LOCUS       NM_014334               8155 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ferric chelate reductase 1 like (FRRS1L), mRNA.
ACCESSION   NM_014334 XM_378078
VERSION     NM_014334.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8155)
  AUTHORS   Mir,A., Amer,F., Ali,M., Alotaibi,W., Alotaibi,M., Hedaithy,A.,
            Aldurayhim,F., Hussain,F., Bashir,S. and Housawi,Y.
  TITLE     Continuous Spikes and Waves During Sleep (CSWS), Severe Epileptic
            Encephalopathy, and Choreoathetosis due to Mutations in FRRS1L
  JOURNAL   Clin EEG Neurosci 54 (5), 526-533 (2023)
   PUBMED   35815844
  REMARK    GeneRIF: Continuous Spikes and Waves During Sleep (CSWS), Severe
            Epileptic Encephalopathy, and Choreoathetosis due to Mutations in
            FRRS1L.
REFERENCE   2  (bases 1 to 8155)
  AUTHORS   Wang,R., Liu,C., Guo,W., Wang,L., Chen,S., Zhao,J., Qin,X., Bai,W.,
            Yang,Z., Kong,D., Jia,Z., Liu,S. and Zhang,W.
  TITLE     Movement disorder caused by FRRS1L deficiency may be associated
            with morphological and functional disorders in Purkinje cells
  JOURNAL   Brain Res Bull 191, 93-106 (2022)
   PUBMED   36330921
  REMARK    GeneRIF: Movement disorder caused by FRRS1L deficiency may be
            associated with morphological and functional disorders in Purkinje
            cells.
REFERENCE   3  (bases 1 to 8155)
  AUTHORS   Abdelmoumen,I., Jimenez,S., Valencia,I., Melvin,J., Legido,A.,
            Diaz-Diaz,M.M., Griffith,C., Massingham,L.J., Yelton,M.,
            Rodriguez-Hernandez,J., Schnur,R.E., Walsh,L.E., Cristancho,A.G.,
            Bergqvist,C.A., McWalter,K., Mathieson,I., Belbin,G.M., Kenny,E.E.,
            Ortiz-Gonzalez,X.R. and Schneider,M.C.
  TITLE     Boricua Founder Variant in FRRS1L Causes Epileptic Encephalopathy
            With Hyperkinetic Movements
  JOURNAL   J Child Neurol 36 (2), 93-98 (2021)
   PUBMED   32928027
  REMARK    GeneRIF: Boricua Founder Variant in FRRS1L Causes Epileptic
            Encephalopathy With Hyperkinetic Movements.
REFERENCE   4  (bases 1 to 8155)
  AUTHORS   Shaheen,R., Al Tala,S., Ewida,N., Abouelhoda,M. and Alkuraya,F.S.
  TITLE     Epileptic encephalopathy with continuous spike-and-wave during
            sleep maps to a homozygous truncating mutation in AMPA receptor
            component FRRS1L
  JOURNAL   Clin Genet 90 (3), 282-283 (2016)
   PUBMED   27239025
REFERENCE   5  (bases 1 to 8155)
  AUTHORS   Madeo,M., Stewart,M., Sun,Y., Sahir,N., Wiethoff,S.,
            Chandrasekar,I., Yarrow,A., Rosenfeld,J.A., Yang,Y., Cordeiro,D.,
            McCormick,E.M., Muraresku,C.C., Jepperson,T.N., McBeth,L.J.,
            Seidahmed,M.Z., El Khashab,H.Y., Hamad,M., Azzedine,H., Clark,K.,
            Corrochano,S., Wells,S., Elting,M.W., Weiss,M.M., Burn,S.,
            Myers,A., Landsverk,M., Crotwell,P.L., Waisfisz,Q., Wolf,N.I.,
            Nolan,P.M., Padilla-Lopez,S., Houlden,H., Lifton,R., Mane,S.,
            Singh,B.B., Falk,M.J., Mercimek-Mahmutoglu,S., Bilguvar,K.,
            Salih,M.A., Acevedo-Arozena,A. and Kruer,M.C.
  TITLE     Loss-of-Function Mutations in FRRS1L Lead to an
            Epileptic-Dyskinetic Encephalopathy
  JOURNAL   Am J Hum Genet 98 (6), 1249-1255 (2016)
   PUBMED   27236917
  REMARK    GeneRIF: Loss-of-Function Mutations in FRRS1L gene is associated
            with Epileptic-Dyskinetic Encephalopathy.
