LOCUS       NM_001278356            6768 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens fibroblast growth factor receptor substrate 2 (FRS2),
            transcript variant 7, mRNA.
ACCESSION   NM_001278356
VERSION     NM_001278356.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6768)
  AUTHORS   Zhu,Y., Liu,Z., Cao,L., Fan,G., Ji,R., Zhang,L., Daji,S., Zhu,H.,
            Wang,Y. and Zhou,G.
  TITLE     FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in
            osteosarcoma
  JOURNAL   Gene 898, 148118 (2024)
   PUBMED   38159618
  REMARK    GeneRIF: FRS2 regulated by miR-429 and miR-206 promotes
            angiogenesis in osteosarcoma.
REFERENCE   2  (bases 1 to 6768)
  AUTHORS   Tian,K., Deng,B., Han,X., Zheng,H., Lin,T., Wang,Z., Zhang,Y. and
            Wang,G.
  TITLE     Over-expression of microRNA-145 Elevating Autophagy Activities via
            Downregulating FRS2 Expression
  JOURNAL   Comb Chem High Throughput Screen 27 (1), 127-135 (2024)
   PUBMED   37264620
  REMARK    GeneRIF: Over-expression of microRNA-145 Elevating Autophagy
            Activities via Downregulating FRS2 Expression.
REFERENCE   3  (bases 1 to 6768)
  AUTHORS   Chen,W.D. and Miao,C.L.
  TITLE     Expression of fibroblast growth factor receptor substrate 2 (FRS2)
            in primary retroperitoneal liposarcoma and its clinical
            implications
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (13), 6273-6281 (2023)
   PUBMED   37458641
  REMARK    GeneRIF: Expression of fibroblast growth factor receptor substrate
            2 (FRS2) in primary retroperitoneal liposarcoma and its clinical
            implications.
REFERENCE   4  (bases 1 to 6768)
  AUTHORS   Yong,J., He,J. and Ning,F.
  TITLE     Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to
            promote nephroblastoma progression
  JOURNAL   Histol Histopathol 38 (5), 559-570 (2023)
   PUBMED   36286392
  REMARK    GeneRIF: Hsa_circ_0093741 competes with FRS2 for miR-562 binding
            sites to promote nephroblastoma progression.
REFERENCE   5  (bases 1 to 6768)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   6  (bases 1 to 6768)
  AUTHORS   Kaplan,D.R. and Miller,F.D.
  TITLE     Signal transduction by the neurotrophin receptors
  JOURNAL   Curr Opin Cell Biol 9 (2), 213-221 (1997)
   PUBMED   9069267
  REMARK    Review article
REFERENCE   7  (bases 1 to 6768)
  AUTHORS   Kanai,M., Goke,M., Tsunekawa,S. and Podolsky,D.K.
  TITLE     Signal transduction pathway of human fibroblast growth factor
            receptor 3. Identification of a novel 66-kDa phosphoprotein
  JOURNAL   J Biol Chem 272 (10), 6621-6628 (1997)
   PUBMED   9045692
REFERENCE   8  (bases 1 to 6768)
  AUTHORS   Ong,S.H., Goh,K.C., Lim,Y.P., Low,B.C., Klint,P.,
            Claesson-Welsh,L., Cao,X., Tan,Y.H. and Guy,G.R.
  TITLE     Suc1-associated neurotrophic factor target (SNT) protein is a major
            FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds
            to the SH2 domain of GRB2
  JOURNAL   Biochem Biophys Res Commun 225 (3), 1021-1026 (1996)
   PUBMED   8780727
REFERENCE   9  (bases 1 to 6768)
  AUTHORS   Wang,J.K., Xu,H., Li,H.C. and Goldfarb,M.
  TITLE     Broadly expressed SNT-like proteins link FGF receptor stimulation
            to activators of Ras
  JOURNAL   Oncogene 13 (4), 721-729 (1996)
   PUBMED   8761293
REFERENCE   10 (bases 1 to 6768)
  AUTHORS   Knudsen,B.S., Feller,S.M. and Hanafusa,H.
  TITLE     Four proline-rich sequences of the guanine-nucleotide exchange
            factor C3G bind with unique specificity to the first Src homology 3
            domain of Crk
  JOURNAL   J Biol Chem 269 (52), 32781-32787 (1994)
   PUBMED   7806500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA311708.1, BP363404.1, AK312477.1, AC018921.22 and CD677411.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001278356.1.
