LOCUS       NM_031894                809 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ferritin heavy chain like 17 (FTHL17), mRNA.
ACCESSION   NM_031894
VERSION     NM_031894.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 809)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 809)
  AUTHORS   Tang,R., Liu,X., Pan,L. and Chen,R.
  TITLE     Novel mutation in FTHL17 gene in pedigree with 46,XY pure gonadal
            dysgenesis
  JOURNAL   Fertil Steril 111 (6), 1226-1235 (2019)
   PUBMED   30922653
  REMARK    GeneRIF: Describe the first 46,XY PGD pedigree that may be
            attributed to mutations of the FTHL17 gene and speculate that the
            FTHL17 gene is involved in the testis-determining pathway and
            tumorigenesis.
REFERENCE   3  (bases 1 to 809)
  AUTHORS   Ruzzenenti,P., Asperti,M., Mitola,S., Crescini,E., Maccarinelli,F.,
            Gryzik,M., Regoni,M., Finazzi,D., Arosio,P. and Poli,M.
  TITLE     The Ferritin-Heavy-Polypeptide-Like-17 (FTHL17) gene encodes a
            ferritin with low stability and no ferroxidase activity and with a
            partial nuclear localization
  JOURNAL   Biochim Biophys Acta 1850 (6), 1267-1273 (2015)
   PUBMED   25749565
  REMARK    GeneRIF: FTHL17 encodes a ferritin-like protein without ferroxidase
            activity. Its restricted embryonic expression and partial nuclear
            localization suggest that this novel ferritin type may have
            functions other than iron storage.
REFERENCE   4  (bases 1 to 809)
  AUTHORS   Poplinski,A., Wieacker,P., Kliesch,S. and Gromoll,J.
  TITLE     Severe XIST hypomethylation clearly distinguishes (SRY+)
            46,XX-maleness from Klinefelter syndrome
  JOURNAL   Eur J Endocrinol 162 (1), 169-175 (2010)
   PUBMED   19812237
REFERENCE   5  (bases 1 to 809)
  AUTHORS   Atanackovic,D., Blum,I., Cao,Y., Wenzel,S., Bartels,K., Faltz,C.,
            Hossfeld,D.K., Hegewisch-Becker,S., Bokemeyer,C. and Leuwer,R.
  TITLE     Expression of cancer-testis antigens as possible targets for
            antigen-specific immunotherapy in head and neck squamous cell
            carcinoma
  JOURNAL   Cancer Biol Ther 5 (9), 1218-1225 (2006)
   PUBMED   16929165
REFERENCE   6  (bases 1 to 809)
  AUTHORS   Lee,S., Lee,S.H., Chung,T.G., Kim,H.J., Yoon,T.K., Kwak,I.P.,
            Park,S.H., Cha,W.T., Cho,S.W. and Cha,K.Y.
  TITLE     Molecular and cytogenetic characterization of two azoospermic
            patients with X-autosome translocation
  JOURNAL   J Assist Reprod Genet 20 (9), 385-389 (2003)
   PUBMED   14531651
REFERENCE   7  (bases 1 to 809)
  AUTHORS   Loriot,A., Boon,T. and De Smet,C.
  TITLE     Five new human cancer-germline genes identified among 12 genes
            expressed in spermatogonia
  JOURNAL   Int J Cancer 105 (3), 371-376 (2003)
   PUBMED   12704671
REFERENCE   8  (bases 1 to 809)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF285592.1 and AC006061.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_031894.2.
            
            Summary: This gene encodes a ferritin heavy chain-like protein.
            This gene is primarily expressed in embryonic germ cells. The
            encoded protein may lack ferroxidase activity. Multiple pseudogenes
            of this gene are found on chromosome X. [provided by RefSeq, Oct
            2016].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100770.1, GQ891506.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359202.5/ ENSP00000368207.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-801               AF285592.1         16-816
            802-809             AC006061.1         43006-43013         c
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     gene            1..809
                     /gene="FTHL17"
                     /gene_synonym="CT38"
                     /note="ferritin heavy chain like 17"
                     /db_xref="GeneID:53940"
                     /db_xref="HGNC:HGNC:3987"
                     /db_xref="MIM:300308"
     exon            1..809
                     /gene="FTHL17"
                     /gene_synonym="CT38"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..640
                     /gene="FTHL17"
                     /gene_synonym="CT38"
                     /note="cancer/testis antigen 38; ferritin, heavy
                     polypeptide-like 17; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="ferritin heavy polypeptide-like 17"
                     /protein_id="NP_114100.1"
                     /db_xref="CCDS:CCDS14227.1"
                     /db_xref="GeneID:53940"
                     /db_xref="HGNC:HGNC:3987"
                     /db_xref="MIM:300308"
                     /translation="MATAQPSQVRQKYDTNCDAAINSHITLELYTSYLYLSMAFYFNR
                     DDVALENFFRYFLRLSDDKMEHAQKLMRLQNLRGGHICLHDIRKPECQGWESGLVAME
                     SAFHLEKNVNQSLLDLYQLAVEKGDPQLCHFLESHYLHEQVKTIKELGGYVSNLRKIC
                     SPEAGLAEYLFDKLTLGGRVKET"
     regulatory      787..792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FTHL17"
                     /gene_synonym="CT38"
                     /note="hexamer: AATAAA"
     polyA_site      809
                     /gene="FTHL17"
                     /gene_synonym="CT38"
                     /note="major polyA site"
ORIGIN      
        1 actatccgcc attcttgtca cctcagctgc tgccctcgct accgcaccga cttcgcccgt
       61 gtgctcgcct gcacttgcgc tgcccgccat ggccaccgcc cagccgtcgc aggtgcgcca
      121 gaagtacgac accaactgcg acgccgccat caacagccac atcacgctgg agctctacac
      181 ctcctacctg tacctgtcta tggccttcta cttcaaccgg gacgacgtgg ccctggagaa
      241 cttcttccgc tacttcctgc gcctgtcgga cgacaaaatg gagcatgccc agaagctgat
      301 gaggctgcag aacctgcgcg gtggccacat ctgccttcac gatatcagga agccagagtg
      361 ccaaggctgg gagagcgggc tcgtggccat ggagtccgcc ttccacctgg agaagaacgt
      421 caaccagagc ctgctggatc tgtaccagct ggccgtggag aagggcgacc cccagctgtg
      481 ccacttcctg gagagccact acctgcacga gcaagtcaag accatcaaag agctgggtgg
      541 ctacgtgagc aacctgcgca agatttgttc cccggaagcc ggcctggctg agtacctgtt
      601 cgacaagctc accctgggcg gccgcgtcaa agagacttga gcccagatgg gccccacagc
      661 cacggggtcc cttccctggg tcaggccact aggcggggcg tgcatgttgc cctttcagaa
      721 cgttctcttc agttttatct ttcagtttta ccattgttag caaaaaagtt atctggttct
      781 caaagcaata aaggtgtcca tttgataca
//