REFERENCE   6  (bases 1 to 8155)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   7  (bases 1 to 8155)
  AUTHORS   Chadwick,B.P., Leyne,M., Gill,S., Liebert,C.B., Mull,J., Mezey,E.,
            Robbins,C.M., Pinkett,H.W., Makalowska,I., Maayan,C.,
            Blumenfeld,A., Axelrod,F.B., Brownstein,M., Gusella,J.F. and
            Slaugenhaupt,S.A.
  TITLE     Cloning, mapping, and expression of a novel brain-specific
            transcript in the familial dysautonomia candidate region on
            chromosome 9q31
  JOURNAL   Mamm Genome 11 (1), 81-83 (2000)
   PUBMED   10603000
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358815.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 2, 2019 this sequence version replaced NM_014334.3.
            
            Summary: This gene encodes a component of the outer-core of an
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            receptor protein in the brain. The encoded protein is thought to
            interact with inner-core components of the receptor, and play a
            role in the modulation of glutamate signaling. Mutations in this
            gene are associated with early infantile epileptic encephalopathy
            37. [provided by RefSeq, Jul 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155065.1, SRR3476690.141842.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000561981.5/ ENSP00000477141.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AL358815.12        74221-74569         c
            350-434             AL358815.12        56956-57040         c
            435-573             AL358815.12        54371-54509         c
            574-820             AL358815.12        48663-48909         c
            821-8155            AL358815.12        37613-44947         c
FEATURES             Location/Qualifiers
     source          1..8155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..8155
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /note="ferric chelate reductase 1 like"
                     /db_xref="GeneID:23732"
                     /db_xref="HGNC:HGNC:1362"
                     /db_xref="MIM:604574"
     exon            1..349
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..993
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /note="brain protein CG-6; DOMON domain-containing protein
                     FRRS1L"
                     /codon_start=1
                     /product="DOMON domain-containing protein FRRS1L
                     precursor"
                     /protein_id="NP_055149.3"
                     /db_xref="CCDS:CCDS35098.2"
                     /db_xref="GeneID:23732"
                     /db_xref="HGNC:HGNC:1362"
                     /db_xref="MIM:604574"
                     /translation="MARPPRQHPGVWASLLLLLLTGPAACAASPADDGAGPGGRGPRG
                     RARGDTGADEAVPRHDSSYGTFAGEFYDLRYLSEEGYPFPTAPPVDPFAKIKVDDCGK
                     TKGCFRYGKPGCNAETCDYFLSYRMIGADVEFELSADTDGWVAVGFSSDKKMGGDDVM
                     ACVHDDNGRVRIQHFYNVGQWAKEIQRNPARDEEGVFENNRVTCRFKRPVNVPRDETI
                     VDLHLSWYYLFAWGPAIQGSITRHDIDSPPASERVVSIYKYEDIFMPSAAYQTFSSPF
                     CLLLIVALTFYLLMGTP"
     exon            350..434
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /inference="alignment:Splign:2.1.0"
     exon            435..573
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /inference="alignment:Splign:2.1.0"
     exon            574..820
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /inference="alignment:Splign:2.1.0"
