LOCUS       NM_002032               1203 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ferritin heavy chain 1 (FTH1), mRNA.
ACCESSION   NM_002032
VERSION     NM_002032.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1203)
  AUTHORS   Li,L., Zeng,J., He,S., Yang,Y. and Wang,C.
  TITLE     METTL14 decreases FTH1 mRNA stability via m6A methylation to
            promote sorafenib-induced ferroptosis of cervical cancer
  JOURNAL   Cancer Biol Ther 25 (1), 2349429 (2024)
   PUBMED   38738555
  REMARK    GeneRIF: METTL14 decreases FTH1 mRNA stability via m6A methylation
            to promote sorafenib-induced ferroptosis of cervical cancer.
REFERENCE   2  (bases 1 to 1203)
  AUTHORS   Park,J.M., Su,Y.H., Fan,C.S., Chen,H.H., Qiu,Y.K., Chen,L.L.,
            Chen,H.A., Ramasamy,T.S., Chang,J.S., Huang,S.Y., Chang,W.W.,
            Lee,A.Y., Huang,T.S., Kuo,C.C. and Chiu,C.F.
  TITLE     Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism
            and mediates cell growth in KRAS-mutant pancreatic cancer cells
  JOURNAL   Exp Mol Med 56 (9), 2065-2081 (2024)
   PUBMED   39294443
  REMARK    GeneRIF: Crosstalk between FTH1 and PYCR1 dysregulates proline
            metabolism and mediates cell growth in KRAS-mutant pancreatic
            cancer cells.
REFERENCE   3  (bases 1 to 1203)
  AUTHORS   Yuan,Z., Yang,L., Li,Y., Li,X., Peng,C., Pan,J. and Cai,D.
  TITLE     FTH1 protects against osteoarthritis by MAPK pathway inhibition of
            extracellular matrix degradation
  JOURNAL   BMC Musculoskelet Disord 25 (1), 282 (2024)
   PUBMED   38609896
  REMARK    GeneRIF: FTH1 protects against osteoarthritis by MAPK pathway
            inhibition of extracellular matrix degradation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1203)
  AUTHORS   Wu,Q., Carlos,A.R., Braza,F., Bergman,M.L., Kitoko,J.Z.,
            Bastos-Amador,P., Cuadrado,E., Martins,R., Oliveira,B.S.,
            Martins,V.C., Scicluna,B.P., Landry,J.J., Jung,F.E., Ademolue,T.W.,
            Peitzsch,M., Almeida-Santos,J., Thompson,J., Cardoso,S.,
            Ventura,P., Slot,M., Rontogianni,S., Ribeiro,V., Domingues,V.D.S.,
            Cabral,I.A., Weis,S., Groth,M., Ameneiro,C., Fidalgo,M., Wang,F.,
            Demengeot,J., Amsen,D. and Soares,M.P.
  TITLE     Ferritin heavy chain supports stability and function of the
            regulatory T cell lineage
  JOURNAL   EMBO J 43 (8), 1445-1483 (2024)
   PUBMED   38499786
  REMARK    GeneRIF: Ferritin heavy chain supports stability and function of
            the regulatory T cell lineage.
REFERENCE   5  (bases 1 to 1203)
  AUTHORS   He,M., Wang,Y., Xie,J., Pu,J., Shen,Z., Wang,A., Li,T., Wang,T.,
            Li,G., Liu,Y., Mei,Z., Ren,Z., Wang,W., Liu,X., Hong,J., Liu,Q.,
            Lei,H., He,X., Du,W., Yuan,Y. and Yang,L.
  TITLE     M7G modification of FTH1 and pri-miR-26a regulates ferroptosis and
            chemotherapy resistance in osteosarcoma
  JOURNAL   Oncogene 43 (5), 341-353 (2024)
   PUBMED   38040806
  REMARK    GeneRIF: M[7]G modification of FTH1 and pri-miR-26a regulates
            ferroptosis and chemotherapy resistance in osteosarcoma.
            Erratum:[Oncogene. 2024 Apr;43(17):1316. doi:
            10.1038/s41388-024-02978-6.. PMID: 38418547]
REFERENCE   6  (bases 1 to 1203)
  AUTHORS   Lawson,D.M., Artymiuk,P.J., Yewdall,S.J., Smith,J.M.,
            Livingstone,J.C., Treffry,A., Luzzago,A., Levi,S., Arosio,P.,
            Cesareni,G. et al.
  TITLE     Solving the structure of human H ferritin by genetically
            engineering intermolecular crystal contacts
  JOURNAL   Nature 349 (6309), 541-544 (1991)
   PUBMED   1992356
REFERENCE   7  (bases 1 to 1203)
  AUTHORS   Hentze,M.W., Keim,S., Papadopoulos,P., O'Brien,S., Modi,W.,
            Drysdale,J., Leonard,W.J., Harford,J.B. and Klausner,R.D.
  TITLE     Cloning, characterization, expression, and chromosomal localization
            of a human ferritin heavy-chain gene
  JOURNAL   Proc Natl Acad Sci U S A 83 (19), 7226-7230 (1986)
   PUBMED   3020541
REFERENCE   8  (bases 1 to 1203)
  AUTHORS   Chou,C.C., Gatti,R.A., Fuller,M.L., Concannon,P., Wong,A.,
            Chada,S., Davis,R.C. and Salser,W.A.
