LOCUS       NM_001007122            6418 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens fibronectin type III and SPRY domain containing 2
            (FSD2), transcript variant 1, mRNA.
ACCESSION   NM_001007122 XM_058721
VERSION     NM_001007122.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6418)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6418)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6418)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6418)
  AUTHORS   Benson,M.A., Tinsley,C.L., Waite,A.J., Carlisle,F.A., Sweet,S.M.M.,
            Ehler,E., George,C.H., Lai,F.A., Martin-Rendon,E. and Blake,D.J.
  TITLE     Ryanodine receptors are part of the myospryn complex in cardiac
            muscle
  JOURNAL   Sci Rep 7 (1), 6312 (2017)
   PUBMED   28740084
  REMARK    GeneRIF: Data identify a novel muscle-expressed TRIM-related
            protein minispryn, encoded by Fsd2, that has extensive sequence
            similarity with the C-terminus of Cmya5. They appear to have
            originated by a chromosomal duplication and are found within
            evolutionarily-conserved gene clusters on different chromosomes.
            Both proteins co-localize with RyR2 at the junctional sarcoplasmic
            reticulum of isolated cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6418)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 6418)
  AUTHORS   Dong,C., Beecham,A., Slifer,S., Wang,L., Blanton,S.H., Wright,C.B.,
            Rundek,T. and Sacco,R.L.
  TITLE     Genomewide linkage and peakwide association analyses of carotid
            plaque in Caribbean Hispanics
  JOURNAL   Stroke 41 (12), 2750-2756 (2010)
   PUBMED   20966410
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK122875.1, AC105339.9 and
            AL833295.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001007122.3.
            
            Summary: This gene encodes a protein that belongs to the FN3/SPRY
            family of proteins. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122875.1, AL833295.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334574.12/ ENSP00000335651.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2335              AK122875.1         1-2335
            2336-2336           AC105339.9         43543-43543
            2337-2679           AK122875.1         2337-2679
            2680-2977           AL833295.1         2681-2978
            2978-6216           AC105339.9         44185-47423
            6217-6415           AL833295.1         6218-6416
            6416-6418           AC105339.9         47623-47625
FEATURES             Location/Qualifiers
     source          1..6418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..6418
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /note="fibronectin type III and SPRY domain containing 2"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
     exon            1..104
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..821
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2432
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /note="isoform a is encoded by transcript variant 1; SPRY
                     domain containing 1; fibronectin type III and SPRY
                     domain-containing protein 2; SPRY domain-containing
                     protein 1; minispryn"
                     /codon_start=1
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2 isoform a"
