LOCUS       NM_001018071            4819 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens FERM and PDZ domain containing 2 (FRMPD2), transcript
            variant 3, mRNA.
ACCESSION   NM_001018071 XM_001127659
VERSION     NM_001018071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4819)
  AUTHORS   Lipinski,S., Grabe,N., Jacobs,G., Billmann-Born,S., Till,A.,
            Hasler,R., Aden,K., Paulsen,M., Arlt,A., Kraemer,L., Hagemann,N.,
            Erdmann,K.S., Schreiber,S. and Rosenstiel,P.
  TITLE     RNAi screening identifies mediators of NOD2 signaling: implications
            for spatial specificity of MDP recognition
  JOURNAL   Proc Natl Acad Sci U S A 109 (52), 21426-21431 (2012)
   PUBMED   23213202
REFERENCE   2  (bases 1 to 4819)
  AUTHORS   Huang,J., Furuya,A., Hayashi,K. and Furuichi,T.
  TITLE     Interaction between very-KIND Ras guanine exchange factor and
            microtubule-associated protein 2, and its role in dendrite
            growth--structure and function of the second kinase noncatalytic
            C-lobe domain
  JOURNAL   FEBS J 278 (10), 1651-1661 (2011)
   PUBMED   21385318
REFERENCE   3  (bases 1 to 4819)
  AUTHORS   Stenzel,N., Fetzer,C.P., Heumann,R. and Erdmann,K.S.
  TITLE     PDZ-domain-directed basolateral targeting of the peripheral
            membrane protein FRMPD2 in epithelial cells
  JOURNAL   J Cell Sci 122 (Pt 18), 3374-3384 (2009)
   PUBMED   19706687
  REMARK    GeneRIF: These results provide novel insights into the molecular
            function of FRMPD2 and into the targeting mechanism of peripheral
            membrane proteins in polarized epithelial cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074325.7 and AC013284.9.
            
            On Nov 22, 2018 this sequence version replaced NM_001018071.3.
            
            Summary: This gene encodes a peripheral membrane protein and is
            located in a region of chromosome 10q that contains a segmental
            duplication. This copy of the gene is full-length and is in the
            telomeric duplicated region. Two other more centromerically
            proximal copies of the gene are partial and may represent
            pseudogenes. This full-length gene appears to function in the
            establishment and maintenance of cell polarization. The protein is
            recruited to cell-cell junctions in an E-cadherin-dependent manner,
            and is selectively localized at the basolateral membrane in
            polarized epithelial cells. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749241.1, SRR1803613.146982.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374201.8/ ENSP00000363317.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC074325.7         33054-33207         c
            155-280             AC074325.7         10077-10202         c
            281-438             AC074325.7         7532-7689           c
            439-504             AC074325.7         3295-3360           c
            505-696             AC013284.9         1138-1329
            697-829             AC013284.9         2998-3130
            830-917             AC013284.9         3798-3885
            918-1050            AC013284.9         5367-5499
            1051-1122           AC013284.9         6937-7008
            1123-1297           AC013284.9         11201-11375
            1298-1445           AC013284.9         20220-20367
            1446-1584           AC013284.9         21039-21177
            1585-1740           AC013284.9         31381-31536
            1741-1926           AC013284.9         36557-36742
            1927-2083           AC013284.9         42106-42262
            2084-2294           AC013284.9         50596-50806
            2295-2395           AC013284.9         56198-56298
            2396-2488           AC013284.9         57845-57937
            2489-2596           AC013284.9         58609-58716
