LOCUS       NM_001463               2637 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens frizzled related protein (FRZB), mRNA.
ACCESSION   NM_001463
VERSION     NM_001463.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2637)
  AUTHORS   Qi,B., Wang,H.Y., Ma,X., Chi,Y.F. and Gui,C.
  TITLE     Exploring the predictive values of SERP4 and FRZB in dilated
            cardiomyopathy based on an integrated analysis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 577 (2024)
   PUBMED   39425025
  REMARK    GeneRIF: Exploring the predictive values of SERP4 and FRZB in
            dilated cardiomyopathy based on an integrated analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2637)
  AUTHORS   An,X., Wang,R., Lv,Z., Wu,W., Sun,Z., Wu,R., Yan,W., Jiang,Q. and
            Xu,X.
  TITLE     WTAP-mediated m6A modification of FRZB triggers the inflammatory
            response via the Wnt signaling pathway in osteoarthritis
  JOURNAL   Exp Mol Med 56 (1), 156-167 (2024)
   PUBMED   38172596
  REMARK    GeneRIF: WTAP-mediated m[6]A modification of FRZB triggers the
            inflammatory response via the Wnt signaling pathway in
            osteoarthritis.
REFERENCE   3  (bases 1 to 2637)
  AUTHORS   Liu,H., Mei,Y., Ma,X., Zhang,X. and Nie,W.
  TITLE     FRZB is Regulated by the Transcription Factor EGR1 and Inhibits the
            Growth and Invasion of Triple-Negative Breast Cancer Cells by
            Regulating the JAK/STAT3 Pathway
  JOURNAL   Clin Breast Cancer 22 (7), 690-698 (2022)
   PUBMED   35787980
  REMARK    GeneRIF: FRZB is Regulated by the Transcription Factor EGR1 and
            Inhibits the Growth and Invasion of Triple-Negative Breast Cancer
            Cells by Regulating the JAK/STAT3 Pathway.
REFERENCE   4  (bases 1 to 2637)
  AUTHORS   Tuerlings,M., van Hoolwerff,M., van Bokkum,J.M., Suchiman,H.E.D.,
            Lakenberg,N., Broekhuis,D., Nelissen,R.G.H.H., Ramos,Y.F.M.,
            Mei,H., Cats,D., Coutinho de Almeida,R. and Meulenbelt,I.
  TITLE     Long non-coding RNA expression profiling of subchondral bone
            reveals AC005165.1 modifying FRZB expression during osteoarthritis
  JOURNAL   Rheumatology (Oxford) 61 (7), 3023-3032 (2022)
   PUBMED   34730803
  REMARK    GeneRIF: Long non-coding RNA expression profiling of subchondral
            bone reveals AC005165.1 modifying FRZB expression during
            osteoarthritis.
REFERENCE   5  (bases 1 to 2637)
  AUTHORS   Xu,R., Zhang,F., Lu,J., Wang,K., Pan,P., Sun,Y. and Zhang,Y.
  TITLE     Secreted frizzled-related protein 3 was genetically and
            functionally associated with developmental dysplasia of the hip
  JOURNAL   Aging (Albany NY) 13 (8), 11281-11295 (2021)
   PUBMED   33820867
  REMARK    GeneRIF: Secreted frizzled-related protein 3 was genetically and
            functionally associated with developmental dysplasia of the hip.
REFERENCE   6  (bases 1 to 2637)
  AUTHORS   Schumann,H., Holtz,J., Zerkowski,H.R. and Hatzfeld,M.
  TITLE     Expression of secreted frizzled related proteins 3 and 4 in human
            ventricular myocardium correlates with apoptosis related gene
            expression
  JOURNAL   Cardiovasc Res 45 (3), 720-728 (2000)
   PUBMED   10728394
REFERENCE   7  (bases 1 to 2637)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   8  (bases 1 to 2637)
  AUTHORS   Mayr,T., Deutsch,U., Kuhl,M., Drexler,H.C., Lottspeich,F.,
            Deutzmann,R., Wedlich,D. and Risau,W.
