LOCUS       NM_001361041            6971 bp    mRNA    linear   PRI 11-FEB-2024
DEFINITION  Homo sapiens ferric chelate reductase 1 (FRRS1), transcript variant
            2, mRNA.
ACCESSION   NM_001361041 XM_005270861
VERSION     NM_001361041.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6971)
  AUTHORS   Sprooten,E., Fleming,K.M., Thomson,P.A., Bastin,M.E., Whalley,H.C.,
            Hall,J., Sussmann,J.E., McKirdy,J., Blackwood,D., Lawrie,S.M. and
            McIntosh,A.M.
  TITLE     White matter integrity as an intermediate phenotype: exploratory
            genome-wide association analysis in individuals at high risk of
            bipolar disorder
  JOURNAL   Psychiatry Res 206 (2-3), 223-231 (2013)
   PUBMED   23218918
REFERENCE   2  (bases 1 to 6971)
  AUTHORS   Vargas,J.D., Herpers,B., McKie,A.T., Gledhill,S., McDonnell,J., van
            den Heuvel,M., Davies,K.E. and Ponting,C.P.
  TITLE     Stromal cell-derived receptor 2 and cytochrome b561 are functional
            ferric reductases
  JOURNAL   Biochim Biophys Acta 1651 (1-2), 116-123 (2003)
   PUBMED   14499595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL451051.6 and AC105270.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001361041.1.
            
            Summary: Members of the cytochrome b561 (CYB561; MIM 600019)
            family, including FRRS1, reduce ferric to ferrous iron before its
            transport from the endosome to the cytoplasm (Vargas et al., 2003
            [PubMed 14499595]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646001.2/ ENSP00000496583.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL451051.6         880-908             c
            30-134              AC105270.2         139214-139318       c
            135-330             AC105270.2         138890-139085       c
            331-467             AC105270.2         137611-137747       c
            468-562             AC105270.2         132496-132590       c
            563-710             AC105270.2         131110-131257       c
            711-893             AC105270.2         128403-128585       c
            894-992             AC105270.2         119967-120065       c
            993-1140            AC105270.2         118810-118957       c
            1141-1254           AC105270.2         109851-109964       c
            1255-1370           AC105270.2         107727-107842       c
            1371-1457           AC105270.2         105903-105989       c
            1458-1555           AC105270.2         102735-102832       c
            1556-1614           AC105270.2         102422-102480       c
            1615-1758           AC105270.2         101123-101266       c
            1759-1820           AC105270.2         99515-99576         c
            1821-6971           AC105270.2         94287-99437         c
FEATURES             Location/Qualifiers
     source          1..6971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.2"
     gene            1..6971
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /note="ferric chelate reductase 1"
                     /db_xref="GeneID:391059"
                     /db_xref="HGNC:HGNC:27622"
                     /db_xref="MIM:611578"
     exon            1..29
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            30..134
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1913
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; SDR-2; stromal cell-derived receptor 2; stromal
                     cell derived factor receptor 2 homolog"
                     /codon_start=1
                     /product="ferric-chelate reductase 1 isoform 2 precursor"
                     /protein_id="NP_001347970.1"
                     /db_xref="CCDS:CCDS91007.1"
