LOCUS       NM_014907               5017 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens FERM and PDZ domain containing 1 (FRMPD1), transcript
            variant 1, mRNA.
ACCESSION   NM_014907
VERSION     NM_014907.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5017)
  AUTHORS   Johnson,E.O., Hancock,D.B., Gaddis,N.C., Levy,J.L., Page,G.,
            Novak,S.P., Glasheen,C., Saccone,N.L., Rice,J.P., Moreau,M.P.,
            Doheny,K.F., Romm,J.M., Brooks,A.I., Aouizerat,B.E., Bierut,L.J.
            and Kral,A.H.
  TITLE     Novel genetic locus implicated for HIV-1 acquisition with putative
            regulatory links to HIV replication and infectivity: a genome-wide
            association study
  JOURNAL   PLoS One 10 (3), e0118149 (2015)
   PUBMED   25786224
  REMARK    GeneRIF: G allele at rs4878712 in FRMPD1 was associated with lower
            HIV-1 acquisition. G allele at this SNP was also associated with
            reduced FBXO10 and increased BCL2 expression levels, whereas higher
            BCL2 levels are known to reduce HIV replication and infectivity.
            Erratum:[PLoS One. 2015 May 29;10(5):e0129671. doi:
            10.1371/journal.pone.0129671.. PMID: 26023777]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5017)
  AUTHORS   Pan,Z., Shang,Y., Jia,M., Zhang,L., Xia,C., Zhang,M., Wang,W. and
            Wen,W.
  TITLE     Structural and biochemical characterization of the interaction
            between LGN and Frmpd1
  JOURNAL   J Mol Biol 425 (6), 1039-1049 (2013)
   PUBMED   23318951
  REMARK    GeneRIF: LGN-TPR motifs are versatile and capable of recognizing
            multiple targets via diverse binding modes.
REFERENCE   3  (bases 1 to 5017)
  AUTHORS   Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
  TITLE     Structural basis for interaction between the conserved cell
            polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
            protein (LGN)
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19210-19215 (2011)
   PUBMED   22074847
REFERENCE   4  (bases 1 to 5017)
  AUTHORS   An,N., Blumer,J.B., Bernard,M.L. and Lanier,S.M.
  TITLE     The PDZ and band 4.1 containing protein Frmpd1 regulates the
            subcellular location of activator of G-protein signaling 3 and its
            interaction with G-proteins
  JOURNAL   J Biol Chem 283 (36), 24718-24728 (2008)
   PUBMED   18566450
  REMARK    GeneRIF: The PDZ and band 4.1 containing protein Frmpd1 regulates
            the subcellular location of activator of G-protein signaling 3 and
            its interaction with G-proteins.
REFERENCE   5  (bases 1 to 5017)
  AUTHORS   Samuelson,D.J., Hesselson,S.E., Aperavich,B.A., Zan,Y., Haag,J.D.,
            Trentham-Dietz,A., Hampton,J.M., Mau,B., Chen,K.S., Baynes,C.,
            Khaw,K.T., Luben,R., Perkins,B., Shah,M., Pharoah,P.D.,
            Dunning,A.M., Easton,D.F., Ponder,B.A. and Gould,M.N.