            2597-2713           AC013284.9         58808-58924
            2714-2919           AC013284.9         62482-62687
            2920-3024           AC013284.9         65339-65443
            3025-3118           AC013284.9         67551-67644
            3119-3204           AC013284.9         68535-68620
            3205-3352           AC013284.9         70397-70544
            3353-3567           AC013284.9         72282-72496
            3568-3666           AC013284.9         74797-74895
            3667-4010           AC013284.9         79819-80162
            4011-4819           AC013284.9         86120-86928
FEATURES             Location/Qualifiers
     source          1..4819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..4819
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /note="FERM and PDZ domain containing 2"
                     /db_xref="GeneID:143162"
                     /db_xref="HGNC:HGNC:28572"
                     /db_xref="MIM:613323"
     exon            1..154
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..4059
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /note="isoform 3 is encoded by transcript variant 3; PDZ
                     domain containing 5C; FERM and PDZ domain-containing
                     protein 2; PDZ domain-containing protein 4"
                     /codon_start=1
                     /product="FERM and PDZ domain-containing protein 2 isoform
                     3"
                     /protein_id="NP_001018081.4"
                     /db_xref="CCDS:CCDS31195.1"
                     /db_xref="GeneID:143162"
                     /db_xref="HGNC:HGNC:28572"
                     /db_xref="MIM:613323"
                     /translation="MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQL
                     LEDLRNDSSDYVVCPWSALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDAS
                     QMHVYSLGMTLYWSAGFHVPPHQPLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRV
                     HEKEVSVYPAPAGLHIRRLVGLVLGTISEVEKRVVEESSSVQQNRSYLLRKRLRGTSS
                     ESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAG
                     RRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGEAPMTLHLPGSVVTKK
                     GKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKE
                     FFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQ
                     LRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMT
                     ALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALG
                     ICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTDSAKTS
                     KYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQRLSCS
                     ENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPM
                     TWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQ
                     ADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELI
                     ISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQ
                     SLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSV
                     PYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLV
                     LERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANG
                     LGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQ
                     EVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILD
                     QEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKL
                     HQERDESTLATSLEKDVRQNCYSVCDIMRLGRYSFSSPLTRLSTDIF"
     exon            155..280
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            281..438
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            439..504
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            505..696
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            697..829
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            830..917