     exon            821..8155
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8131..8136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /note="hexamer: ATTAAA"
     polyA_site      8155
                     /gene="FRRS1L"
                     /gene_synonym="C9orf4; CG-6; CG6; DEE37; EIEE37"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgcgc gggcgcgtgc tggtggcctc ggcggaggct cagtcccggc ccgcgcccgc
       61 ggcgcccccg ctgcggcccg agcggcctgg ctgcgggatc tgtgcgcacg gatggcgcgg
      121 ccgccccggc agcacccggg ggtctgggcg tcgctgctcc tgctgctact gacggggccc
      181 gccgcctgcg cagccagccc cgcggacgac ggtgcgggcc cggggggccg gggaccccgg
      241 ggacgcgcgc ggggggacac gggcgccgac gaggcggtgc cgcgccacga ctcctcctac
      301 ggcaccttcg cgggggagtt ctacgacctg cgctacctgt cggaggaggg ttaccccttc
      361 cctactgctc ctcctgtgga tccatttgcc aaaatcaaag tggacgactg tggaaaaact
      421 aagggatgct ttagatatgg caaaccaggc tgtaatgcag agacctgtga ctatttcctc
      481 agctaccgga tgataggggc tgatgtagaa tttgagctga gtgcagacac agatggttgg
      541 gtagcagttg gattctcttc agacaagaaa atgggtggtg atgatgtcat ggcctgcgtc
      601 catgatgaca atggcagggt ccgcatacag cacttctata atgtaggcca gtgggcaaag
      661 gagattcaga gaaaccctgc cagagatgaa gaaggagttt ttgagaacaa tcgcgtcacc
      721 tgcagattta aacgccctgt gaatgttccc agagatgaaa caattgttga tctgcatttg
      781 agttggtatt atctgtttgc ttggggtcca gccattcagg gctctatcac tcgacatgat
      841 atagactcac cgccggcttc agagcgtgtt gtcagtattt acaagtatga agacattttt
      901 atgccatcag ctgcctatca aaccttctca tctccatttt gtttgcttct gattgttgct
      961 ctgaccttct acctattgat gggaaccccc taaccacagc tgcagggcca acagattaca
     1021 tggattggga agtctttagt ataaatatat tttttaaaga atatccagta taattttagc
     1081 ttcaattatt taagaaaaaa aacctcatat aatttcagct ttttggaaga aagaacaagc
     1141 ttcttttgta gtcaaagaag attgtttaat aatgacccta tacttttgga acatacttac
     1201 accttttcta agcactttca catatgtttt cttatttaac ttcacaacat ctctgagttg
     1261 gattgatgaa aattgtgatt gccatcttcc tgaatgggat ttgagaccca aaaagactgc
     1321 ctttttatga tccacatacc atataacttt ggctagaaat gacaaataga aaggcagaga
     1381 aggaactaag tatagaaatc atgtctcaaa acagtcttta ctatgagtgc tatagcacag
     1441 agagttattt tgaatattac tagggagaac tttactgaat gtcataagtt cacagtcagc
     1501 cttttgggca gaagaaattt caaatttccg taaagcagaa gtgcttttgg atatttacac
     1561 agccaatggg gagattggag gaaaatacaa tgatatgaaa atagttcata tttatttgaa
     1621 attttggccg agcatggtgg ctcacgcctg tgatcccagc actttaggag gccaagacgg
     1681 gcaggtcacc tgaggtcagg agttcgagac cagcctggcc aatgtggtga aacccccgtc
     1741 tctattaaaa agtacaaaaa tgagccaggc gtggtggtgc acacctataa tcccagctat
     1801 tcgggaggct gaggcaggag aattgctgga acccaggagg cggaggttgc agtgagccga
     1861 gattgtgcca gtgcactcca gcctaggtga cagagccaga ctctgtctca aaaataacta
     1921 actaaataaa taatatttat ttgaaatttc ttctcagtta gagagcagct atgggaaaac
     1981 atttttactg ctatttgcaa aggttggaga ccaaactgtg agcattcctg aagatgtaaa
     2041 gttgtgttaa tgatattaaa aaaaaaaaaa aagggaattc ttagcagtta gaatttgaac
     2101 ttttctacca ctgaatttta taaaactaag gtattcatct gtggttacag tgaattctct
     2161 tgtcagagcc agcatacctt aagtgtgatt aaaaatgtat tttttttttt ttttgcgatg
     2221 aattttccct cttgtcgccc aggctggagt acaatggtgt gatctcagct tcactgcaac
     2281 ctccgcctcc caggttcaag tgattctcct gcctcagcct cctgagtaga tgggattaca
     2341 ggcatgtgcc actatgcctg gctaattttt ttgtattttt agtagagatg gagtttcacc
     2401 attttagtca ggctggtctc gaactcctga cctcaggtga tccacctgct ttggcctccc
     2461 agagtgctag gattacaggt gtgagccacc gtgcctggcc taaaaatgtg ttatatcaga
