LOCUS       NM_020116               4796 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens follistatin like 5 (FSTL5), transcript variant 1,
            mRNA.
ACCESSION   NM_020116
VERSION     NM_020116.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4796)
  AUTHORS   Khanshour,A.M., Kidane,Y.H., Kozlitina,J., Cornelia,R., Rafipay,A.,
            De Mello,V., Weston,M., Paria,N., Khalid,A., Hecht,J.T.,
            Dobbs,M.B., Richards,B.S., Vargesson,N., Hamra,F.K., Wilson,M.,
            Wise,C., Gurnett,C.A. and Rios,J.J.
  TITLE     Genetic association and characterization of FSTL5 in isolated
            clubfoot
  JOURNAL   Hum Mol Genet 29 (22), 3717-3728 (2021)
   PUBMED   33105483
  REMARK    GeneRIF: Genetic association and characterization of FSTL5 in
            isolated clubfoot.
REFERENCE   2  (bases 1 to 4796)
  AUTHORS   Zhang,D.Y., Lei,J.S., Sun,W.L., Wang,D.D. and Lu,Z.
  TITLE     Follistatin Like 5 (FSTL5) inhibits epithelial to mesenchymal
            transition in hepatocellular carcinoma
  JOURNAL   Chin Med J (Engl) 133 (15), 1798-1804 (2020)
   PUBMED   32740091
  REMARK    GeneRIF: Follistatin Like 5 (FSTL5) inhibits epithelial to
            mesenchymal transition in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 4796)
  AUTHORS   Li,C., Dai,L., Zhang,J., Zhang,Y., Lin,Y., Cheng,L., Tian,H.,
            Zhang,X., Wang,Q., Yang,Q., Wang,Y., Shi,G., Cheng,F., Su,X.,
            Yang,Y., Zhang,S., Yu,D., Wei,Y. and Deng,H.
  TITLE     Follistatin-like protein 5 inhibits hepatocellular carcinoma
            progression by inducing caspase-dependent apoptosis and regulating
            Bcl-2 family proteins
  JOURNAL   J Cell Mol Med 22 (12), 6190-6201 (2018)
   PUBMED   30255547
  REMARK    GeneRIF: Mechanistic investigation demonstrated that FSTL5 promoted
            Hepatocellular carcinoma (HCC) cell apoptosis in a
            caspase-dependent manner and regulated Bcl-2 family proteins. These
            results indicate that FSTL5 may be a potential novel target for HCC
            treatment, and a biomarker for tumor prognosis.
            Erratum:[J Cell Mol Med. 2021 Apr;25(7):3665. doi:
            10.1111/jcmm.16364.. PMID: 33835689]
REFERENCE   4  (bases 1 to 4796)
  AUTHORS   Zhang,D., Ma,X., Sun,W., Cui,P. and Lu,Z.
  TITLE     Down-regulated FSTL5 promotes cell proliferation and survival by
            affecting Wnt/beta-catenin signaling in hepatocellular carcinoma
  JOURNAL   Int J Clin Exp Pathol 8 (3), 3386-3394 (2015)
   PUBMED   26045876
  REMARK    GeneRIF: FSTL5 plays a suppressive role in hepatocellular
            carcinoma. Down-regulation of FSTL5 could promote growth and
            survival of HCC cells by activation of Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4796)
  AUTHORS   Schmit,S.L., Schumacher,F.R., Edlund,C.K., Conti,D.V., Raskin,L.,
            Lejbkowicz,F., Pinchev,M., Rennert,H.S., Jenkins,M.A., Hopper,J.L.,
            Buchanan,D.D., Lindor,N.M., Le Marchand,L., Gallinger,S.,
            Haile,R.W., Newcomb,P.A., Huang,S.C., Rennert,G., Casey,G. and
            Gruber,S.B.
  TITLE     A novel colorectal cancer risk locus at 4q32.2 identified from an
            international genome-wide association study
  JOURNAL   Carcinogenesis 35 (11), 2512-2519 (2014)
   PUBMED   25023989
REFERENCE   6  (bases 1 to 4796)
  AUTHORS   Dowling,J.K., Becker,C.E., Bourke,N.M., Corr,S.C., Connolly,D.J.,
            Quinn,S.R., Pandolfi,P.P., Mansell,A. and O'Neill,L.A.J.
