Zhang,W., Zhao,J.D., Liu,X.C., Fang,Z.H. and
            Gao,J.R.
  TITLE     Comprehensive analysis of the m6A demethylase FTO in endothelial
            dysfunction by MeRIP sequencing
  JOURNAL   Exp Cell Res 442 (2), 114268 (2024)
   PUBMED   39343042
  REMARK    GeneRIF: Comprehensive analysis of the m[6]A demethylase FTO in
            endothelial dysfunction by MeRIP sequencing.
REFERENCE   4  (bases 1 to 11573)
  AUTHORS   Nabeel-Shah,S., Pu,S., Burke,G.L., Ahmed,N., Braunschweig,U.,
            Farhangmehr,S., Lee,H., Wu,M., Ni,Z., Tang,H., Zhong,G., Marcon,E.,
            Zhang,Z., Blencowe,B.J. and Greenblatt,J.F.
  TITLE     Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the
            telomeric zinc finger protein ZBTB48
  JOURNAL   Genome Biol 25 (1), 246 (2024)
   PUBMED   39300486
  REMARK    GeneRIF: Recruitment of the m[6]A/m6Am demethylase FTO to target
            RNAs by the telomeric zinc finger protein ZBTB48.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11573)
  AUTHORS   Hussain,M., Waheed,A., Elahi,A. and Mustafa,G.
  TITLE     Fat Mass and Obesity-Related (FTO) Gene Variant Is a Predictor of
            CVD in T2DM Patients
  JOURNAL   J Diabetes Res 2024, 5914316 (2024)
   PUBMED   39257882
  REMARK    GeneRIF: Fat Mass and Obesity-Related (FTO) Gene Variant Is a
            Predictor of CVD in T2DM Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11573)
  AUTHORS   Zeggini,E., Weedon,M.N., Lindgren,C.M., Frayling,T.M.,
            Elliott,K.S., Lango,H., Timpson,N.J., Perry,J.R., Rayner,N.W.,
            Freathy,R.M., Barrett,J.C., Shields,B., Morris,A.P., Ellard,S.,
            Groves,C.J., Harries,L.W., Marchini,J.L., Owen,K.R., Knight,B.,
            Cardon,L.R., Walker,M., Hitman,G.A., Morris,A.D., Doney,A.S.,
            McCarthy,M.I. and Hattersley,A.T.
  CONSRTM   Wellcome Trust Case Control Consortium (WTCCC)
  TITLE     Replication of genome-wide association signals in UK samples
            reveals risk loci for type 2 diabetes
  JOURNAL   Science 316 (5829), 1336-1341 (2007)
   PUBMED   17463249
  REMARK    Erratum:[Science. 2007 Aug 24;317(5841):1035-6]
REFERENCE   7  (bases 1 to 11573)
  AUTHORS   Scott,L.J., Mohlke,K.L., Bonnycastle,L.L., Willer,C.J., Li,Y.,
            Duren,W.L., Erdos,M.R., Stringham,H.M., Chines,P.S., Jackson,A.U.,
            Prokunina-Olsson,L., Ding,C.J., Swift,A.J., Narisu,N., Hu,T.,
            Pruim,R., Xiao,R., Li,X.Y., Conneely,K.N., Riebow,N.L., Sprau,A.G.,
            Tong,M., White,P.P., Hetrick,K.N., Barnhart,M.W., Bark,C.W.,
            Goldstein,J.L., Watkins,L., Xiang,F., Saramies,J., Buchanan,T.A.,
            Watanabe,R.M., Valle,T.T., Kinnunen,L., Abecasis,G.R., Pugh,E.W.,
            Doheny,K.F., Bergman,R.N., Tuomilehto,J., Collins,F.S. and
            Boehnke,M.
