LOCUS       NM_001368397            8453 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens FERM and PDZ domain containing 4 (FRMPD4), transcript
            variant 3, mRNA.
ACCESSION   NM_001368397 XM_011545613
VERSION     NM_001368397.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8453)
  AUTHORS   Li,R.K., Li,H., Tian,M.Q., Li,Y., Luo,S., Liang,X.Y., Liu,W.H.,
            Li,B.M., Shi,X.Q., Li,J., Li,B. and Shu,X.M.
  CONSRTM   China Epilepsy Gene 1.0 Project
  TITLE     Investigation of FRMPD4 variants associated with X-linked epilepsy
  JOURNAL   Seizure 116, 45-50 (2024)
   PUBMED   37330374
  REMARK    GeneRIF: Investigation of FRMPD4 variants associated with X-linked
            epilepsy.
REFERENCE   2  (bases 1 to 8453)
  AUTHORS   Wang,M., Lin,L., Shi,Y., He,L., Wang,C. and Zhu,J.
  TITLE     Structure of the FERM domain of a neural scaffold protein FRMPD4
            implicated in X-linked intellectual disability
  JOURNAL   Biochem J 477 (23), 4623-4634 (2020)
   PUBMED   33216857
  REMARK    GeneRIF: Structure of the FERM domain of a neural scaffold protein
            FRMPD4 implicated in X-linked intellectual disability.
REFERENCE   3  (bases 1 to 8453)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8453)
  AUTHORS   Piard,J., Hu,J.H., Campeau,P.M., Rzonca,S., Van Esch,H.,
            Vincent,E., Han,M., Rossignol,E., Castaneda,J., Chelly,J.,
            Skinner,C., Kalscheuer,V.M., Wang,R., Lemyre,E., Kosinska,J.,
            Stawinski,P., Bal,J., Hoffman,D.A., Schwartz,C.E., Van
            Maldergem,L., Wang,T. and Worley,P.F.
  TITLE     FRMPD4 mutations cause X-linked intellectual disability and disrupt
            dendritic spine morphogenesis
  JOURNAL   Hum Mol Genet 27 (4), 589-600 (2018)
   PUBMED   29267967
  REMARK    GeneRIF: The findings point to an important role of FRMPD4 in
            normal cognitive development and function in humans and mice, and
            support the hypothesis that FRMPD4 mutations cause ID by disrupting
            dendritic spine morphogenesis in glutamatergic neurons.
REFERENCE   5  (bases 1 to 8453)
  AUTHORS   Matosin,N., Green,M.J., Andrews,J.L., Newell,K.A. and
            Fernandez-Enright,F.
  TITLE     Possibility of a sex-specific role for a genetic variant in FRMPD4
            in schizophrenia, but not cognitive function
  JOURNAL   Neuroreport 27 (1), 33-38 (2016)
   PUBMED   26555035
  REMARK    GeneRIF: Study suggests that the variant rs5979717 in FRMPD4 may
            play a role in schizophrenia etiology in females
REFERENCE   6  (bases 1 to 8453)
  AUTHORS   Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
  TITLE     Structural basis for interaction between the conserved cell
            polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
            protein (LGN)
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19210-19215 (2011)
   PUBMED   22074847
REFERENCE   7  (bases 1 to 8453)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 8453)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 8453)
  AUTHORS   Lee,H.W., Choi,J., Shin,H., Kim,K., Yang,J., Na,M., Choi,S.Y.,
            Kang,G.B., Eom,S.H., Kim,H. and Kim,E.
  TITLE     Preso, a novel PSD-95-interacting FERM and PDZ domain protein that
            regulates dendritic spine morphogenesis
  JOURNAL   J Neurosci 28 (53), 14546-14556 (2008)
   PUBMED   19118189
  REMARK    GeneRIF: Preso positively regulates spine density through its
            interaction with the synaptic plasma membrane, actin filaments,
            PSD-95, and the betaPix-based Rac1 signaling pathway.
REFERENCE   10 (bases 1 to 8453)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002981.1, AC112499.8,
            AC119619.5 and AC112655.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 9, 2019 this sequence version replaced XM_011545613.2.