  TITLE     Rat Mcs5a is a compound quantitative trait locus with orthologous
            human loci that associate with breast cancer risk
  JOURNAL   Proc Natl Acad Sci U S A 104 (15), 6299-6304 (2007)
   PUBMED   17404222
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513165.12, AB023184.1, AL591470.12 and BX648967.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014907.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023184.1, SRR1660809.73286.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377765.8/ ENSP00000366995.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL513165.12        146623-146723
            102-2256            AB023184.1         1-2155
            2257-2257           AL591470.12        43333-43333
            2258-3977           AB023184.1         2157-3876
            3978-4489           AL591470.12        48558-49069
            4490-5017           BX648967.1         4941-5468
FEATURES             Location/Qualifiers
     source          1..5017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..5017
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /note="FERM and PDZ domain containing 1"
                     /db_xref="GeneID:22844"
                     /db_xref="HGNC:HGNC:29159"
                     /db_xref="MIM:616919"
     exon            1..141
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..246
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..4882
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /note="FERM domain-containing protein 2"
                     /codon_start=1
                     /product="FERM and PDZ domain-containing protein 1"
                     /protein_id="NP_055722.2"
                     /db_xref="CCDS:CCDS6612.1"
                     /db_xref="GeneID:22844"
                     /db_xref="HGNC:HGNC:29159"
                     /db_xref="MIM:616919"
                     /translation="MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPA
                     RNPTQTLIPVRHTVKIDKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQ
                     MNNEPAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVH
                     FAEEVLISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRS
                     IEYFALALEEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKED
                     PVAFEYLYLQSCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKD
                     WGIENFISPTLLRNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGE
                     LKTYGGRIFNATLMLQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELT
                     EESEKVSVVKVYLQDVKVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQ
                     AHRVSAEEGYESRACSDSEESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTP
                     EVARRGPSTCGASSTTDSAESEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSR
                     STFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLDLAQRANPQCQKTEFSESAALET
                     FGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQ
                     GWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTPPGPPSGPRDVSTAEPSAT
                     SLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRSFLQTDYTSQVSFPLVP
                     SASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETKALGLLAPLRETKST
                     NPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVPAASSSASTPHCS
                     NPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDPNPDRACLASN
                     PGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRDEPRSDECG
                     INPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDVSNNVSQ
                     TLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKLFVEL
                     DLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPLPC
                     PQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
