LOCUS       NM_001256141            5391 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens fibrinogen silencer binding protein (FSBP), mRNA.
ACCESSION   NM_001256141
VERSION     NM_001256141.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5391)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5391)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 5391)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5391)
  AUTHORS   Lau,K.F., Perkinton,M.S., Rodriguez,L., McLoughlin,D.M. and
            Miller,C.C.
  TITLE     An X11alpha/FSBP complex represses transcription of the GSK3beta
            gene promoter
  JOURNAL   Neuroreport 21 (11), 761-766 (2010)
   PUBMED   20531236
  REMARK    GeneRIF: we show here that through its PDZ domains, X11alpha
            interacts with a novel transcription factor, fibrinogen silencer
            binding protein
REFERENCE   5  (bases 1 to 5391)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023632.19, AF007866.1 and AK074272.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001256141.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.158991.1,
                                           SRR1660805.101710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267778 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000481490.3/ ENSP00000420405.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC023632.19        22767-22806         c
            41-1160             AF007866.1         1-1120
            1161-5175           AC023632.19        13794-17808         c
            5176-5391           AK074272.1         1956-2171
FEATURES             Location/Qualifiers
     source          1..5391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..5391
                     /gene="FSBP"
                     /note="fibrinogen silencer binding protein"
                     /db_xref="GeneID:100861412"
                     /db_xref="HGNC:HGNC:43653"
                     /db_xref="MIM:616306"
     exon            1..450
                     /gene="FSBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..976
                     /gene="FSBP"
                     /codon_start=1
                     /product="fibrinogen silencer-binding protein"
                     /protein_id="NP_001243070.1"
                     /db_xref="CCDS:CCDS59106.1"
                     /db_xref="GeneID:100861412"
                     /db_xref="HGNC:HGNC:43653"
                     /db_xref="MIM:616306"
                     /translation="MVGKARSSNFTLSEKLDLLKLVKPYVKILEEHTNKHSVIVEKNR
                     CWDIIAVNYNAIGVDRPPRTAQGLRTLYKRLKEYAKQELLQQKETQSDFKSNISEPTK
                     KVMEMIPQISSFCLVRDRNHIQSANLDEEAQAGTSSLQVMLDHHPVAITVEVKQEEDI
                     KPPPPLVLNSQQSDTLEQREEHELVHVMERSLSPSLSSVDMRMTSSPSSIPRRDDFFR
                     HESGEHFRSLLGYDPQILQMLKEEHQIILENQKNFGLYVQEKRDGLKRRQQLEEELLR
                     AKIEVEKLKAIRLRHDLPEYNSL"
     exon            451..5391
                     /gene="FSBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSBP"
                     /note="hexamer: ATTAAA"
     polyA_site      1161
                     /gene="FSBP"
                     /note="major polyA site"
     regulatory      5371..5376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSBP"
                     /note="hexamer: AATACA"
     polyA_site      5391
                     /gene="FSBP"
                     /note="major polyA site"