            
            Summary: This gene encodes a multi-domain (WW, PDZ, FERM)
            containing protein. Through its interaction with other proteins
            (such as PSD-95), it functions as a positive regulator of dendritic
            spine morphogenesis and density, and is required for the
            maintenance of excitatory synaptic transmission. [provided by
            RefSeq, Jan 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675598.1/ ENSP00000502607.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               AC002981.1         19266-19805
            541-657             AC112499.8         23646-23762         c
            658-818             AC119619.5         89284-89444
            819-921             AC112655.4         2189-2291
            922-967             AC112655.4         62273-62318
            968-1072            AC112655.4         70893-70997
            1073-1180           AC112655.4         73507-73614
            1181-1312           AC112655.4         77605-77736
            1313-1432           AC112655.4         81745-81864
            1433-1569           AC112655.4         89284-89420
            1570-1696           AC112655.4         91769-91895
            1697-1786           AC112655.4         94236-94325
            1787-1969           AC112655.4         94879-95061
            1970-2108           AC112655.4         97809-97947
            2109-3173           AC112655.4         103479-104543
            3174-4463           AC112655.4         104911-106200
            4464-8453           AC112655.4         107944-111933
FEATURES             Location/Qualifiers
     source          1..8453
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..8453
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="FERM and PDZ domain containing 4"
                     /db_xref="GeneID:9758"
                     /db_xref="HGNC:HGNC:29007"
                     /db_xref="MIM:300838"
     exon            1..540
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..5788
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="isoform c is encoded by transcript variant 3;
                     PSD-95-interacting FERM and PDZ domain protein; Preso; PDZ
                     domain-containing protein 10; PSD-95-interacting regulator
                     of spine morphogenesis"
                     /codon_start=1
                     /product="FERM and PDZ domain-containing protein 4 isoform
                     c"
                     /protein_id="NP_001355326.1"
                     /db_xref="CCDS:CCDS94551.1"
                     /db_xref="GeneID:9758"
                     /db_xref="HGNC:HGNC:29007"
                     /db_xref="MIM:300838"
                     /translation="MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTAN
                     RDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVR
                     SVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKS
                     AFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSF
                     RFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRP
                     SSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLA
                     ALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQN
                     LVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHV
                     INTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLT
                     AGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTFIGEGEQ
                     EAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRS
                     LAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEML
                     EKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDIC
                     YAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDF
                     LLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTS
                     AEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSS
                     EMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALA
                     ARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSK
                     LADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRK
                     DSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQ
                     GDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQS
                     EGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSE
                     ERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKET
                     TALTEPGKERRGGMPSAWSQHPEADPILLPSNIHSESKVPIPNQDPNDFSQANQAYGE
                     AVSWRPPDLRGGSLRTPPSQKALRHSSSILSGSVDLETFRERTKGAVSLKCPGITEAQ
                     EASSERRAELPLGRKLTKSFSQSSMHLSSEGRFHKRSPVAHKDSKLYRTLPLRKLEGS
                     NWRCRGPFSYCFLNRGQDEDGEEEEERGEATVQVSCLYRPQMTQAMPEPSSPCLAVAI
                     QKQRGELSRGSVLKVWAEDLRDPDDLDFSNLAFDARIARINALKESTYAMPDGFLAAQ
                     NDANELLCLVRATKEKREESRPEAYDLTLSQYKQLLSIESRQLGSACRKMAMAEKSPE
                     EMLLAMTSSFQVLCCLTEACMRLVKVVNSETQRQEIVGKIDEVVINYICLLKAAEAAT
                     GKNPGDPNVGLSARHSTTMAALVSTLTRSLKRLLNK"
     exon            541..657
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            658..818
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            819..921
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            922..967
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1072
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1180
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1312
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1432
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1569
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1696
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1786
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1969
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2108
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..3173
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..4463
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..8453
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6319..6324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="hexamer: AATAAA"
     polyA_site      6341
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="major polyA site"
     regulatory      8429..8434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="hexamer: AATAAA"
     regulatory      8433..8438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="hexamer: AATGAA"
     regulatory      8437..8442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="hexamer: AATGAA"
     polyA_site      8446
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="major polyA site"
     polyA_site      8450
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="major polyA site"
     polyA_site      8453
                     /gene="FRMPD4"
                     /gene_synonym="MRX104; PDZD10; PDZK10; XLID104"
                     /note="major polyA site"
ORIGIN      
        1 agctgcagtg ctgcgagggg tgcgtgcgcg tgtgcccagc tcgcctgccg tctcccggct