            
            Transcript Variant: This variant (7) lacks two exons in the 5' UTR,
            compared to variant 3. All variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.20369.1,
                                           SRR1803612.151253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549921.6/ ENSP00000450048.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA311708.1         42-43
            3-42                BP363404.1         10-49
            43-1928             AK312477.1         1-1886
            1929-6225           AC018921.22        64630-68926         c
            6226-6768           CD677411.1         1-543
FEATURES             Location/Qualifiers
     source          1..6768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..6768
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /note="fibroblast growth factor receptor substrate 2"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
     exon            1..143
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..239
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..282
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..377
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..469
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1930
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /note="FGFR signalling adaptor; FGFR substrate 2;
                     FGFR-signaling adaptor SNT; suc1-associated neurotrophic
                     factor target 1; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="fibroblast growth factor receptor substrate 2"
                     /protein_id="NP_001265285.1"
                     /db_xref="CCDS:CCDS41809.1"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
                     /translation="MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTE
                     LILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQ
                     EIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDAS
                     SHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEA
                     RVSNAESSTPKEEPSSIEDRDPQILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQV
                     SGSGANNTEWDTGYDSDERRDAPSVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQ
                     NINNSAQRRTALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNY
                     VNTENVTVPASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNP
                     QTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM
                     "
     exon            470..656
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..815
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..979
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..6768
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6134..6139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     polyA_site      6157
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /note="major polyA site"
     regulatory      6664..6669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     polyA_site      6685
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
     regulatory      6737..6742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /note="hexamer: AATAAA"
     polyA_site      6768
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /note="major polyA site"
ORIGIN      
        1 caagattcgg gccggagaga ggccttgtag gcacagcggc tgagactcga tctgctccaa
       61 gtaggggctc cagcgcgggt cggagtctgg gggttcgcgc ccgccgaccc gcgccctgct
      121 ccctctcagc acctgggcgg acgaaatgac cattaagaag tagatgccca gatgcaaaag
      181 tgatgaaaca gtccatttgt cataaagtaa gatgcagctg tggcatgtca accagcttgg
      241 aacaaaattg tatctgtttt tctcagaaga gaattccaca aggttaaatc agcaaacaaa
      301 gaaaacatgg tattttgaaa tatgattaaa ctcctgatgc tgcagcagag gctaagaata
      361 ttaatggcca gatctagtgc acacatggtc ttctgaagaa gccatgggta gctgttgtag
      421 ctgtccagat aaagacactg tcccagataa ccatcggaac aagtttaagg tcattaatgt