  TITLE     A genome-wide association study of type 2 diabetes in Finns detects
            multiple susceptibility variants
  JOURNAL   Science 316 (5829), 1341-1345 (2007)
   PUBMED   17463248
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 11573)
  AUTHORS   Dina,C., Meyre,D., Gallina,S., Durand,E., Korner,A., Jacobson,P.,
            Carlsson,L.M., Kiess,W., Vatin,V., Lecoeur,C., Delplanque,J.,
            Vaillant,E., Pattou,F., Ruiz,J., Weill,J., Levy-Marchal,C.,
            Horber,F., Potoczna,N., Hercberg,S., Le Stunff,C., Bougneres,P.,
            Kovacs,P., Marre,M., Balkau,B., Cauchi,S., Chevre,J.C. and
            Froguel,P.
  TITLE     Variation in FTO contributes to childhood obesity and severe adult
            obesity
  JOURNAL   Nat Genet 39 (6), 724-726 (2007)
   PUBMED   17496892
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            GeneRIF: Association with obesity in adult and childre.
            Interestingly, this association receives clear confirmation under a
            Transmission Disequilibrium Test design which is robust to
            population stratification.
REFERENCE   9  (bases 1 to 11573)
  AUTHORS   Frayling,T.M., Timpson,N.J., Weedon,M.N., Zeggini,E., Freathy,R.M.,
            Lindgren,C.M., Perry,J.R., Elliott,K.S., Lango,H., Rayner,N.W.,
            Shields,B., Harries,L.W., Barrett,J.C., Ellard,S., Groves,C.J.,
            Knight,B., Patch,A.M., Ness,A.R., Ebrahim,S., Lawlor,D.A.,
            Ring,S.M., Ben-Shlomo,Y., Jarvelin,M.R., Sovio,U., Bennett,A.J.,
            Melzer,D., Ferrucci,L., Loos,R.J., Barroso,I., Wareham,N.J.,
            Karpe,F., Owen,K.R., Cardon,L.R., Walker,M., Hitman,G.A.,
            Palmer,C.N., Doney,A.S., Morris,A.D., Smith,G.D., Hattersley,A.T.
            and McCarthy,M.I.
  TITLE     A common variant in the FTO gene is associated with body mass index
            and predisposes to childhood and adult obesity
  JOURNAL   Science 316 (5826), 889-894 (2007)
   PUBMED   17434869
  REMARK    GeneRIF: A genome-wide search for type 2 diabetes-susceptibility
            genes identified a common variant in the FTO gene that predisposes
            to diabetes through an effect on body mass index
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association and gene-environment interaction. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 11573)
  AUTHORS   Peters,T., Ausmeier,K. and Ruther,U.
  TITLE     Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft)
            mouse mutation
  JOURNAL   Mamm Genome 10 (10), 983-986 (1999)
   PUBMED   10501967
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA324897.1, AK096554.1,
            AB051539.1, BC001284.1, BC030798.1, U79260.1 and AC007347.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080432.2.
            
            Summary: This gene is a nuclear protein of the AlkB related
            non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily
            but the exact physiological function of this gene is not known.