       61 ccgtctgcgc tcctcggtgc gtggggcacg agggtccgag ggccgggaag ccagagcagc
      121 gcctctcgcc caggcctcgc tttctctgga cgcccggcag tccccggggc tagagcgcac
      181 ggggcggggc gcgagacccg ggccgcgctc cccgcccccg cctcttgcgc cctgcctggc
      241 tccctctcca ttgagttttc ctgcctcggg tgcctatcaa tggtcctgct cggggatgca
      301 cacgcagctc gcggccggag gggggtagca gccgccgcct ccaggtgcag gttctctccg
      361 gccgccgccg ccacccgctg tcgccgcgac tcgagccccg ggcgcactga ggtcttggcc
      421 atggggctgc ggaggctgct gttgctggcg tgagaagggg cgacggagtt gtcgcgctcg
      481 ggggtcccca gctgcctgca tggatgtctt cagctttgtg aagattgcaa agctttcgag
      541 ccacaggacg aagtcttcag gctggccgcc tccctcggga acctggggct tgagccaggt
      601 gccgccctat ggatgggaga tgacggcaaa ccgagatggg cgagactact tcatcaatca
      661 catgacacag gcaatccctt ttgacgaccc tcggttagag agctgccaaa tcatccctcc
      721 ggctcctcgg aaggtggaga tgagaaggga ccccgtgctg ggatttggtt ttgtggcagg
      781 cagtgaaaag ccagtggtcg ttcgctcagt aacaccaggt ggcccctctg aaggcaagct
      841 gatcccggga gatcagattg taatgattaa tgatgaaccg gtcagcgctg cacccagaga
      901 gcgggtcatc gatctggtca gaagctgcaa agaatcgata ctcctcactg tcattcagcc
      961 ttacccttct cccaaatcag catttattag tgctgcaaaa aaggcaagat taaagtccaa
     1021 tcctgtcaaa gtacgcttct ctgaggaggt catcatcaac ggccaagtgt cggaaactgt
     1081 taaggacaac tcacttcttt ttatgccaaa tgttttgaaa gtctatctgg aaaatgggca
     1141 gaccaaatca tttcgttttg actgcagcac ttccattaag gatgtcatct taacccttca
     1201 agagaagctc tccatcaaag gcattgaaca cttctctctc atgctggagc agaggacaga
     1261 aggggctgga acgaagctgc tcttgcttca tgaacaggag actctaactc aggtgacaca
     1321 gaggcccagc tcccataaga tgagatgtct tttccgaatt agcttcgtcc caaaagatcc
     1381 aattgacctt ttaaggagag atccagttgc tttcgagtat ctctatgttc agagttgtaa
     1441 cgatgtggtt caggagcgat ttgggccgga gctgaaatat gacatagccc tgcggctggc
     1501 cgcattacaa atgtacattg caaccgttac caccaagcaa acgcagaaaa tctccctcaa
     1561 atacatcgaa aaagaatggg gattagagac ttttcttccc tctgctgtgc tgcaaagcat
     1621 gaaagagaag aacataaaga aagcactttc acaccttgtc aaagcaaatc aaaacttggt
     1681 accaccgggt aaaaagctct ctgcactaca agccaaggtc cattatctca agttcctcag
     1741 tgacctacga ttgtatgggg gccgtgtgtt caaggcaaca ttagtgcagg cagaaaagcg
     1801 ctcggaagtg actctcctgg ttgggccccg gtatggcata agccatgtca tcaacaccaa
     1861 aaccaatctg gtggctcttt tagccgactt tagccacgtc aacaggatcg aaatgttttc
     1921 cgaggaggag agcttggtgc gggtagaact ccacgtgcta gatgtgaagc ctatcacgct
     1981 tctgatggaa tcctcagatg ccatgaacct ggcctgcttg acggctggat actaccggct
     2041 gcttgttgat tccaggaggt cgatatttaa catggccaac aagaaaaaca cagcgaccca
     2101 ggaaacagga cctgaaaaca aggggaagca taacctcctt ggcccagatt ggaactgtat
     2161 accccaaatg accaccttta ttggcgaagg ggaacaagaa gcccagataa catacataga
     2221 ttcaaagcag aagacggtgg agatcacaga cagcaccatg tgtccaaaag agcaccggca
     2281 cttgtacata gacaatgcct atagttcaga tggacttaac cagcagctga gccagcccgg
     2341 ggaggccccc tgtgaggcag actacagaag tctagctcag cggtccctat tgaccctctc
     2401 aggaccagaa actctgaaga aagcacagga atctccgaga ggagctaaag tgtcctttat
     2461 ttttggagac ttcgccttgg atgatggtat tagtccccca acccttggct atgaaacgct
     2521 actagatgag ggtcctgaaa tgctggagaa gcagagaaat ctctacattg gcagtgccaa
     2581 tgacatgaag ggcctggatc tcactccaga ggcagagggc atccagtttg tggaaaattc
     2641 tgtttatgca aacataggcg atgtgaagag cttccaggcc gcggagggga tcgaggaacc
     2701 cctcttgcat gacatctgtt atgcagaaaa cactgatgac gcggaggacg aggacgaggt
     2761 gagctgcgag gaggacctcg tggtggggga gatgaaccag ccggccatcc tcaacctgtc
