LOCUS       NM_001018080            1825 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens follicle stimulating hormone subunit beta (FSHB),
            transcript variant 2, mRNA.
ACCESSION   NM_001018080
VERSION     NM_001018080.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Bianco,B., Loureiro,F.A., Trevisan,C.M., Christofolini,D.M.,
            Lagana,A.S. and Barbosa,C.P.
  TITLE     Implication of FSHB rs10835638 variant in endometriosis in
            Brazilian women
  JOURNAL   Einstein (Sao Paulo) 21, eAO0483 (2023)
   PUBMED   37909652
  REMARK    GeneRIF: Implication of FSHB rs10835638 variant in endometriosis in
            Brazilian women.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Zitzmann,M., Schubert,M., Sansone,A. and Kliesch,S.
  TITLE     Spontaneous alterations in semen parameters are associated with
            age, accessory gland function and the FSHB c.-211G>T variant
  JOURNAL   Andrology 11 (7), 1386-1397 (2023)
   PUBMED   36908159
  REMARK    GeneRIF: Spontaneous alterations in semen parameters are associated
            with age, accessory gland function and the FSHB c.-211G>T variant.
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Castellucci,G.A., Kovach,C.K., Howard,M.A. 3rd, Greenlee,J.D.W. and
            Long,M.A.
  TITLE     A speech planning network for interactive language use
  JOURNAL   Nature 602 (7895), 117-122 (2022)
   PUBMED   34987226
  REMARK    GeneRIF: A speech planning network for interactive language use.
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Krenz,H., Sansone,A., Kliesch,S., Gromoll,J. and Schubert,M.
  TITLE     FSHB Genotype Identified as a Relevant Diagnostic Parameter
            Revealed by Cluster Analysis of Men With Idiopathic Infertility
  JOURNAL   Front Endocrinol (Lausanne) 12, 780403 (2021)
   PUBMED   34992580
  REMARK    GeneRIF: FSHB Genotype Identified as a Relevant Diagnostic
            Parameter Revealed by Cluster Analysis of Men With Idiopathic
            Infertility.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1825)
  AUTHORS   Bianco,B., Loureiro,F.A., Trevisan,C.M., Peluso,C.,
            Christofolini,D.M., Montagna,E., Lagana,A.S. and Barbosa,C.P.
  TITLE     Effects of FSHR and FSHB Variants on Hormonal Profile and
            Reproductive Outcomes of Infertile Women With Endometriosis
  JOURNAL   Front Endocrinol (Lausanne) 12, 760616 (2021)
   PUBMED   34659133
  REMARK    GeneRIF: Effects of FSHR and FSHB Variants on Hormonal Profile and
            Reproductive Outcomes of Infertile Women With Endometriosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1825)
  AUTHORS   Keene,J.L., Matzuk,M.M., Otani,T., Fauser,B.C., Galway,A.B.,
            Hsueh,A.J. and Boime,I.
  TITLE     Expression of biologically active human follitropin in Chinese
            hamster ovary cells
  JOURNAL   J Biol Chem 264 (9), 4769-4775 (1989)
   PUBMED   2494176
REFERENCE   7  (bases 1 to 1825)
  AUTHORS   Jameson,J.L., Becker,C.B., Lindell,C.M. and Habener,J.F.
  TITLE     Human follicle-stimulating hormone beta-subunit gene encodes
            multiple messenger ribonucleic acids
  JOURNAL   Mol Endocrinol 2 (9), 806-815 (1988)
   PUBMED   3139991
REFERENCE   8  (bases 1 to 1825)
  AUTHORS   Shome,B., Parlow,A.F., Liu,W.K., Nahm,H.S., Wen,T. and Ward,D.N.
  TITLE     A reevaluation of the amino acid sequence of human follitropin
            beta-subunit
  JOURNAL   J Protein Chem 7 (4), 325-339 (1988)
   PUBMED   3151250
REFERENCE   9  (bases 1 to 1825)
  AUTHORS   Watkins,P.C., Eddy,R., Beck,A.K., Vellucci,V., Leverone,B.,
            Tanzi,R.E., Gusella,J.F. and Shows,T.B.
  TITLE     DNA sequence and regional assignment of the human
            follicle-stimulating hormone beta-subunit gene to the short arm of
            human chromosome 11
  JOURNAL   DNA 6 (3), 205-212 (1987)
   PUBMED   2885163
REFERENCE   10 (bases 1 to 1825)
  AUTHORS   Saxena,B.B. and Rathnam,P.
  TITLE     Amino acid sequence of the beta subunit of follicle-stimulating
            hormone from human pituitary glands
  JOURNAL   J Biol Chem 251 (4), 993-1005 (1976)
   PUBMED   1249074
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358944.12, BI033915.1 and
            CD108062.1.
            
            On Apr 27, 2020 this sequence version replaced NM_001018080.2.