                     /db_xref="GeneID:391059"
                     /db_xref="HGNC:HGNC:27622"
                     /db_xref="MIM:611578"
                     /translation="MAVSGFTLGTCILLLHISYVANYPNGKVTQSCHGMIPEHGHSPQ
                     SVPVHDIYVSQMTFRPGDQIEVTLSGHPFKGFLLEARNAEDLNGPPIGSFTLIDSEVS
                     QLLTCEDIQGSAVSHRSASKKTEIKVYWNAPSSAPNHTQFLVTVVEKYKIYWVKIPGP
                     IISQPNAFPFTTPKATVVPLPTLPPVSHLTKPFSASDCGNKKFCIRSPLNCDPEKEAS
                     CVFLSFTRDDQSVMVEMSGPSKGYLSFALSHDQWMGDDDAYLCIHEDQTVYIQPSHLT
                     GRSHPVMDSRDTLEDMAWRLADGVMQCSFRRNITLPGVKNRFDLNTSYYIFLADGAAN
                     DGRIYKHSQQPLITYEKYDVTDSPKNIGGSHSVLLLKVHGALMFVAWMTTVSIGVLVA
                     RFFKPVWSKAFLLGEAAWFQVHRMLMFTTTVLTCIAFVMPFIYRGGWSRHAGYHPYLG
                     CIVMTLAVLQPLLAVFRPPLHDPRRQMFNWTHWSMGTAARIIAVAAMFLGMDLPGLNL
                     PDSWKTYAMTGFVAWHVGTEVVLEVHAYRLSRKVEILDDDRIQILQSFTAVETEGHAF
                     KKAVLAIYVCGNVTFLIIFLSAINHL"
     exon            135..330
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..467
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..562
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..710
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..893
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..992
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1140
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1254
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1370
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1457
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1555
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1614
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1758
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1820
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..6971
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3503..3508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /note="hexamer: AATAAA"
     polyA_site      3531
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /note="major polyA site"
     regulatory      5100..5105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /note="hexamer: AATAAA"
     polyA_site      5130
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
     regulatory      6954..6959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
                     /note="hexamer: AATAAA"
     polyA_site      6971
                     /gene="FRRS1"
                     /gene_synonym="SDFR2; SDR2"
ORIGIN      
        1 agttggttag gctgccttcg cttctcaagg taaggaagtg gaggattaaa tgatttgccc
       61 aaagtctcac agtaatttgt agagctgaga ttgaaattcg ggtgaaactt cacatatcac
      121 attcttttta tcagatggca gtttctggat ttactcttgg tacctgcata cttctgttgc
      181 acattagtta tgtggctaat tatcccaatg gaaaagtaac acagtcatgc catggaatga
      241 ttcctgaaca tggtcatagt ccacagtctg ttcctgttca tgacatttac gtgagtcaga
      301 tgacattcag gccaggagat cagattgaag ttactttgtc agggcatcca tttaaaggct
      361 ttctcctaga agcgcgtaat gctgaggatc tgaatggccc tcctattggc tccttcacat
      421 tgattgacag tgaagtgtca caacttttga cctgtgaaga tatacaggga tcagcagtga
      481 gtcacagaag tgcatctaaa aaaacagaaa ttaaagtcta ctggaatgct ccaagcagtg
      541 ctccaaatca cacacagttt ctagtcacag ttgttgagaa gtataaaatc tactgggtga
      601 agattcctgg tcctataatt tcacaaccaa atgcatttcc ttttacaaca cctaaagcta
      661 cagtagtacc tttgccaacg ttacctcccg tttcccactt aaccaaacca ttcagtgcct
      721 cagattgtgg gaacaagaag ttctgtatta ggagtccttt gaactgtgac ccagagaagg
      781 aggcttcctg tgtcttcttg tccttcacaa gagatgacca atcggtgatg gttgaaatga
      841 gcggccccag taaaggctat ttatcctttg cattgtctca tgatcagtgg atgggtgatg
      901 atgatgctta tctgtgtatt catgaagatc agactgtgta catccagcct tcccatttaa
      961 cggggcgaag tcaccctgta atggactcca gggataccct tgaggatatg gcttggaggt
