LOCUS       NM_005860               2501 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens follistatin like 3 (FSTL3), mRNA.
ACCESSION   NM_005860
VERSION     NM_005860.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Li,J.P., Liu,Y.J., Yin,Y., Li,R.N., Huang,W. and Zou,X.
  TITLE     Stroma-associated FSTL3 is a factor of calcium channel-derived
            tumor fibrosis
  JOURNAL   Sci Rep 13 (1), 21317 (2023)
   PUBMED   38044354
  REMARK    GeneRIF: Stroma-associated FSTL3 is a factor of calcium
            channel-derived tumor fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Bielka,W., Przezak,A. and Pawlik,A.
  TITLE     Follistatin and follistatin-like 3 in metabolic disorders
  JOURNAL   Prostaglandins Other Lipid Mediat 169, 106785 (2023)
   PUBMED   37739334
  REMARK    GeneRIF: Follistatin and follistatin-like 3 in metabolic disorders.
            Review article
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Ibrahim,H.M., Abdelrahman,A.E., Elwan,A., Bakry,A., Fahmy,M.M.,
            Abdelhamid,M.I., Abdelwanis,A.H. and Fouad,E.M.
  TITLE     Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon
            Cancer: Clinicopathologic Study
  JOURNAL   Appl Immunohistochem Mol Morphol 31 (10), 673-681 (2023)
   PUBMED   37751246
  REMARK    GeneRIF: Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients
            of Colon Cancer: Clinicopathologic Study.
REFERENCE   4  (bases 1 to 2501)
  AUTHORS   Duan,W., Shi,R., Yang,F., Zhou,Z., Wang,L., Huang,Z. and Zang,S.
  TITLE     FSTL3 partially mediates the association of increased nonalcoholic
            fatty liver disease fibrosis risk with acute myocardial infarction
            in patients with type 2 diabetes mellitus
  JOURNAL   Cardiovasc Diabetol 22 (1), 297 (2023)
   PUBMED   37904173
  REMARK    GeneRIF: FSTL3 partially mediates the association of increased
            nonalcoholic fatty liver disease fibrosis risk with acute
            myocardial infarction in patients with type 2 diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2501)
  AUTHORS   Li,C.H., Fang,C.Y., Chan,M.H., Chen,C.L., Chang,Y.C. and Hsiao,M.
  TITLE     The cytoplasmic expression of FSTL3 correlates with colorectal
            cancer progression, metastasis status and prognosis
  JOURNAL   J Cell Mol Med 27 (5), 672-686 (2023)
   PUBMED   36807490
  REMARK    GeneRIF: The cytoplasmic expression of FSTL3 correlates with
            colorectal cancer progression, metastasis status and prognosis.
REFERENCE   6  (bases 1 to 2501)
  AUTHORS   Hill,J.J., Davies,M.V., Pearson,A.A., Wang,J.H., Hewick,R.M.,
            Wolfman,N.M. and Qiu,Y.
  TITLE     The myostatin propeptide and the follistatin-related gene are
            inhibitory binding proteins of myostatin in normal serum
  JOURNAL   J Biol Chem 277 (43), 40735-40741 (2002)
   PUBMED   12194980
REFERENCE   7  (bases 1 to 2501)
  AUTHORS   Bartholin,L., Maguer-Satta,V., Hayette,S., Martel,S., Gadoux,M.,
            Corbo,L., Magaud,J.P. and Rimokh,R.
  TITLE     Transcription activation of FLRG and follistatin by activin A,
            through Smad proteins, participates in a negative feedback loop to
            modulate activin A function
  JOURNAL   Oncogene 21 (14), 2227-2235 (2002)
   PUBMED   11948405
  REMARK    GeneRIF: Transcription activation of FLRG and follistatin by
            activin A, through Smad proteins, participates in a negative
            feedback loop to modulate activin A function
REFERENCE   8  (bases 1 to 2501)
  AUTHORS   Bartholin,L., Maguer-Satta,V., Hayette,S., Martel,S., Gadoux,M.,
            Bertrand,S., Corbo,L., Lamadon,C., Morera,A.M., Magaud,J.P. and
            Rimokh,R.
