LOCUS       NM_152597               2816 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fibrous sheath interacting protein 1 (FSIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_152597
VERSION     NM_152597.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Chen,G., Sun,L., Gu,X., Ai,L., Yang,J., Zhang,Z., Hou,P., Wang,Y.,
            Ou,X., Jiang,X., Qiao,X., Ma,Q., Niu,N., Xue,J., Zhang,H., Yang,Y.
            and Liu,C.
  TITLE     FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in
            triple-negative breast cancer patients by activating the Nanog
            pathway
  JOURNAL   Sci China Life Sci 66 (12), 2805-2817 (2023)
   PUBMED   37460715
  REMARK    GeneRIF: FSIP1 enhances the therapeutic sensitivity to CDK4/6
            inhibitors in triple-negative breast cancer patients by activating
            the Nanog pathway.
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Yan,X., Dai,J., Han,Y., You,Q. and Liu,Y.
  TITLE     FSIP1 Is Associated with Poor Prognosis and Can Be Used to
            Construct a Prognostic Model in Gastric Cancer
  JOURNAL   Dis Markers 2022, 2478551 (2022)
   PUBMED   35692888
  REMARK    GeneRIF: FSIP1 Is Associated with Poor Prognosis and Can Be Used to
            Construct a Prognostic Model in Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Chen,M., Wu,Y., Li,W., Zhang,X., Chen,L., Zheng,X., Zuo,X.,
            Zhou,F., Hong,Y., Cheng,H., Zhang,M., Chen,Z., Wu,Q., Zhang,X. and
            Zhang,B.
  TITLE     Loss-of-function variants in FSIP1 identified by targeted
            sequencing are associated with one particular subtype of mucosal
            melanoma
  JOURNAL   Gene 759, 144964 (2020)
   PUBMED   32717308
  REMARK    GeneRIF: Loss-of-function variants in FSIP1 identified by targeted
            sequencing are associated with one particular subtype of mucosal
            melanoma.
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Li,X., Song,X., Ma,J., Zhao,Y., Jiang,Q., Zhao,Z. and Li,M.
  TITLE     FSIP1 is correlated with estrogen receptor status and poor
            prognosis
  JOURNAL   Mol Carcinog 59 (1), 126-135 (2020)
   PUBMED   31713931
  REMARK    GeneRIF: FSIP1 overexpression correlated with decreased overall
            survival in hormone receptor-positive breast cancer patients.
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Yan,M., Wang,J., Ren,Y., Li,L., He,W., Zhang,Y., Liu,T. and Li,Z.
  TITLE     Over-expression of FSIP1 promotes breast cancer progression and
            confers resistance to docetaxel via MRP1 stabilization
  JOURNAL   Cell Death Dis 10 (3), 204 (2019)
   PUBMED   30814489
  REMARK    GeneRIF: FSIP1 bound to the multidrug resistance protein 1 (MRP1)
            and stabilized it, and knocking out FSIP1 decreased MRP1 expression
            and increased cellular docetaxel accumulation. In sum, FSIP1
            promotes breast carcinogenesis and mediates docetaxel resistance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Zhang,H., Luo,M., Jin,Z., Wang,D., Sun,M., Zhao,X., Zhao,Z.,
            Lei,H., Li,M. and Liu,C.
  TITLE     Expression and clinicopathological significance of FSIP1 in breast
            cancer
  JOURNAL   Oncotarget 6 (12), 10658-10666 (2015)
   PUBMED   25826084
  REMARK    GeneRIF: FSIP1 may play an important role in the tumorigenesis and
            invasion of breast cancer and is a potential biomarker for breast
            cancer diagnosis or prognosis.
REFERENCE   7  (bases 1 to 2816)
  AUTHORS   Chapman,K.B., Prendes,M.J., Kidd,J.L., Sternberg,H., West,M.D. and
            Wagner,J.
  TITLE     Elevated expression of cancer/testis antigen FSIP1 in ER-positive
            breast tumors
  JOURNAL   Biomark Med 7 (4), 601-611 (2013)
   PUBMED   23905897
  REMARK    GeneRIF: prevalence and uniformity of FSIP1 expression in breast
            tumors
REFERENCE   8  (bases 1 to 2816)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   9  (bases 1 to 2816)
  AUTHORS   Kim,J.Y., Kim,J.H., Park,T.J., Bae,J.S., Lee,J.S., Pasaje,C.F.,
            Park,B.L., Cheong,H.S., Park,J.S., Park,S.W., Uh,S.T., Kim,M.K.,
            Choi,I.S., Cho,S.H., Choi,B.W., Park,C.S. and Shin,H.D.
