LOCUS       NM_007085               5682 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens follistatin like 1 (FSTL1), mRNA.
ACCESSION   NM_007085
VERSION     NM_007085.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5682)
  AUTHORS   Suresh,A.P., Vijayarengan,M., Aggarwal,P., Soundaram,R., Gnanesh
            Kumar,B.S. and Sundaram,G.M.
  TITLE     A site-specific phosphorylation in FSTL1 determines its
            promigratory role in wound healing
  JOURNAL   Biochimie 225, 106-113 (2024)
   PUBMED   38768802
  REMARK    GeneRIF: A site-specific phosphorylation in FSTL1 determines its
            promigratory role in wound healing.
REFERENCE   2  (bases 1 to 5682)
  AUTHORS   Du,R., Li,K., Guo,K., Chen,Z., Han,L. and Bian,H.
  TITLE     FSTL1: A double-edged sword in cancer development
  JOURNAL   Gene 906, 148263 (2024)
   PUBMED   38346455
  REMARK    GeneRIF: FSTL1: A double-edged sword in cancer development.
            Review article
REFERENCE   3  (bases 1 to 5682)
  AUTHORS   Yu,S., Cui,X., Zhou,S., Li,Y., Feng,W., Zhang,X., Zhong,Y. and
            Zhang,P.
  TITLE     THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic
            target in cutaneous squamous cell carcinoma
  JOURNAL   J Transl Med 22 (1), 347 (2024)
   PUBMED   38605354
  REMARK    GeneRIF: THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a
            therapeutic target in cutaneous squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5682)
  AUTHORS   Nam,J.S., Park,S.J., Ahn,C.W., Cho,E.S., Kim,H.J. and Kim,Y.
  TITLE     Follistatin-like 1 is a myokine regulating lipid mobilization
            during endurance exercise and recovery
  JOURNAL   Obesity (Silver Spring) 32 (2), 352-362 (2024)
   PUBMED   38018497
  REMARK    GeneRIF: Follistatin-like 1 is a myokine regulating lipid
            mobilization during endurance exercise and recovery.
REFERENCE   5  (bases 1 to 5682)
  AUTHORS   Liu,Z., Zhang,H. and Hu,X.
  TITLE     Analysis of the expression and mechanism of follistatin-like
            protein 1 in cervical cancer
  JOURNAL   Oncol Rep 50 (6) (2023)
   PUBMED   37888756
  REMARK    GeneRIF: Analysis of the expression and mechanism of
            follistatin-like protein 1 in cervical cancer.
REFERENCE   6  (bases 1 to 5682)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 5682)
  AUTHORS   Ciarmela,P., Florio,P., Sigurdardottir,M., Toti,P.,
            Maguer-Satta,V., Rimokh,R., Altomare,A., Tosi,P. and Petraglia,F.
  TITLE     Follistatin-related gene expression, but not follistatin
            expression, is decreased in human endometrial adenocarcinoma
  JOURNAL   Eur J Endocrinol 151 (2), 251-257 (2004)
   PUBMED   15296481
  REMARK    GeneRIF: Whilst follistatin expression is unchanged,
            follistatin-related gene is down-regulated in endometrial
            carcinoma.
REFERENCE   8  (bases 1 to 5682)
  AUTHORS   Vertegaal,A.C., Kuiperij,H.B., van Laar,T., Scharnhorst,V., van der
            Eb,A.J. and Zantema,A.
  TITLE     cDNA micro array identification of a gene differentially expressed
            in adenovirus type 5- versus type 12-transformed cells
  JOURNAL   FEBS Lett 487 (2), 151-155 (2000)
   PUBMED   11150499
REFERENCE   9  (bases 1 to 5682)
  AUTHORS   Tanaka,M., Ozaki,S., Osakada,F., Mori,K., Okubo,M. and Nakao,K.
  TITLE     Cloning of follistatin-related protein as a novel autoantigen in
            systemic rheumatic diseases
  JOURNAL   Int Immunol 10 (9), 1305-1314 (1998)
   PUBMED   9786430
REFERENCE   10 (bases 1 to 5682)
  AUTHORS   Zwijsen,A., Blockx,H., Van Arnhem,W., Willems,J., Fransen,L.,
            Devos,K., Raymackers,J., Van de Voorde,A. and Slegers,H.