            Other non-heme iron enzymes function to reverse alkylated DNA and
            RNA damage by oxidative demethylation. Studies in mice and humans
            indicate a role in nervous and cardiovascular systems and a strong
            association with body mass index, obesity risk, and type 2
            diabetes. [provided by RefSeq, Jul 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.127247.1,
                                           SRR1803614.160619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471389.6/ ENSP00000418823.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               DA324897.1         195-473
            280-1200            AK096554.1         280-1200
            1201-2926           AB051539.1         1178-2903
            2927-3457           BC001284.1         175-705
            3458-3654           BC030798.1         2417-2613
            3655-4095           BC001284.1         902-1342
            4096-4099           U79260.1           1406-1409
            4100-11573          AC007347.3         145357-152830
FEATURES             Location/Qualifiers
     source          1..11573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.2"
     gene            1..11573
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /note="FTO alpha-ketoglutarate dependent dioxygenase"
                     /db_xref="GeneID:79068"
                     /db_xref="HGNC:HGNC:24678"
                     /db_xref="MIM:610966"
     exon            1..74
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1547
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /EC_number="1.14.11.53"
                     /note="isoform 3 is encoded by transcript variant 3;
                     alpha-ketoglutarate-dependent dioxygenase FTO; fat mass
                     and obesity-associated protein; AlkB homolog 9; fat mass
                     and obesity associated; m6A(m)-demethylase FTO; tRNA
                     N1-methyl adenine demethylase FTO; mRNA
                     N(6)-methyladenosine demethylase FTO; mRNA
                     (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small
                     nuclear RNA N(6)-methyladenosine-demethylase FTO; U6 small
                     nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO;
                     intragenic FTO exon 9 containing transcript"
                     /codon_start=1
                     /product="alpha-ketoglutarate-dependent dioxygenase FTO
                     isoform 3"
                     /protein_id="NP_001073901.1"
                     /db_xref="CCDS:CCDS32448.1"
                     /db_xref="GeneID:79068"
                     /db_xref="HGNC:HGNC:24678"
                     /db_xref="MIM:610966"
                     /translation="MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQL
                     KYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNP
                     GCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAK
                     EKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEE
                     PYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKI
                     SWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYI
                     LQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKC
                     TDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRR
                     EWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP"
     exon            75..152
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            153..780
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            781..924
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1004
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1148
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1268
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1393
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..11573
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /note="hexamer: ATTAAA"
     polyA_site      4095
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /note="major polyA site"
     regulatory      11555..11560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
                     /note="hexamer: AATAAA"
     polyA_site      11573
                     /gene="FTO"
                     /gene_synonym="ALKBH9; BMIQ14; GDFD; IFEX9"
ORIGIN      
        1 gcggtggcga aggcggcttt agtggcagca tgaagcgcac cccgactgcc gaggaacgag
       61 agcgcgaagc taagaaactg aggcttcttg aagagcttga agacacttgg ctcccttatc
      121 tgacccccaa agatgatgaa ttctatcagc agtggcagct gaaatatcct aaactaattc
      181 tccgagaagc cagcagtgta tctgaggagc tccataaaga ggttcaagaa gcctttctca
      241 cactgcacaa gcatggctgc ttatttcggg acctggttag gatccaaggc aaagatctgc
      301 tcactccggt atctcgcatc ctcattggta atccaggctg cacctacaag tacctgaaca
      361 ccaggctctt tacggtcccc tggccagtga aagggtctaa tataaaacac accgaggctg
      421 aaatagccgc tgcttgtgag accttcctca agctcaatga ctacctgcag atagaaacca
      481 tccaggcttt ggaagaactt gctgccaaag agaaggctaa tgaggatgct gtgccattgt
      541 gtatgtctgc agatttcccc agggttggga tgggttcatc ctacaacgga caagatgaag
      601 tggacattaa gagcagagca gcatacaacg taactttgct gaatttcatg gatcctcaga
      661 aaatgccata cctgaaagag gaaccttatt ttggcatggg gaaaatggca gtgagctggc
      721 atcatgatga aaatctggtg gacaggtcag cggtggcagt gtacagttat agctgtgaag
      781 gccctgaaga ggaaagtgag gatgactctc atctcgaagg cagggatcct gatatttggc
      841 atgttggttt taagatctca tgggacatag agacacctgg tttggcgata ccccttcacc
      901 aaggagactg ctatttcatg cttgatgatc tcaatgccac ccaccaacac tgtgttttgg
      961 ccggttcaca acctcggttt agttccaccc accgagtggc agagtgctca acaggaacct
     1021 tggattatat tttacaacgc tgtcagttgg ctctgcagaa tgtctgtgac gatgtggaca
     1081 atgatgatgt ctctttgaaa tcctttgagc ctgcagtttt gaaacaagga gaagaaattc
     1141 ataatgaggt cgagtttgag tggctgaggc agttttggtt tcaaggcaat cgatacagaa
     1201 agtgcactga ctggtggtgt caacccatgg ctcaactgga agcactgtgg aagaagatgg
     1261 agggtgtgac aaatgctgtg cttcatgaag ttaaaagaga ggggctcccc gtggaacaaa
     1321 ggaatgaaat cttgactgcc atccttgcct cgctcactgc acgccagaac ctgaggagag
     1381 aatggcatgc caggtgccag tcacgaattg cccgaacatt acctgctgat cagaagccag
     1441 aatgtcggcc atactgggaa aaggatgatg cttcgatgcc tctgccgttt gacctcacag
     1501 acatcgtttc agaactcaga ggtcagcttc tggaagcaaa accctagaag gagcacaagt