  TITLE     Positive association between aspirin-intolerant asthma and genetic
            polymorphisms of FSIP1: a case-case study
  JOURNAL   BMC Pulm Med 10, 34 (2010)
   PUBMED   20513247
  REMARK    GeneRIF: association between the variants in FSIP1 and aspirin
            intolerant asthma occurrence among asthmatics in a Korean
            population
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2816)
  AUTHORS   Brown,P.R., Miki,K., Harper,D.B. and Eddy,E.M.
  TITLE     A-kinase anchoring protein 4 binding proteins in the fibrous sheath
            of the sperm flagellum
  JOURNAL   Biol Reprod 68 (6), 2241-2248 (2003)
   PUBMED   12606363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023908.6, BX642685.1, AK093308.1 and AC037198.7.
            
            On Nov 23, 2018 this sequence version replaced NM_152597.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045191.2, SRR1660803.215047.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350221.4/ ENSP00000280236.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC023908.6         97141-97143         c
            4-22                BX642685.1         2-20
            23-2054             AK093308.1         2-2033
            2055-2816           AC037198.7         65376-66137         c
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..2816
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /note="fibrous sheath interacting protein 1"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
     exon            1..214
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            215..347
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1967
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /codon_start=1
                     /product="fibrous sheath-interacting protein 1"
                     /protein_id="NP_689810.3"
                     /db_xref="CCDS:CCDS10050.1"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
                     /translation="MDIIKGNLDGISKPASNSRIRPGSRSSNASLEVLSTEPGSFKVD
                     TASNLNSGKEDHSESSNTENRRTSNDDKQESCSEKIKLAEEGSDEDLDLVQHQIISEC
                     SDEPKLKELDSQLQDAIQKMKKLDKILAKKQRREKEIKKQGLEMRIKLWEEIKSAKYS
                     EAWQSKEEMENTKKFLSLTAVSEETVGPSHEEEDTFSSVFHTQIPPEEYEMQMQKLNK
                     DFTCDVERNESLIKSGKKPFSNTEKIELRGKHNQDFIKRNIELAKESRNPVVMVDREK
                     KRLVELLKDLDEKDSGLSSSEGDQSGWVVPVKGYELAVTQHQQLAEIDIKLQELSAAS
                     PTISSFSPRLENRNNQKPDRDGERNMEVTPGEKILRNTKEQRDLHNRLREIDEKLKMM
                     KENVLESTSCLSEEQLKCLLDECILKQKSIIKLSSERKKEDIEDVTPVFPQLSRSIIS
                     KLLNESETKVQKTEVEDADMLESEECEASKGYYLTKALTGHNMSEALVTEAENMKCLQ
                     FSKDVIISDTKDYFMSKTLGIGRLKRPSFLDDPLYGISVSLSSEDQHLKLSSPENTIA
                     DEQETKDAAEECKEP"
     exon            348..531
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            532..686
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            687..780
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            781..876
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1001
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1112
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1271
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1409
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1920
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2816
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /note="major polyA site"
     regulatory      2790..2795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /note="hexamer: AATAAA"
     polyA_site      2816