  TITLE     Characterization of a rat C6 glioma-secreted follistatin-related
            protein (FRP). Cloning and sequence of the human homologue
  JOURNAL   Eur J Biochem 225 (3), 937-946 (1994)
   PUBMED   7957230
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB289587.1, BC000055.2,
            AI813946.1 and AC063952.15.
            
            On Nov 22, 2018 this sequence version replaced NM_007085.4.
            
            Summary: This gene encodes a protein with similarity to
            follistatin, an activin-binding protein. It contains an FS module,
            a follistatin-like sequence containing 10 conserved cysteine
            residues. This gene product is thought to be an autoantigen
            associated with rheumatoid arthritis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.218353.1,
                                           SRR1803614.218028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295633.8/ ENSP00000295633.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB289587.1         80-93
            15-1697             BC000055.2         1-1683
            1698-3535           BC000055.2         1685-3522
            3536-3761           AI813946.1         4-229               c
            3762-5682           AC063952.15        126802-128722       c
FEATURES             Location/Qualifiers
     source          1..5682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..5682
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /note="follistatin like 1"
                     /db_xref="GeneID:11167"
                     /db_xref="HGNC:HGNC:3972"
                     /db_xref="MIM:605547"
     exon            1..96
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1023
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /note="follistatin-related protein 1; follistatin-like
                     protein 1"
                     /codon_start=1
                     /product="follistatin-related protein 1 precursor"
                     /protein_id="NP_009016.1"
                     /db_xref="CCDS:CCDS2998.1"
                     /db_xref="GeneID:11167"
                     /db_xref="HGNC:HGNC:3972"
                     /db_xref="MIM:605547"
                     /translation="MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAV
                     TEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKK
                     SVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGD
                     SRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEF
                     LKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQ
                     TQTEEEMTRYVQELQKHQETAEKTKRVSTKEI"
     exon            97..159
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            160..264
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            265..394
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            395..427
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            428..558
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            559..677
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            678..790
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            791..901
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            902..978
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     exon            979..5682
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3678..3683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /note="hexamer: AATAAA"
     polyA_site      3696
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /note="major polyA site"
     regulatory      3733..3738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /note="hexamer: AATAAA"
     polyA_site      3753