  TITLE     Promyelocytic leukemia protein interacts with the
            apoptosis-associated speck-like protein to limit inflammasome
            activation
  JOURNAL   J Biol Chem 289 (10), 6429-6437 (2014)
   PUBMED   24407287
REFERENCE   7  (bases 1 to 4796)
  AUTHORS   Remke,M., Hielscher,T., Korshunov,A., Northcott,P.A., Bender,S.,
            Kool,M., Westermann,F., Benner,A., Cin,H., Ryzhova,M., Sturm,D.,
            Witt,H., Haag,D., Toedt,G., Wittmann,A., Schottler,A., von
            Bueren,A.O., von Deimling,A., Rutkowski,S., Scheurlen,W.,
            Kulozik,A.E., Taylor,M.D., Lichter,P. and Pfister,S.M.
  TITLE     FSTL5 is a marker of poor prognosis in non-WNT/non-SHH
            medulloblastoma
  JOURNAL   J Clin Oncol 29 (29), 3852-3861 (2011)
   PUBMED   21911727
  REMARK    GeneRIF: FSTL5 expression denoted a dismal prognosis both within
            and across medulloblastoma subgroups.
REFERENCE   8  (bases 1 to 4796)
  AUTHORS   Croteau-Chonka,D.C., Marvelle,A.F., Lange,E.M., Lee,N.R.,
            Adair,L.S., Lange,L.A. and Mohlke,K.L.
  TITLE     Genome-wide association study of anthropometric traits and evidence
            of interactions with age and study year in Filipino women
  JOURNAL   Obesity (Silver Spring) 19 (5), 1019-1027 (2011)
   PUBMED   20966902
REFERENCE   9  (bases 1 to 4796)
  AUTHORS   Glusman,G., Kaur,A., Hood,L. and Rowen,L.
  TITLE     An enigmatic fourth runt domain gene in the fugu genome: ancestral
            gene loss versus accelerated evolution
  JOURNAL   BMC Evol Biol 4, 43 (2004)
   PUBMED   15527507
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4796)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     3,400 new expressed sequence tags identify diversity of transcripts
            in human brain
  JOURNAL   Nat Genet 4 (3), 256-267 (1993)
   PUBMED   8358434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI549596.1, DA243182.1, BC036502.2, AB033089.1 and AA350666.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020116.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036502.2, SRR1803617.105443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306100.10/ ENSP00000305334.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BI549596.1         40-190
            152-319             DA243182.1         169-336
            320-2100            BC036502.2         355-2135
            2101-4794           AB033089.1         2062-4755
            4795-4796           AA350666.1         6-7                 c
FEATURES             Location/Qualifiers
     source          1..4796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.2"
     gene            1..4796
                     /gene="FSTL5"
                     /note="follistatin like 5"
                     /db_xref="GeneID:56884"
                     /db_xref="HGNC:HGNC:21386"
                     /db_xref="MIM:620128"
     exon            1..386
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            387..528
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..2946
                     /gene="FSTL5"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; follistatin-related protein 5; follistatin-like
                     protein 5"
                     /codon_start=1
                     /product="follistatin-related protein 5 isoform a
                     precursor"
                     /protein_id="NP_064501.2"
                     /db_xref="CCDS:CCDS3802.1"
                     /db_xref="GeneID:56884"
                     /db_xref="HGNC:HGNC:21386"
                     /db_xref="MIM:620128"
                     /translation="MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQE
                     KNQESSRVKGFMIQDGPFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCG
                     SDGEFYENHCEVHRAACLKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKY
                     IMQENENPNGDDISRKKLLVDQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTL
                     YVLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTL
                     RPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI
                     FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQ
                     ANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEGLGI
                     GNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWASAVN
                     VKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGTLEK
                     TSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTTTLIITHMRFGFILHKDEA
                     ALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYYFIGCKPDSTGAVSPQVMVDGV
                     TDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYITIRGEIQEAFDIYTNLHIS
                     DLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKSLKEPLKAEEWPWNRKNR
                     QIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTVIWVGDA"
     exon            529..562
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            563..811
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1008
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1129
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1296
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1417
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1579
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1714
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1741
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1860
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2010
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2118
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2243
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..4796
                     /gene="FSTL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4580..4585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL5"
                     /note="hexamer: AATAAA"
     polyA_site      4597
                     /gene="FSTL5"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL5"
                     /note="hexamer: AATAAA"
     polyA_site      4796
                     /gene="FSTL5"
                     /note="major polyA site"
ORIGIN      
        1 agtgactgag acaaactgga ggtgaaagga gctggtactg tccactgtgc tgtcggtgct
       61 gaacctgaga cgcgagcgga ccagttgctc cagcacctga aggcaacgcc ctcttgcacc
      121 ctctgtgccc tgtgggaccc gcttcaccaa caggacccat atcaacttga caaaggagtg
      181 tggtatcgga cgtgggagag agtcctctgt ttgccacctg ggcgctcatt caggcgtgac
      241 tttggagatt tctatagttt tagaccaaac tatttttttt tccccagcta agacgatctt
      301 ttgagagttt ttttttttta ttgtgattta tatttccaca gcgtttagga atctttctgg
      361 gggacttttg tgactgttaa aataaggtga aaagcaataa ggatgtttaa gtgctggtca
      421 gttgtcttgg ttctcggatt catttttctg gagtcggaag gaaggccaac caaagaagga
      481 ggatatggcc ttaaatccta tcagcctcta atgagattgc gacataagca ggaaaaaaat
      541 caagaaagtt caagagtcaa aggatttatg attcaggatg gcccttttgg atcttgtgaa
      601 aataagtact gtggtttggg aagacactgt gttaccagca gagagacagg gcaagcagaa
      661 tgtgcctgta tggacctttg caaacgtcac tacaaacctg tgtgtggatc tgacggagaa
      721 ttctatgaaa accactgtga agtgcacaga gctgcttgcc tgaaaaaaca aaagattacc
      781 attgttcaca atgaagactg cttctttaaa ggagataagt gcaagactac tgaatacagc
      841 aagatgaaaa atatgctatt agatttacaa aatcaaaaat atattatgca agaaaatgaa
      901 aatcctaatg gcgacgacat atctcggaag aagctattgg tggatcaaat gtttaaatat
      961 tttgatgcag acagtaatgg acttgtagat attaatgaac taactcaggt gataaaacag
     1021 gaagaacttg gcaaggatct ctttgattgt actttgtatg ttctattgaa atatgatgat
     1081 tttaatgctg acaagcacct ggctcttgaa gaattttata gagcattcca agtgatccag
     1141 ttgagtctgc cagaagatca gaaactaagc atcactgcag caactgtggg acaaagtgct
     1201 gttctgagct gtgccattca aggaaccctg agacctccca ttatctggaa aaggaacaat
     1261 attattctaa ataatttaga tttggaagac atcaatgact ttggagatga tgggtccttg
     1321 tatattacta aggttaccac aactcacgtt ggcaattaca cctgctatgc agatggctat
     1381 gaacaagtct atcagactca catcttccaa gtgaatgttc ctccagtcat ccgggtgtat
     1441 ccagagagtc aggctagaga gcctggggta actgccagtc ttaggtgcca tgcagagggc
     1501 ataccaaagc ctcagcttgg ctggttgaag aatggaattg atattacacc aaagctttcc
