LOCUS       NM_177478                952 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ferritin mitochondrial (FTMT), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_177478
VERSION     NM_177478.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Xu,X., Ye,X., Zhu,M., Zhang,Q., Li,X. and Yan,J.
  TITLE     FtMt reduces oxidative stress-induced trophoblast cell dysfunction
            via the HIF-1alpha/VEGF signaling pathway
  JOURNAL   BMC Pregnancy Childbirth 23 (1), 131 (2023)
   PUBMED   36859279
  REMARK    GeneRIF: FtMt reduces oxidative stress-induced trophoblast cell
            dysfunction via the HIF-1alpha/VEGF signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Abu Bakar,Z.H., Bellier,J.P., Yanagisawa,D., Kato,T., Mukaisho,K.I.
            and Tooyama,I.
  TITLE     LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt
            Accumulation in Nigral Neurons of Patients with Progressive
            Supranuclear Palsy
  JOURNAL   Int J Mol Sci 23 (1), 537 (2022)
   PUBMED   35008961
  REMARK    GeneRIF: LC3/FtMt Colocalization Patterns Reveal the Progression of
            FtMt Accumulation in Nigral Neurons of Patients with Progressive
            Supranuclear Palsy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 952)
  AUTHORS   Wang,X., Ma,H., Sun,J., Zheng,T., Zhao,P., Li,H. and Yang,M.
  TITLE     Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis
            Via Mitophagy in Type 2 Diabetic Osteoporosis
  JOURNAL   Biol Trace Elem Res 200 (1), 298-307 (2022)
   PUBMED   33594527
  REMARK    GeneRIF: Mitochondrial Ferritin Deficiency Promotes Osteoblastic
            Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis.
REFERENCE   4  (bases 1 to 952)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 952)
  AUTHORS   Mi,S., Du,J., Liu,J., Hou,K., Ji,H., Ma,S., Ba,Y., Chen,L., Xie,R.
            and Hu,S.
  TITLE     FtMt promotes glioma tumorigenesis and angiogenesis via lncRNA
            SNHG1/miR-9-5p axis
  JOURNAL   Cell Signal 75, 109749 (2020)
   PUBMED   32858123
  REMARK    GeneRIF: FtMt promotes glioma tumorigenesis and angiogenesis via
            lncRNA SNHG1/miR-9-5p axis.
REFERENCE   6  (bases 1 to 952)
  AUTHORS   Bou-Abdallah,F., Biasiotto,G., Arosio,P. and Chasteen,N.D.
  TITLE     The putative 'nucleation site' in human H-chain ferritin is not
            required for mineralization of the iron core
  JOURNAL   Biochemistry 43 (14), 4332-4337 (2004)
   PUBMED   15065877
  REMARK    GeneRIF: In contrast to previously published literature, this study
            demonstrates that the putative nucleation site does not play an
            important role in iron uptake or mineralization in H-chain
            ferritin.
REFERENCE   7  (bases 1 to 952)
  AUTHORS   Cazzola,M., Invernizzi,R., Bergamaschi,G., Levi,S., Corsi,B.,
            Travaglino,E., Rolandi,V., Biasiotto,G., Drysdale,J. and Arosio,P.
  TITLE     Mitochondrial ferritin expression in erythroid cells from patients
            with sideroblastic anemia
  JOURNAL   Blood 101 (5), 1996-2000 (2003)
   PUBMED   12406866
  REMARK    GeneRIF: RT-PCR studies showed MtF mRNA in circulating
            reticulocytes of 2 X-linked sideroblastic anemia patients but not
            controls. Most of the iron in perinuclear mitochondria of ring
            sideroblasts is in the form of MtF, a specific marker of
            sideroblastic anemia.
REFERENCE   8  (bases 1 to 952)
  AUTHORS   Drysdale,J., Arosio,P., Invernizzi,R., Cazzola,M., Volz,A.,
            Corsi,B., Biasiotto,G. and Levi,S.
  TITLE     Mitochondrial ferritin: a new player in iron metabolism
  JOURNAL   Blood Cells Mol Dis 29 (3), 376-383 (2002)
   PUBMED   12547228
  REMARK    Review article
REFERENCE   9  (bases 1 to 952)
  AUTHORS   Corsi,B., Cozzi,A., Arosio,P., Drysdale,J., Santambrogio,P.,
            Campanella,A., Biasiotto,G., Albertini,A. and Levi,S.