  TITLE     Structure and expression of ferritin genes in a human promyelocytic
            cell line that differentiates in vitro
  JOURNAL   Mol Cell Biol 6 (2), 566-573 (1986)
   PUBMED   3023856
REFERENCE   9  (bases 1 to 1203)
  AUTHORS   Costanzo,F., Colombo,M., Staempfli,S., Santoro,C., Marone,M.,
            Frank,R., Delius,H. and Cortese,R.
  TITLE     Structure of gene and pseudogenes of human apoferritin H
  JOURNAL   Nucleic Acids Res 14 (2), 721-736 (1986)
   PUBMED   3003694
REFERENCE   10 (bases 1 to 1203)
  AUTHORS   Arosio,P., Adelman,T.G. and Drysdale,J.W.
  TITLE     On ferritin heterogeneity. Further evidence for heteropolymers
  JOURNAL   J Biol Chem 253 (12), 4451-4458 (1978)
   PUBMED   659425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ887222.1, BC000857.1,
            M97164.1 and BM971420.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002032.2.
            
            Summary: This gene encodes the heavy subunit of ferritin, the major
            intracellular iron storage protein in prokaryotes and eukaryotes.
            It is composed of 24 subunits of the heavy and light ferritin
            chains. Variation in ferritin subunit composition may affect the
            rates of iron uptake and release in different tissues. A major
            function of ferritin is the storage of iron in a soluble and
            nontoxic state. Defects in ferritin proteins are associated with
            several neurodegenerative diseases. This gene has multiple
            pseudogenes. Several alternatively spliced transcript variants have
            been observed, but their biological validity has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20941.1, M97164.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273550.12/ ENSP00000273550.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BQ887222.1         27-41
            16-922              BC000857.1         1-907
            923-945             M97164.1           842-864
            946-1203            BM971420.1         17-274              c
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1203
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /note="ferritin heavy chain 1"
                     /db_xref="GeneID:2495"
                     /db_xref="HGNC:HGNC:3976"
                     /db_xref="MIM:134770"
     exon            1..323
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..761
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /EC_number="1.16.3.1"
                     /note="apoferritin; placenta immunoregulatory factor;
                     ferritin, heavy polypeptide 1; proliferation-inducing
                     protein 15; ferritin H subunit; cell
                     proliferation-inducing gene 15 protein; H-ferritin"
                     /codon_start=1
                     /product="ferritin heavy chain"
                     /protein_id="NP_002023.2"
                     /db_xref="CCDS:CCDS41655.1"
                     /db_xref="GeneID:2495"
                     /db_xref="HGNC:HGNC:3976"
                     /db_xref="MIM:134770"
                     /translation="MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDR
                     DDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAME
                     CALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMG
                     APESGLAEYLFDKHTLGDSDNES"
     exon            324..470
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /inference="alignment:Splign:2.1.0"
     exon            471..596
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1203
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      903..908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /note="hexamer: AATAAA"
     polyA_site      925
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /note="major polyA site"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
                     /note="hexamer: AATAAA"
     polyA_site      1203
                     /gene="FTH1"
                     /gene_synonym="FHC; FTH; FTHL6; HFE5; NBIA9; PIG15; PLIF"
ORIGIN      
        1 gccagacgtt cttcgccgag agtcgtcggg gtttcctgct tcaacagtgc ttggacggaa
       61 cccggcgctc gttccccacc ccggccggcc gcccatagcc agccctccgt cacctcttca
      121 ccgcaccctc ggactgcccc aaggcccccg ccgccgctcc agcgccgcgc agccaccgcc
      181 gccgccgccg cctctcctta gtcgccgcca tgacgaccgc gtccacctcg caggtgcgcc
      241 agaactacca ccaggactca gaggccgcca tcaaccgcca gatcaacctg gagctctacg
      301 cctcctacgt ttacctgtcc atgtcttact actttgaccg cgatgatgtg gctttgaaga
      361 actttgccaa atactttctt caccaatctc atgaggagag ggaacatgct gagaaactga
      421 tgaagctgca gaaccaacga ggtggccgaa tcttccttca ggatatcaag aaaccagact
      481 gtgatgactg ggagagcggg ctgaatgcaa tggagtgtgc attacatttg gaaaaaaatg
      541 tgaatcagtc actactggaa ctgcacaaac tggccactga caaaaatgac ccccatttgt
      601 gtgacttcat tgagacacat tacctgaatg agcaggtgaa agccatcaaa gaattgggtg
      661 accacgtgac caacttgcgc aagatgggag cgcccgaatc tggcttggcg gaatatctct
      721 ttgacaagca caccctggga gacagtgata atgaaagcta agcctcgggc taatttcccc
      781 atagccgtgg ggtgacttcc ctggtcacca aggcagtgca tgcatgttgg ggtttccttt
      841 accttttcta taagttgtac caaaacatcc acttaagttc tttgatttgt accattcctt
      901 caaataaaga aatttggtac ccaggtgttg tctttgaggt cttgggatga atcagaaatc
      961 tatccaggct atcttccaga ttccttaagt gccgttgttc agttctaatc acactaatca
     1021 aaaagaaacg agtatttgta tttattaaac tcattagttt gggcagtata ctaaggtgtg
     1081 gctgtcttgg attcagatag aactaagggt tcccgactct gaatccagag tctgagttaa
     1141 atgtttccaa tggttcagtc tagctttcac agtttttatg aataaaaggc attaaaggct
     1201 gaa
//