     2521 caaaacatct tagtaaaaat ttagggcatt ttaataataa gccaacagtt tttgagactg
     2581 tagagatttt gagtagaatt ttttttatga ggtggctttt taaaaaataa ttgaaaatgg
     2641 gaaaatgacc cataaagtga attcacctag aatatccatt taaatgttca gacttgtggc
     2701 tgagcgcggt ggctcacacc tgtaatccca gcactttggg aggccaaggc aggcggatca
     2761 cctgaggtca ggagttcgag accagtctgg ccaacatggc aaaaccttgt ctccactaaa
     2821 aatacaaaaa ttagccgggt gtggtggcac atgcctgtaa tcccagccac ttgggaggct
     2881 gaggcacgag aatcacttga accttggagg cagagcttgc agtgagccaa aattgtgcca
     2941 cttgcactcc agcctgggtg acagagggag accctgtctc aaaaaaataa gtaaaataaa
     3001 atgttcagac ttataaacta gacaggtagt cagcataatt catagtaatg ccttgacatt
     3061 aggcgcccca aaggactcct ttgttctttg ttccaaatgt ctgtgctaac tgcccatttt
     3121 gaggagagaa gtctgcaggt atagttagtg ctgctgagac atttccactc tggcattcta
     3181 gagttctctg gcttgccctt gttgctttaa agctggttcc aacttcgtgg gctttatgat
     3241 tgagcaacac tggtgattgt gatttctaat accaccctcc agattcatgt cacaggtgaa
     3301 agtctgcctg tggggagagc tttcacattc tcctggagtt gaaccaaaat aaggaaaaca
     3361 tcaacaaaca cagttaccaa aagcttccaa ggagggatgg aggagaaatt ctgttcattg
     3421 cagatgggga gaaattaaat gacatcaagt gcataatgga actgggtagg attcaaactc
     3481 aagtcccctg gttcaagtcc ttgactccac tctgggcatg gctaagtctg gcctgtgtct
     3541 catcttctca gctctagtgg ctgtttagta gtgaagatac tgatatgcag gcagccatgt
     3601 tgtaaataag aagcaaatat ttttatattt ctctctctta tgtgtataat atttgagcta
     3661 caaacaggtt aaaacaaaag agagacttca gcttagtagc aggcagggaa ggaagaagtg
     3721 aatgcagctt ccttccgctt acatttctaa tcaagctaat tatttcacta gtgatttctc
     3781 atttgattac cgattttgct tatttatgct tagaactttc aatgacttct cagtgccatt
     3841 aaggtaaaat gcaagccatt tctgtgacct gcaatatcat cttttgccac tcctcctcac
     3901 ttgctatgtc ttagcaagac tgagaggctc tcagttcttc agacctgctc tatctcacct
     3961 ctcattttgt tcatattctc cacctcttgt gcttgatgaa ctcctattca cctatcaggt
     4021 cacaacttaa atattttttc ctccaaatct ctggactaca taggtccagg cccccatcaa
     4081 atgctcccat agcacattgg gcttcctcat caacatgctc gttatacttt tctagaattg
     4141 ctggcttgtc ctccttgtta tctccctaat gcagagacca ttactcatca ttgtagcaga
     4201 tatttatcca tatcaggtac tcagcaaaca tttgtggaat gaatctatat gtgaaactat
     4261 acttctatgg caagtttgtt tggttcagaa ggcttgcatt tcatgtatat tgggagactg
     4321 gccaacattt ttatattctt cctcctatgc tcaaaccata aataattatg ttagcaaaca
     4381 ctgaactttg tcttttgaaa cataaataga aacatcctta gtaacagtac taacagtaat
     4441 catttttcag aaataagaat tcacaccagt gatacagaat ggcctttgac cattatctca
     4501 gagaactagc agtcgataga catgctgaag tgataattcc aaaaacttca gtttcattca
     4561 tccctactta aatataagag aatcaacttc tattttatgt ctgtattccc attttctaat
     4621 atactacttg tcacagagga gatgcccaac cagtgttttt cgtaaagtac ctgaatagat
     4681 taataataat gctagtgaaa tatatttagt gctgttctaa gcactttaca tgaattaact
     4741 catttaatcc tcaccgcaac cataggaagt agattctatt atttatccaa ttttacagat
     4801 gaaaaaactg aggctggtca cttgacataa attaccagtg ctggccagga ctttagagac
     4861 catttaatcc aatgctctta ttttacagag gtgcagctga agcctaagga ggtgatatga
     4921 tttcctacac attcatgcac cttcgtgcac atccattaaa acttttatta aatggaaccc
     4981 actatccata ctccaattag ctaggtgcct tttttccccc atttagtaat ttacaattaa
     5041 ttggaggact ttttatagtt atatttagag gaaaggagca tgttttactc tatatcaact
     5101 ttcttttctg cttaaaagca ttttgattct ttattttacc agtcatttta gttcttttaa
     5161 taggtttaat acacagatca aacaagactt aaatacattt ttaacaatgt aacaatttaa
     5221 aagaaattgc ctaaaaccta ggtcttctaa cttggagccc agtgcttttt ttattgctcc
     5281 gctgagtcaa aaggtgaata tataaacatg atttcagata gaatgcagaa gctgtattta