     2821 tgggtcaagc gatgacatca ttgacctcac atccctgccc cctccagaag gtgatgacaa
     2881 tgaggatgac ttcctgttgc gttccttgaa catggccatt gccgcacccc cacctggctt
     2941 tagagacagt tcagatgaag aggactctca gagccaggca gcttccttcc ccgaggacaa
     3001 ggagaaaggc agcagcctgc aaaatgatga gatccccgtg tccctcattg acgctgtgcc
     3061 caccagcgcc gaaggcaagt gtgagaaggg actggataat gccgtcgtct ccacgctggg
     3121 agctctagag gctctatccg tgtcagaaga acagcagacc agtgacaatt caggtgtagc
     3181 catcttgcgg gcttatagtc ctgagtcttc gtcagactcg ggcaatgaaa ctaactcttc
     3241 tgaaatgact gagagttctg aactggccac agcacaaaaa cagtcagaaa acctctcccg
     3301 catgttcttg gccactcacg aaggctacca cccccttgca gaagagcaga ccgagttccc
     3361 ggcctccaag acccccgctg ggggcttgcc tccaaagtcc tcgcacgccc tggctgctag
     3421 gccagcaacc gacctcccgc ccaaagttgt gccttccaag cagttacttc actcagacca
     3481 catggagatg gagcctgaaa ctatggagac taagtcggtc actgactatt ttagcaaact
     3541 gcacatgggg tcggtggcat actcctgcac tagcaaaagg aaaagcaagc tggccgatgg
     3601 tgaggggaag gcacccccta atgggaacac aacaggaaaa aaacagcagg ggaccaaaac
     3661 ggcagagatg gaggaggagg ccagtggtaa atttggtact gtgtcttcac gagacagtca
     3721 acacctgagc acttttaatc tggagagaac tgcctttcgc aaggacagtc aaagatggta
     3781 tgtggccact gaaggtggga tggctgaaaa aagtggatta gaagcagcaa cagggaaaac
     3841 ctttccaaga gcttctggtc ttggggcaag ggaggccgaa gggaaggaag aaggagctcc
     3901 tgatggagaa accagtgatg gctcaggact tggtcaaggg gaccgcttct taactgacgt
     3961 gacctgtgca tcttcagcca aagacttaga taacccagag gacgctgact cgtccacctg
     4021 cgaccatcct tccaagcttc ctgaggctga tgagagtgtg gcccgccttt gtgactacca
     4081 cttggccaag cggatgtcat cactgcaaag cgagggccat ttttctctgc agagctccca
     4141 aggctcttca gtggatgcag gctgtggcac aggcagcagt ggcagtgcct gtgccacacc
     4201 cgtggagtcg ccgctctgcc cctccctggg gaagcacttg attcctgacg cttctgggaa
     4261 aggcgtgaat tacattcctt cagaggagag agcccctggg cttcccaacc acggagccac
     4321 ctttaaggaa ctgcacccac agacagaagg gatgtgtcca cggatgacag tgcctgctct
     4381 gcacacagcc attaacaccg aacccctgtt tggcacattg agagatggat gccatcggct
     4441 ccccaagatt aaggaaacca cagctttgac agagcctggg aaggagagac gaggaggcat
     4501 gccttcagct tggtctcaac atcctgaagc tgatcccatc ctgctaccat caaacattca
     4561 ctcggaatca aaggtgccaa ttccaaatca agaccctaat gatttctccc aagcaaatca
     4621 ggcatacgga gaggctgtga gctggcggcc accggatctg agagggggga gcctcaggac
     4681 acctcccagc cagaaggctc tgagacatag cagcagtatc ctctccggat ctgtcgattt
     4741 ggagaccttc cgagagagaa ccaagggtgc agtcagctta aagtgtccag gcatcacaga
     4801 agcacaggag gccagttctg aaaggcgagc agaactcccc ctggggagga agctcaccaa
     4861 aagtttttcc caaagctcaa tgcacttgag ctctgagggg aggtttcaca aaaggtcccc
     4921 agtggctcat aaagactcaa agctgtatag gacattaccc ttgcggaagc tggagggcag
     4981 caattggaga tgccggggac ccttcagcta ttgcttcctg aaccgagggc aggatgaaga
     5041 tggtgaggaa gaagaggaga ggggagaggc caccgtccag gtctcttgcc tctatagacc
     5101 acagatgact caagccatgc cagaaccaag cagcccatgc ctggctgtgg cgattcagaa
     5161 gcaacgaggg gagctatcca gagggtcagt gctgaaggtc tgggcagaag acctgcgaga
     5221 cccagatgac ttggacttca gcaacctggc ttttgatgcc cggattgcaa gaataaatgc
     5281 cctaaaggag agcacatatg caatgcctga tgggttcctt gcagcccaaa atgatgccaa
     5341 tgagctgctc tgtctcgtca gggcaaccaa ggagaagagg gaggagtcac gccctgaagc
     5401 gtacgacctt acactttctc agtacaagca actgttatcc attgagtcca gacagttggg
     5461 aagtgcctgt aggaaaatgg cgatggctga gaaaagcccg gaggagatgc tcctagctat
     5521 gacttccagc tttcaagtgc tctgttgcct aacagaagct tgcatgcgat tagttaaagt
     5581 cgtgaactca gaaacacagc ggcaggaaat tgtagggaag atcgatgaag tggtcataaa