     1561 ctcaggcgga ggagaaaaag agatcggctt ttctcctcca acgttgtcat gggcttaagc
     1621 aagagcagtg gagacttctc ttggccccta gattgtagca cccgggtccc aatccaaaac
     1681 agctaggaaa tggtgcccat gaagttttaa atgttttaaa atgaccctgt gttatagtct
     1741 gatttggtgt taaacaggac cttcttcccc caaaattgtt cagattataa aatgtgagcc
     1801 attcagcccc caaggtccag ggcaggcgac aggaacgagc ccagcgtgtg acaaagccta
     1861 acctactttc ctctttccca agctttttca gagactctgg agtggaccca gccctctggg
     1921 gaaagacaga acttagagac atcccagtta ctcaccacac ccatagtgct gtccaatatg
     1981 gtagccacta gctagctgtg gctacttcaa tttaaattca gttttaattt taattaaaaa
     2041 tgcagctctt cagtcgccct ggccacattt caagtgctta acagcctcat gtggctagtg
     2101 actgctgtat tggacggtac agatatggaa cattttcatc atcgaagaaa gtcctattgg
     2161 acaacacttc tataaaaagt ttgagagcag gaattctcat ttccattcgt ctgtagcttc
     2221 tatccccaaa ggcaaagaaa ctaaaagaga aatgactcat tgaagattgg cctctttcct
     2281 ttctctaaga caaacctaag taaaagcctg agctttgagt cctatgctca gcacacggga
     2341 aggagatgtt aataattaaa ataaagttga tatcctgtct ttagggagtt cccttgatct
     2401 cttgaaagag acacagcccc atttacatta tttcgtggat ttcaccagca tagtatagtt
     2461 tttttctgta agtccctcat tcttatgtaa taacaggtgg aactgaggtt tgaagaacct
     2521 cagtggccca tcctgatgac attggagact caaagagaca agagagagta gggtttaaaa
     2581 cctgagcttt aagactccca ctagcttcgt gtcctttggc atgttaacgt gcctcagttt
     2641 cctcatctgt ataatgggga tatatgaaag gcaccagtcc taaggtgaac attaagtgag
     2701 atgattctag ttacagactt agaacaattt ccagcacata gttaaatatc caggaaattc
     2761 tggtactgtt atgtgtgggt gagctgacct ggatgtagat gttttcctct ctcttgctga
     2821 cccctccgcc agttttgtct tgtgatgcca ttaacacatc tctccctttc tgacctggct
     2881 cctgcccatt ggtgtcccaa gaaatcgtga gaatagttag ccccccgtct ccccagcctg
     2941 ttgctttctc gtgtagttgt tcacagtagt tgagaagttg aagagctttt gcctattgaa
     3001 ggtgcactga gaataaactc tttcctgcca ccagaattgc agtggttcac ggcctgcact
     3061 cattcccatg aatgcagtta atagccacag aaatgtcaca ttaagcaaag cagccagggt
     3121 ctcatcgtgt tgagactcga gtctctcaga ccttggattc attccctggt gtctttgagc
     3181 ctcagtttcc tcattggtaa aagagaagtg aagcagtgtc tcacagggtc attacagaga
     3241 ttaaatgaaa taaatgaaat aacatagacc aggagggcgt ggtgtttaaa agtcacagat
     3301 ggggcaccct cgggccatcc agcccagtgt tttctttagc ccctatgatg ttcatttttt
     3361 gttatatccc attaggtgcc catatttaaa aattgggaga tttcacataa aattaaaagg
     3421 tctgcatttt cttttttctt ttcttttttt ttttttttga gacacagtct cactctgtca
     3481 ccaggctaga gtgcagtggc acgatctcag ctcactgcaa cctctgcctc ccaggttcaa
     3541 gtaattctcc tgcctcagcc tcccaagtag ctgggactac aggcacgtgc caccacgccc
     3601 agctaatttt tgtattttta gcagagatgg ggtttcacca cattggccag gatggtctcg
     3661 atctcaacct cgtgatccac ccacctcggt ctcccaaagc gctgggatta caggcgtgag
     3721 ccaccgcgcc aagccaaggt ctgcattttt ctttagaact cagaacaccc aatagtccta
     3781 ggcccccatc ctcgcatggc agcaagctaa ataagcatct tcccactgcg agttggggca
     3841 tgacccagcc tatggtttgc catactccct ctttttctcc gttttttcat taattgtgaa
     3901 cctgacctgc atcacccttt catgtcagtg ctctccaaac ctgcttgctt gcacccctct
     3961 agtcgaaata ttttgtgctt accccaatat atgtgtgtga ctattgaact ctattcgtag
     4021 actgcttgta ctaatgtcat ttgcatcata aaatattcat atccaataaa catattaaaa