                     /protein_id="NP_001007123.1"
                     /db_xref="CCDS:CCDS45332.1"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
                     /translation="MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMR
                     KVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSE
                     YPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEE
                     YECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHK
                     NMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQA
                     LGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKF
                     LKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRV
                     CWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTA
                     HNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQA
                     ESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYF
                     RLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYW
                     EVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRI
                     TVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGI
                     SMPKHVTFY"
     exon            822..917
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1148
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1171
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1293
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1449
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1584
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1735
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1869
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2002
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2179
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..6418
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3127..3132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /note="hexamer: AATAAA"
     polyA_site      3147
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /note="major polyA site"
     regulatory      6395..6400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /note="hexamer: AATAAA"
     polyA_site      6418
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
ORIGIN      
        1 atgcagaggt cactaggaag gaaagcctgc tgaacacaga ttcaattttc tagcagaact
       61 ccaggtcctc tgagttaaag gaagcattta tggacgctta gcagggccca gatattcact
      121 attaagtgtc caggaaggat ctttcttata taaaggtgct tctgaggact tccagagtta
      181 caatggagga ggaatcgggg gaggaactgg ggctggacag gtctactccc aaggatttcc
      241 acttttacca catggacctg tatgactctg aagacagact gcacctcttt ccagaagaga
      301 acactaggat gaggaaagta gtccaagctg aaatggccaa tgagtcaaga ggagcagggg
      361 atggtaaggc tcaaagagac cttcaagagg aagtggatga acttgtccac ttatatggac
      421 ttgaagatga tcatgaatta ggggatgagt ttgttgatga aaacataccc agaacagggg
      481 tttcagaata tcctccttat atgatgaaga ggagagaccc agccagggag cagagagact
      541 ggagacttag tggagaggca gcggaggccg aggacctggg cttcggaggg tggggctcag
      601 caggccagtg ccaggacttg cgggaagcct ataggtacac acacggccgt gccagcgagg
      661 agtatgaatg ctatgtcatc cccgaggaag aggatgaaga agaagctgct gatgtcttct
      721 gtgtcacttg taagactcca ataagagctt ttcagaaggt ttttgatgaa cataaggagc
      781 atgaagtgat cccactcaat gaagcactgg aaagtgccaa ggatgaaatt cacaaaaaca
      841 tgtacaaatt ggaaaagcag ataattgaga tggaaaactt tgcaaatcat ttggaggagg
      901 ttttcatcac tgtggaggag aattttggaa aacaagaaca aaactttgag tcacattaca