  TITLE     Human mitochondrial ferritin expressed in HeLa cells incorporates
            iron and affects cellular iron metabolism
  JOURNAL   J Biol Chem 277 (25), 22430-22437 (2002)
   PUBMED   11953424
  REMARK    GeneRIF: Human mitochondrial ferritin expressed in HeLa cells
            incorporates iron and affects cellular iron metabolism
REFERENCE   10 (bases 1 to 952)
  AUTHORS   Levi,S., Corsi,B., Bosisio,M., Invernizzi,R., Volz,A., Sanford,D.,
            Arosio,P. and Drysdale,J.
  TITLE     A human mitochondrial ferritin encoded by an intronless gene
  JOURNAL   J Biol Chem 276 (27), 24437-24440 (2001)
   PUBMED   11323407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117523.2 and BC034419.1.
            
            On Nov 23, 2018 this sequence version replaced NM_177478.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC034419.1, ERR279838.7296.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000321339.3/
                                                  ENSP00000313691.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC117523.2         106620-106692
            74-952              BC034419.1         1-879
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..952
                     /gene="FTMT"
                     /gene_synonym="MTF"
                     /note="ferritin mitochondrial"
                     /db_xref="GeneID:94033"
                     /db_xref="HGNC:HGNC:17345"
                     /db_xref="MIM:608847"
     exon            1..952
                     /gene="FTMT"
                     /gene_synonym="MTF"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..811
                     /gene="FTMT"
                     /gene_synonym="MTF"
                     /EC_number="1.16.3.1"
                     /note="mitochondrial ferritin; ferritin H subunit"
                     /codon_start=1
                     /product="ferritin, mitochondrial precursor"
                     /protein_id="NP_803431.1"
                     /db_xref="CCDS:CCDS4128.1"
                     /db_xref="GeneID:94033"
                     /db_xref="HGNC:HGNC:17345"
                     /db_xref="MIM:608847"
                     /translation="MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIA
                     PRRPLAAAASSRDPTGPAAGPSRVRQNFHPDSEAAINRQINLELYASYVYLSMAYYFS
                     RDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRIRLQDIKKPEQDDWESGLHAM
                     ECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGDHVHNLVKM
                     GAPDAGLAEYLFDTHTLGNENKQN"
     regulatory      929..934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FTMT"
                     /gene_synonym="MTF"
                     /note="hexamer: AATAAA"
     polyA_site      952
                     /gene="FTMT"
                     /gene_synonym="MTF"
                     /note="major polyA site"
ORIGIN      
        1 gatcagatct gacgcctcca gcgcccgacc ccacgccaag agggccgggc ctcagtttcc
       61 ccacttccaa ggaggcggcg ctatgctgtc ctgcttcagg ctcctctcca ggcacatcag
      121 cccttcgctg gcgtctctgc gcccggtgcg ctgctgcttc gcgctcccgc tgcgttgggc
      181 cccggggcgc cccttggacc ccaggcagat cgccccccgc cgccccctgg ccgcagccgc
      241 ctcctcccgg gaccctaccg ggcccgccgc cggcccctct cgggtgcgcc agaacttcca
      301 ccccgactcc gaggctgcca tcaaccgcca gatcaacctc gagctctatg cgtcctacgt
      361 gtacttgtcc atggcctatt acttctcccg ggatgacgtg gccttgaaca acttctccag
      421 gtatttcctt caccagtccc gggaggagac cgagcacgcg gagaagctga tgaggctgca
      481 gaaccagcga ggaggccgga tccgcctgca ggacatcaag aagccggaac aggacgactg
      541 ggaaagcggg ctgcatgcca tggagtgtgc tctactcttg gaaaagaacg tgaaccagtc
      601 gttgctggaa ttgcacgctc tagcctcaga taaaggtgac ccccatttgt gcgatttcct
      661 ggaaacctac tacctgaatg agcaggtgaa gtctatcaaa gaactaggtg accacgtgca
      721 caacttagtg aagatggggg ccccggatgc tggcctggcg gagtaccttt ttgacacaca
      781 tacccttgga aatgaaaaca agcagaacta agccacgagc tgccttcctc ccaggctagt
      841 ggatccaaag accaaagtca gctgtctcct gctttcttgc ccttaaaatc acctccatct
      901 ttatattctt ctgttatact attcctccaa taaagtgatt tgtagaaaaa aa
//