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /note="major polyA site"
ORIGIN      
        1 atcgcgcatc tggttgccag ggaaacagcg gtcccacagg caggagggat ctggaccggc
       61 ggcttcttcc actaccagag aggctgaggt ggcgggagag acccctctcc tctgggggta
      121 agtggctggc gcggcgagtg tctgcggcgc gcttctgcgg ccatctgcgc cctgactgac
      181 ggcggccagt tcctcgagga ggcccggcgg gaaggatttc aatggatatt ataaagggaa
      241 acctagatgg aatttcaaaa ccagcttcaa attcaagaat acgccctggg agcagaagtt
      301 caaatgcttc tttggaggtg ctctcaacag aaccaggatc cttcaaggtc gatactgcaa
      361 gcaacttgaa ctctggtaaa gaggaccact ccgaaagcag taatacagag aacagaagaa
      421 ctagtaatga tgataagcag gaaagctgct ctgagaaaat aaaattggct gaagagggat
      481 cagatgaaga tctggatttg gttcaacatc agataatctc tgagtgttca gatgaaccca
      541 aattaaaaga attagattct caacttcaag atgctattca gaagatgaaa aaacttgata
      601 aaatattggc aaagaaacaa cgcagagaaa aagaaattaa gaagcaaggt ctagaaatga
      661 gaataaagct gtgggaagaa attaagtctg caaaatatag tgaagcttgg caaagtaaag
      721 aggagatgga aaatacaaaa aaatttttat ctttgactgc tgtttctgaa gaaactgttg
      781 gtccttctca tgaggaggaa gacacctttt cctcagtgtt tcatactcaa atccctccag
      841 aagaatatga aatgcagatg cagaaactca ataaagattt tacctgtgat gtggaaagaa
      901 atgagtcatt gatcaaatca ggaaagaaac ctttctcgaa tacagaaaag attgagctca
      961 ggggtaaaca caaccaggat tttattaaga gaaacattga gttggccaag gaatcaagaa
     1021 acccagtggt tatggttgac agagagaaga aaaggctggt tgagcttttg aaggacttgg
     1081 atgagaaaga ttccgggctc tccagttctg agggtgatca gtctggctgg gtggtcccag
     1141 taaaaggata tgaacttgca gtcacccagc atcagcagct tgctgaaatt gatataaaac
     1201 tccaagaact ctctgcagcc tcccctacaa tttccagttt ttctccaaga cttgaaaatc
     1261 ggaataatca gaaacctgac cgtgatggtg aaagaaatat ggaagtaact ccaggagaaa
     1321 agatacttag gaacaccaaa gagcaacgcg atctgcataa tcggctgaga gagattgatg
     1381 aaaagctgaa aatgatgaag gaaaatgtgt tagagtccac atcatgtctc tctgaagaac
     1441 agttaaagtg tcttctggat gaatgcatac ttaaacaaaa atccatcatt aaactttctt
     1501 cagaaagaaa aaaggaagac attgaggacg taacacctgt gttcccccag ctttccaggt
     1561 ccatcatctc taaattgcta aatgaatcag aaacaaaggt ccagaaaact gaggtagaag
     1621 atgcagatat gcttgagagt gaagaatgtg aagcttctaa aggctactat ctcactaaag
     1681 ccttgactgg acataacatg tcagaagctc ttgtcactga agcagagaat atgaaatgcc
     1741 ttcaattttc caaggacgtt attattagtg acacaaaaga ctattttatg tcgaagactc
     1801 ttggcattgg gagactgaaa aggccctcct tcttagatga tccactgtat ggtatcagtg
     1861 tgagcctttc atcagaagac caacatctga aactcagttc tccagagaat acaatagcag
     1921 atgagcagga gactaaagat gcagcagaag aatgtaaaga accctaatca aggacttgct
     1981 gggtgtgctt ttcagaaagt tggtaatgaa gttaaattaa atttcttatt gaattatttg
     2041 aattcaatga atgcactgca gagactattc tttattgatt ttgacatttg gagtcgctct
     2101 ttgtggatta tatttccttg atatttttga gacttggggt gtaattgttc agtggttttt
     2161 gctcattaaa atttctggga ccattgttta taaatttatt gctaatctta cagtattagg
     2221 attcattata aaaaccaaca ttttaatgta tacgtgttag ggtaaaactc gttgaagtgc
     2281 tgtgattgtc ctgtattcaa ttttgtatgt ttcacctcta ctgtgattca gacagatcat
     2341 ggtggtcact gggaattttt gctgtggccc tgcttttcct tcttcccact tgtctcatgt
     2401 ctgtgaaact ggtacaacct gccataagat gaaatgaatt gtctcaacaa agcaatatta
     2461 gaagagcctt tactatctta ttggtgatga cacgtttctt aagtaggagt ttgagtgaat
     2521 tatttgatat attactttgt taataatagt taacaatagt ttcttatttt ctttcagagt
     2581 ttgggccttt tagattgcat caaataaaga tgagctactt taaaagacag tctgcggtac
     2641 tatttgaaga gagatggttt agttacaagt cagtaactta gattcatgag aaaattttgt
     2701 gttgacattc cataagatga gttggcatta gaattggaag tccagtttat ttctgaatca
     2761 aaaaatgagc gggctattgt gctgccttta ataaaatttg agtgatgtat acataa
//