                     MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVL
                     PWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDIL
                     ETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTF
                     QHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVK
                     LLARQCTALTAAVFCLTQKFRASTAL"
     exon            247..404
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..507
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..553
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..661
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..757
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..883
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1003
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1140
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1267
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1363
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1546
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1694
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..2501
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..5017
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4996..5001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /note="hexamer: AATAAA"
     polyA_site      5017
                     /gene="FRMPD1"
                     /gene_synonym="FRMD2"
                     /note="major polyA site"
ORIGIN      
        1 aggcggagcc cgagccgagc ccgagcagcg ctgcttcccg agccttggcc gcgaccgtgc
       61 ccgccgctgg gcggggccgc ccttctccga gagcgtcagc ccgctaggtc cttgtccgcg
      121 cgggcggcac ctcctctgca ggtaaatgga agagctggag accagtttat tccagacacg
      181 gaaagcacat agaatagaac aaatggtggc aagatggctt cggcgctccc gggacagctc
      241 ggcccgggct aaagttgctg cagctgatgg gcccgccagg aacccaactc agaccctcat
      301 ccctgtgcga cacacagtaa agatagacaa agacaccctc ctccaggact atggatttca
      361 catttctgag agccttcccc ttacagtggt ggctgtcaca gcaggaggct ctgctcacgg
      421 caagcttttc cctggtgatc agatcctcca aatgaacaat gagcctgctg aagacctttc
      481 ctgggaacga gcagtcgata ttctcaggga agcagaagat tctctttcaa tcacagttgt
      541 tcgctgcacg tcgggagtcc ctaaatcgtc cttcctgacc gaggagaaga gagccagact
      601 gaagaccaac cccgtgaagg tgcactttgc tgaagaagtg ctcatcagtg gacacagcca
      661 gggtaattct ctgctgtgta tgcccaacgt gctcaagcta tacttggaga atggacagac
      721 caaagctttc aagtttgagg caaacacaac cgtgaaggac atcatcctca ccgtgaagga
      781 gaagctgtcc atccgaagta tcgagtactt tgcactggcc ctggaagagc agtacagcat
      841 ctcccggctg cacctgctgc acgaagagga actcatccag caggtggtag aaagggagga
      901 gtcacatgac taccgctgcc tcttcagggt ctgttttgtt cccaaggacc ccctggacct
      961 cctgaaagaa gaccccgtgg cctttgaata cctctatctg cagagctgca gcgatgtgct
     1021 ccaggagcgc tttgctgtag aaatgaaatg tagctctgca ctccgactcg cggctctgca
     1081 catccaggaa cggatctacg cctgtgccca gccacagaag atctctttaa agtatataga
     1141 gaaagactgg ggaatagaga actttatatc tccaacttta ctccgaaaca tgaaaggcaa
     1201 agacatcaag aaagccatta gcttccacat gaagaggaac cagaatttgc tggaaccccg
     1261 acagaagcaa cttatttctg ctgcccagct acgtttaaat tatctacaga tcctcggaga
     1321 actcaagaca tatggtggaa gaatctttaa tgctacttta atgttacagg atagagaatc
     1381 ctacattgcc cttctagttg gagccaagta tgggattagc caggttatca atagcaaact
     1441 caacatcatg tccacattgg cagagtttgc aaacatcagc cgtgtagagc taacggaaga
     1501 gtctgagaaa gtgagcgtcg tcaaagtgta tcttcaggac gtcaaggttc tgactttgct
     1561 gctggaatcc aacagtgcaa aagacctagc ctgcctgatt gctgggtact acaggctgtt
     1621 ggttgaccca gttacctcca ttttcctctg gcctggaaac aaacaacaag cgcaccgggt
     1681 atctgcagaa gaaggctatg aatccagggc ctgcagtgac tcagaggagt cctctgaggt
     1741 ggactgcgta ctcgaacctc tctctgacag gcgcctggtg aaactggcac cctgcagatc
     1801 actcataaag gaggagcagc ctcctgggaa cagccccaca cctgaggtgg ctaggagggg
     1861 ccccagcacc tgcggggcca gcagcacgac agacagtgcc gagtccgagg cgtccgactc