      481 ggatgatgat gggaatgagt taggttctgg cataatggaa cttacagaca cagaactgat
      541 tttatacacc cgcaaacgtg actcagtaaa atggcactac ctctgcctgc gacgctatgg
      601 ctatgactcg aatctctttt cttttgaaag tggtcgaagg tgtcaaactg gacaaggaat
      661 ctttgccttt aagtgtgccc gtgcagaaga attatttaac atgttgcaag agattatgca
      721 aaataatagt ataaatgtgg tggaagagcc agttgtagaa agaaataatc atcagacaga
      781 attggaagtc cctagaacac ctcgaacacc tacaactcca ggatttgctg ctcagaactt
      841 acctaatgga tatccccgat atccctcatt tggagatgct tcatcccatc cgtcaagcag
      901 acatccttct gtgggaagtg ctcgcctgcc ttcagtaggg gaagaatcta cacatccttt
      961 gcttgtggct gaggaacaag tacataccta tgtcaacact acaggtgtgc aagaagagcg
     1021 gaaaaaccgc acaagtgtgc atgttccatt ggaggcgagg gtttctaacg ctgaaagcag
     1081 cacaccaaaa gaagaaccaa gtagtattga ggacagggat cctcagattc ttcttgaacc
     1141 tgaaggagtc aaatttgttt tagggccaac ccctgttcaa aagcagttaa tggaaaaaga
     1201 gaaactggag caacttggaa gagatcaagt tagtggaagt ggagcaaata acacagaatg
     1261 ggacactggc tatgacagtg atgaacgaag agatgcaccc tctgttaaca aactggtgta
     1321 tgaaaatata aatgggctat ctatccctag tgcctcaggg gtcaggagag gtcgtctgac
     1381 atccaccagt acctcagata cccagaatat caacaactca gctcagagaa gaactgcatt
     1441 attaaactat gaaaatctac catctttgcc tcctgtttgg gaagcccgca agctaagtag
     1501 ggatgaagat gacaatttag gaccaaagac cccatctcta aatggctacc ataataatct
     1561 agatccaatg cataactatg taaatacaga gaatgtaaca gtgccagcaa gtgctcacaa
     1621 aatagaatat tcaaggcgtc gggactgtac accaacagtc tttaactttg atatcagacg
     1681 cccaagttta gaacacaggc agcttaatta catacaggtt gacttggaag gtggcagtga
     1741 ctctgacaac cctcagactc caaaaacgcc tacaactccc cttccacaaa cccctaccag
     1801 gcgcacagag ctgtatgccg tgatagacat cgagagaact gctgctatgt caaatttgca
     1861 gaaagcactg ccacgagatg atggtacatc taggaaaact agacacaata gtactgatct
     1921 gcccatgtga gcctggaaag cattgtgttg tttgcacctt tgtgaagttt ttaaaaatga
     1981 agatgcaagt gcttcatttt catttctaaa cactaactcc ttttatagac tgataaaatt
     2041 tttttctgaa tatttcatgt gcatctttaa ctaaagggaa ttaatgtaga gcaggtactc
     2101 cttaaagaac actaatttca ttatatacta ctcgttgtac agcagcattc ccgttttcac
     2161 agtgcctatt taaaatgaga gttgaagtaa atgacatgct ggttgatttt tatcaatatt
     2221 ctggacttaa cgcatacctt tcatgtctaa gtcatggttg gcttttaaaa ctttttataa
     2281 agcctcttga caatgtacat tgctaacagg taactatagg ctttgaaagt aatgctcgta
     2341 gattcagtgt tcacagtatg tggcctccag catgtaacat gaggaatcct ttatttcatt
     2401 aattaatggc tttttgactt gagccaaaac atatgtaaag gaaacagaag taccgcacct
     2461 cctcttacac cagtcagctc ctttgccttc agtgttacta gaaagcggcc tgtgtccatg
     2521 agtgtgcttt gctgttggtg cactgaaagg caggaaggag acaagatttt ctatttactc
     2581 atctcatgat gtcatttgaa gggcatgtcc agatatctta aaattataat aggctcaaga
     2641 atcagtctca ggtcacttta cccaaaaaca tttgaaaatc tgaaccacaa tctcctgaaa
     2701 gtttttctcc tatagattgt tgacaacaca ttgttttctg gaggcatttg tgccattagg
     2761 tttccattta tcttcagttt ttttctttgg tgtttgggat gtcttatttt gttgccttat
     2821 gtccttttca atttaaaatg tttgagtttg tatatagttt tgaaattgga ttatgtgttc
     2881 attgttgttt agtttgcatt tttgtcaaat tatggttttg aaggttcatt tggaacttac
     2941 tgttagtctg taacagggtt gcccttgtcc agtatttatt tataagctgt ttacttttca
     3001 agttgataaa aacattctcc aattctaaat ttgcttgtgt ccataggtga tctctttagc
     3061 aaactgagaa aaaaaggaag ctacttttaa catgcaaagt tccctcaagg tgtaccgtgt
     3121 tgtctctgtg ggcactcttc cccagcactt tagcagtaat tcccccagct acacgctgca
     3181 gttgtactct gcccactcta gtgttcctca gctctgctgt ccttttactt gtagctggat
     3241 ctttgattat ccttcgattt ccatgaaata ttaatattgt tgccagcata gcaggtacag
     3301 tggaagtctt gtagcagtga gattgtatca taatttagga tttaaaatga attaaagttt
     3361 atataaactg aagagtctcc atatgtcaaa ctcttggaaa atcaaagatg ttccaatttc
     3421 ctaaacacta gagaatacga gagaaggtag agtggaaaag gttaggtaac cttgcaaaat
     3481 attttactat tttctctaaa tatgaggaag tttgagatta tgatctggat ctaccagata
     3541 taactaaggt taatttagca tgaaaaagtt ttagtcatat tggcatccaa cctattcagt