     1021 tggcggacgg tgttatgcag tgttctttca gaagaaacat tacccttcct ggagttaaga
     1081 atagatttga tctaaacaca agctattaca tatttctagc agatggtgca gctaatgatg
     1141 gtcgaattta caagcactct cagcaacctt tgattaccta tgaaaaatat gatgtgacag
     1201 actctccaaa gaacatagga ggatcccatt ctgtactcct tctgaaggtt catggtgcct
     1261 taatgtttgt ggcatggatg actactgtta gcataggtgt actggttgcc cggttcttca
     1321 agccagtttg gtcaaaagct ttcttgcttg gtgaagcagc ttggtttcag gtgcatcgga
     1381 tgctcatgtt caccacaact gtcctcacct gcattgcttt tgttatgccg tttatataca
     1441 ggggaggctg gagtaggcat gcaggttacc acccatacct cggctgtata gtgatgactt
     1501 tggcagttct tcagcctctt ctggcagtct tcaggccacc tttacatgac ccaagaaggc
     1561 aaatgtttaa ctggactcat tggagtatgg gaacagctgc tagaataata gcagtggcag
     1621 cgatgttcct gggaatggat ttaccaggac tgaatcttcc tgattcatgg aaaacctatg
     1681 caatgaccgg attcgtagcc tggcatgttg ggactgaggt tgttctggag gtacatgctt
     1741 atcggctctc tcgcaaagtt gaaatattgg atgatgacag aattcagatc cttcagtcat
     1801 ttactgcagt ggaaacagag ggtcatgctt ttaaaaaggc agtgttggca atttatgtct
     1861 gtgggaatgt tacttttctc atcatatttt tatctgcaat caaccatcta tgagcaagca
     1921 aagaccttgg cttttgcagg ccaagtgata attatcatca aaccaaagaa acttgaagcc
     1981 tgtcctgact gcctggagca tatttgtgaa ttctcacttg gaagactggg gtcatgtctg
     2041 tagaggaatt ctgaagtcca gcctttagag aacaacattc aagagggtca tatagactat
     2101 aaattaatgt catgccctat atgtaattct gggtcttaaa ggaaagattg tacttcagga
     2161 gaagtaactc tcaaatattt catgccaaga ttttaagaat gttggtattt aagaaaataa
     2221 atagtgattt ggaaaatcac aacagatgtc actaggataa taaagagata tattacgata
     2281 tatatatata tatatatata tatatatata tatatttttt tttttttttt tttttttttt
     2341 tttgagacag agtcttgctc tgtcgcccag gctggagtgc agtggtgcaa tctcggctca
     2401 ctgcaagctc tgcctcctgg gttcacacca ttctcctgcc tcagcctcct gagtagctgg
     2461 gactacaggt gcccgccacc atgccgggct aatttttttt atatttttag tagagacagg
     2521 gtttcaccat tcacaggatg gtctcgatct cctgaccttg tgatctgcct gcctcagctt
     2581 cccaaagtgc tgggattaca ggcgtgagcc accacgccca gcctatggta aatatatttt
     2641 gaactacaaa ggtgctgtgg tactttaaag aaaaactatt tttactagtt tatctgaatg
     2701 gtctgtggac tttatttaga aactgttttt cagtttagtt ttttggacat atcctttgct
     2761 cagtgtattt tgttacttct ctagtaaagg tagaagtgaa gcagatgcca ttgtaggttt
     2821 taccagcatt taaatatatt atgaattgct tagcaatgaa atgcaagtat gcatctttta
     2881 cttaaagata ctatttatgt attcagctac agagatgaaa tagcatttta tgtgttaatt
     2941 gttttggcta taaaatttaa gtccttacag catttgggga ttatacactt ggatttcaaa
     3001 attgataaaa cccttgtgaa catatctaat agatattctg tttacttgta gaaataatat
     3061 aatgtgtctg gttctgtttt gttagacatt ttttatgttc tactgaatca gaatagtcag
     3121 tgttatattc cttatttcaa gaattcatct attttatggc tacatctcat atgtgctatg
     3181 aggacttcta gccagtgggt ggcgctgtaa taccgaagta ctgcactgct ttgttcctgt
     3241 ttccttgtgc tgattccttt ctagtattta ggtaacatta ccggatggca tttcccttaa
     3301 attccaccaa ctcttaatct ttattttaaa aatggctact ttttttgggt ggttggggta
     3361 agggttaaaa ccttaaatta gtaaccgctg tttattttcc agtttatttg ttttctgtga
     3421 ttatttataa taattgatat ttgtttttac aagtcccctg accctgtaat aatgaatgca
     3481 gctatcttag gcaaagcaaa taaataaact gggcattttt aaaataaaaa atttaggaag
     3541 tcatacttta tttctttagg tattctttct gattatgtta tagtttctgc ttggcccgag
     3601 aacctaattt ctatatggtg tgaataatag cctcagctat gtagcctaca tctttatttt
     3661 attaatattt ttcaaaaatt ttctcattat ttctttttta tatttttatt ttttgaattt
     3721 acttaaccaa ctttctacta atagcctaca tcttttactg ggtaaaataa tgtggaagtt
     3781 tagtttttgt tccttttata ggtgtttatc ataagtggct tagggcttag atatgaactt
     3841 tctgtgttca tattctatat gtgccatgct acttataatc taaattttcc ttttgaaggt
     3901 ctttattaaa aaaatttagt atagcaaatt aagtgtgtac taaagttatt ttcctccagt
     3961 tttctatact aaggagctta aatgttaata aatttctctt aagttatatt ctacatctga