     1921 agccaacact gagagccgcg gctacaggac cagtggctcg agtgagtcca tggacgctct
     1981 ggaagaggat gacttagaca cctgctcctc cagcaggtcc accttcttcc actttggctc
     2041 gccaggcctc gcagagagca ttgactctga cagccaggag gagagaagcg ggattgaaac
     2101 cagtggcttc ctctgtctcc tggacctggc ccagagagcc aacccccagt gccagaagac
     2161 agagttttcc gagagtgctg ctttggagac atttggctgg gcaccagaac tgagcacagt
     2221 caggctggac cccaggctgt atgaaggcag ccacgctgac tactacagcc tgtgttccag
     2281 tgtctccccg gccagctacc tgagtgacag ttccgagagt acagcttccc ggcaaggggg
     2341 agccccgcca gcctggggtc agcagggctg gactgaggcc cagcccagtt ccatgctgga
     2401 acccctggcc ctgcacccac cactggcctt tgaggatggc agctcagatg aggaatacta
     2461 tgacgcggct gataagctca ctcccccagg ccccccgtca gggcccagag atgtttctac
     2521 tgcagaaccc agtgccacaa gcttgcagaa taaggccagc acttctagcc ctgagaacag
     2581 cctgccttgt gggccagatg gaagacagcc aagcaggagg ggaggggtga agaaatatgc
     2641 caagaccctg aggaaaagaa ggtctttcct acagaccgac tacacctctc aggtctcatt
     2701 tcccctggtg ccatcagcct ccctggagag tgtagacgac gtgtgctact atgacaggga
     2761 gccctacctg gcccttggtg caccctcccc aactgtgtcc tctctgcagg acatgcaggg
     2821 tgagcctggc cttctggaga ccaaggcctt ggggctgctg gctcctctga gggagaccaa
     2881 gagcacaaac ccagcctcca gggtcatgga gatggagccc gagaccatgg aaaccaaatc
     2941 agtcatcgac tctcgagtgt cttctatttc tgccattcgc ttccggattg accccaacaa
     3001 taaagagaat tctggtgttg tccctgctgc cagctcctca gcaagcactc ctcactgttc
     3061 taacccaggt tcatctggcc cagatactgc tcaggcaagg ccttcccaaa tcttacctct
     3121 atctcaagac ctggatggga ttgcccccaa agaaccaacc atagagcatg gagacagctc
     3181 cttctccctc tccagtggtg accctaaccc agacagagcc tgcctggcca gcaacccagg
     3241 actaaataat gtctctcaag gagacacact agagctccag ttggagcccc atgtccagtt
     3301 ggaaatggga ttggaatctt tttgtacaaa tcatatacaa gaaactgccc ccaaatacac
     3361 agagcctttg ttgtctccta gagatgagcc tagaagtgat gaatgtggaa taaatccagg
     3421 agagaagata gcttctatcc ctacaaagga agagccacaa ggacaactat ctctggaaag
     3481 agacagagaa gttacaaaca aaaatggcac caacgtattt caggaggagt ctaggaagga
     3541 ttcaggtgac tccccgggtg atgtgtcaaa taatgtttca cagactcttg atattagctc
     3601 tccagctggt aaaatagtaa cctccctttc tttagatgct cctgtaacag ggaccgagca
     3661 gatcccacca catcccccta gagaccctca aggacagagc agagaacccc cagggcaagg
     3721 ctgccaggct caagaacaaa aactattcgt agagttggat ttagaccctg atttctttct
     3781 tgggaagcag acagtttcac cagccgtccc tccagagggg atcaaggcag aggcacctaa
     3841 ccatgtgaca gggcaagata tagcccctag ggacagccct gagtgggtct gttttaatcc
     3901 tgagccttcc ctgccagaac cactaccatg tccacaagag gatcctcact tagaaacttc
     3961 aaaccattgc ttactctcag aaggcaaaag tgacagctct agcatctgcc tttctgctga
     4021 gaagtctttt ctgtgctttg ccccagaaag ccatcctgaa gtctctgcca gtctcagggt
     4081 ggccacatct ttgggttttg caggcatgaa tgagatggtg gctcccagga tagggatgga
     4141 ccagtgcagc tgtcagttct cctatgccac atgcttccgt ggcccgcagc ctgagacaga
     4201 ggaagaagac agggacttgg aagcacaccc catggccccc ctcacctcac cgccctctgc
     4261 gggaagcccg gtggttctgc cctggaggcc tgcccgagcc cacagctgca ccaccgcacc
     4321 cctgtcgagg aaaagccaca tctggccaga gtactgctcc agggcactga gacagctgaa
     4381 agccacccct gccagcaccc ctgagggctt catccaactc atggagagct tgctggagct
     4441 acaagacatt ttagaaactt cctggggggt tggaaacaaa catcccccag agaagtgcac
     4501 ctggcacttt accgaaagcc ggagccgcct ctgcatgggc tcccagaagc tcctgtcgag
     4561 ctgtcggcat gtgatcagaa tggaccagtc ccccgaagag atgcaggggg ccgtgcgtga
     4621 caccttccag cacctggtcc agctggccgg cctgtgcttt cagttcacag actgtagccg
     4681 ctgctccgcc cggcacaggg aggcagcggg gaacctgagg gatgtggtgt acacctacca
     4741 tcagtttata gaggctgcta aatcgacctg cgagagaggc taccacgacc tgagtgtgaa
     4801 actcctggcc cgtcagtgca cggccctcac ggccgccgtg ttctgtttga cccagaagtt
     4861 ccgggcatcc acggccctgt aaacaggtca acggcccaag ggcctcctgc cctgtcctgc
     4921 cttggacact tccctgagaa gccccttcca ctctcccacc caccctcttc aaatgtttac
     4981 tatatagagt attcaaataa actgctgctt aatcttg
//