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
     regulatory      5660..5665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
                     /note="hexamer: ATTAAA"
     polyA_site      5682
                     /gene="FSTL1"
                     /gene_synonym="FRP; FSL1; MIR198; OCC-1; OCC1; tsc36"
ORIGIN      
        1 cctccgaggc tggcgatcgg cggagctccc acctccgctt acagctcgct gccgccgtcc
       61 tgccccgcgc ccccaggaga cctggaccag accacgatgt ggaaacgctg gctcgcgctc
      121 gcgctcgcgc tggtggcggt cgcctgggtc cgcgccgagg aagagctaag gagcaaatcc
      181 aagatctgtg ccaatgtgtt ttgtggagcc ggccgggaat gtgcagtcac agagaaaggg
      241 gaacccacct gtctctgcat tgagcaatgc aaacctcaca agaggcctgt gtgtggcagt
      301 aatggcaaga cctacctcaa ccactgtgaa ctgcatcgag atgcctgcct cactggatcc
      361 aaaatccagg ttgattacga tggacactgc aaagagaaga aatccgtaag tccatctgcc
      421 agcccagttg tttgctatca gtccaaccgt gatgagctcc gacgtcgcat catccagtgg
      481 ctggaagctg agatcattcc agatggctgg ttctctaaag gcagcaacta cagtgaaatc
      541 ctagacaagt attttaagaa ctttgataat ggtgattctc gcctggactc cagtgaattc
      601 ctgaagtttg tggaacagaa tgaaactgcc atcaatatta caacgtatcc agaccaggag
      661 aacaacaagt tgcttagggg actctgtgtt gatgctctca ttgaactgtc tgatgaaaat
      721 gctgattgga aactcagctt ccaagagttt ctcaagtgcc tcaacccatc tttcaaccct
      781 cctgagaaga agtgtgccct ggaggatgaa acgtatgcag atggagctga gaccgaggtg
      841 gactgtaacc gctgtgtctg tgcctgtgga aattgggtct gtacagccat gacctgtgac
      901 ggaaagaatc agaagggggc ccagacccag acagaggagg agatgaccag atatgtccag
      961 gagctccaaa agcatcagga aacagctgaa aagaccaaga gagtgagcac caaagagatc
     1021 taatgaggag gcacagacca gtgtctggat cccagcatct tctccacttc agcgctgagt
     1081 tcagtataca caagtgtctg ctacagtcgc caaatcacca gtatttgctt atatagcaat
     1141 gagttttatt ttgtttattt gttttgcaat aaaggatatg aaggtggctg gctaggaagg
     1201 gaagggccac agccttcatt tctaggagtg ctttaagaga aactgtaaat ggtgctctgg
     1261 ggctggaggc tagtaaggaa actgcatcac gattgaaaga ggaacagacc caaatctgaa
     1321 cctcttttga gtttactgca tctgtcagca ggctgcaggg agtgcacacg atgccagaga
     1381 gaacttagca gggtgtcccc ggaggagagg tttgggaagc tccacggaga ggaacgctct
     1441 ctgcttccag cctctttcca ttgccgtcag catgacagac ctccagcatc cacgcatctc
     1501 ttggtcccaa taactgcctc tagatacata gccatactgc tagttaaccc agtgtccctc
     1561 agacttggat ggagtttctg ggagggtaca cccaaatgat gcagatactt gtatactttg
     1621 agccccttag cgacctaacc aaattttaaa aatacttttt accaaaggtg ctatttctct
     1681 gtaaaacact tttttttggc aagttgactt tattcttcaa ttattatcat tatattattg
     1741 ttttttaata ttttattttc ttgactaggt attaagcttt tgtaattatt tttcagtagt
     1801 cccaccactt cataggtgga aggagtttgg ggttcttcct ggtgcagggg ctgaaataac
     1861 ccagatgccc ccaccctgcc acatactaga tgcagcccat agttggcccc cctagcttcc
     1921 agcagtccac tatctgccag aggagcaagg gtgccttaga ccgaagccag gggaagaagc
     1981 atcttcataa aaaactttca agatccaaac attaatttgt ttttatttat tctgagaagt
     2041 tgaggcaaat cagtattccc aaggatggcg acaagggcag ccaagcaggg cttaggatat
     2101 cccagcctac caatatgctc attcgactaa ctaggagggt gagttggccc tgtctcttct
     2161 tttttctgga cctcagtttc ctcagtgagc tggtaagaat gcactaacct tttgatttga
     2221 taagttataa attctgtggt tctgatcatt ggtccagagg ggagataggt tcctgtgatt
     2281 tttccttctt ctctatagaa taaatgaaat cttgttacta gaacaagaaa tgtcagatgg
     2341 ccaaaaacaa gatgaccaga tttgatctca gcctgatgac cctacaggtc gtgctatgat
     2401 atggagtcct catgggtaaa gcaggaagag agtgggaaag agaaccaccc cactctgtct
     2461 tcatatttgc atttcatgtt taacctccgg ctggaaatag aaagcattcc cttagagatg
     2521 aggataaaag aaagtttcag attcaacagg gggaagaaaa tggagattta atcctaaaac
     2581 tgtgacttgg ggaggtcagt catttacagt tagtcctgtg tctttcgact tctgtgatta
     2641 ttaaccccac tcactaccct gtttcagatg catttggaat accaaagatt aaatccttga