            
            Summary: The pituitary glycoprotein hormone family includes
            follicle-stimulating hormone, luteinizing hormone, chorionic
            gonadotropin, and thyroid-stimulating hormone. All of these
            glycoproteins consist of an identical alpha subunit and a
            hormone-specific beta subunit. This gene encodes the beta subunit
            of follicle-stimulating hormone. In conjunction with luteinizing
            hormone, follicle-stimulating hormone induces egg and sperm
            production. Alternative splicing results in two transcript variants
            encoding the same protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: Variants 1, 2 and 3 all encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: CD108062.1, AV754501.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: PMID: 3139991
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL358944.12        21383-21384         c
            3-35                AL358944.12        21350-21382         c
            36-73               BI033915.1         383-420             c
            74-268              CD108062.1         1-195
            269-1825            AL358944.12        17204-18760         c
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..1825
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="follicle stimulating hormone subunit beta"
                     /db_xref="GeneID:2488"
                     /db_xref="HGNC:HGNC:3964"
                     /db_xref="MIM:136530"
     exon            1..35
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /inference="alignment:Splign:2.1.0"
     exon            36..200
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..431
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="follitropin, beta chain; follitropin subunit beta;
                     FSH-B; FSH-beta; follicle stimulating hormone, beta
                     polypeptide; follicle stimulating hormone beta subunit"
                     /codon_start=1
                     /product="follitropin subunit beta precursor"
                     /protein_id="NP_001018090.1"
                     /db_xref="CCDS:CCDS7868.1"
                     /db_xref="GeneID:2488"
                     /db_xref="HGNC:HGNC:3964"
                     /db_xref="MIM:136530"
                     /translation="MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTT
                     WCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHC
                     GKCDSDSTDCTVRGLGPSYCSFGEMKE"
     exon            201..1825
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="hexamer: AATAAA"
     polyA_site      1670
                     /gene="FSHB"
                     /gene_synonym="HH24"
     regulatory      1805..1810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="hexamer: ATTAAA"
     polyA_site      1825
                     /gene="FSHB"
                     /gene_synonym="HH24"
                     /note="major polyA site"
ORIGIN      
        1 ctacagctct tgccaggcaa ggcagccgac cacagaccag gatgaagaca ctccagtttt
       61 tcttcctttt ctgttgctgg aaagcaatct gctgcaatag ctgtgagctg accaacatca
      121 ccattgcaat agagaaagaa gaatgtcgtt tctgcataag catcaacacc acttggtgtg
      181 ctggctactg ctacaccagg gatctggtgt ataaggaccc agccaggccc aaaatccaga
      241 aaacatgtac cttcaaggaa ctggtatacg aaacagtgag agtgcccggc tgtgctcacc
      301 atgcagattc cttgtataca tacccagtgg ccacccagtg tcactgtggc aagtgtgaca
      361 gcgacagcac tgattgtact gtgcgaggcc tggggcccag ctactgctcc tttggtgaaa
      421 tgaaagaata aagatcagtg gacatttcag gccacatacc cttgtcctga aggaccaaga
      481 tattcaaaaa gtctgtgtgt gtgcaatgtg cccaggggac aaaccactgg atcaggggat
      541 tcagactcta ctgatccctg gtctactggc agagggaact ctgggaattg agagtgctgg
      601 gggccaggac tccatcatga ttcagctcta tattcctagg tctgatttca taaggtttat
      661 tcagtcttaa ctcacagact tgtgcctggt ttcttcttta aaaatcttag aaatcttctc
      721 aggcaatgcc tctctcttag ggggaaacat aagcctagaa ggaggaagca gtaatgggag
      781 tgagtgaaag aactaactgc agcagtcttc tggtagactc ttgggccctc tagagcaagg
      841 tcagcatctt cagcattgta gcgtcaatgc ctagcactct gcctggaact tagaaacaca
      901 acaatgactt ctttagatca gaaaggtcaa gggtagaaaa tactggaaga cgatgtttga
      961 ggtaagctga tgaggctgcc cgcagccaca ccagtcccat gaaagttagt ggcatcagtt
     1021 ccacctcgcc ttttctccag cacatggagt attgagacat gatgtatctt tctgaattgt
     1081 ttggtacaga tggggagtaa cagagctcaa gatttccaag ctattactac caagcctgtt
     1141 agttaagggc aaaggcaaga aattgtaatt tggggctgtg gaaattagcc tgcctctatt
     1201 cattacttaa acaaattgat cacatgctac taggctcctg caaaactcct ttttgagata
     1261 aagggaaaaa accaaactat ctcaccctac cctccctagg atccacttct ttggaatgac
     1321 aaaggatttg aaagtaggtt tgaaagcagt ttcagcaatt taataaatat aattaatttg
     1381 tctacaaata tatttgtata aataaatagc tcctttagaa agaattagcc atgggggacg
     1441 aggggaaact gctgttttct aggatcctgt ctacatcaat cttctatttt atccatccat
     1501 gttctcccaa atctgtgctt tctttcaaca ggttatatat taaaactatt tcatgagttg
     1561 atttctttta aacgtgttaa ctgtcttagt tatgcactca gtttcacact catattgttt
     1621 aactaattta tttaaatctt atttttttaa taaagatgct agccaccaga gtcacaggct
     1681 tggattgttt tatgtacaaa cagatgactt agatattctg tattttataa tattagtgga
     1741 atgaaatctt aaaatataat tcccagtgtt tctataaata ttacctttcc ttatctttgg
     1801 agatattaaa aataattttg ttgga
//