  TITLE     Fritz: a secreted frizzled-related protein that inhibits Wnt
            activity
  JOURNAL   Mech Dev 63 (1), 109-125 (1997)
   PUBMED   9178261
REFERENCE   9  (bases 1 to 2637)
  AUTHORS   Leyns,L., Bouwmeester,T., Kim,S.H., Piccolo,S. and De Robertis,E.M.
  TITLE     Frzb-1 is a secreted antagonist of Wnt signaling expressed in the
            Spemann organizer
  JOURNAL   Cell 88 (6), 747-756 (1997)
   PUBMED   9118218
REFERENCE   10 (bases 1 to 2637)
  AUTHORS   Hoang,B., Moos,M. Jr., Vukicevic,S. and Luyten,F.P.
  TITLE     Primary structure and tissue distribution of FRZB, a novel protein
            related to Drosophila frizzled, suggest a role in skeletal
            morphogenesis
  JOURNAL   J Biol Chem 271 (42), 26131-26137 (1996)
   PUBMED   8824257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU117730.1, U24163.1, U91903.1,
            BF058813.1, BE549700.1 and AC105396.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001463.3.
            
            Summary: The protein encoded by this gene is a secreted protein
            that is involved in the regulation of bone development. Defects in
            this gene are a cause of female-specific osteoarthritis (OA)
            susceptibility. [provided by RefSeq, Apr 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.126961.1,
                                           SRR1660807.264009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295113.5/ ENSP00000295113.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               AU117730.1         134-636
            504-1353            U24163.1           627-1476
            1354-1902           U91903.1           1338-1886
            1903-2199           BF058813.1         7-303               c
            2200-2547           BE549700.1         96-443              c
            2548-2548           AC105396.2         96462-96462         c
            2549-2637           BE549700.1         6-94                c
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..2637
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /note="frizzled related protein"
                     /db_xref="GeneID:2487"
                     /db_xref="HGNC:HGNC:3959"
                     /db_xref="MIM:605083"
     exon            1..563
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1063
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /note="secreted frizzled-related protein 3; frizzled
                     homolog-related; sFRP-3; frezzled; frizzled-related
                     protein 1"
                     /codon_start=1
                     /product="secreted frizzled-related protein 3 precursor"
                     /protein_id="NP_001454.2"
                     /db_xref="CCDS:CCDS2286.1"
                     /db_xref="GeneID:2487"
                     /db_xref="HGNC:HGNC:3959"
                     /db_xref="MIM:605083"
                     /translation="MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCK
                     SLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQH
                     EPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGAD
                     FPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVE
                     VKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAE
                     KWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN"
     exon            564..611
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /inference="alignment:Splign:2.1.0"
     exon            612..677
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..882
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /inference="alignment:Splign:2.1.0"
     exon            883..946
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /inference="alignment:Splign:2.1.0"
     exon            947..2637
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /note="hexamer: AATAAA"
