LOCUS       NM_020369               2137 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens fascin actin-bundling protein 3 (FSCN3), mRNA.
ACCESSION   NM_020369
VERSION     NM_020369.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
REFERENCE   2  (bases 1 to 2137)
  AUTHORS   Tubb,B., Mulholland,D.J., Vogl,W., Lan,Z.J., Niederberger,C.,
            Cooney,A. and Bryan,J.
  TITLE     Testis fascin (FSCN3): a novel paralog of the actin-bundling
            protein fascin expressed specifically in the elongate spermatid
            head
  JOURNAL   Exp Cell Res 275 (1), 92-109 (2002)
   PUBMED   11925108
REFERENCE   3  (bases 1 to 2137)
  AUTHORS   Tubb,B.E., Bardien-Kruger,S., Kashork,C.D., Shaffer,L.G.,
            Ramagli,L.S., Xu,J., Siciliano,M.J. and Bryan,J.
  TITLE     Characterization of human retinal fascin gene (FSCN2) at 17q25:
            close physical linkage of fascin and cytoplasmic actin genes
  JOURNAL   Genomics 65 (2), 146-156 (2000)
   PUBMED   10783262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF281049.1, BC035606.1 and AC073934.1.
            
            On May 17, 2019 this sequence version replaced NM_020369.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.251273.1,
                                           SRR5189667.317789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265825.6/ ENSP00000265825.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1782              AF281049.1         102-1883
            1783-1790           BC035606.1         1759-1766
            1791-2137           AC073934.1         122077-122423       c
FEATURES             Location/Qualifiers
     source          1..2137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..2137
                     /gene="FSCN3"
                     /note="fascin actin-bundling protein 3"
                     /db_xref="GeneID:29999"
                     /db_xref="HGNC:HGNC:3961"
                     /db_xref="MIM:615800"
     exon            1..262
                     /gene="FSCN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1615
                     /gene="FSCN3"
                     /note="testis fascin; fascin homolog 3, actin-bundling
                     protein, testicular; fascin actin-bundling protein 3,
                     testicular; testicular secretory protein Li 18"
                     /codon_start=1
                     /product="fascin-3"
                     /protein_id="NP_065102.1"
                     /db_xref="CCDS:CCDS34746.1"
                     /db_xref="GeneID:29999"
                     /db_xref="HGNC:HGNC:3961"
                     /db_xref="MIM:615800"
                     /translation="MDETEWIHRHPKAEDLRVGLISWAGTYLTFEACKNTVTATAKSL
                     GRRQTWEILVSNEHETQAVVRLKSVQGLYLLCECDGTVCYGRPRTSHHGCFLLRFHRN
                     SKWTLQCLISGRYLESNGKDVFCTSHVLSAYHMWTPRPALHVHVILYSPIHRCYARAD
                     PTMGRIWVDAAVPCLEECGFLLHFRDGCYHLETSTHHFLSHVDRLFSQPSSQTAFHMQ
                     VRPGGLVALCDGEGGMLYPQGTHLLLGMGCNPMRGEEWFILQHCPTWVSLRSKTGRFI
                     SVIYDGEVRAASERLNRMSLFQFECDSESPTVQLRSANGYYLSQRRHRAVMADGHPLE
                     SDTFFRMHWNCGRIILQSCRGRFLGIAPNSLLMANVILPGPNEEFGILFANRSFLVLR
                     GRYGYVGSSSGHDLIQCNQDQPDRIHLLPCRPGIYHFQAQGGSFWSITSFGTFRPWGK
                     FALNFCIELQGSNLLTVLAPNGFYMRADQSGTLLADSEDITRECIWEF"
     exon            263..959
