LOCUS       NM_001382289            1856 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens follicle stimulating hormone subunit beta (FSHB),
            transcript variant 3, mRNA.
ACCESSION   NM_001382289
VERSION     NM_001382289.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Bianco,B., Loureiro,F.A., Trevisan,C.M., Christofolini,D.M.,
            Lagana,A.S. and Barbosa,C.P.
  TITLE     Implication of FSHB rs10835638 variant in endometriosis in
            Brazilian women
  JOURNAL   Einstein (Sao Paulo) 21, eAO0483 (2023)
   PUBMED   37909652
  REMARK    GeneRIF: Implication of FSHB rs10835638 variant in endometriosis in
            Brazilian women.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Zitzmann,M., Schubert,M., Sansone,A. and Kliesch,S.
  TITLE     Spontaneous alterations in semen parameters are associated with
            age, accessory gland function and the FSHB c.-211G>T variant
  JOURNAL   Andrology 11 (7), 1386-1397 (2023)
   PUBMED   36908159
  REMARK    GeneRIF: Spontaneous alterations in semen parameters are associated
            with age, accessory gland function and the FSHB c.-211G>T variant.
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Castellucci,G.A., Kovach,C.K., Howard,M.A. 3rd, Greenlee,J.D.W. and
            Long,M.A.
  TITLE     A speech planning network for interactive language use
  JOURNAL   Nature 602 (7895), 117-122 (2022)
   PUBMED   34987226
  REMARK    GeneRIF: A speech planning network for interactive language use.
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Krenz,H., Sansone,A., Kliesch,S., Gromoll,J. and Schubert,M.
  TITLE     FSHB Genotype Identified as a Relevant Diagnostic Parameter
            Revealed by Cluster Analysis of Men With Idiopathic Infertility
  JOURNAL   Front Endocrinol (Lausanne) 12, 780403 (2021)
   PUBMED   34992580
  REMARK    GeneRIF: FSHB Genotype Identified as a Relevant Diagnostic
            Parameter Revealed by Cluster Analysis of Men With Idiopathic
            Infertility.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Bianco,B., Loureiro,F.A., Trevisan,C.M., Peluso,C.,
            Christofolini,D.M., Montagna,E., Lagana,A.S. and Barbosa,C.P.
  TITLE     Effects of FSHR and FSHB Variants on Hormonal Profile and
            Reproductive Outcomes of Infertile Women With Endometriosis
  JOURNAL   Front Endocrinol (Lausanne) 12, 760616 (2021)
   PUBMED   34659133
  REMARK    GeneRIF: Effects of FSHR and FSHB Variants on Hormonal Profile and
            Reproductive Outcomes of Infertile Women With Endometriosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Keene,J.L., Matzuk,M.M., Otani,T., Fauser,B.C., Galway,A.B.,
            Hsueh,A.J. and Boime,I.
  TITLE     Expression of biologically active human follitropin in Chinese
            hamster ovary cells
  JOURNAL   J Biol Chem 264 (9), 4769-4775 (1989)
   PUBMED   2494176
REFERENCE   7  (bases 1 to 1856)
  AUTHORS   Jameson,J.L., Becker,C.B., Lindell,C.M. and Habener,J.F.
  TITLE     Human follicle-stimulating hormone beta-subunit gene encodes
            multiple messenger ribonucleic acids
  JOURNAL   Mol Endocrinol 2 (9), 806-815 (1988)
   PUBMED   3139991
REFERENCE   8  (bases 1 to 1856)
  AUTHORS   Shome,B., Parlow,A.F., Liu,W.K., Nahm,H.S., Wen,T. and Ward,D.N.
  TITLE     A reevaluation of the amino acid sequence of human follitropin
            beta-subunit
  JOURNAL   J Protein Chem 7 (4), 325-339 (1988)
   PUBMED   3151250
REFERENCE   9  (bases 1 to 1856)
  AUTHORS   Watkins,P.C., Eddy,R., Beck,A.K., Vellucci,V., Leverone,B.,
            Tanzi,R.E., Gusella,J.F. and Shows,T.B.
  TITLE     DNA sequence and regional assignment of the human
            follicle-stimulating hormone beta-subunit gene to the short arm of
            human chromosome 11
  JOURNAL   DNA 6 (3), 205-212 (1987)
   PUBMED   2885163
REFERENCE   10 (bases 1 to 1856)
  AUTHORS   Saxena,B.B. and Rathnam,P.
