LOCUS       NM_024333               1833 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens fibronectin type III and SPRY domain containing 1
            (FSD1), transcript variant 1, mRNA.
ACCESSION   NM_024333 XM_940073
VERSION     NM_024333.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Gao,S., Zhao,Z., Wu,R., Wu,L., Tian,X. and Zhang,Z.
  TITLE     MiR-1 inhibits prostate cancer PC3 cells proliferation through the
            Akt/mTOR signaling pathway by binding to c-Met
  JOURNAL   Biomed Pharmacother 109, 1406-1410 (2019)
   PUBMED   30551391
  REMARK    GeneRIF: Proliferation of PC cells by targeting the c-Met/Akt/mTOR
            signaling pathway.
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   Tu,H.Q., Qin,X.H., Liu,Z.B., Song,Z.Q., Hu,H.B., Zhang,Y.C.,
            Chang,Y., Wu,M., Huang,Y., Bai,Y.F., Wang,G., Han,Q.Y., Li,A.L.,
            Zhou,T., Liu,F., Zhang,X.M. and Li,H.Y.
  TITLE     Microtubule asters anchored by FSD1 control axoneme assembly and
            ciliogenesis
  JOURNAL   Nat Commun 9 (1), 5277 (2018)
   PUBMED   30538248
  REMARK    GeneRIF: The centrosome protein FSD1 anchors microtubule asters to
            interphase centrosomes by binding to microtubules.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Xu,W., Zhang,Z., Zou,K., Cheng,Y., Yang,M., Chen,H., Wang,H.,
            Zhao,J., Chen,P., He,L., Chen,X., Geng,L. and Gong,S.
  TITLE     MiR-1 suppresses tumor cell proliferation in colorectal cancer by
            inhibition of Smad3-mediated tumor glycolysis
  JOURNAL   Cell Death Dis 8 (5), e2761 (2017)
   PUBMED   28471448
  REMARK    GeneRIF: Overexpression of miR-1 mimics significantly decreased
            tumor glycolysis, including lactate production and glucose uptake,
            and cell proliferation, and these effects were reversed by ectopic
            expression of Smad3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Han,C., Shen,J.K., Hornicek,F.J., Kan,Q. and Duan,Z.
  TITLE     Regulation of microRNA-1 (miR-1) expression in human cancer
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (2), 227-232 (2017)
   PUBMED   27923712
  REMARK    GeneRIF: These regulatory mechanisms of miR-1 expression could help
            us to understand the functions of altered miR-1 expression.
            Review article
REFERENCE   5  (bases 1 to 1833)
  AUTHORS   Xiao,H., Zeng,J., Li,H., Chen,K., Yu,G., Hu,J., Tang,K., Zhou,H.,
            Huang,Q., Li,A., Li,Y., Ye,Z., Wang,J. and Xu,H.
  TITLE     MiR-1 downregulation correlates with poor survival in clear cell
            renal cell carcinoma where it interferes with cell cycle regulation
            and metastasis
  JOURNAL   Oncotarget 6 (15), 13201-13215 (2015)
   PUBMED   26036633
  REMARK    GeneRIF: Taken together, our findings established a tumor
            suppressive role for miR-1 in the progression of ccRCC by targeting
            CDK4, CDK6, Caprin1 and Slug and suggested miR-1 can be served as a
            novel potential therapeutic target for ccRCC.
            Erratum:[Oncotarget. 2019 Dec 24;10(67):7183-7184. doi:
            10.18632/oncotarget.27357.. PMID: 31903176]
REFERENCE   6  (bases 1 to 1833)
  AUTHORS   Manabe,Ri., Whitmore,L., Weiss,J.M. and Horwitz,A.R.
  TITLE     Identification of a novel microtubule-associated protein that
            regulates microtubule organization and cytokinesis by using a
            GFP-screening strategy
  JOURNAL   Curr Biol 12 (22), 1946-1951 (2002)
   PUBMED   12445389
REFERENCE   7  (bases 1 to 1833)
  AUTHORS   Stein,P.A., Toret,C.P., Salic,A.N., Rolls,M.M. and Rapoport,T.A.
  TITLE     A novel centrosome-associated protein with affinity for
            microtubules
  JOURNAL   J Cell Sci 115 (Pt 17), 3389-3402 (2002)
   PUBMED   12154070
  REMARK    GeneRIF: Data report the identification of MIR1, a protein with
            microtubule-binding activity which is located at the centrosome and
            is related to MID1/midin. [MIR1]
REFERENCE   8  (bases 1 to 1833)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     Characterization of human FSD1, a novel brain specific gene on
            chromosome 19 with paralogy to 9q31
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 200-203 (2001)
   PUBMED   11267680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA690632.1, BC003124.1 and
            AC008616.6.
            
            On Nov 22, 2018 this sequence version replaced NM_024333.2.