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1050
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1122
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1297
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1445
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1584
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1740
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1926
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2083
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2294
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2395
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2488
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2596
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2713
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2919
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3024
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3118
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3204
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3352
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3567
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3666
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..4010
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4819
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4592..4597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /note="hexamer: AATAAA"
     polyA_site      4610
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /note="major polyA site"
     regulatory      4798..4803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
                     /note="hexamer: ATTAAA"
     polyA_site      4819
                     /gene="FRMPD2"
                     /gene_synonym="PDZD5C; PDZK4; PDZK5C"
ORIGIN      
        1 agtaaacaaa gacagcggca acagtgctgg tggcagggag ctccgcggac agacttgcaa
       61 gagacccctg ctccttgttg gaaagttgtc ccatgatgaa ggcctagacc tggtcacgga
      121 gacttttgga tgcagccttt aacgaaggac gcaggcatga gcctgtcctc tgtgacgctg
      181 gccagcgccc tacaggtcag gggtgaagct ctgtctgagg aggaaatctg gtccctcctg
      241 ttcctggccg ctgagcagct cctggaagac ctccgcaacg attcctcgga ctatgtggtt
      301 tgcccctggt cagccctgct ttctgcagct ggaagccttt ctttccaagg ccgtgtttct
      361 catatagagg ctgctccttt caaggcccct gaactgctac agggacagag tgaggatgag
      421 cagcctgatg catctcagat gcatgtctat tctttaggaa tgaccctcta ctggtcagca
      481 gggtttcatg ttccgccaca tcagcccctg cagctctgcg agcccctgca ctccatcctg
      541 ctgaccatgt gtgaagacca gcctcacagg cggtgcacgt tgcagtcggt tctggaagct
      601 tgtcgggttc atgagaaaga agtgtctgtc tacccagccc ctgctggtct ccacatcaga
      661 aggctggttg gcttggttct gggtaccatt tctgaggtgg agaaaagagt tgtggaggaa
      721 agctcctctg tgcagcagaa cagaagctac ctgctcagga agaggctgcg tgggacaagc
      781 agcgagagcc cagcggcaca ggccccggag tgtctgcatc cttgcagagt ttcagaaaga
      841 agcacggaga cccagagctc accagagccc cattggagca ccttgacaca cagtcactgc
      901 agcctccttg ttaaccgcgc tcttccagga gcagatcccc aggaccagca ggcgggccgg
      961 aggctcagct ctggatctgt gcactcggca gcagacagct catggccaac aactccttct
     1021 cagaggggtt ttctgcaaag aaggagcaag ttttccaggc cagagttcat cctgttggct
     1081 ggagaggccc cgatgacact acatctgccg ggatcggttg tgaccaaaaa agggaaatcc
     1141 tatttggctc tcagggacct ctgtgtggtc ctgctgaacg ggcagcacct ggaggtaaaa
     1201 tgtgatgttg aatcaacagt gggagctgtc ttcaatgccg tgacatcctt tgccaacctc
     1261 gaggaactca cctactttgg cttggcgtat atgaaaagca aagagttctt tttcctggac
     1321 agtgaaacca gattgtgcaa aatagctcct gaaggctgga gagagcagcc tcagaagacc
     1381 tccatgaata ccttcacact cttcctgagg ataaagttct ttgtcagcca ctatgggctg
     1441 ctccagcaca gcctgacaag gcaccagttt tacctgcagc ttcggaaaga tatcctggag
     1501 gagaggctgt actgcaatga agagatactg ctgcagctgg gggtccttgc cttgcaggct
     1561 gagtttggca attaccctaa ggagcaggtg gagagtaagc catactttca cgttgaagat
     1621 tacatcccag cgagtctgat cgagaggatg accgctctac gggtccaggt tgaagtctca