     polyA_site      1358
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /note="major polyA site"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /note="major polyA site"
     regulatory      2614..2619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
                     /note="hexamer: AATAAA"
     polyA_site      2637
                     /gene="FRZB"
                     /gene_synonym="FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1;
                     FZRB; hFIZ; OS1; SFRP3; SRFP3"
ORIGIN      
        1 acttgcagcg ggggaggcgg agacggcgga gcgggccttt tggcgtccac tgcgcggctg
       61 caccctgccc catcctgccg ggatcatggt ctgcggcagc ccgggaggga tgctgctgct
      121 gcgggccggg ctgcttgccc tggctgctct ctgcctgctc cgggtgcccg gggctcgggc
      181 tgcagcctgt gagcccgtcc gcatccccct gtgcaagtcc ctgccctgga acatgactaa
      241 gatgcccaac cacctgcacc acagcactca ggccaacgcc atcctggcca tcgagcagtt
      301 cgaaggtctg ctgggcaccc actgcagccc cgatctgctc ttcttcctct gtgccatgta
      361 cgcgcccatc tgcaccattg acttccagca cgagcccatc aagccctgta agtctgtgtg
      421 cgagcgggcc cggcagggct gtgagcccat actcatcaag taccgccact cgtggccgga
      481 gaacctggcc tgcgaggagc tgccagtgta cgacaggggc gtgtgcatct ctcccgaggc
      541 catcgttact gcggacggag ctgattttcc tatggattct agtaacggaa actgtagagg
      601 ggcaagcagt gaacgctgta aatgtaagcc tattagagct acacagaaga cctatttccg
      661 gaacaattac aactatgtca ttcgggctaa agttaaagag ataaagacta agtgccatga
      721 tgtgactgca gtagtggagg tgaaggagat tctaaagtcc tctctggtaa acattccacg
      781 ggacactgtc aacctctata ccagctctgg ctgcctctgc cctccactta atgttaatga
      841 ggaatatatc atcatgggct atgaagatga ggaacgttcc agattactct tggtggaagg
      901 ctctatagct gagaagtgga aggatcgact cggtaaaaaa gttaagcgct gggatatgaa
      961 gcttcgtcat cttggactca gtaaaagtga ttctagcaat agtgattcca ctcagagtca
     1021 gaagtctggc aggaactcga acccccggca agcacgcaac taaatcccga aatacaaaaa
     1081 gtaacacagt ggacttccta ttaagactta cttgcattgc tggactagca aaggaaaatt
     1141 gcactattgc acatcatatt ctattgttta ctataaaaat catgtgataa ctgattatta
     1201 cttctgtttc tcttttggtt tctgcttctc tcttctctca acccctttgt aatggtttgg
     1261 gggcagactc ttaagtatat tgtgagtttt ctatttcact aatcatgaga aaaactgttc
     1321 ttttgcaata ataataaatt aaacatgctg ttaccagagc ctctttgctg gagtctccag
     1381 atgttaattt actttctgca ccccaattgg gaatgcaata ttggatgaaa agagaggttt
     1441 ctggtattca cagaaagcta gatatgcctt aaaacatact ctgccgatct aattacagcc
     1501 ttatttttgt atgccttttg ggcattctcc tcatgcttag aaagttccaa atgtttataa
     1561 aggtaaaatg gcagtttgaa gtcaaatgtc acataggcaa agcaatcaag caccaggaag
     1621 tgtttatgag gaaacaacac ccaagatgaa ttatttttga gactgtcagg aagtaaaata
     1681 aataggagct taagaaagaa cattttgcct gattgagaag cacaactgaa accagtagcc
     1741 gctggggtgt taatggtagc attcttcttt tggcaataca tttgatttgt tcatgaatat
     1801 attaatcagc attagagaaa tgaattataa ctagacatct gctgttatca ccatagtttt
     1861 gtttaatttg cttcctttta aataaaccca ttggtgaaag tctttttttt tctcttcttt
     1921 taaaataaat cagaattgcc gtattgacca ggaaaagatt atgtatgcac gtgcaccagg
     1981 gttagttttt aaaagtacat ggctccataa aaatgctgta gattacagag tgataaaata
     2041 tgcaggtttt tttgtttttg ttttttctgt tgtgtgtgtg tctgtatttg tgtacatgtg
     2101 tgtccttgca ctcacaccca aggtggatta aaatacaggc ctgcaaactg gcctgcactt
     2161 tatcatttgg atttgtgctg cttaatgctc agcgaaaaat gtctagtaaa atgaattatg
     2221 gttgtcagga gagaggttat ttcgactttt gaaccaattg cacatttctc attacccaag
     2281 ctgtggtgag atcccagggg ctgtggtgaa caaatgatgc ttttatagat ggtccctagc
     2341 ttacaatgat tcaatttaca atgcttcaat ttaacaattt gttgacttac aatgggttta
     2401 tcaggatgta acccaatgca tttcaactta cgatattttc agtttcgaat gggtttatcc
     2461 agatgtaacc ccatcgtaaa tggcggagca tctgtacttc cttcctctgg cagagttcct
     2521 tagagcctgt gccaattact tgaaagtttc attctctgcc atttacatgt gtgctattag
     2581 tagaaccaaa tttctaagct gtggcgtgct gaaaataaaa tgcttatgaa gcaaaaa
//
