LOCUS       NM_006653               2174 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor receptor substrate 3 (FRS3),
            mRNA.
ACCESSION   NM_006653
VERSION     NM_006653.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2174)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2174)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2174)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   4  (bases 1 to 2174)
  AUTHORS   Minegishi,Y., Shibagaki,Y., Mizutani,A., Fujita,K., Tezuka,T.,
            Kinoshita,M., Kuroda,M., Hattori,S. and Gotoh,N.
  TITLE     Adaptor protein complex of FRS2beta and CIN85/CD2AP provides a
            novel mechanism for ErbB2/HER2 protein downregulation
  JOURNAL   Cancer Sci 104 (3), 345-352 (2013)
   PUBMED   23279575
  REMARK    GeneRIF: an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of
            ErbB2 may regulate ErbB2 protein levels in physiological and
            pathological settings
REFERENCE   5  (bases 1 to 2174)
  AUTHORS   Iejima,D., Minegishi,Y., Takenaka,K., Siswanto,A., Watanabe,M.,
            Huang,L., Watanabe,T., Tanaka,F., Kuroda,M. and Gotoh,N.
  TITLE     FRS2beta, a potential prognostic gene for non-small cell lung
            cancer, encodes a feedback inhibitor of EGF receptor family members
            by ERK binding
  JOURNAL   Oncogene 29 (21), 3087-3099 (2010)
   PUBMED   20228838
  REMARK    GeneRIF: Mechanisms by which FRS2beta acts as a feedback inhibitor
            of EGFR family members and suggest a role for FRS2beta as a tumor
            suppressor.
REFERENCE   6  (bases 1 to 2174)
  AUTHORS   Yamada,M., Suzuki,K., Mizutani,M., Asada,A., Matozaki,T.,
            Ikeuchi,T., Koizumi,S. and Hatanaka,H.
  TITLE     Analysis of tyrosine phosphorylation-dependent protein-protein
            interactions in TrkB-mediated intracellular signaling using
            modified yeast two-hybrid system
  JOURNAL   J Biochem 130 (1), 157-165 (2001)
   PUBMED   11432792
REFERENCE   7  (bases 1 to 2174)
  AUTHORS   Ong,S.H., Guy,G.R., Hadari,Y.R., Laks,S., Gotoh,N., Schlessinger,J.
            and Lax,I.
  TITLE     FRS2 proteins recruit intracellular signaling pathways by binding
            to diverse targets on fibroblast growth factor and nerve growth
            factor receptors
  JOURNAL   Mol Cell Biol 20 (3), 979-989 (2000)
   PUBMED   10629055
REFERENCE   8  (bases 1 to 2174)
  AUTHORS   Lim,Y.P., Low,B.C., Lim,J., Wong,E.S. and Guy,G.R.
  TITLE     Association of atypical protein kinase C isotypes with the docker
            protein FRS2 in fibroblast growth factor signaling
  JOURNAL   J Biol Chem 274 (27), 19025-19034 (1999)
   PUBMED   10383403
REFERENCE   9  (bases 1 to 2174)
  AUTHORS   Xu,H., Lee,K.W. and Goldfarb,M.
  TITLE     Novel recognition motif on fibroblast growth factor receptor
            mediates direct association and activation of SNT adapter proteins
  JOURNAL   J Biol Chem 273 (29), 17987-17990 (1998)
   PUBMED   9660748
REFERENCE   10 (bases 1 to 2174)
  AUTHORS   Wang,J.K., Xu,H., Li,H.C. and Goldfarb,M.
  TITLE     Broadly expressed SNT-like proteins link FGF receptor stimulation
            to activators of Ras
  JOURNAL   Oncogene 13 (4), 721-729 (1996)
   PUBMED   8761293
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY036161.1 and AF036718.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006653.4.