     4021 caaagaaaaa ttctctcttt tttttttttg tgacaaagtc tcactctgtt gtctaggctg
     4081 gagtgcagtg gtgcaatgtt ggctcactgc agcctccacc tcctgggttc aagcgagtct
     4141 tgtctcagtc tcctgaatag ctgggactac aggtgtgcac caccagtctc ggctaatttt
     4201 tatattttta gtagagacgg gggtttcaca ttttggccag gctggtccca aactcctggt
     4261 ctaaagtaat ccacccgcct cagcctccca aagtgctggg attacaggca cgagccactg
     4321 tgcccagctg aaaattcttt taagggaaag atgagtcttg atgtgtttgg tcttcaaata
     4381 tgtgggcttg ctatatttcg agtgttgagg ctaagatatt ttaacttttt ctttttcagt
     4441 gcttcatatg ttggcactat tttggtcttt gccaacttac atacagagtt ccccgaataa
     4501 gcctttgcat ttaatctttt tttttttttt ttgagacagg gtcttactct gttgcccagg
     4561 ctggagtgca gtggtgcgat cttagcccac tgcagccttg acctcttggg ctttagtgat
     4621 cctcccactg cagcctccag agtagctgga actacaggca ccaactccgt gcaccaccac
     4681 agccagctaa ttaaaaaaaa attttttttt ttttttggta gagaagggat ctccctttgt
     4741 tgcccaggct gatctcgaac tcctgggctc aagcaatccc cttgcctcag actcccaaag
     4801 tgttgggatt ataggcatga gccattgcac ctggccccaa atagaccaaa tcttttgatt
     4861 agaaccaaat tattcttctt ctgcttatgg gtggttggta tccacaaatt gcaaatgcct
     4921 agtcttcact cctctcagtt tttctttttg tttctgtaat aaacactctg ggaagttttt
     4981 caaaagttat ttcttttgat agtaattatt gttaaattaa atgcttttat atctttagca
     5041 atgttgccaa aaacaatgag caaaatcatg ttttcttcta aagaagtgat gcaatatgaa
     5101 ataaagatgt gtgtgctttt cagaaagaaa tgaaagaaat tctagaaaat tgtggttggg
     5161 ctggcattaa tagctgaggc aataaaaaaa ttctctggtc tgcagaaatc aatcttaagg
     5221 gcaaaggtag tctatagtat gggttatcaa gtaaatgaat caaattcact ttagtacttt
     5281 atttttgtca aggattttgt ctctaatgtg tgttaagcaa tacctcatcc cttccacatc
     5341 ctgcaccagt ccaggctgca gtgggaaaag acaaatgcag cagatgccaa ctaggaagct
     5401 ctcagggcac atgtagtgtt tggctgaaat tctatttatc tgtatattct catgaggcag
     5461 ggaaaaaaag aacaaaggtc cttgtttaag ataatccatt ataggttgga atgaaaggaa
     5521 agattcttct aagagtcctt tttaaatcag attaggatat tcacagttcc tatccacatc
     5581 ctgcttcttt cttccttgtg cagcccctac caagctcatc tctgcaccca ggtcacagat
     5641 ggttaccagc ctggaatgcc cttctcagtg aaacgggaaa tgttcccttg tcccccttgc
     5701 agggtgtgga atggggatgt ggctggcttc ttcagtgccc cactgctcaa atctagggga
     5761 gcatacagat gggcaggctg tggggctccg accccacagc aatgtctagg ggtgaatgtt
     5821 tgcagctgaa gccccagtgg gcatgtgtta ccacgtgctc ttttagttta gctgtccata
     5881 gttagcttgt gttagctcaa ttagacccct gccttattgc aaggacagag ggctttctgt
     5941 atccctgggt tcttgccttg gtgtaccagg agaatcggat cacacctggg cttgaagaac
     6001 gagtgcaagg ttttactgag tagaagtagc tctcagcaga tgggggagcc agaagggaga
     6061 tggttttccc ctggagttgg gccgctagac tgcctgggct ctcctctgat tgccccggcc
     6121 aaactccgcc aactgttcct ccttccgcca gtcgtggcct gtcggcatgc tgggatctgt
     6181 cgtgtgctct tcctctggcg tgctcccatc cacatcctct cgctgtccag ctgcttgtgt
     6241 cttctgcgat gtgttcctct ccacgtccag ctgcttgtgt gtctgcctgc tagaatcttg
     6301 gaggttttta taggcacagg atgggggcgt ggtgagccag ggtggtctta ggaaatgcaa
     6361 catttgggcg ctgaaggcag gggtgcctgt cctcacttag acccgtgggc acgggtttgg
     6421 gggtggagcc ctcgccaggg accacgccct cctctaccca gcacttcctt tccctccttt
     6481 cctgttattt aaagggacca cgcccttccc agcacttccc tcccgttatc acttacaaaa
     6541 gctagtttat caagttctag ctccttccct gacttgctgt ccaacattgg tatctttttg
     6601 ttttgaccat ccttataaat gggatgggag gcagctgatc ctgtaaatta aaaaggactg
     6661 gaaattagaa gacctgaatg tgcatgtttg cttgttggtt tacaagctgc atgtccttgg
     6721 gtaagtcact tatcttccct gggctctatt ctttcatctg taaagcccat ctcacagagc
     6781 agctgtgagg atccaatgaa gtgatgccag caaaaggtgc ttgcttcgta catgtttttg
     6841 atgatgtctt tgccatttga ttgcagtgtt aaacttaata aattttgcat gtaaaatgta
     6901 tactttttat aaaaaatatt tgatattcat cttgaaaaca ttatgctgaa taaaataaag
     6961 cagacgcagg a
//
