LOCUS       NM_015082               5396 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens follistatin like 4 (FSTL4), mRNA.
ACCESSION   NM_015082 XM_048786
VERSION     NM_015082.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5396)
  AUTHORS   Guo,Y., Tomlinson,B., Chu,T., Fang,Y.J., Gui,H., Tang,C.S.,
            Yip,B.H., Cherny,S.S., Hur,Y.M., Sham,P.C., Lam,T.H. and
            Thomas,N.G.
  TITLE     A genome-wide linkage and association scan reveals novel loci for
            hypertension and blood pressure traits
  JOURNAL   PLoS One 7 (2), e31489 (2012)
   PUBMED   22384028
  REMARK    Erratum:[PLoS One. 2012;7(6).
            doi:10.1371/annotation/4415f88f-ab10-44dd-8ba9-1a57ade740c1]
REFERENCE   2  (bases 1 to 5396)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 5396)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 5396)
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study of 14,000 cases of seven common
            diseases and 3,000 shared controls
  JOURNAL   Nature 447 (7145), 661-678 (2007)
   PUBMED   17554300
REFERENCE   5  (bases 1 to 5396)
  AUTHORS   Glusman,G., Kaur,A., Hood,L. and Rowen,L.
  TITLE     An enigmatic fourth runt domain gene in the fugu genome: ancestral
            gene loss versus accelerated evolution
  JOURNAL   BMC Evol Biol 4, 43 (2004)
   PUBMED   15527507
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005195.1, BC024300.1, AB028984.1 and AC010307.7.
            
            On Nov 23, 2018 this sequence version replaced NM_015082.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.242628.1,
                                           SRR1803611.116974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265342.12/ ENSP00000265342.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC005195.1         50037-50045         c
            10-946              BC024300.1         33-969
            947-5391            AB028984.1         275-4719
            5392-5396           AC010307.7         53907-53911         c
FEATURES             Location/Qualifiers
     source          1..5396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..5396
                     /gene="FSTL4"
                     /note="follistatin like 4"
                     /db_xref="GeneID:23105"
                     /db_xref="HGNC:HGNC:21389"
     exon            1..217
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            218..353
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2756
                     /gene="FSTL4"
                     /note="follistatin-related protein 4; follistatin-like
                     protein 4"
                     /codon_start=1
                     /product="follistatin-related protein 4 precursor"
                     /protein_id="NP_055897.1"
                     /db_xref="CCDS:CCDS34238.1"
                     /db_xref="GeneID:23105"
                     /db_xref="HGNC:HGNC:21389"
                     /translation="MKPGGFWLHLTLLGASLPAALGWMDPGTSRGPDVGVGESQAEEP
                     RSFEVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCG
                     SDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQ
                     PLQEGDSRQDPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSP
                     GDLLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDL
                     RPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHV
                     LQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLL
                     ANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSV
                     GNMFYVFSDDGIIVIHPVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVN
                     VRNRYIYVAQPALSRVLVVDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHK
                     SRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKV
                     DLETMMPLKTIGLHHHGCVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVDSVTDSVL
                     GPNGDVTGTPHTSPDGRFIVSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQ
                     RSFTESNQYNIYAALHTEPDLLFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDS
                     GLFGQYLLTPARESLFLINGRQNTLRCEVSGIKGGTTVVWVGEV"
     exon            354..387
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..636
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..830
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            831..954
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1121
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1242
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1404
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1539
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1566
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1685
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1835
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1943
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2053
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..5396
                     /gene="FSTL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3360..3365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL4"
                     /note="hexamer: ATTAAA"
     polyA_site      3386
                     /gene="FSTL4"
                     /note="major polyA site"
     regulatory      5375..5380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL4"
                     /note="hexamer: AATAAA"
     polyA_site      5396
                     /gene="FSTL4"
ORIGIN      
        1 agaaataggg cagccgcggc ggcggtggca cagcagcggg cagcggcggc tcagggagct
       61 ggagcctcaa cagcctccag cgagcccggg acccgccgac agcccgagaa accagccgaa
      121 ggacgcgggg cggggtcgcc gccgccgcca cggggtgctc cctccctccc gcccaagtcc
      181 ggccacctgg tcttcccctc ggccccggcc gtctcagact catcaaaatg aaaccaggag
      241 gcttttggct gcatctcaca ctgctcggag cctccctgcc ggctgcgctg ggatggatgg
      301 acccaggaac cagcagaggc ccggatgtgg gtgtggggga gtcacaggca gaggagccca
      361 gaagctttga agtcacaaga agagaagggc tttccagcca caacgagctg ctggcctcct
      421 gcgggaagaa gttctgcagc cgagggagcc ggtgcgtgct cagcaggaag acaggggagc
      481 ccgaatgcca gtgcctggag gcatgcaggc ccagctacgt gcctgtgtgc ggctctgatg
      541 ggaggtttta tgaaaaccac tgtaagctcc accgtgctgc ttgcctcctg ggaaagagga
      601 tcaccgtcat ccacagcaag gactgtttcc tcaaaggtga cacgtgcacc atggccggct
      661 acgcccgctt gaagaatgtc cttctggcac tccagacccg tctgcagcca ctccaagaag
      721 gagacagcag acaagaccct gcctcccaga agcgcctcct ggtggaatct ctgttcaggg
      781 acttagatgc agatggcaat ggccacctca gcagctccga actggctcag catgtgctga
      841 agaagcagga cctggatgaa gacttacttg gttgctcacc aggtgacctc ctccgatttg
      901 acgattacaa cagtgacagc tccctgaccc tccgcgagtt ctacatggcc ttccaagtgg
      961 ttcagctcag cctcgccccc gaggacaggg tcagtgtgac cacagtgacc gtggggctga
     1021 gcacagtgct gacctgcgcc gtccatggag acctgaggcc accaatcatc tggaagcgca
     1081 acgggctcac cctgaacttc ctggacttgg aagacatcaa tgactttgga gaggatgatt
     1141 ccctgtacat caccaaggtg accaccatcc acatgggcaa ttacacctgc catgcttccg
     1201 gccacgagca gctgttccag acccacgtcc tgcaggtgaa tgtgccgcca gtcatccgtg
     1261 tctatccaga gagccaggca caggagcctg gagtggcagc cagcctaaga tgccatgctg
     1321 agggcattcc catgcccaga atcacttggc tgaaaaacgg cgtggatgtc tcaactcaga
     1381 tgtccaaaca gctctccctt ttagccaatg ggagcgaact ccacatcagc agtgttcggt
     1441 atgaagacac aggggcatac acctgcattg ccaaaaatga agtgggtgtg gatgaagata
     1501 tctcctcgct cttcattgaa gactcagcta gaaagaccct tgcaaacatc ctgtggcgag
     1561 aggaaggcct cagcgtggga aacatgttct atgtcttctc cgacgacggt atcatcgtca
     1621 tccatcctgt ggactgtgag atccagaggc acctcaaacc cacggaaaag attttcatga
     1681 gctatgaaga aatctgtcct caaagagaaa aaaatgcaac ccagccctgc cagtgggtat
     1741 ctgcagtcaa tgtccggaac cggtacatct atgtggccca gccagcactg agcagagtcc
     1801 ttgtggtcga catccaagcc cagaaagtcc tacagtccat aggtgtggac cctctgccgg
     1861 ctaagctgtc ctatgacaag tcacatgacc aagtgtgggt cctgagctgg ggggacgtgc
     1921 acaagtcccg accaagtctc caggtgatca cagaagccag caccggccag agccagcacc
     1981 tcatccgcac accctttgca ggagtggatg atttcttcat tcccccaaca aacctcatca
     2041 tcaaccacat caggtttggc ttcatcttca acaagtctga tcctgcagtc cacaaggtgg
     2101 acctggaaac aatgatgccc ctcaagacca tcggcctgca ccaccatggc tgcgtgcccc