     2701 cataagatct catttgcaga aagcagatta aagaccatca gaaggaaatt atttaggttg
     2761 taatgcacag gcaactgtga gaaactgttg tgccaaaaat agaattcctt ctagtttttc
     2821 ttgttctcat ttgaaaggag aaaattccac tttgtttagc atttcaagct tttatgtatc
     2881 catcccatct aaaaactctt caaactccac ttgttcagtc tgaaatgcag ctccctgtcc
     2941 aagtgccttg gagaactcac agcagcacgc cttaatcaaa ggttttacca gcccttggac
     3001 actatgggag gagggcaaga gtacaccaat ttgttaaaag caagaaacca cagtgtctct
     3061 tcactagtca tttagaacat ggttatcatc caagactact ctaccctgca acattgaact
     3121 cccaagagca aatccacatt cctcttgagt tctgcagctt ctgtgtaaat agggcagctg
     3181 tcgtctatgc cgtagaatca catgatctga ggaccattca tggaagctgc taaatagcct
     3241 agtctgggga gtcttccata aagttttgca tggagcaaac aaacaggatt aaactaggtt
     3301 tggttccttc agccctctaa aagcataggg cttagcctgc aggcttcctt gggctttctc
     3361 tgtgtgtgta gttttgtaaa cactatagca tctgttaaga tccagtgtcc atggaaacat
     3421 tcccacatgc cgtgactctg gactatatca gtttttggaa agcagggttc ctctgcctgc
     3481 taacaagccc acgtggacca gtctgaatgt ctttccttta cacctatgtt tttaagtagt
     3541 caaacttcaa gaaacaatct aaacaagttt ctgttgcata tgtgtttgtg aacttgtatt
     3601 tgtatttagt aggcttctat attgcattta acttgttttt gtaactcctg attcttcctt
     3661 ttcggatact attgatgaat aaagaaatta aagtgatggt tttattggtt tcctttcccc
     3721 caattaaggc caaataaagt cgtgagaaca ttacccattt acttcctaag agtggatttg
     3781 agtttcagga gccttaaaaa ggactgaaga gtttctcctg ggactacagc ttggatggaa
     3841 agtttactcg gggactggta gaacaagttt ctttgaaagg atcatggata gtgggtctgg
     3901 agtagaaggt gatgacaagt cagaaagtgt cttagtccct tcaagttgct ataacaaaat
     3961 gcctcagact gggtaattat aggcaacaga aatgtattgc tcacagttct gaaggctggg
     4021 aagcctaaga tcaaggtacc agcagattca gtgtctgatg acggcttgtt gaagcttgcc
     4081 tgcttcaaag aatgcacctt tttgatgcat ccccacatgg tgaaaagggt gaacaaactc
     4141 ccttaggcct cttttataag ggcacttacc cattcatgag ggttaaactt tgatgaccta
     4201 atcatctccc aagagcctca cctctcaata ccattgcttt ggggattcaa ttttaacata
     4261 tgaattttgg gggacataaa cattcaaacc atagcaggtg cattcctgta ttgggaagac
     4321 attaaattaa atgactcgta aatcccccat atgatttagg agactaaatg gcatccagtg
     4381 aggctgactg cagtagcctg tgagaaggca aataaacatg ggaaggtagt acagggaaca
     4441 tggaatcatt gccagggaca ggctaaataa ccttaatggc acttccttga tacacacatt
     4501 ccatgggggt aaacagttcc aagtgggctg aacgttagct ggttaaaacc tcttttgctt
     4561 ggggacacat gactaacgct ttccaacctg ccattttcat atgtatcatg cactctccac
     4621 ccacaataat tctgcctccc aaaagagcat attatagtca atgaggttta aggtttcttc
     4681 ggttcagtca tgtggaagtt ttgctttcct aaaattatag ctggatcact ttgattggat
     4741 ttgggatatt acccaaatgc taatcaaata ttaaaaggca atcttttttg ttatgtgatt
     4801 gctacagatt actgctctta cagtttgatt cttcaaattt tcattctcag aagggaatct
     4861 taaacccagt ttgaagggta ccttgtccac aaccactttt aaattttggc taacttccca
     4921 accttccacc atgttctggg aaaacttttt ctgctgttat agtatgtatg tattcaggaa
     4981 gtgcaacatt attaaactaa gcataattca gaagctaagt ttcctttcat caaaatttaa
     5041 tattacgaat tgtgcaaaga agtatgttac tttgatcagc tttattttag agcttcttta
     5101 tcaagttatc atcagtcctc ttgaattatt tctgaaataa ggggaaggaa ggaagggaaa
     5161 aaatatgaat gcatagatag atctaagcag atgccttcag agccctggaa taatcctagc
     5221 tgggatatgg gacatgaaaa caactctggc ctactgctgc tgggggctgt tgcatggtgt
     5281 gacataggaa gtaaaatgtt gctgtatgaa taggaaggag ggtcttcctg tcaatgagaa
     5341 ttaatgtttt cctaatgatt taactttttt actgaaaaaa taatatgtgt acatggtaaa
     5401 aatccaaatt gtatcacaga aaatacagtg aataaaacca tcctcttaag agggtgtgta
     5461 catttataaa tttgcctatg attgcctata aagtcaaaga agttgcacca gtatgcatga
     5521 ctgccaaaag tacataaact gagcatatcc atttccctac attcttgcaa acattgtgcc
     5581 ttcgaacttt ttggcctctg atagaggaaa aatggtaact ccttgtttta ttttttatat
     5641 tcattattcc ttttgtaaga ttaaatatca tctcatgaat aa
//