     4081 ggatgagata agaaaccgag agattttgct gtttttttcc ttttgcatgg atgagccagc
     4141 ttcactgtcc tgggtggggc ccaggtggaa ttagttctca aagtcctcca ggtggagtca
     4201 gggaatgtgc aacagggttg gagaaatcac tactttaagt gaatccgaaa ggtgagatca
     4261 catttgctct aaagaaatgg tgatcccagc actttgggag gctgaggcag cagatcactg
     4321 gaggtcagga gttcgagacc agcctggcca acacggtgaa accccgtctc tactgaaaac
     4381 acaaaaatta gctgggtgtg gtggtgtgtg cctgtaatcc cagctactcg ggaggctgag
     4441 gcaggcaaat cgcttggccc gggaggcgga ggttgcagtg agccgagatc atgccactgc
     4501 actccagcct gggccacgga gcgagagaag aaagaaatgg tgactttcat tgatcatgtg
     4561 tttgaggatt tcatgtgctc tccagggagg tttcaggtgg gtagaaggag gtgggcaaga
     4621 cccaataaaa aagcagctgg tgcgggcaat gacaatgaac tcgtatcctg cagggtcaaa
     4681 ggaaggcttg cttctgctgt gaattggaga aggactttcc tggaagcaca ggcccagaaa
     4741 tcgcaccctt ctccccatgt gtgcggataa gggaccactt ccatcagcag cagccccctc
     4801 ctgctttcct gccagtcctc cctgtggtcc caggtctctt gagaaaagtg atctaagaga
     4861 tccctttgca atgaggtgct actgactgcc ctacctccct cccttcctcc catgaatgtt
     4921 tcttggtgct gaccacagcc tcagcaatga ggcaagcctg gggacccaag acagatctct
     4981 gcctcccagg ctagtggatg ccctgggata tgtagtcacc aaaataggaa cttaccccat
     5041 agtggggaaa tagacagtaa gcagcaaatc aataacaaga gtgttccaga tggttgtaag
     5101 tgccaggaag ggaaccaact gggagaggga caagaggaga tggtgactga ccaaggggac
     5161 cttgatcagg ctgtggggaa gggaggtggt tgggaagagc ttcccaggaa aggggacggc
     5221 gggcccaggc aggagagcct tgggaggggg tgcccaagga aggaaaaggg ccctgagcct
     5281 gaagccgaga agaccaggag gggagaaggg gagatgtagg gcagagcaga cgggagccgc
     5341 tcgggtttta ttccacacac cccaggaagc atgagagggt ttcaagcagc aagggcatgg
     5401 aagtaacttg gtgagatatt tttatgcatt agatcatcgc tctatctgga ttccagaggg
     5461 tctctgagag agcaaacagc ttaatccaaa ggagcggctt tccaactggg aatgtccccc
     5521 tggctgggtg agatctcaag atggcctgcg gcccctctag attgcctgcc tacagagttc
     5581 actctaaaca gcccctcccc tccacacccc agcagatcca ttcctgacgc cctcactggc
     5641 aggctccagc cccacagagc tttctagaca taaaagagca gggtcatggc atcattggtg
     5701 acacaatttt agtaataagc ttcaaaaccc atcactccac tgaatccagg gatgccagaa
     5761 ttgagagtcc ataggacccg tttaacggat cccacattca gtagacggtt ttttgtatgc
     5821 ttcgagggaa ggaaggtatt ttcaaatgca acttcttttt tttttttctt gctctagtta
     5881 gggctgattt taccactggg caaattgcat acatttggat ccatgccacg ctaaaaactg
     5941 tttattttgg agatctgtca gaggcaagca catggaagac aaggggattc tggtttgaaa
     6001 aggcaattct catccagaca gattcagatg gagaggagcg gtgtggatta aaatgcgccg
     6061 aagtggtaat gccgtttatc ccgtttgcct ttgttactct gtgattaaat ggtattttta
     6121 attaagtttc attgggagcc ataggtatcg cggtggtgaa atcaatttga caaccataaa
     6181 ggggagagac ggcacaggcg tgttgtgatg attgcggctg tagggaaagc cgggcagctt
     6241 gcagaggatg ggtgggagga ggggaagccg gctaagaatg acttcctgca agacagcaag
     6301 ggcacccctg ggccactgct gtgtttggga ggcaggtttt gggggttgtc agaaggcatt
     6361 cacctggttc tctcgctcac ctgagacacc cgatagattc ctggaaactc caggaaagta
     6421 tctgaagatc tggttctcca ttctctctta ttaacaagga gaaccacaag tgccccccag
     6481 atcccggcta gaaggaccag acagctttcc accccggttc ccaggcagcc ctgctcccat