     2161 aggccatggc acacacccac ctgggcggct acttcttcat ccagtgccga caggacagcc
     2221 ccgcctctgc tgcccgacag ctgctcgttg acagtgtcac agactctgtg cttggcccca
     2281 atggtgatgt aacaggcacc ccacacacat cccccgacgg gcgcttcata gtcagtgctg
     2341 cagctgacag cccctggctg cacgtgcagg agatcacagt gcggggcgag atccagaccc
     2401 tgtatgacct gcaaataaac tcgggcatct cagacttggc cttccagcgc tccttcactg
     2461 aaagcaatca atacaacatc tacgcggctc tgcacacgga gccggacctg ctgttcctgg
     2521 agctgtccac ggggaaggtg ggcatgctga agaacttaaa ggagccaccc gcagggccag
     2581 ctcagccctg ggggggtacc cacagaatca tgagggacag tgggctgttt ggacagtacc
     2641 tcctcacacc agcccgagag tcactgttcc tcatcaatgg gagacaaaac acgctgcggt
     2701 gtgaggtgtc aggtataaag ggggggacca cagtggtgtg ggtgggtgag gtatgaaggg
     2761 cccagagcag agccctgggc caaggaacac cccctagtcc tgacactgca gcctcaagca
     2821 ggtacgctgt acatttttac agacaaaagc aaaaacctgt actcgctttg tggttcaaca
     2881 ctggtctcct tgcaagtttc ctagtataag gtatgcgctg ctaccaagat tggggttttt
     2941 tcgttaggaa gtatgattta tgccttgagc tacgatgaga acatatgctg ctgtgtaaag
     3001 ggatcatttc tgtgccaagc tgcacaccga gtgacctggg gacatcatgg aaccaaggga
     3061 tcctgctctc caagcagaca cctctgtcag ttgccttcac atagtcattg tcccttactg
     3121 ccagacccag ccagactttg ccctgacgga gtggcccgga agcagaggcc gaccaggagc
     3181 aggggcctcc ctcccgaact gaaagcccat ccgtcctcgc gtgggaccgc atcttctccc
     3241 tcgcagctgc ttcttgcttt tctttccatt tgacttgctg taagcctgag ggagagccaa
     3301 caagacttac tgcatcttgg gggatgggga aatcactcac tttattttgg aaatttttga
     3361 ttaaaaaaaa attttataat ctcaaatgct agtaagcaga aagatgctct ccgaggtcca
     3421 actatatcct tccctgcctt aggccgagtc tcgggggtgg tcacaacccc acatcccaca
     3481 gccagaaaga acaatggtca tctgagaata ctggccctgt cgactattgc caccctgctt
     3541 ctccaagagc agaccaggcc acctcatccg taaggactcg gttctgtgtt gggaccccaa
     3601 aaaaccagaa caagttctgt gtgcctcctt tcagcacaga agggagacat ctcattagtc
     3661 aggtctggta ccccagattc agggcagact gggcttgcct ggcaaggtat gggtggcctc
     3721 caggctcaat gcagaaaccc caaggacacg agtggggcca ggtgagttcc tgaagctata
     3781 ccttttcaaa acagattttg ttttcctacc tgtggcccat ccactcctct ctggtacccc
     3841 atccccgcat cagcactgca gagagaacac atttcggcga gggttttctt acccacattc
     3901 cccaatcaat acacacacac tgcagaaccc agaacagaag gccacaggct ggcactactg
     3961 cattctcctt atgtgtctca ggctgtggtg actctcacat gggcatcgaa gaagtacaac
     4021 ccacatagcc ctctggagac cgcctagatc agagactcag caaaaacagg ctcgccttcc
     4081 ctctcccaca tatgagtgga acttacatgt gtcctggttt gaatgatcat tttgcaagcc
     4141 acacgggttg ggagaggtgg tctcaccaca gacgtctttg ctaatttggc caccttcacc
     4201 tactgacatg accaggattt tcctttgcca ttaaggaatg aactctttca aggagaggaa
     4261 accctagact ctgtgtcact ctcaacacac acagctcctt tcactcctgc ctgactgcca
     4321 agccacctgc atcccccgcc ccagatctca tgagatcaat cacttgtatg tctcacgcaa
     4381 cttggtccac caaacgcctg tcccctgtaa ctcctagggg tgcgcctaga caggtacgtc
     4441 tgttttttat tttaaaagat atgctatgta gatataagtt gaggaagctc acctcaaaag
     4501 cctagaatgc agtttcacag tagctgggat gcatggatga cccatctcac cccttttttt
     4561 ttcctgcctc aatatcttga tatgttatgt ttactcccaa tctcccattt ttaccactaa
     4621 aattctccaa ctttcataaa cttttttttg gaaaaatttc cattgtatca gcccctgaca
     4681 gaaaaaggat ctctgagcct aaaggaggaa aagtcccacc aactaccaga ccagaacacg
     4741 agcccctctg ggcagcagga ttcctaagtc aaagaccagt ttgacccaaa ctggcctttt
     4801 aaaataatca ggagtgacag agtcaacttc tgcagcacct gcttctcccc cactgtccct
     4861 tccatcttgg aatgtgtcta aaaaagcata gctgcccttt gctgtcctca gagtgcattt
     4921 cctggagacg gcaggcttag gtctcactga cagcatgcca gacacaactg aatcgaagca
     4981 ggcctgaagc ctaggtcagg gtttcaggag tccagcccca ggaggcaaag tcaccaatgc
     5041 agggaggtaa atgccttttg gcaggaaaac caatagagtt ggttgggtgg ggagtcaggg
     5101 gtgggaggag aaggaggaag aggaggaagg ccagactggc ctgccctttc tcccatactt
     5161 caccccagca gaggttcatg ggacacagtt ggaaagccac tgggaggaaa tgcctcacta
     5221 caggggggcc tcctgtagca agcccagccg gtaatcctcc taatgaaccc acaaggtcaa
     5281 ttcacaactg atatcttagc tattaaagaa gtactgactt taccaaaaga atcatcaaga
     5341 aagctattta tataaacccc ctcagtcatt ttgaaataaa attaatttta caaaaa
//