ORIGIN      
        1 gtttgtgaaa agagctgagc agagctgaag gctgcatggt ggtttcagaa actgcctact
       61 taatttgaaa agaacaatgg taggaaaggc tagatcttcc aattttacct tatccgaaaa
      121 gcttgatttg ctaaagcttg tgaagccata tgtgaaaatt ctcgaagaac acactaataa
      181 acattcagta atagtagaaa agaatagatg ttgggatatc atagcagtta actataatgc
      241 aattggagta gaccgccctc ctcgaacagc acagggccta cgcacccttt ataaaaggct
      301 caaagaatat gccaaacagg agctattgca gcaaaaagag acccaatcag attttaaaag
      361 caatatttct gagccaacca agaaagttat ggagatgatt ccccagattt ccagtttttg
      421 cctggtaaga gacaggaacc acatacaaag tgcaaacttg gatgaggagg cacaggctgg
      481 taccagttca ctacaggtaa tgttggatca ccatcctgtt gctattacag tggaggtgaa
      541 gcaagaagaa gacattaaac cacctcctcc actggtttta aattctcaac agagtgatac
      601 tttagagcaa agagaagaac atgaattagt acatgttatg gaaagatcct tgtcgccttc
      661 actttcctct gttgatatga gaatgacatc gtctccatct tctattccaa ggagagatga
      721 tttttttcgg catgagagtg gtgaacactt taggtcacta ttagggtatg atcctcagat
      781 cctgcaaatg ttgaaagagg agcatcagat aattttagaa aatcaaaaaa attttggatt
      841 gtatgttcag gagaagaggg atggattgaa aagaaggcag cagctagagg aagagctact
      901 aagagcaaaa attgaagtgg agaagctgaa agcaattcgc ttacggcatg atctacctga
      961 atataacagt ctctaagttt ttttttcaat cttgcaattt gataattttg attttggcca
     1021 aattacttta atttgggaat atcctgaaac agaatacacg ttcttgaaaa atgttgttaa
     1081 tctctattat ggaaaaactt tttagatata attttctaat tattttcttt tgagatatta
     1141 aaatttactg gttggttggc atggttatag tttttattgt cttctttttt ttttccctaa
     1201 gtttaattgt tgaccttaca aaagatattt tattctgatc actaagatat acacaaatgc
     1261 atatacaaac acatattctt tcaaagttct gagtcttcaa catttttagt tagaactttg
     1321 aaagctataa ttagagattt ttaagtcagt ctaatttagg agctatacta acctaatacc
     1381 aagaagcttg tctgtatgac attggttttt atgcttttat cttttgaagg agtaaatcct
     1441 aggattttag agatggaaga tatttggaga acactttttt tccatctctg cagtttaggg
     1501 gtaatgaaac aggtccaggg agaactcaat gacttactta gggtaacaaa gctatttatg
     1561 gcagagcaga gaccagcact tagtttttct ttgtgtaatt tccatcccgc tattcgatag
     1621 aagtaaatat ccactaaaac attctctaga tttaaatatt agaagcattt ctttcattaa
     1681 aattgccttt aaagattgtt aggttgtgaa atcaggataa ttacatcaat tacccccatt
     1741 ctctctctat ttttgttcca gcaaaataga taaggtattc cattgaagct attatatatt
     1801 ttggctgtgt gatttaaaga catgtcttaa ttcattttga atgtcctgtt ctggaaaaaa
     1861 tttctttcac agtaaaaatc agaatgaaca aaattaaaat tttatgtatt ttataagtat
     1921 tgttatttta gtattcatgg aaataaaacc tcaattctta aagcatacat attaaattta
     1981 tattaaatct ctaatatgta tgttacttaa gaatttctat ttttgctggg gttttgttga
     2041 gaagggattt ttaagccaag ttgtagaatg gggtgggtgt aatttcagca gtgaagggga
     2101 ccatgggtgt ttgaagtcaa gagtgagacg ctggaaaaaa gacaaaagaa tgggaaaaag
     2161 tggattgagt atataagcac aaatgcagtg ctaagccatt gattttaagt gaatgtagag
     2221 agagtcaatt tgggctgtag tatcctggac taggaaggac atctccctgg actaggtagg
     2281 gtagctgctg tttagctcca gcagaatttt cacatgcggg gataaaccag aaatctgcat
     2341 tttttaatga ggaatcttcc aattttaaaa tgtttgcaaa taacacaaaa tgcttttaaa
     2401 acattataca gacaacatgt gagtgggcct cactgagcca ttgggcttcc actttgtggc
     2461 ctttggagta gaccaatggt tttccaagta tgggtcctga ccagcagcat cagcatcact
     2521 tgagaacttg ttagaaatgt aaatccattt ccaagtgaat tagaaaccct gggggtgtca
     2581 gcaatctctt ttaataaacc ctttagcgat tctgatgcat gctaaagttt gagaaccagt
     2641 gaaacagagt attttggaac ctcgcttggt gcctaaatca tactagtctc aaaatttttg