     5341 attaagttgg cttttgtcat taaagaaatc agaaagtttg gacaactcag gaatggattt
     5401 ccatcctaga tggtatttac tactatttct ggaattaagt ttactgtcta tattcaggat
     5461 tttgtgcata agagacgtga ccactgaggt tgtgtgtcat tcttatctct actccagggg
     5521 tcagcaaact ttctctgtta agggtcagat agtagttttt tggcttttca gtctctgttt
     5581 ggctctgcta taaacaatac ataaatgaat gagcatggct atgttccaat aaaacttaat
     5641 tgacactgaa ctttgaattt catgtacttt tcaaatgtca caaatgtttt ccttttgatt
     5701 tttttcagaa agccattaaa aaaatccaaa gaccattctt agcttgcagg ctgcacaaaa
     5761 acaggaagca ggcggggttt gcttatggac tgtggctttc ccacccttgt tcttagatag
     5821 ggacacacca atatatcatg attagttgta aaggatactg ccagtaacat attattactg
     5881 gttagttgta agaatatcaa agttagtgaa taatttgctt ttaaaataaa ttattgttga
     5941 tttattttta taaataaatg gcacagggca tctcatgctc ttgcattcta atatattttc
     6001 tggaattgat gcaaaagtgg tggcagtaaa gtacagagcc ggctaagcag cagttttgtc
     6061 ttaagtaact gtggtgatca tggacaacca ttgcgctgaa ctgctcttca tggtaaggat
     6121 ttcagtgttt cagagtaatt cattaaccta gagatgtttt aaaaagttgt atcggccggg
     6181 cgcggtggct caagcctgta atcccagcac ttcgggaggc cgaggtgggc ggatcacgag
     6241 atcaggagat cgagaccatc ctggctgaca cggtgaaacc ccatctctac taaaaataca
     6301 aaaaaaatta gctgggcgtg gtggcgggag cctgtagtcc cagctactca ggaggctgag
     6361 gcaagagaat ggcgtgaacc cgggaggtgg agctttcaat gagccgagat tgcccctctg
     6421 cactccagcc tgggtaacag agcaagactc cgtctaaaaa ataaataaat aaaataaaat
     6481 aaaataaaat aaaagttgta tcaaaatctg ctgcaccatg ggagtgtttt acacatgtga
     6541 tgtggcatct accttatgta ccataatgga aaaatgtttg agaaccactg cactaggcca
     6601 aaggctggga tgtgtatact ttgctgccgt gtataattgt atgtccttgt tctctaaacg
     6661 gaattggtta tgtttagtga acagttaggt ggttctccat gtgtttatat acacagacga
     6721 tccccgaatt tggatggttc aacttaagag ttttcaaact tacgatgata tgaaagtgat
     6781 atacatttga tacattccta caacttacaa tggggttatg tcccataatt gttttgactt
     6841 atgatatttt caacttacaa ttgatgggtt tactgagaca taaccctctt gtaacttgag
     6901 gagcatgtgt atatttgtac atacatgatg gtgtgtgttt atacacaaag gcctgaatat
     6961 acacaccatg agcatttgaa ggtctttgtc aaggttgttt ctgtttctga tctcttgcct
     7021 actttaaaac ccaagaggta gaacattatg catattacag gcaaaactat gcttgagttt
     7081 atagcaatgt agtttgtaga aaggattcct ggatgtttta ctaagccttt cctcctccat
     7141 tcaacattat atgaattgtt aagaacatat aaagtaccac tgttgaatgt gacttttcta
     7201 tactgttagt taagaaacca agactagtgt tagctgagta actggcatgt tgatgcaacc
     7261 tatacaggtt ttgtatttaa ttaggttcct tattcagtta ttcaagtatc cagttattta
     7321 gtttcaaggt agatttcttt gtttttatat ttaataaaag acttgcatat aagttcctct
     7381 tcatgaaaat agtggctagg ctagtgtgat tttaagtatg tctggcaact caaaatgtaa
     7441 tggattcatc aagctatttg ggatttttaa cataaaacac actgctgctt gattaatgtg
     7501 ttcagttttc ccctggatat ttgctattag gctgatagcc atttggttgg attcttctgg
     7561 agagtaattg attctctaag gtaatggggt gctgcagtgg gtgtagcatt cacccaggtc
     7621 actagaatcc tacctgtttc atcacataga aggccctggc catggggaag agtgaatgca
     7681 gcttctccgg atgccttatt tccacagaca tgctgatatg ctggaacaat ctggctccag
     7741 gagtattaat atactttttt gagactgtct acaaaatact attttgtaaa aactatgcct
     7801 ttacatagac attgataggt tatatttgtt ttataacaat tgtgtaccta atgtttgtga
     7861 ttaattttga gatttatgta tatttataag cctatcttat gtaaattttt actctaagat
     7921 gtgtggcaca ttactaataa agacgtggat ttctatttat gtaaagtaat tgtagcaata
     7981 ttcctagatg ctacctaaat gattgttctg tccatttgcc atcacaaata cttttatctt
     8041 tggatgatta tgttagtcag aatatattaa ttagatttaa actttaaaat aagaattaca
     8101 acatagtttg aaattcttcc tgttgatgta attaaagtta gtttataatt cctta
//