     5641 ttacatttgt ctactgaaag ctgccgaagc agccactgga aagaaccctg gggaccctaa
     5701 tgttggactc tcggcgcgac actcaaccac catggccgct ctcgtaagca cactgacacg
     5761 ttctctcaag aggcttttaa acaaataaat atggaagtca cgtcataatc tacctttgca
     5821 aagccataca tgaactttta tttactttgt gtgtatgatg aacagatgtc tcctttcttc
     5881 tctctgtata ttttgttatt ttatataaaa taggagataa aagtcacatt gatgaaatgt
     5941 tgaaatgtac taatcagatg tattctgttt atattataca tatatataca cgtaaaagaa
     6001 atatccaaga aagtgatgac atttggctat ttttcatata gttaaaactc caggtatatg
     6061 atgtgaaatt ttaaattcta ccatgttaga gcaaaacaat gaatcctatc ccctttcttt
     6121 ccaagtagct acttggaaac catatcattc atatttagaa gtaaaacaca aaacaaaaaa
     6181 gagagagaaa agaaaagaaa tcacaatgta tataaaacag tacttatgtt ttaaaattat
     6241 gatttttaag cattggaaat agcaaaaaga catttaaaat tcaagaagct attatgaatt
     6301 actagagaat atatctgtaa taaattaatt ttttgctcat agtatttggt tactggatgc
     6361 tttcttccaa gaatcccaca tatttaattt gggtttttgc tactggggct acaaattggt
     6421 ggggatggat tctactgtgt cagcacaaat gctcttcaca gtggttctag catttaaaaa
     6481 acttcccggg gagaagaaca gaggggatga tgggcagttt cctaggtaac acctagagtt
     6541 atagaatatc tcattacata aaatgtatgg aattaataat accaaaatta attatttgat
     6601 ggaaagatct gctttgacta aatgtcaaaa atctgcaaac caaagacatt atcttcccct
     6661 catcccaact caactacgaa acttaaaatt ccctttagag tgataggaca tttagtaaag
     6721 tatttgcaaa cttaaaaaaa ggaacattta atgatcatca aaattaagta cagattcagt
     6781 aatgtagacc agaccacaca ccagcacctg tgagtctcat ctcagatcac agctctcagc
     6841 atagggcttc atgcatcacc gcctctacag aggctaaggc tgccagtcaa atttggaatt
     6901 atagcgtagt actgggacaa aatctcaaat cttggatgtt ccagaaaatc agggagagat
     6961 ggctactgta atcatgggag ccatgagtaa atagttaagt atttattaaa taaatactta
     7021 atctggattg gctgataaaa atatgaaatc tgaaaaaaaa aagaaagaaa tggaagtggt
     7081 atatttgacc agttcaagtg aaaccaatgg aatgcaaaga actttccagg actgtcacat
     7141 ctctaaaagt accctgcagt cataaaataa aatcgatatg tatatatgta tttcctgggt
     7201 cattcagtgc tcaagttaca tgcactccta cttagacagg tggctcctta agaacatgat
     7261 gggagtacac caggtgcaaa tatttctact tttgtagcct gctgagaagg agtcataaca
     7321 cagtccacaa ttgcaatctc tctctagtca gccattccac agggactcaa caacaaaagc
     7381 cgcacgtggt tatggatggc agcaaaggaa aggagtttag gtgtgtgtta ttataaataa
     7441 tgtttaacta aataataaaa cattatttca ttacaattat aattataaat attggtgttt
     7501 tgatattgag agatattagt ggtgtttact gtggaaaatc ttagtaaata tcattctgtg
     7561 tactaaaatc ctaacctatt aataggatgt gtgccctatg tcagacagtg tgctaagcat
     7621 attaactata ttatctcatt taatcatcac aacaatctgc tggtttggac actattctct
     7681 ctggaggcaa tatggatgag ttcttacgga tatggggttt ggggtcagaa acatcttgat
     7741 taaaattttg actctgccat tttctagccc ttttatgttg ggaaagctac tttttctagt
     7801 ctcaatttcc tcataataaa atgaaaatca attataagat cgatttccat agggttgtca
     7861 tgagttttga gtaaaaatgt gtatgtaaag ttcttaccac aatacctggc agagagtaag
     7921 tattcaatta atgttagcta ttattatcat cataatcgtt gtgttaaata tattgcccaa
     7981 gataatatgt gggggaatgt ttgttttata tgcatattgt atcctgactg tgtgcagaac
     8041 acattatgtg tattgcatat atgtaaaaga agtgtacaag gaagtggcca tccttgttca
     8101 agttacgtat ctagttagaa caacttccca gtccattgga gttctttgag aagcctcagg
     8161 gaagtagctc tgggtccttc taatcaacct cccattactg cgccagtaag tttctgtttc
     8221 ttataaataa actctttgct attcagaaaa cctcaagggg cccccacatt cactaagcat
     8281 ggggctccta actggggtcc aggtccatag agtgtaggaa gaacatatta gaacaatact
     8341 tgtgcttatt tttatctagc ttttttatgt ttgtgtatgt tttataatgg cataatagta
     8401 caatggtaca tgtacataat tttaaataaa taaatgaatg aatgaataaa taa
//