      961 acgagatctt ggaaacactt gctcaaaaat atgaggaaaa aatacaagct ctaggggaga
     1021 aaaagaaaga gaagctggaa gccttatatg gacaactggt cagctgtgga gaaaacctag
     1081 atacttgcaa agaactgatg gaaacaatag aggagatgtg tcacgaggag aaggtggatt
     1141 tcataaagga tgcagtggct atggctgaca gactcgggaa attcctgaaa acaaaaacag
     1201 acgtggaaat ctctgcacag cctgagtttg aagaccagac cttggatttc tctgatgtgg
     1261 agcagctgat gggctccatt aacaccattc cagctccttc tgctccagtc ataaatccac
     1321 aggtccctaa ctcagccaca ggttcctcag tccgagtgtg ctggagctta tactccgacg
     1381 acactgtgga gagctatcag ctgtcctacc ggccagtgca ggacagctca cctgggacgg
     1441 accaagcaga gtttacagtg actgtcaaag aaacatattg ctcagtgaca aaccttgtgc
     1501 caaataccca gtatgaattt tgggtcacag ctcacaacag ggctggcccc agcccctcta
     1561 gcgagcgtgc agtgtacatg acagcacctt ctccccccat tattaaaacc aaagagataa
     1621 ggagctgtga agaggctgtg ctgatttgct gggagtctgg gaacctgaat cctgtggact
     1681 cgtacactgt ggagctgacc caggctgaaa gtccagaagc ctcgggtgta actgagtctg
     1741 ttgtgggcat cccgacctgc gagtccgtgg tgcagctgca gccggggcgg agctacatta
     1801 tctatgtgcg agccctcaat atggggggcc ccagcgtgag gagcgagcca gctacagtcc
     1861 acaccatagg aagctacttt cgcctaaaca aggacacttg ccatccctgg ctgaccattt
     1921 ctgaagacgg acttacggct gtacgaagtg aaaggagaac ccccgccagg gagctgtcac
     1981 ccagcgacac tcacttcacc aggtgtgttg ctgtcatggg aaatctaatt ccagtccgag
     2041 ggcaccatta ctgggaggtg gaggtggatg agcatttgga ctacagagtt ggtgtggcct
     2101 ttgcagatgt ccgtaaacag gaggatctgg gagcaaattg cctctcctgg tgcatgaggc
     2161 acacatttgc atcatcaagg cataagtatg aatttctgca caacagaaca actccagata
     2221 taagaataac agttccacca aagaagattg gcattctatt agactatgaa cattcaaagt
     2281 tgtcattttt caatgtggac ctttctcagc atctatatac atttagttgt cagcttcacg
     2341 aatttgtgca tccctgtttt tctttggaaa agcctgggtg tctaaaggta cataatggca
     2401 tttcaatgcc aaaacatgtc actttctatt agaacattct gatgtccagt ttcctgtctt
     2461 ccatgcctac ccctctcgca gctgctcacg ccttagctgg ctgaacctgg cacttaagca
     2521 ccatgtgccc agcacaattt atggctcatg ctattatctg actggtgtgc tagcgctcat
     2581 ttcacccaac ctggattcta gtcctgtgtg ctgctacctg tgtgctgcta ggatagtcat
     2641 taccaggccc agctgtaaaa taaaggctca gactaaacga actcaaaagt ctttgaagct
     2701 gtcaaactat attcgtgtat atgcaaaata tcttgagttt ccaagaccta gagagcttgg
     2761 gagaggacga gggtagtctt aatggctcca gcagcaccag tacacccatg catttcatga
     2821 gtcagccaag aatacacttg agaaggcgag aggctgtctg tagagaacca gggaagctgt
     2881 gtgcccttct caatgtcttc taccctcgtt ttcccaatag tgagcagcac tgtggtgagg
     2941 tcccttccac tgtgtactct gcatacaggg tattccctgt tccactccta cacagtatgc
     3001 accactctct aattttgaaa ttacctctat aatgcctaat tccatgaagg gagggacagt
     3061 gcctgttttg ttcattgcta gatcaccaag ggctaacaca taacagctgt caccaagtat
     3121 ttgttgaata aattagtatc ttcttcagcc actgctcttt ggcctcttac tgctctccat
     3181 gtgaaggatg gcagggctct ttcaaaacta cagcaaagga cctatggcca agaaatggga
     3241 aaaaacctag aatggaggca gcgtgaaaga acagaagggc atctgtggca tattagcaaa
     3301 tgcacaacaa ttttttaaaa gaaattaaca gcccaccaaa gggcaaagct gagcacggga
     3361 aggaagactg atctctagct aggcagcttt caggcatcct gcctcactgc ccccaggcca
     3421 ttctgtgagc tcaatgccca actccatcag ctacattcct ggttctcctg ttcaagtttc
     3481 cagttgccac ttaagctctg cacacacagc attttcaaag cttgtgagtg aagctgcaga
     3541 ataattccat ttgtgaagca attacaattc agtatcatgt cccacagatg cctctaaacc
     3601 cagatatgcc ctaatctcat catttaaggt tttgtgttta aaaaaaaaaa gtccactttt
