LOCUS       NM_003088               2784 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens fascin actin-bundling protein 1 (FSCN1), mRNA.
ACCESSION   NM_003088
VERSION     NM_003088.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2784)
  AUTHORS   Abdullah,A.R., Gamal El-Din,A.M., Ismail,Y. and El-Husseiny,A.A.
  TITLE     The FSCN1 gene rs2966447 variant is associated with increased serum
            fascin-1 levels and breast cancer susceptibility
  JOURNAL   Gene 927, 148743 (2024)
   PUBMED   38964493
  REMARK    GeneRIF: The FSCN1 gene rs2966447 variant is associated with
            increased serum fascin-1 levels and breast cancer susceptibility.
REFERENCE   2  (bases 1 to 2784)
  AUTHORS   Tian,Q., Huang,J., Zhang,Q. and Zhao,J.
  TITLE     N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3
            contributes to human papillomavirus type 16-infected cervical
            squamous cell carcinoma
  JOURNAL   Clin Exp Pharmacol Physiol 51 (6), e13864 (2024)
   PUBMED   38679464
  REMARK    GeneRIF: N6-methyladenosine methylation on FSCN1 mediated by
            METTL14/IGF2BP3 contributes to human papillomavirus type
            16-infected cervical squamous cell carcinoma.
REFERENCE   3  (bases 1 to 2784)
  AUTHORS   Galal,E.R., Abdelhakam,D.A., Ahmed,L.K., Elhusseny,Y., Sayed,S.E.P.
            and Eltaweel,N.H.
  TITLE     The association of FSCN1 (rs852479, rs1640233) and HOTAIR
            (rs920778) polymorphisms with the risk of breast cancer in Egyptian
            women
  JOURNAL   Mol Biol Rep 51 (1), 495 (2024)
   PUBMED   38587571
  REMARK    GeneRIF: The association of FSCN1 (rs852479, rs1640233) and HOTAIR
            (rs920778) polymorphisms with the risk of breast cancer in Egyptian
            women.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2784)
  AUTHORS   Hashimoto,Y., Kim,D.J. and Adams,J.C.
  TITLE     The roles of fascins in health and disease
  JOURNAL   J Pathol 224 (3), 289-300 (2011)
   PUBMED   21618240
  REMARK    Review article
REFERENCE   5  (bases 1 to 2784)
  AUTHORS   Bros,M., Ross,X.L., Pautz,A., Reske-Kunz,A.B. and Ross,R.
  TITLE     The human fascin gene promoter is highly active in mature dendritic
            cells due to a stage-specific enhancer
  JOURNAL   J Immunol 171 (4), 1825-1834 (2003)
   PUBMED   12902483
  REMARK    GeneRIF: Fascin regulatory sequences are found solely in the
            5'-flanking promoter region; the promoter exerts robust activity in
            dendritic cells (DC) and a fascin-positive neuronal cell line;
            promoter activity in DC markedly increases with maturation of DC.
REFERENCE   6  (bases 1 to 2784)
  AUTHORS   Pinkus,G.S., Pinkus,J.L., Langhoff,E., Matsumura,F., Yamashiro,S.,
            Mosialos,G. and Said,J.W.
  TITLE     Fascin, a sensitive new marker for Reed-Sternberg cells of
            hodgkin's disease. Evidence for a dendritic or B cell derivation?
  JOURNAL   Am J Pathol 150 (2), 543-562 (1997)
   PUBMED   9033270
REFERENCE   7  (bases 1 to 2784)
  AUTHORS   Mosialos,G., Yamashiro,S., Baughman,R.W., Matsudaira,P., Vara,L.,
            Matsumura,F., Kieff,E. and Birkenbach,M.
  TITLE     Epstein-Barr virus infection induces expression in B lymphocytes of
            a novel gene encoding an evolutionarily conserved 55-kilodalton
            actin-bundling protein
  JOURNAL   J Virol 68 (11), 7320-7328 (1994)
   PUBMED   7933116
REFERENCE   8  (bases 1 to 2784)
  AUTHORS   Duh,F.M., Latif,F., Weng,Y., Geil,L., Modi,W., Stackhouse,T.,
            Matsumura,F., Duan,D.R., Linehan,W.M., Lerman,M.I. et al.