     3601 aaccgaatca taggacaatg atggattagg agaacaatag agtgggatca ttataaagaa
     3661 aataaattat taaaggtgtc tttatcgttt tagtgccatt tttagtgtct ttactataaa
     3721 tcaatatcag tgtattttat cattctatgt gcatagcaga attttctttt ctcccttttg
     3781 ttcccctgtg aacttggtgc ttattaaagt gctcactgtt ctcttaaaag agagcagtgg
     3841 tataggtgtg cagtttccat gatgcaggtt ccatttttaa tatattgttc cacttatcct
     3901 ttcttctgag taaattgcta attgtgccaa atttatgtaa tagtttttgt aatgtggaat
     3961 aagaattatg atggaaccat tgcacatttt tttctgaaac agccagtcaa ggcagaacat
     4021 taatctccaa atgcaagggc tgatctattt attcattttg gaggttgggt actttattct
     4081 ttctttccgt catccttttc attgtttccc ccggattcta attagttttt atttttttta
     4141 gataactcca atataatcat tacagtttat gctttaaata ctatgtgctt taaaaaggaa
     4201 aatgggacca atttgtctgc taagaatttg attttaggta ctataagagt attaggaaaa
     4261 tatatacaac tggtgttaat ttctagatat tttctagaaa tcacttgtgt tcctatttaa
     4321 taaaaggtaa tttagaatac tacttgtcct ttgcagtagt ttagtaatgg gcattaagct
     4381 gtgtcctcga aggatgtacc tattactagg tgcattttag aatgaaatat tgatatttta
     4441 ttagcatata attgtggcca tatatctcag attttctgag gcagatctaa ttttagataa
     4501 ttctgttggt agaccatgtg atccttcttt ttggttttgg aaatataatc attgttaatg
     4561 ttttccctcc aaatagaata ctgttttatc catacaaatc ataacagcat ctatcccatg
     4621 ctagggttgg aaactgatat tggtattact tgtgtttttt cttagtgtgt tttatttccc
     4681 agtttcatct tcttctaaaa atgaaaatat ggtgccttcc ctccctccag gaagactggc
     4741 aaatatttcc ttttatttac tgctgctgtg gagtgatgag atatgcactt tactctttaa
     4801 gattcagcaa aaagcttttc acttctcagt atatccagaa tacatcatat ctgggactta
     4861 ggaaaatttg ccaagcaatc tttgttttta tagatactaa tgttgaccct ctccagcgtt
     4921 caatgttata aatagaacaa gtcaagctag tgtttatctc ctccccctcc ccaaaactgt
     4981 ggcacagcat ataaaaatgt acctcaataa tgttctatta aaaatgggac aggggcctta
     5041 tgttttcata atttcccaac aatgtgccgc catatttttg cctcaaggta aaggttttaa
     5101 cagatgaaaa agtacttccc aattcccccg tgctattcct aacctataat gcccaaatgt
     5161 tttgtgcaat gtgtagtgtg tgtgtataaa tacatatatt cttgaaatag acataccatc
     5221 agagacatca ttcacaagta actgatgtat tggcatctca ttcatatttc tgatgtgtga
     5281 ggtatatggt actaattacc ttttccttga tgtttgccaa atttgaataa aggcattggt
     5341 acgaaattac agaatgtaaa gaaaatgttt ttggcttgaa aaattaacat attttatgac
     5401 gtaccacagt atactctgcc caaaccagca ccctatctat ctttcctgtt ctttacatcc
     5461 ctgttcccca tccctacttc ctcatttttg gtataacaca gttcttttgt agcatcatta
     5521 taattgcagt tctatggcaa ttggacagtt atagcatgga aacagactgg tataagtagt
     5581 acagtagtca ccagtgtgcc acatttgcat tagtaatgca aaatatacat tttataaagg
     5641 acaaactttg tgttatgttt tattttcatt acattgtata atattgtaag actattgtat
     5701 gtcctaattt gcattataaa tgtttttttc ctacgtaaag gcataaatat agcaactttg
     5761 tataaaggta gcttattaga tttttaattt tttcttttat aaaaaattgt ccaacagtgg
     5821 gactaccatt gccaaattgt atatgaaata tgaattttac ccccatggtt aatttctttt
     5881 ataaacattc catatttctc taataaaaag acataagtga tactgtacta tgcatacatt
     5941 gtatcttaat gctgtttcag atcagcattt taaattttgg tttgcatttt taatattggc
     6001 aaaacgtaac cactgttaat taaaataaaa ccttgttgta tatgtaacaa cataattttc
     6061 cctctatccc ttcccaccct ttgttctcta tttctcccta tcagtgccaa cttcatacat
     6121 tttgtagcat ggcaataaaa tataactttt acactgaggc cgagtgtggc tttttggagg
     6181 aagtggggat gggacgattg ccctctagtt gtcctttgca tatgactgtt ttttgccata
     6241 taagccatgt catcaggcat gaaaagtttt ctcatatatg atgtaaactt gcttttaagg
     6301 acaagtgtga atgtgctttt taagcttaat ttttgtcatg acaactaatt ttttttatct
     6361 ttggagaagt cagagttctt tacaatcaaa cgtttattaa ctggagtact tagaataagc
     6421 tagtaattga atttagttca agggctaagc aacacatttt taaatcctta tttattgtag
     6481 agtattagta tactgtccta caaattatgt aaaatatggt ttaatattag atgactttgg
     6541 attttgcaat gccttactgt tgtcattcta gcataaatat ccataatgag gtactcaagt
     6601 tgatactgga agctgagctg atcatacact gacctgaagc attcatgaaa agctgcttta
     6661 ttgaataaag tctgattgga gttcttttca tgctcacttt ccccttattg ctgaaagtag
     6721 attgcaataa aaccccaata aaacgtttgg tcggatatct acttaaaa
//