     6541 agtcctgtgt cccatcggcc ccatgctccc aggacagtcc taattcccac ctctcagaac
     6601 cttgtcagcc aagttcttcc tgctctctgg cccaaatcct cctcctacat tggaaactga
     6661 gcctctctgc atcctctgct ctttctatcc cgctgtcatt catcagattt tccaaatctt
     6721 tggattcctg agtggcagaa gaggttttct gagtttaagt tctgattctg tgtgtgattc
     6781 tcactctacc acctcttcaa acctttgttg tcttatctac aaaatagaat agtagtaatc
     6841 catcacctaa ggttgttgtg aaggttcaat aagttaatgc gtatttaaaa tgcctcccac
     6901 agtacctgac atatactggg cttcagtgag gtactagcta ttattattaa ccaagtttcc
     6961 tgtggtaaca gttgtagctt tgtgactggg ccaaatcact taacccctct gcgctccagt
     7021 ctttgtttct ataatgggga tgatgataat gcctagctca ttggattgtt ctgtccccta
     7081 cgatcagcca tgttaagtga ttcatatcat gtctggtact taaaaatcac gccacgcatg
     7141 tacattatta tgatgaaaaa tatgatccgt gatatcctga ccaaaatatt aaagggacta
     7201 aagatagctg tggcttgttc aagaagaata ttgtgtcact atcccatata ttatcccatt
     7261 tgctcttcac agcttccatt tttcgctagg cggatggcat ggaacttttt ataaatgaga
     7321 tattatgaaa aatgatgttt taggactctc atttctacag tgggagtagg tcacccattg
     7381 caattttgga tttgcttaaa aaaattcttg ccatcacctt ctaatggatg atctgtgtac
     7441 aacaattgtt tattgactct gaatgtctaa gtaccagggt cagtctattt caaggggagg
     7501 gaagcattaa ttaacctcca gcattagatt cagtgattct tttccaatga tgcagttcat
     7561 gactttgctc gcatttactt ttcatcaatc ctgaaagaat tgaggtaaaa tagttcctct
     7621 gcacatgtgt gtcaagctaa atggataaca gcagatacag atctgtttgc ctgtctgcac
     7681 ttgcctttag acaaaattca tcaattttac aaaagccact gactaaacat ggcaccaata
     7741 caaatgaagc acttctagca ggcggagatt ccctttgttt ctgatctggt aaatgcggta
     7801 gtttcctgct gagagatggg aagtgctggc ctaggacagc aaggtgccct acaggtgggg
     7861 ccaaaagggt caagaccgtt ctacaggaag tttaggagaa gttcaatggt tccagatcct
     7921 gtgtgcttcg ggtaattctg accctcttca ttagtgataa tggcatgaag ctctttcaca
     7981 cagtcttttt tttttttctt tttttttttc agacagggtc tcaccctgtc acgtaggctg
     8041 gagtgcagtg gtgagatcac ggctcactgc agcctcgact tcatgggctc aagcgattct
     8101 cctgcctcag cctcctaagt agtcgggatc ataggcactt gccaccacat ccggctaatt
     8161 tttttgtaga gacaggattt caccacatta cacaggctgg tttcaaactc cgaggctcaa
     8221 gtgatctgcc tgcatcggcc tcccaaagcg ctgagattac aagcgtgagc cactacgcct
     8281 tgccctccac acagccttgc ttggtgttaa agattaaaca aagaccacag gtgatcactg
     8341 tcttcgtggt gccagtttca agggcaccct tcttcccttc ccagcctccg agagaaggag
     8401 agagggtcca caagccagat ccatccccat ccacacaggt aaaaccacga ctgtgcagct
     8461 agcaggtgga gataacattt ggaaaaaggc tttgtaaatg ctaaagtcct actcaagtcc
     8521 aagggagaga aattattatt attcgttttg tgaaaccaat ttagtttggc tgggtaatgg
     8581 aagaatttct acatacattc attacttctg atcaggcaag accagtctga cacaggaaca
     8641 gtctatggct cactcttaaa gccacagcag gctgccaggg cttggagaaa tagaaacctc
     8701 tcttgcacaa gaatagtctc aatgaatcat gttaaggcct ctttaggttt ttcagactcc
     8761 atgcaccctg tggaaactgc ctttcttgag tagaggtacg ttcagcactt cataaaataa
     8821 tcttggagcc tccagacaca cggatggagg agcatgattt catttgtttc tttgcaaaac
     8881 tgctgtcccc aactgaaaaa cctgattatc ctttcaaata gggaattcgg ctttccacgt
     8941 tggaaccaga acagttaacc ttcaaacccc caaggcttgc aagagatgaa tcagtttctc
     9001 agacagccaa agccgtggct tataactcat ccaacccaga aaactggacc gctggtcacc