     3661 cttttttctg gcgaaacccc gtctctacta aaaatacaaa aaattagccg ggcatggtgg
     3721 tgggcgcctg taatcccagc tactcaggag gctgaggcag gagaattgct tgaacccggg
     3781 ggcagaggct gcagtgagcc gagattgtgc cactgcactc cagccttggc aacaagagcg
     3841 caactctgtc tcaaaaacaa acaaacaaac aaacaaaaaa cctctgatgt tttccagcac
     3901 ctgcaaagtc tgacaaactg aaagactctc atctcctact aaactctgcc tactcgtata
     3961 aatggcagct cagattcctg aattaacaat tcacactgac aatttaataa ctcgttatac
     4021 acacacacac ctatcctgcc aagctggact gtctactctg aaacaaggga cagcagatgt
     4081 aagcacagaa atagttccag ttataaacaa ttaaaagata catatcatgt atatttaaaa
     4141 atgttctcgg ccgggcgcgg tggctcacgc ctgtaatccc agcactttgg ggggccaagg
     4201 tggatggatc acaaggtcag gagatcgaga ccatcctggc taatacggtg aaaccccgtc
     4261 tctactaaaa atacaaaaaa attagccggg actggtggcg ggcgcctgta gtcccagcta
     4321 ctcgggaggc tgaggcagga gaatggcgtg aacccgggag gtggagcttg cagtgagccg
     4381 agatggctca cagatcaaga ctccatctca aaaaaaaaaa aaaaaaaagt tctcagctac
     4441 tgaaatagaa actaccaagt aagaaacagg atatcacaga gaaggcaagt ttgaattcag
     4501 ggttctaata ggctttatgg aatactacac gttagtatga acacggataa atggattaaa
     4561 aactcaacac gtataaagtt ttaattaaat ttttatttga ccaagaaaaa actgtctaga
     4621 attgcctgac atttaaaatc cacttaaagc agattagcaa cttcaagcat cacaattatt
     4681 cagcataaag agcctttgtt gaaacatctt tctcatttat ttagaagaaa acatctagaa
     4741 cagaaccaag caaaactttt gtatttttgt aaaaaatctc aattcctgaa actactataa
     4801 acaatctact gaaactgtat tcagcaaggg acagatttac ctcaaggcca tgttcacctg
     4861 caacctgctg ataagtctgt taaaaaacaa agcaaaaaaa agagttttta aaaattagac
     4921 cactgtagcc acaatcccta acactggaca gttaaaacaa aagttatcaa aatctgttct
     4981 tttcttagct ttacctgtat cactttataa ctcctgagaa agtcattcac ataagctgtg
     5041 gcctccccac cttaacaaag gggaaaaaga atatgtaaaa ccaccacaga atcttggcgt
     5101 aaactaacat gggtttagta atacagagta cagtattcag gatttaaggc acccttacaa
     5161 gtcagaattg gaaagttggt ttgagacttg caatctaaaa tgacactgat ttctgataaa
     5221 attaaatgac ttttatttag aaaagtgtgt ttaataaatt acttcctgct ggttcaaatg
     5281 acacacaatc actttgtata catccaataa gatatttctg aagtgtatac ttggtcaaaa
     5341 gtaaaaagca gagcaaatgc atggacagtg gggccttctt cttaatactt ctcatcctcc
     5401 aaaatctgtt aaaatcatca tcttccacaa ctcacacact ggaagctgtc cacagcacaa
     5461 ttcactgtga tgtggcattc tgtaaataag actacattgg tcttgatgca aggcggttca
     5521 gctaccagac tgcactataa gaaaagtcct ctcctcaact taccaagaaa acttcgccaa
     5581 tttctagtca ccttcctatc aattagtaga gcaagattct cacatgttca ctatgtcttt
     5641 ctccagtttt ctcatctata agtgtactac tcctattttc tataggaaga caatggaaag
     5701 cgtgtaattg ctgttggtag ataagtaggt cttgaattta ttttgcaaac aagacctgtt
     5761 ctatctacct tttcatttag gaggctaaaa gcagagtcag cttgatttca aggactctat
     5821 tttcttagtc tccagaagaa cataaccaaa tccagctttt aaaacactgt cctttaacaa
     5881 gtcaagatac tcaaataaag atcatgtata acttcaagct ataggagatt aactctgtac
     5941 atatgcttgt ttcactgtaa ccaatggtta attaatctaa atgcaagaga aaagttattt
     6001 ggaaagaaga ccccagctgg tcagcatctt ttctgtcatc aggaagtctc ctggaaggag
     6061 tatgactatg acctgggcac aacaactgcc cctaagttag tacttatttt agagttgcta
     6121 ctgaacaggt ggtggttctt gtcaagtata tcatgtctga ctactttact gcttgttttc
     6181 tgctatcacc agttccagaa aaaaaaaaaa aaaaaattaa gcccaactca ctaattgatt
     6241 gctttttcat tttcccagac tgtgacagaa tcatggtttt tagctctatt ttcaccttac
     6301 tcaaatcctg gaggaattaa actatcattt atttgaaatg ttacaaatta gcctgcagtt
     6361 gattcaaaca acatgtagtc actcagacat agcaaataaa aatgttttgg tatatgaa
//