     1681 gagatgcacc ggctcagctc tgcactgtgg ggagaggatg ctgagctgaa gttcttgagg
     1741 gtcactcagc agctcccaga atacggtgtg ctggttcacc aagtattctc agagaagagg
     1801 aggccagaag aggagatggc cctggggatc tgtgccaagg gtgtcatagt ctatgaagtg
     1861 aaaaacaaca gcagaattgc aatgttacgg tttcagtgga gagaaaccgg gaagatttct
     1921 acttatcaaa aaaagttcac catcacaagc agtgtcactg ggaagaagca cacatttgtc
     1981 acagattcag ccaagaccag taaatactta ctggacctct gctcagccca gcatgggttt
     2041 aatgcacaga tgggctctgg gcagccttcc catgttttat ttgaccatga taagtttgtg
     2101 caaatggcca atttgagtcc tgcacaccag gcccggtcta agcctctcat ttggattcag
     2161 agattgtcat gctcagaaaa cgagttgttt gtatccaggc ttcagggtgc tgcaggaggc
     2221 ctgctgagta catcaatgga taacttcaac gtggacggca gcaaggaggc tggagcagaa
     2281 ggcatcgggc gcagcccctg cactggccgg gagcagctga agagtgcctg tgtgatccag
     2341 aagccaatga cctgggactc tctctctgga ccacctgttc agagcatgca tgcaggctca
     2401 aagaataata ggaggaagag ctttatagct gaaccgggcc gagaaattgt acgtgtgaca
     2461 ctgaaacgtg acccacatcg tggttttggg tttgtcatta atgagggaga gtattcaggc
     2521 caagctgacc ctggcatttt tatatcttct attatacctg gaggaccagc agaaaaagca
     2581 aaaacgatca aaccaggagg gcagatacta gccctgaatc acatcagtct ggagggcttc
     2641 acattcaaca tggctgttag gatgatccag aattcccctg acaacataga attaattatt
     2701 tctcagtcaa aaggtgttgg tggaaataac ccagatgaag aaaagaatag cacagccaat
     2761 tctggggtct cctctacaga catcctgagc ttcgggtacc agggaagttt gttgtcacac
     2821 acacaagacc aggacagaaa tactgaagaa ctagacatgg ctggggtgca gagcttagtg
     2881 cccaggctga gacatcagct ttcctttctg ccgttaaagg gtgctggttc ttcttgtcct
     2941 ccatcacctc cagaaatcag tgctggtgaa atctactttg tggaactggt taaagaagat
     3001 gggacacttg gattcagtgt aactggtggc attaacacca gtgtgccata tggtggtatc
     3061 tatgtgaaat ccattgttcc tggaggacca gctgccaagg aagggcagat cctacagggt
     3121 gaccgactcc tgcaggtgga tggagtgatt ctgtgcggcc tcacccacaa gcaggctgtg
     3181 cagtgcctga cgggtcctgg gcaggttgca agactggtct tagagagaag agtccccagg
     3241 agtacacagc agtgtccttc tgctaatgac agcatgggag atgaacgcac ggctgtttcc
     3301 ttggtaacag ccttgcctgg caggccttcg agctgtgtct cagtgacaga tggtcctaag
     3361 tttgaagtca aactaaaaaa gaatgccaat ggtttgggat tcagtttcgt gcagatggag
     3421 aaagagagct gcagccatct caaaagtgat cttgtgagga ttaagaggct ctttccgggg
     3481 cagccagctg aggagaatgg ggccattgca gctggtgaca ttatcctggc cgtgaatgga
     3541 aggtccacgg aaggcctcat cttccaggag gtgctgcatt tactgagagg ggccccacag
     3601 gaagtcacgc tcctcctttg ccgaccccct ccaggtgcgc tgcctgagct ggagcaggaa
     3661 tggcagacac ctgaactctc agctgacaaa gaattcacca gggcaacatg tactgactca
     3721 tgtaccagcc ccatcctgga tcaagaggac agctggaggg acagtgcctc cccagatgca
     3781 ggggaaggcc tgggtctcag gccagagtct tcccaaaagg ccatcagaga ggcacaatgg
     3841 ggccaaaaca gagagagacc ttgggccagt tccttgacac attctcctga gtcccaccct
     3901 catttatgca aacttcacca agaaagggat gaatcaacat tggcgacctc tttggaaaag
     3961 gatgtgaggc aaaactgcta ttcagtttgt gatatcatga gacttggaag atattccttc
     4021 tcatctcctc taaccagact ttcgacagat attttctgag caccttctct gcatgtctgc
     4081 agtgctgtgt aaaatgccct acctttgcat ggactattct ttctaatcaa gaggcgtgtg
     4141 tggcgaactt ggggcagccc ctggaagtct tgttctttga ccattacgtc tgcggctgca
     4201 tcaccagata atgagcttca ccactcgtct gcctcctgtg tccttccgcg gggagtaaat
     4261 gtcacttcag cttgccgcat ctctaaatag gcaaattttc agtgctcaga aaaggacctg
     4321 atctttgcac aaagtgcttt gatggttgcc tgcttgagtc actcccaatc ccttcctgaa
     4381 gccctttctt tataattctt ctgttgaaat agccatcata ttcacagtac taatcacagc
     4441 atctcacatt tactaaaaac ttaccccata ccaggaaccc agagttgggg gggctgtgtc
     4501 agaattatgt aatttacgtg tcccaataat cctagacgct tcttgaccat ctagttttgt
     4561 caaatgagaa aactgaggtt ccaaagaagt caataaactt gtccaaagtc tgaccgactc
     4621 tgcttgccat gtgacgagtc tgtcttagaa ctgggtcatt gccctgcttg caatgctgtg
     4681 ccctctggca agccccccca tccccccggt ctcctgagct cggtaaggtg ctccagctgc
     4741 ttctatcata gcacttccta catggactgt aacatttctt tactgctcca acttctcatt
     4801 aaattggggg ctcctcaaa
//