            
            Summary: This gene encodes a substrate for the fibroblast growth
            factor receptor. The encoded protein is found in the peripheral
            plasma membrane and links fibroblast growth factor receptor
            stimulation to activators of Ras. The encoded protein
            down-regulates extracellular regulated kinase 2 through direct
            binding. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.307638.1,
                                           SRR1803615.490577.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373018.7/ ENSP00000362109.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               HY036161.1         7-252
            247-2174            AF036718.1         131-2058
FEATURES             Location/Qualifiers
     source          1..2174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2174
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /note="fibroblast growth factor receptor substrate 3"
                     /db_xref="GeneID:10817"
                     /db_xref="HGNC:HGNC:16970"
                     /db_xref="MIM:607744"
     exon            1..85
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..229
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /inference="alignment:Splign:2.1.0"
     exon            230..318
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1731
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /note="suc1-associated neurotrophic factor target 2 (FGFR
                     signalling adaptor); FGFR substrate 3; FGFR-signaling
                     adaptor SNT2; testicular tissue protein Li 71"
                     /codon_start=1
                     /product="fibroblast growth factor receptor substrate 3"
                     /protein_id="NP_006644.1"
                     /db_xref="CCDS:CCDS4860.1"
                     /db_xref="GeneID:10817"
                     /db_xref="HGNC:HGNC:16970"
                     /db_xref="MIM:607744"
                     /translation="MGSCCSCLNRDSVPDNHPTKFKVTNVDDEGVELGSGVMELTQSE
                     LVLHLHRREAVRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQ
                     DLMQCNSINVMEEPVIITRNSHPAELDLPRAPQPPNALGYTVSSFSNGCPGEGPRFSA
                     PRRLSTSSLRHPSLGEESTHALIAPDEQSHTYVNTPASEDDHRRGRHCLQPLPEGQAP
                     FLPQARGPDQRDPQVFLQPGQVKFVLGPTPARRHMVKCQGLCPSLHDPPHHNNNNEAP
                     SECPAQPKCTYENVTGGLWRGAGWRLSPEEPGWNGLAHRRAALLHYENLPPLPPVWES
                     QAQQLGGEAGDDGDSRDGLTPSSNGFPDGEEDETPLQKPTSTRAAIRSHGSFPVPLTR
                     RRGSPRVFNFDFRRPGPEPPRQLNYIQVELKGWGGDRPKGPQNPSSPQAPMPTTHPAR
                     SSDSYAVIDLKKTVAMSNLQRALPRDDGTARKTRHNSTDLPL"
     exon            319..505
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..667
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..816
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..2174
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /note="hexamer: AATATA"
     polyA_site      2174
                     /gene="FRS3"
                     /gene_synonym="FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2"
                     /note="major polyA site"
ORIGIN      
        1 ggggaggcct tagctccggg cgggcggcgg ctgctgcagc gggacccggg agcggggccc
       61 ggcgccgccc gggccgcggg gcgatgtgag ccccaggtgt atcccagagg gatccgggtg
      121 acttctctgc agactgtttg ccatgacagc ccaccaagga cggggggaat aaagtgggaa
      181 cccttcccca tgcccctccc acggtcagct ccccgatggc ctgggtgagg gcaggctggc
      241 tgctctgaca ccatggggag ctgctgcagc tgcctgaaca gagacagcgt tccagacaac
      301 caccccacca agttcaaggt gacaaatgtg gatgatgagg gggtggagct gggctctggg
      361 gtgatggagc tgacgcagag tgagctggtg ctgcacctgc atcggcgtga ggccgtccgc
      421 tggccttatc tctgcttgcg gcgctatggc tacgactcca acctcttctc ctttgagagt
      481 ggccgccgat gtcagacagg ccagggaata tttgcattta agtgttcccg ggctgaggaa
      541 atcttcaacc tccttcagga tctgatgcag tgcaacagca tcaatgtgat ggaagagcct
      601 gtcatcatca cccgcaatag ccaccccgct gagcttgacc tccctcgagc cccccagcca
      661 cccaatgctc taggctacac tgtctccagc ttttccaatg gctgccctgg agagggccca
      721 cgattctcag ctccccggcg gctctcgaca agcagcctgc ggcacccctc gcttggggaa
      781 gagtccaccc atgccctcat tgctcctgat gagcagtccc acacctatgt caacacaccg
      841 gccagtgaag atgaccaccg caggggccgc cactgcctgc agcccctgcc tgagggtcag
      901 gcacccttcc tcccgcaggc ccggggacct gaccaacggg acccacaggt gttcttgcag
      961 ccaggccagg tgaagtttgt gttgggcccg acccctgctc ggcggcacat ggtgaagtgc
     1021 cagggcctct gtcccagcct gcatgacccc ccacaccaca ataataacaa tgaggcccct
     1081 tctgagtgtc cagcccagcc caagtgcacc tacgagaacg tcaccggggg gctgtggcga
     1141 ggggctggct ggagactgag cccagaggag ccgggctgga atggccttgc ccaccgccgg
     1201 gccgccctgc tgcactatga gaacctgccc ccactgcccc ctgtgtggga aagccaagcc
     1261 cagcagctgg gaggggaggc tggggatgat ggggactcga gggatgggct cacaccctct
     1321 tccaatggct tccctgatgg tgaggaggac gagaccccac tgcagaagcc caccagcacc
     1381 cgggccgcca tccgcagcca cggcagcttt cctgtgccac tgacccgccg ccgcggctcc
     1441 ccaagggtct tcaactttga tttccgccgg ccggggcccg agcccccaag gcagcttaac
     1501 tacatccagg tggagctaaa gggctggggt ggagaccgcc ctaaggggcc ccagaacccc
     1561 tcgagccccc aagcccccat gcccaccacc caccctgccc gaagctcaga ctcctacgcc
     1621 gtgattgacc tcaaaaagac cgtggccatg tccaacctgc agagagctct gccccgagac
     1681 gatggcaccg ccaggaaaac ccggcacaac agcaccgacc tgcctctgta gggacttccc
     1741 ggtcctcacc accctctgcc ccaccatgat ccagcctctg cctcacactc ctgtcctctg
     1801 aacccaccct ccccagggtt cagggttgct ttgcagaagg catggaggtg ggaccagatg
     1861 cttccctgtg ctggctggag tccccagaga tatcagccac cgagtctcct ggtctgtctc
     1921 caggctgggg agagaagggt gaccaggcga ggagggagcc gagacgtcaa ctgtgaaggg
     1981 ttcctgtgat tgcgtttagc gccctcccgt tctgtccatt tgtcttgtct gccgactgtc
     2041 cgtgtgtgtt ttttttggtt ggaattttga aacattttgt acctgttgat tttatttatc
     2101 agtttatttt tctatttatt gttttaaatg taatttaaca tatttattat taatataatt
     2161 atttttaaat tctg
//