     9061 ttccttcccc ctgcccccaa ctctgcagac agaggtttcc cgttgattat gccttgatta
     9121 gagtcaggag agaagcaaac caggtatata ggattccatt atccttccct cctctgctcc
     9181 caaccagggt cacgctgaga gggatctcgg tgaacatgtg aacaatcaag ccatgtttac
     9241 catggacgtt tagttttctt ttctcaaaat caaaacagag tttagtaggc agcgtatttc
     9301 atacatgccc cttgatcaat ggaatgatct gtcagaagcc attaaagccc ccattagctt
     9361 gaatgcattc aaagctaaac tattggatca tttaagggct gcagtgattg tttttaatat
     9421 accgtacatt gatttctccc tgtgagcagc aacataagtt tgaaactaac tgtgtatgac
     9481 taaggctcca tttgctgtct ccaaccctct gtgagaagca tggtttcact tcgaccagaa
     9541 atgtctgtgt atagttttca aagagatgca gaccctgttc gatttcccaa gatttagact
     9601 gggtcgggtt gttatttctt ttttccctga gctttctccc atttctttgt gcccattaag
     9661 tgagctgtgc gtgcagaatg ggagaggcat ccctgccaag gacttcaagt gaaaggcggt
     9721 gggagaaatt gttctgaaag catgaagccc agctgaggcc aaaatcaaag tgaatttgac
     9781 agccttgggc cagcaaaact ctgtacccag cagaaaacaa tagatgtgtg gctgtgtcag
     9841 gggcatcctc actgggacat agcttgggga gctgaaggta ccttggaagg gccagatgag
     9901 gaagctagcc aaggccacag gccttccttt gactgccata ttgccagctc ttcatagtat
     9961 tgactcttca gtcttagcca acacacactt gttgattcct tccggaatgt cagactctgc
    10021 tagcaacaca aggtccctgt cctcaaaatc ctattcttaa tcagcatttc taatttctgc
    10081 cctttgctca ttttaataca gagcctgagg ataggagagc agcgtggtga aagaagcaat
    10141 agttaccaca tttgcaaagg cacatacccc aaagagaagt ttttaatatg tcacacccat
    10201 attttataga tggggcaatg gaagtccaga tgggagaagt tatttcaggt gaattataga
    10261 aactggattt caagtttctg ataagtattg aatttgggaa ggctgtgaac attcttgagc
    10321 ccccctccca agttcacctt caacatccta aagcaggttg aagaggaaga tggttccagg
    10381 tcacttacaa gaacaggaac agcccctccc tccaaatttg agcccagaaa ggagaacctt
    10441 tgttactcta gaaaacagtg tgtgtgctat tgttttctcc ataggtcaca aacatccaca
    10501 agatattggt gattttacat attattagag ccactgaaat ttatgatgca ggatattaac
    10561 gtcaaagagg ccaagatgca tcattcagaa cactggcagg tcaagcagaa accaccgtag
    10621 taaaattgaa agctggagtc agcaaagtat agcccacagc caaatctggc ccatcccctg
    10681 ttcttataaa gttttattgg aacgcagcca tgctcatcgg tttatgtatt atctatggct
    10741 gtttccaact acagtggcag agctgaatag ttgcaaagga ccatagggct atcaaagccc
    10801 caaatagtca ttgtctgacc cttcatagaa aaattttgct gaactgtagt ctagctccaa
    10861 ggattgttgt atcacctgtg atcgtgccta ttaagcaatt aacgtcatgt ctagtactta
    10921 gtaatgactc agcatgtatc aattacgatg ataaatatta tcatggcatc caaaccaaaa
    10981 tactcatgcc aacatctctc tgtacagaaa catggaaaaa gagcgatgct attaaggagg
    11041 aaaatggagc caggagcaaa acctaaggct atttctgaac taaagaggcc tgaataaggt
    11101 agtgaaagga ccagggaaag ccttcccacg gggatggaga gccacctcct ccccggcttt
    11161 ctggttcaga tgtcttgtct caacagacgg cagattcgca gggaagcagg ccgagcctga
    11221 tcttttctcc gctagaactg ctcaacaggt gaagaatctt tttccagcac tcctgagccc
    11281 ttcgggtcgc ggaacagtgc gaagattatt ccaatgcctc attcggagag gtgataatct
    11341 ggtctgtggt ttctttttcg gtggggcatg gggtgggggt gagtgtcatg ctttctaagg
    11401 cacagggctg actaaagggt gtcctattta taagtcagta aaacacagcg gcttcatact
    11461 ctgtgcttat tacccagaag ccccggctct tagagtttct attaagatgt acctcataaa
    11521 tatatacgcc tcctatgtac ccacaaaaat taaaaataaa aaaattgaaa tca
//