     2701 tcgaagagta gttgaaagtg aactgaggga tataaatttg gatgatggtt gataccagat
     2761 tatgaattac attaaatact tttttttttt ttttttgaga tggagtcttg ctttgtcacc
     2821 taggttggag tgcagtggtg cgatgttggc tcactgcaat ctccgtttcc tgggttcaag
     2881 cgattctcct gcttcagctt cccaagtagc tgggactaca ggcgcaccac catgcctggc
     2941 taattttttg tgtttttagt agagacgggg tttcactgtg ttagccagga tggtcttgat
     3001 ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagt gctgggatta caggcttgag
     3061 ccaccgtgcc cagcctaaat actattttta atgagtcaga cttaacgtac aatgagaagc
     3121 cattgaatgc tttgaattag agggctaatt tgattatagt tgtgatttag gaggagtggc
     3181 atttagggac aggcattgta ttggaagaac ttaaatcaga aatttaagtt atggctatag
     3241 aaatagaaaa aaatgaactc aaggtactat tttagcatgt tgactactta atttcattgg
     3301 ttggattaaa aagagggtgt tttatagctg gtagagttaa cttctttaat tataaagatg
     3361 tcctgaatat ataacttgat atatcctttt gacaatgtta ccttttctct ttaatctgtg
     3421 ctatgacttt tctttgagtc taatgaatct tgtaattctt aatttgaggt aatgtttccc
     3481 agtataattc tagtaaacac atcttggcag tagtaagctt tattttttga aattattgaa
     3541 agcacatata tgagatgtaa ttcactttac agtttcagca tgctactaag aattgataat
     3601 gaatgttcaa tttaaatgtt ggcttttaca gcaaatcaga gttttcccaa gtgtgttctg
     3661 tggaacatta attctgtgag atgtttctag aaaagagatc tgtgttaaaa aaaagtgcag
     3721 tatacatctt ttttattttt ggtggttagg ttctaaaata attgtggaag gtaaaaatta
     3781 tgtatataca aaatagccct tgaaaattcc tttgctgccc ataaaatagc ataaacatag
     3841 tctgctacaa tcatattttt ctgcagcatt gtttaagatt gctttttctt tagtgtgtta
     3901 ggtgacacaa ttcattagca tttaggggct gtatacaata agaaacctat ttttacatat
     3961 ttttaaacac cagaatcaca ctctttgagt ttactgcagc aacttttcca agtcaatctt
     4021 gtttttctcc aagtcagtct tgtttacttt taatttgcaa aagtttaaat gcatataatt
     4081 ctcctcattg tctacctccc cttgtataac catgattaac atagtatagt ttatgagaat
     4141 tcctgtataa agaaaattat ttatttgacc atagaatcct tttccgaggc tgtttattat
     4201 cttacagagt atcttagggt aatttggaac caaacctttt tttttcttct tttttgtatt
     4261 gagacttttt tgagttaggg gactacttac caactaacat tagcagtttt tgttgaggac
     4321 aagtttcatt aaggggaata tataggggaa agtttgctag tacaatggaa tgtacacttg
     4381 gctttctatc tgcaggtttc acatctgcag attgaactac tgtggattga aaatattcag
     4441 gcagaaaaat aaataacagt acaacaataa aaagtaatac gaaatttaaa aagacggtat
     4501 aactgaggta ggagttgggc taatccccag ttttggggct cacttgtcct gtatcctaac
     4561 aactatttac atagtattta cattatatta gccattgtaa gtaatctaga gatgatttaa
     4621 agtatatgga aggatgtgtg taaattgtat gtgaatacaa acattttata taagggactt
     4681 gagtatctgt ggatcttgat ggggtagggg gtgtcctgaa accaatcccc cttggatact
     4741 gagggatgac tatacactta agccaccaga catcttgcat atcatagaca attgtttggg
     4801 gtccatgagc tttaattaca aaatgtaatg ctgggagaac atagagaaga gtgattttgt
     4861 tttttaaatg tagacttgat tctgtagaaa tatactacat ttgataaata tactaagtat
     4921 atagattatt tcatccaata tattagtaat ttagatagtg gatagccact ttcctatctt
     4981 tctcttatcc atatgaatgt aatggatatg ttgttacaac ttatgatttt ctaaactagc
     5041 tgtgatttat aatgacatcc tgagaaaagt cagtgaaact catttctaac gaataccaga
     5101 tttcttaaaa tagtcaagta tttttctttt gtgtatgatg agatattaac ttggtgttat
     5161 ttcatttttt tttttaagga gtcattctac cctgttctat ctttacttat gtgaaaatgt
     5221 ttaaactatg agtttttttc atgtgccttc ttttggagta atgtcaactt ttaaatacac
     5281 atgtttaaat aacttagagt gtaataaatt gtgtttaata tatactgtag ataatgatgg
     5341 ttaaatgctt tgttaacaca tgttctttta aatacaagat actactttgt a
//