  TITLE     Amino acid sequence of the beta subunit of follicle-stimulating
            hormone from human pituitary glands
  JOURNAL   J Biol Chem 251 (4), 993-1005 (1976)
   PUBMED   1249074
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358944.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The pituitary glycoprotein hormone family includes
            follicle-stimulating hormone, luteinizing hormone, chorionic
            gonadotropin, and thyroid-stimulating hormone. All of these
            glycoproteins consist of an identical alpha subunit and a
            hormone-specific beta subunit. This gene encodes the beta subunit
            of follicle-stimulating hormone. In conjunction with luteinizing
            hormone, follicle-stimulating hormone induces egg and sperm
            production. Alternative splicing results in two transcript variants
            encoding the same protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: Variants 1, 2 and 3 all encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: CD108062.1, BC113488.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000533718.2/ ENSP00000433424.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL358944.12        21350-21384         c
            36-231              AL358944.12        20337-20532         c
            232-1856            AL358944.12        17204-18828         c
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..1856
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="follicle stimulating hormone subunit beta"
                     /db_xref="GeneID:2488"
                     /db_xref="HGNC:HGNC:3964"
                     /db_xref="MIM:136530"
     exon            1..35
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /inference="alignment:Splign:2.1.0"
     exon            36..231
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..462
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="follitropin, beta chain; follitropin subunit beta;
                     FSH-B; FSH-beta; follicle stimulating hormone, beta
                     polypeptide; follicle stimulating hormone beta subunit"
                     /codon_start=1
                     /product="follitropin subunit beta precursor"
                     /protein_id="NP_001369218.1"
                     /db_xref="CCDS:CCDS7868.1"
                     /db_xref="GeneID:2488"
                     /db_xref="HGNC:HGNC:3964"
                     /db_xref="MIM:136530"
                     /translation="MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTT
                     WCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHC
                     GKCDSDSTDCTVRGLGPSYCSFGEMKE"
     exon            232..1856
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="hexamer: AATAAA"
     polyA_site      1701
                     /gene="FSHB"
                     /gene_synonym="HH24"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="hexamer: ATTAAA"
     polyA_site      1856
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="major polyA site"
ORIGIN      
        1 ctacagctct tgccaggcaa ggcagccgac cacagtttct agtgggcttc attgtttgct
       61 tcccagacca ggatgaagac actccagttt ttcttccttt tctgttgctg gaaagcaatc
      121 tgctgcaata gctgtgagct gaccaacatc accattgcaa tagagaaaga agaatgtcgt
      181 ttctgcataa gcatcaacac cacttggtgt gctggctact gctacaccag ggatctggtg
      241 tataaggacc cagccaggcc caaaatccag aaaacatgta ccttcaagga actggtatac
      301 gaaacagtga gagtgcccgg ctgtgctcac catgcagatt ccttgtatac atacccagtg
      361 gccacccagt gtcactgtgg caagtgtgac agcgacagca ctgattgtac tgtgcgaggc
      421 ctggggccca gctactgctc ctttggtgaa atgaaagaat aaagatcagt ggacatttca
      481 ggccacatac ccttgtcctg aaggaccaag atattcaaaa agtctgtgtg tgtgcaatgt
      541 gcccagggga caaaccactg gatcagggga ttcagactct actgatccct ggtctactgg
      601 cagagggaac tctgggaatt gagagtgctg ggggccagga ctccatcatg attcagctct
      661 atattcctag gtctgatttc ataaggttta ttcagtctta actcacagac ttgtgcctgg
      721 tttcttcttt aaaaatctta gaaatcttct caggcaatgc ctctctctta gggggaaaca
      781 taagcctaga aggaggaagc agtaatggga gtgagtgaaa gaactaactg cagcagtctt
      841 ctggtagact cttgggccct ctagagcaag gtcagcatct tcagcattgt agcgtcaatg
      901 cctagcactc tgcctggaac ttagaaacac aacaatgact tctttagatc agaaaggtca
      961 agggtagaaa atactggaag acgatgtttg aggtaagctg atgaggctgc ccgcagccac
     1021 accagtccca tgaaagttag tggcatcagt tccacctcgc cttttctcca gcacatggag
     1081 tattgagaca tgatgtatct ttctgaattg tttggtacag atggggagta acagagctca
     1141 agatttccaa gctattacta ccaagcctgt tagttaaggg caaaggcaag aaattgtaat
     1201 ttggggctgt ggaaattagc ctgcctctat tcattactta aacaaattga tcacatgcta
     1261 ctaggctcct gcaaaactcc tttttgagat aaagggaaaa aaccaaacta tctcacccta
     1321 ccctccctag gatccacttc tttggaatga caaaggattt gaaagtaggt ttgaaagcag
     1381 tttcagcaat ttaataaata taattaattt gtctacaaat atatttgtat aaataaatag
     1441 ctcctttaga aagaattagc catgggggac gaggggaaac tgctgttttc taggatcctg
     1501 tctacatcaa tcttctattt tatccatcca tgttctccca aatctgtgct ttctttcaac
     1561 aggttatata ttaaaactat ttcatgagtt gatttctttt aaacgtgtta actgtcttag
     1621 ttatgcactc agtttcacac tcatattgtt taactaattt atttaaatct tattttttta
     1681 ataaagatgc tagccaccag agtcacaggc ttggattgtt ttatgtacaa acagatgact
     1741 tagatattct gtattttata atattagtgg aatgaaatct taaaatataa ttcccagtgt
     1801 ttctataaat attacctttc cttatctttg gagatattaa aaataatttt gttgga
//