  TITLE     cDNA cloning and expression of the human homolog of the sea urchin
            fascin and Drosophila singed genes which encodes an actin-bundling
            protein
  JOURNAL   DNA Cell Biol 13 (8), 821-827 (1994)
   PUBMED   8068206
REFERENCE   9  (bases 1 to 2784)
  AUTHORS   Yamashiro-Matsumura,S. and Matsumura,F.
  TITLE     Intracellular localization of the 55-kD actin-bundling protein in
            cultured cells: spatial relationships with actin, alpha-actinin,
            tropomyosin, and fimbrin
  JOURNAL   J Cell Biol 103 (2), 631-640 (1986)
   PUBMED   3525578
REFERENCE   10 (bases 1 to 2784)
  AUTHORS   Yamashiro-Matsumura,S. and Matsumura,F.
  TITLE     Purification and characterization of an F-actin-bundling
            55-kilodalton protein from HeLa cells
  JOURNAL   J Biol Chem 260 (8), 5087-5097 (1985)
   PUBMED   3886649
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK095254.1 and BC000521.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003088.3.
            
            Summary: This gene encodes a member of the fascin family of
            actin-binding proteins. Fascin proteins organize F-actin into
            parallel bundles, and are required for the formation of actin-based
            cellular protrusions. The encoded protein plays a critical role in
            cell migration, motility, adhesion and cellular interactions.
            Expression of this gene is known to be regulated by several
            microRNAs, and overexpression of this gene may play a role in the
            metastasis of multiple types of cancer by increasing cell motility.
            Expression of this gene is also a marker for Reed-Sternberg cells
            in Hodgkin's lymphoma. A pseudogene of this gene is located on the
            long arm of chromosome 15. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.32387.1, U03057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382361.8/ ENSP00000371798.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AK095254.1         9-120
            113-2784            BC000521.2         15-2686
FEATURES             Location/Qualifiers
     source          1..2784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..2784
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="fascin actin-bundling protein 1"
                     /db_xref="GeneID:6624"
                     /db_xref="HGNC:HGNC:11148"
                     /db_xref="MIM:602689"
     exon            1..953
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1603
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="55 kDa actin-bundling protein; singed-like (fascin
                     homolog, sea urchin); fascin homolog 1, actin-bundling
                     protein; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="fascin"
                     /protein_id="NP_003079.1"
                     /db_xref="CCDS:CCDS5342.1"
                     /db_xref="GeneID:6624"
                     /db_xref="HGNC:HGNC:11148"
                     /db_xref="MIM:602689"
                     /translation="MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQ
                     IWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWS
                     LQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPA
                     DEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRS
                     GKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTR
                     QGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASC
                     YFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEH
                     GFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVD
                     FFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY"
     exon            954..1110
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1232
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1400