  TITLE     FLRG, an activin-binding protein, is a new target of TGFbeta
            transcription activation through Smad proteins
  JOURNAL   Oncogene 20 (39), 5409-5419 (2001)
   PUBMED   11571638
REFERENCE   9  (bases 1 to 2501)
  AUTHORS   Tortoriello,D.V., Sidis,Y., Holtzman,D.A., Holmes,W.E. and
            Schneyer,A.L.
  TITLE     Human follistatin-related protein: a structural homologue of
            follistatin with nuclear localization
  JOURNAL   Endocrinology 142 (8), 3426-3434 (2001)
   PUBMED   11459787
REFERENCE   10 (bases 1 to 2501)
  AUTHORS   Hayette,S., Gadoux,M., Martel,S., Bertrand,S., Tigaud,I.,
            Magaud,J.P. and Rimokh,R.
  TITLE     FLRG (follistatin-related gene), a new target of chromosomal
            rearrangement in malignant blood disorders
  JOURNAL   Oncogene 16 (22), 2949-2954 (1998)
   PUBMED   9671416
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX439786.2 and AY358917.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005860.2.
            
            Summary: Follistatin-like 3 is a secreted glycoprotein of the
            follistatin-module-protein family. It may have a role in
            leukemogenesis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005839.2, AY358917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000166139.9/ ENSP00000166139.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BX439786.2         17-32
            17-2501             AY358917.1         1-2485
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2501
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /note="follistatin like 3"
                     /db_xref="GeneID:10272"
                     /db_xref="HGNC:HGNC:3973"
                     /db_xref="MIM:605343"
     exon            1..135
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..824
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /note="follistatin-related protein 3; follistatin-like
                     protein 3; follistatin-related gene protein;
                     follistatin-like 3 (secreted glycoprotein)"
                     /codon_start=1
                     /product="follistatin-related protein 3 precursor"
                     /protein_id="NP_005851.1"
                     /db_xref="CCDS:CCDS12040.1"
                     /db_xref="GeneID:10272"
                     /db_xref="HGNC:HGNC:3973"
                     /db_xref="MIM:605343"
                     /translation="MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQ
                     EATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGV
                     ECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLS
                     VMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTY
                     ISSCHMRQATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV"
     exon            136..321
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /inference="alignment:Splign:2.1.0"
     exon            322..537
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /inference="alignment:Splign:2.1.0"
     exon            538..765
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /inference="alignment:Splign:2.1.0"
     exon            766..2501
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /note="hexamer: GATAAA"
     polyA_site      1166
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /note="major polyA site"