            
            Summary: This gene encodes a centrosome associated protein that is
            characterized by an N-terminal coiled-coil region downstream of
            B-box (BBC) domain, a central fibronectin type III domain, and a
            C-terminal repeats in splA and RyR (SPRY) domain. The encoded
            protein associates with a subset of microtubules and may be
            involved in the stability and organization of microtubules during
            cytokinesis. [provided by RefSeq, Apr 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.965954.1,
                                           SRR3476690.765012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221856.11/ ENSP00000221856.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                DA690632.1         5-100
            97-376              BC003124.1         1-280
            377-377             AC008616.6         18936-18936         c
            378-1833            BC003124.1         282-1737
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1833
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /note="fibronectin type III and SPRY domain containing 1"
                     /db_xref="GeneID:79187"
                     /db_xref="HGNC:HGNC:13745"
                     /db_xref="MIM:609828"
     exon            1..164
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1640
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fibronectin type 3 and SPRY domain containing 1;
                     fibronectin type 3 and SPRY (spla, ryanodine) domain
                     containing (with coiled-coil motif) 1;
                     microtubule-associated protein GLFND; midline 1-related
                     protein 1; fibronectin type III and SPRY domain-containing
                     protein 1; MID1-related protein 1"
                     /codon_start=1
                     /product="fibronectin type III and SPRY domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_077309.1"
                     /db_xref="CCDS:CCDS12127.1"
                     /db_xref="GeneID:79187"
                     /db_xref="HGNC:HGNC:13745"
                     /db_xref="MIM:609828"
                     /translation="MEEQREALRKIIKTLAVKNEEIQSFIYSLKQMLLNVEANSAKVQ
                     EDLEAEFQSLFSLLEELKEGMLMKIKQDRASRTYELQNQLAACTRALESSEELLETAN
                     QTLQAMDSEDFPQAAKQIKDGVTMAPAFRLSLKAKVSDNMSHLMVDFAQERQMLQALK
                     FLPVPSAPVIDLAESLVADNCVTLVWRMPDEDSKIDHYVLEYRRTNFEGPPRLKEDQP
                     WMVIEGIRQTEYTLTGLKFDMKYMNFRVKACNKAVAGEFSEPVTLETPAFMFRLDAST
                     SHQNLRVDDLSVEWDAMGGKVQDIKAREKDGKGRTASPINSPARGTPSPKRMPSGRGG
                     RDRFTAESYTVLGDTLIDGGEHYWEVRYEPDSKAFGVGVAYRSLGRFEQLGKTAASWC
                     LHVNNWLQVSFTAKHANKVKVLDAPVPDCLGVHCDFHQGLLSFYNARTKQVLHTFKTR
                     FTQPLLPAFTVWCGSFQVTTGLQVPSAVRCLQKRGSATSSSNTSLT"
     exon            165..260
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..392
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..494
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..517
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..639
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..849
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..948
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1108
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1188
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1440
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1529
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1833
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /note="hexamer: AATAAA"
     polyA_site      1833
                     /gene="FSD1"
                     /gene_synonym="GLFND; MIR1"
                     /note="major polyA site"
ORIGIN      
        1 gcaatgcgcg cggtgatgga gcgctaaccg ggggcgcggc ggcggcgagg gctcggcggg
       61 ccattggcta ccggccgcgg caaaggcagc ttggggaccc agcgtgcgcg gggcccgcgg
      121 gccgggccgg ggtgacctgg gctgcagcca tggaagaaca gagggaggcc ctgaggaaga
      181 tcatcaaaac actggctgtg aagaatgaag aaattcagag ctttatctac tccctgaaac
      241 agatgctgct gaacgtggag gcgaactcgg cgaaggtgca ggaggacctc gaagcagagt
      301 tccagtccct cttctccctc ctggaggagc tgaaagaagg catgcttatg aagataaaac
      361 aggaccgtgc cagccgtacc tacgagctgc agaaccagct ggctgcctgc acgcgggccc
      421 tggagagctc cgaggagctt ctggagacag ccaaccagac tctgcaggcc atggacagcg
      481 aggactttcc tcaggctgcc aagcaaatca aagatggagt gaccatggcc cctgccttcc
      541 ggctatcatt gaaagcgaag gtcagtgaca acatgagtca cctcatggtg gacttcgcgc
      601 aagagcggca gatgctacag gcactcaagt tcctgcctgt gcccagcgca cccgtgatcg
      661 acctggctga gtccctggtg gcagataact gtgtgaccct ggtgtggcgc atgccggatg
      721 aggacagcaa gattgaccac tacgtgctgg agtaccggcg gaccaacttc gagggcccgc
      781 cccgcctcaa ggaggaccag ccctggatgg tcatcgaggg catccggcag acagagtaca
      841 ccctgacagg tctcaagttt gacatgaaat acatgaactt ccgtgtgaag gcctgtaaca
      901 aggcagttgc aggagagttc tctgagccgg tgactctgga gacaccagcg ttcatgttcc
      961 gcctggatgc gtccacatcc caccagaacc tgcgggtgga tgatctctcc gtggagtggg
     1021 acgctatggg cgggaaggtg caggatatca aggctcgcga gaaagatggc aaggggcgga
     1081 cggcgtctcc catcaactcc ccagccagag gtactccatc tcccaagagg atgccctcag
     1141 gtcgtggggg acgggaccgc ttcaccgctg agtcctacac agttctgggg gacacgctga
     1201 tcgacggcgg ggagcattac tgggaggtgc gctacgagcc ggacagcaag gcgttcggcg
     1261 tgggcgtggc ctaccgcagc ctgggccgct tcgagcaact gggcaagacg gccgcctcct
     1321 ggtgcctgca cgtcaacaat tggctgcagg tcagcttcac ggccaagcac gccaacaagg
     1381 tcaaggtgct ggacgccccc gtgcccgact gcctgggtgt gcactgtgac ttccaccaag
     1441 gcctcctgtc cttctacaat gcccgcacca aacaagtgct gcacactttc aagaccaggt
     1501 tcacacagcc gctgctgcct gctttcacgg tatggtgtgg cagcttccag gtgacgacag
     1561 gcctgcaggt ccccagtgct gtgcgctgcc tgcaaaagcg aggcagtgct accagcagct
     1621 ccaacaccag cctcacctag gcccccaggc acccacccag ctggggtgtt tttgggggag
     1681 tcgccgccaa gcccaggctg ctggagccag gcaccctcct ctgtcacttg ctgcttggag
     1741 ccttaactcc agatgggggg gtcaccaaga gggagtgggc accctggcgg gccctctccc
     1801 cacctcacct cttaataaag gtcagacact ggc
//