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..2784
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2758..2763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="hexamer: AATAAA"
     polyA_site      2784
                     /gene="FSCN1"
                     /gene_synonym="FAN1; HSN; p55; SNL"
                     /note="major polyA site"
ORIGIN      
        1 gtggagcgct gcggagggtg cgtgcgggcc gcggcagccg aacaaaggag caggggcgcc
       61 gccgcaggga cccgccaccc acctcccggg gccgcgcagc ggcctctcgt ctactgccac
      121 catgaccgcc aacggcacag ccgaggcggt gcagatccag ttcggcctca tcaactgcgg
      181 caacaagtac ctgacggccg aggcgttcgg gttcaaggtg aacgcgtccg ccagcagcct
      241 gaagaagaag cagatctgga cgctggagca gccccctgac gaggcgggca gcgcggccgt
      301 gtgcctgcgc agccacctgg gccgctacct ggcggcggac aaggacggca acgtgacctg
      361 cgagcgcgag gtgcccggtc ccgactgccg tttcctcatc gtggcgcacg acgacggtcg
      421 ctggtcgctg cagtccgagg cgcaccggcg ctacttcggc ggcaccgagg accgcctgtc
      481 ctgcttcgcg cagacggtgt cccccgccga gaagtggagc gtgcacatcg ccatgcaccc
      541 tcaggtcaac atctacagcg tcacccgtaa gcgctacgcg cacctgagcg cgcggccggc
      601 cgacgagatc gccgtggacc gcgacgtgcc ctggggcgtc gactcgctca tcaccctcgc
      661 cttccaggac cagcgctaca gcgtgcagac cgccgaccac cgcttcctgc gccacgacgg
      721 gcgcctggtg gcgcgccccg agccggccac tggctacacg ctggagttcc gctccggcaa
      781 ggtggccttc cgcgactgcg agggccgtta cctggcgccg tcggggccca gcggcacgct
      841 caaggcgggc aaggccacca aggtgggcaa ggacgagctc tttgctctgg agcagagctg
      901 cgcccaggtc gtgctgcagg cggccaacga gaggaacgtg tccacgcgcc agggtatgga
      961 cctgtctgcc aatcaggacg aggagaccga ccaggagacc ttccagctgg agatcgaccg
     1021 cgacaccaaa aagtgtgcct tccgtaccca cacgggcaag tactggacgc tgacggccac
     1081 cgggggcgtg cagtccaccg cctccagcaa gaatgccagc tgctactttg acatcgagtg
     1141 gcgtgaccgg cgcatcacac tgagggcgtc caatggcaag tttgtgacct ccaagaagaa
     1201 tgggcagctg gccgcctcgg tggagacagc aggggactca gagctcttcc tcatgaagct
     1261 catcaaccgc cccatcatcg tgttccgcgg ggagcatggc ttcatcggct gccgcaaggt
     1321 cacgggcacc ctggacgcca accgctccag ctatgacgtc ttccagctgg agttcaacga
     1381 tggcgcctac aacatcaaag actccacagg caaatactgg acggtgggca gtgactccgc
     1441 ggtcaccagc agcggcgaca ctcctgtgga cttcttcttc gagttctgcg actataacaa
     1501 ggtggccatc aaggtgggcg ggcgctacct gaagggcgac cacgcaggcg tcctgaaggc
     1561 ctcggcggaa accgtggacc ccgcctcgct ctgggagtac tagggccggc ccgtccttcc
     1621 ccgcccctgc ccacatggcg gctcctgcca accctccctg ctaacccctt ctccgccagg
     1681 tgggctccag ggcgggaggc aagccccctt gcctttcaaa ctggaaaccc cagagaaaac
     1741 ggtgccccca cctgtcgccc ctatggactc cccactctcc cctccgcccg ggttccctac
     1801 tcccctcggg tcagcggctg cggcctggcc ctgggaggga tttcagatgc ccctgccctc
     1861 ttgtctgcca cggggcgagt ctggcacctc tttcttctga cctcagacgg ctctgagcct
     1921 tatttctctg gaagcggcta agggacggtt gggggctggg agccctgggc gtgtagtgta
     1981 actggaatct tttgcctctc ccagccacct cctcccagcc ccccaggaga gctgggcaca
     2041 tgtcccaagc ctgtcagtgg ccctccctgg tgcactgtcc ccgaaacccc tgcttgggaa
     2101 gggaagctgt cgggtgggct aggactgacc cttgtggtgt ttttttgggt ggtggctgga
     2161 aacagcccct ctcccacgtg gcagaggctc agcctggctc ccttccctgg agcggcaggg
     2221 cgtgacggcc acagggtctg cccgctgcac gttctgccaa ggtggtggtg gcgggcgggt
     2281 aggggtgtgg gggccgtctt cctcctgtct ctttcctttc accctagcct gactggaagc
     2341 agaaaatgac caaatcagta ttttttttaa tgaaatatta ttgctggagg cgtcccaggc
     2401 aagcctggct gtagtagcga gtgatctggc ggggggcgtc tcagcaccct ccccaggggg
     2461 tgcatctcag ccccctcttt ccgtccttcc cgtccagccc cagccctggg cctgggctgc
     2521 cgacacctgg gccagagccc ctgctgtgat tggtgctccc tgggcctccc gggtggatga
     2581 agccaggcgt cgccccctcc gggagccctg gggtgagccg ccggggcccc cctgctgcca
     2641 gcctcccccg tccccaacat gcatctcact ctgggtgtct tggtctttta ttttttgtaa
     2701 gtgtcatttg tataactcta aacgcccatg atagtagctt caaactggaa atagcgaaat
     2761 aaaataactc agtctgcagc ccca
//