                     /gene="FSCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1078
                     /gene="FSCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1238
                     /gene="FSCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1409
                     /gene="FSCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1615
                     /gene="FSCN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..2137
                     /gene="FSCN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSCN3"
                     /note="hexamer: AATACA"
     polyA_site      1790
                     /gene="FSCN3"
                     /note="major polyA site"
ORIGIN      
        1 ctctctggga acatctggtg ggtactacag gccctattcc aggccctatg gcctgtggaa
       61 cctcaccacg ggggggaggg ctgggccaga cggagacatc acctgtggtg tcagccccat
      121 ggatgagaca gagtggatac acagacatcc caaggctgag gacctaaggg ttgggctcat
      181 cagctgggca ggaacctacc tcacctttga ggcatgcaag aatacagtca ctgcaactgc
      241 gaagagtttg ggcaggagac agacctggga gatcttggtg agcaatgagc atgagacaca
      301 ggccgtggtg cgactaaaga gcgtgcaggg cctctacctg ctgtgtgagt gtgatggcac
      361 cgtgtgttat ggccgcccaa ggaccagcca ccatgggtgc tttctactgc gtttccaccg
      421 gaacagcaag tggaccctcc agtgcctaat ctctggtcgt tatttggagt ccaatggcaa
      481 ggacgtgttt tgcacttccc acgtcctctc agcttaccac atgtggaccc cccgaccagc
      541 cctccatgtc cacgtgatcc tctacagccc catccaccgc tgctatgccc gggctgaccc
      601 cactatgggc cgcatctggg tggacgcagc agttccctgc ctggaggagt gtggcttcct
      661 gttgcatttc cgagatggat gctaccacct ggagacctct acacaccact tcttgtccca
      721 tgtagaccgg ctgttctccc aaccctcatc acagacagct tttcacatgc aagtgcggcc
      781 tggagggctt gtggcactgt gtgatggaga aggaggcatg ttatatccac agggcacgca
      841 tctgctcttg ggcatgggct gcaaccccat gaggggtgag gagtggttca tcctacagca
      901 ctgcccaacc tgggtcagcc tcaggtcaaa gactgggcgg ttcatctcag tcatctacga
      961 tggtgaggtg cgtgctgctt ctgagcgctt aaaccgaatg tccttgttcc agtttgaatg
     1021 tgacagtgag agccccactg tgcagcttcg ttcagccaat ggctactacc tatcccagag
     1081 gcgccacagg gcagtaatgg ctgatgggca ccccctggag tctgacacgt tcttccgaat
     1141 gcactggaac tgtggcagga tcatcctgca gtcctgcagg gggcgcttcc tgggcattgc
     1201 acccaacagc ctgctgatgg ccaatgtcat ccttccaggc ccaaatgagg aatttgggat
     1261 tttatttgcc aatcgctcct tccttgtatt gcgaggtcgt tatggctatg tgggctcctc
     1321 atcgggccat gacctcatac agtgcaacca ggatcagccc gaccgcattc atctactacc
     1381 ctgccgaccg ggtatctacc acttccaggc acagggggga tccttctggt caataacatc
     1441 ctttggcacc tttcgccctt ggggcaagtt tgccctcaac ttctgtatcg agcttcaggg
     1501 gagcaactta ctcactgtac tggcccccaa tggcttctac atgcgagccg accaaagtgg
     1561 caccctgttg gcagacagtg aagacattac cagagagtgt atctgggaat tttaggtcaa
     1621 tgggatgtca cctaccaaaa tccaaatcct ccaggaaaaa ctactacact aaatggacca
     1681 ggaacctcag agtcaagatc caagagaaga acatctgtta caacttttcc tacccagttt
     1741 agcaaaacac ctgttttatg caacaataca tcacaacagg ccacccccaa gatccttgtg
     1801 tgcatctgac tcaatataga ataggggtct ggatgagggt tgaaacagac accccaggct
     1861 gctctaagtt ctatacagga gagaccaaat ggcaagcagt tcttccactg atcttccccg
     1921 tccccatcca gaactgctag actttttcca gtgaacccat gagcagccag cattgccctg
     1981 aagggtttag aatccagtta tgactttaaa tatctttttg gtttagaaaa aaggaaagat
     2041 tgttaatctc gtgagcacag gataatggta ataacacctt atgcctgtat aggccacttt
     2101 acctcctcct accacgattt atttaacttc cccaccc
//