     1561 aaacaactca cgcttcaagc aaatggcagt gaggttcaca taagcaatgt gcgctatgaa
     1621 gatactggag catacacttg tatcgcaaag aatgaagcag gagtggatga agacatctct
     1681 tctctttttg tggaagactc tgctagaaag accctagcta acatattatg gagagaagaa
     1741 ggtctgggaa ttgggaacat gttctatgtt ttttatgaag atggaatcaa agtgatacaa
     1801 cccatagaat gtgaatttca gaggcacatt aagcctagtg aaaagctcct tggatttcag
     1861 gatgaagtct gtcccaaagc tgagggagat gaagttcaga ggtgtgtgtg ggcatcagct
     1921 gttaatgtca aagacaagtt catttatgtt gcacagccaa ctttggacag agtccttatt
     1981 gttgatgtgc agtcccaaaa agttgttcag gcagtgagca cagaccctgt cccagttaaa
     2041 ttacactatg acaaatcaca tgatcaggtc tgggtgctaa gctggggtac cttggagaag
     2101 acatcaccaa cactacaggt aattaccctg gccagtggga atgtgcctca ccacacgatc
     2161 cacacccaac cagtgggaaa gcaatttgac agagtggatg attttttcat tcccaccaca
     2221 acactcatta tcacccatat gaggtttgga tttattcttc ataaagatga agctgcacta
     2281 caaaaaattg atcttgaaac catgtcatac atcaagacaa ttaacttgaa ggactataag
     2341 tgcgttcctc agtcattggc atatacacac ttgggaggct actacttcat tggctgcaaa
     2401 cctgacagca ccggagcagt ttccccacag gtcatggtgg acggtgtaac tgactcagtc
     2461 attgggttca atagtgatgt gacgggcact ccatatgtct ctccagatgg ccactacctt
     2521 gtcagcatta atgatgtgaa aggtcttgta agggttcagt acattaccat cagaggagaa
     2581 atacaggagg cttttgatat ttacacaaat ctgcacatat ctgatctggc atttcaacca
     2641 tcctttactg aagcccacca atataacatc tacggtagtt caagcacaca aactgatgtg
     2701 ctctttgtgg agctctcttc tgggaaggtc aagatgataa agagtctcaa ggaaccactc
     2761 aaggcagaag aatggccttg gaaccggaaa aacaggcaaa tccaggacag tggcttgttt
     2821 ggtcaatacc tgatgacacc ttccaaggac tctctcttca tcctagatgg acgactcaat
     2881 aaattaaact gtgagatcac tgaagttgaa aaaggaaata cagtcatttg ggttggagat
     2941 gcctaaaaac cctacgatac aattattgaa tgaagcgttt tacaatacat tgcacttaat
     3001 ccattgttta aatttacaac ttaactttcc aagtttatat cctagtcaaa caaaatttac
     3061 ttggttggtc caaataaaat aaattgtttt tgactaagtg actaagacat acacaattaa
     3121 ttatattggt taattagaaa tactcagcac aatatttaat gagaaatcac atcagtcaca
     3181 agaatcaaat atgtaaatta tgctttaaac aataaagtag gatttaaatc atttaaaaaa
     3241 ctaaactgca gggaatttca gatgacataa agcattattt cattttgagg gtagtttatt
     3301 ttttttctct gtccttttgg tatgattaaa caagaaataa aaggtgttgt ggaaacttaa
     3361 aattcttaat tcaaaatatt cggtcctgtc cactgtttat aatattttgt gccttgaagg
     3421 gaatgtcaca ggaggaaaag gaagactaaa gcctgcatac taaatgctct cataactata
     3481 aatctcttgt tgttaaaaaa catctcttgc accaaatcct gtcttcagtc ttttgtttaa
     3541 ccctcaatga actaccaatt gaaggcataa gttggtctta ggttgtatac aggtgtcaaa
     3601 ctccacttga catttactgt ataatctgca gcatgctata gaaagtgggg aggaagggag
     3661 gaaaaataat tacagtcaaa atatttgcaa tctatctact cattttgctt tcaatcacta
     3721 gagtgcatta tgtttttaat gcaagtttgt ctgggatgtc aactgcctac agatgtttat
     3781 tactagcaga atagattatt tattaataga ttgtttcttt tcatatagtc caatgtttca
     3841 tcatcaggaa ctttcggttt taaaaaagaa acattacttt tgtctgctaa agtaaaccat
     3901 atatagggaa attaacacct aggaaaagaa aactggcaag agaattgatg aggtattagt
     3961 ggcttagaag aattagtaat ataagttggg aataaagggg tagcccgaca gtggtaagta
     4021 aaaatgtagt actccattgt ttttgctatt taaatataat gtatcaaaaa cctttattct
     4081 aaaatttcca caaatgattc cttttatcca tcttcttgta atcctaaaag catcttctca
     4141 ctatgtgctg tagtttgaaa cctaacgaat cctcctactt gagacactgt agaaaagtaa
     4201 aaattgttgc ttctgttttg ttttaagagg aaatgagaag gccagcagaa gtagattaaa
     4261 actagagagc tggtttatta aaataagcag ataattatcc aggcttaaag taatagctta
     4321 catgttttga aaatccttgt acttattttt gtttttattg ttgcaaaaaa atgttaatgg
     4381 gctgttgaaa tgacctccat ttacttaagg taatccaata aggtcttttt taaatataca
     4441 aattttactc aagtttaaat tgtataaaac tgcttagaaa cctgaaattt tatagtgtgt
     4501 aatatcttat gtgtatatag catcctgagc tgtgtgatac agtagatttc ttcttagcag
     4561 aaacatgcga ggtagattta ataaacaaca aaaatcagct tatgtttcta cttattgaat
     4621 ctgctttact ttttagcaat tttcttcctt gtgaacatga accatataaa gtgtctgtga
     4681 cttaatgatt tcatgtaagt ctgtcgcata catccttctt ttgtagctta caccatgtgg
     4741 atgctctgtc tgtagacact gcttgataaa aggagaataa acctcttaca ttttaa
//