     regulatory      2489..2494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /note="hexamer: AATAAA"
     polyA_site      2501
                     /gene="FSTL3"
                     /gene_synonym="FLRG; FSRP"
                     /note="major polyA site"
ORIGIN      
        1 aagtcggtgc cgctgccgtc tctgcgttcg ccatgcgtcc cggggcgcca gggccactct
       61 ggcctctgcc ctggggggcc ctggcttggg ccgtgggctt cgtgagctcc atgggctcgg
      121 ggaaccccgc gcccggtggt gtttgctggc tccagcaggg ccaggaggcc acctgcagcc
      181 tggtgctcca gactgatgtc acccgggccg agtgctgtgc ctccggcaac attgacaccg
      241 cctggtccaa cctcacccac ccggggaaca agatcaacct cctcggcttc ttgggccttg
      301 tccactgcct tccctgcaaa gattcgtgcg acggcgtgga gtgcggcccg ggcaaggcgt
      361 gccgcatgct ggggggccgc ccgcgctgcg agtgcgcgcc cgactgctcg gggctcccgg
      421 cgcggctgca ggtctgcggc tcagacggcg ccacctaccg cgacgagtgc gagctgcgcg
      481 ccgcgcgctg ccgcggccac ccggacctga gcgtcatgta ccggggccgc tgccgcaagt
      541 cctgtgagca cgtggtgtgc ccgcggccac agtcgtgcgt cgtggaccag acgggcagcg
      601 cccactgcgt ggtgtgtcga gcggcgccct gccctgtgcc ctccagcccc ggccaggagc
      661 tttgcggcaa caacaacgtc acctacatct cctcgtgcca catgcgccag gccacctgct
      721 tcctgggccg ctccatcggc gtgcgccacg cgggcagctg cgcaggcacc cctgaggagc
      781 cgccaggtgg tgagtctgca gaagaggaag agaacttcgt gtgagcctgc aggacaggcc
      841 tgggcctggt gcccgaggcc ccccatcatc ccctgttatt tattgccaca gcagagtcta
      901 atttatatgc cacggacact ccttagagcc cggattcgga ccacttgggg atcccagaac
      961 ctccctgacg atatcctgga aggactgagg aagggaggcc tgggggccgg ctggtgggtg
     1021 ggatagacct gcgttccgga cactgagcgc ctgatttagg gcccttctct aggatgcccc
     1081 agcccctacc ctaagaccta ttgccgggga ggattccaca cttccgctcc tttggggata
     1141 aacctattaa ttattgctac tatcaagagg gctgggcatt ctctgctggt aattcctgaa
     1201 gaggcatgac tgcttttctc agccccaagc ctctagtctg ggtgtgtacg gagggtctag
     1261 cctgggtgtg tacggagggt ctagcctggg tgagtacgga gggtctagcc tgggtgagta
     1321 cggagggtct agcctgggtg agtacggagg gtctagcctg ggtgtgtatg gaggatctag
     1381 cctgggtgag tatggagggt ctagcctggg tgagtatgga gggtctagcc tgggtgtgta
     1441 tggagggtct agcctgggtg agtatggagg gtctagcctg ggtgtgtatg gagggtctag
     1501 cctgggtgag tatggagggt ctagcctggg tgtgtacgga gggtctagtc tgagtgcgtg
     1561 tggggacctc agaacactgt gaccttagcc cagcaagcca ggcccttcat gaaggccaag
     1621 aaggctgcca ccattccctg ccagcccaag aactccagct tccccactgc ctctgtgtgc
     1681 ccctttgcgt cctgtgaagg ccattgagaa atgcccagtg tgccccctgg gaaagggcac
     1741 ggcctgtgct cctgacacgg gctgtgcttg gccacagaac cacccagcgt ctcccctgct
     1801 gctgtccacg tcagttcatg aggcaacgtc gcgtggtctc agacgtggag cagccagcgg
     1861 cagctcagag cagggcactg tgtccggcgg agccaagtcc actctggggg agctctggcg
     1921 gggaccacgg gccactgctc acccactggc cccgaggggg gtgtagacgc caagactcac
     1981 gcatgtgtga catccggagt cctggagccg ggtgtcccag tggcaccact aggtgcctgc
     2041 tgcctccaca gtggggttca cacccagggc tccttggtcc cccacaacct gccccggcca
     2101 ggcctgcaga cccagactcc agccagacct gcctcaccca ccaatgcagc cggggctggc
     2161 gacaccagcc aggtgctggt cttgggccag ttctcccacg acggctcacc ctcccctcca
     2221 tctgcgttga tgctcagaat cgcctacctg tgcctgcgtg taaaccacag cctcagacca
     2281 gctatgggga gaggacaaca cggaggatat ccagcttccc cggtctgggg tgaggaatgt
     2341 ggggagcttg ggcatcctcc tccagcctcc tccagccccc aggcagtgcc ttacctgtgg
     2401 tgcccagaaa agtgccccta ggttggtggg tctacaggag cctcagccag gcagcccacc
     2461 ccaccctggg gccctgcctc accaaggaaa taaagactca a
//
