LOCUS       NM_031904               3685 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens FERM domain containing 8 (FRMD8), transcript variant
            1, mRNA.
ACCESSION   NM_031904
VERSION     NM_031904.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3685)
  AUTHORS   Kong,X., Wang,Q., Wang,X., Yang,K., Nie,S., Li,Y., Lao,W., Yu,X.,
            Zhang,Y., Li,Z., Liu,Y., Ning,J., Wang,Y., Bi,C., Wu,C. and Zhai,A.
  TITLE     LINC01002 functions as a ceRNA to regulate FRMD8 by sponging
            miR-4324 for the development of COVID-19
  JOURNAL   Virol J 21 (1), 109 (2024)
   PUBMED   38734674
  REMARK    GeneRIF: LINC01002 functions as a ceRNA to regulate FRMD8 by
            sponging miR-4324 for the development of COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3685)
  AUTHORS   Yu,M., Wu,W., Sun,Y., Yan,H., Zhang,L., Wang,Z., Gong,Y., Wang,T.,
            Li,Q., Song,J., Wang,M., Zhang,J., Tang,Y., Zhan,J. and Zhang,H.
  TITLE     FRMD8 targets both CDK4 activation and RB degradation to suppress
            colon cancer growth
  JOURNAL   Cell Rep 42 (8), 112886 (2023)
   PUBMED   37527040
  REMARK    GeneRIF: FRMD8 targets both CDK4 activation and RB degradation to
            suppress colon cancer growth.
REFERENCE   3  (bases 1 to 3685)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3685)
  AUTHORS   Postnikova,O.A., Rogozin,I.B., Samuel,W., Nudelman,G.,
            Babenko,V.N., Poliakov,E. and Redmond,T.M.
  TITLE     Volatile Evolution of Long Non-Coding RNA Repertoire in Retinal
            Pigment Epithelium: Insights from Comparison of Bovine and Human
            RNA Expression Profiles
  JOURNAL   Genes (Basel) 10 (3), 205 (2019)
   PUBMED   30857256
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3685)
  AUTHORS   Kunzel,U., Grieve,A.G., Meng,Y., Sieber,B., Cowley,S.A. and
            Freeman,M.
  TITLE     FRMD8 promotes inflammatory and growth factor signalling by
            stabilising the iRhom/ADAM17 sheddase complex
  JOURNAL   Elife 7, e35012 (2018)
   PUBMED   29897336
  REMARK    GeneRIF: FRMD8 promotes inflammatory and growth factor signaling by
            stabilizing the iRhom2/ADAM17 sheddase complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3685)
  AUTHORS   Oikonomidi,I., Burbridge,E., Cavadas,M., Sullivan,G., Collis,B.,
            Naegele,H., Clancy,D., Brezinova,J., Hu,T., Bileck,A., Gerner,C.,
            Bolado,A., von Kriegsheim,A., Martin,S.J., Steinberg,F.,
            Strisovsky,K. and Adrain,C.
  TITLE     iTAP, a novel iRhom interactor, controls TNF secretion by policing
            the stability of iRhom/TACE
  JOURNAL   Elife 7, e35032 (2018)
   PUBMED   29897333
  REMARK    GeneRIF: iTAP (FRMD8) is a novel iRhom2 interactor that controls
            TNF-alpha secretion by policing the stability of iRhom2/ADAM17
            complex.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000944.4.
            
            On Nov 23, 2018 this sequence version replaced NM_031904.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044658.1, SRR1660807.250905.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317568.10/ ENSP00000319726.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AP000944.4         127485-127609
            126-210             AP000944.4         127885-127969
            211-378             AP000944.4         130209-130376
            379-480             AP000944.4         134421-134522
            481-539             AP000944.4         134889-134947
            540-706             AP000944.4         135107-135273
            707-928             AP000944.4         137647-137868
            929-1052            AP000944.4         140584-140707
            1053-1196           AP000944.4         141572-141715
            1197-1401           AP000944.4         145712-145916
            1402-3685           AP000944.4         152090-154373
FEATURES             Location/Qualifiers
     source          1..3685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3685
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /note="FERM domain containing 8"
                     /db_xref="GeneID:83786"
                     /db_xref="HGNC:HGNC:25462"
                     /db_xref="MIM:618337"
     exon            1..125
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1520
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /note="isoform 1 is encoded by transcript variant 1; FERM
                     domain-containing protein 8; iRhom Tail-Associated
                     Protein; bili; band4.1 inhibitor LRP interactor"
                     /codon_start=1
                     /product="FERM domain-containing protein 8 isoform 1"
                     /protein_id="NP_114110.1"
                     /db_xref="CCDS:CCDS8102.1"
                     /db_xref="GeneID:83786"
                     /db_xref="HGNC:HGNC:25462"
                     /db_xref="MIM:618337"
                     /translation="MDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPL
                     AVENLPSLSAHELHRAVREVLQLPDIALDVFALWLVSPLLEVQLKPKHQPYKLGRQWP
                     ELLLRFTSAPDDDVAMDEPFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAAR
                     YPCDVEDCEALGALVCRVQLGPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRG
                     RGARAGPGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEV
                     DKPAQGFLHRGGRKPVSVAISLEGVHVIDSREKHVLLGLRFQELSWDHTSPEEEEPIL
                     WLEFDGDSEGTPVNKLLKIYSKQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPS
                     SSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKPKRTTSFFSRQLSLGQG
                     SYTVVQPGDSLEQG"
     exon            126..210
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            211..378
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            379..480
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            481..539
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            540..706
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            707..928
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1052
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1196
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1401
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..3685
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3664..3669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /note="hexamer: ATTAAA"
     polyA_site      3685
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcttccc ggtcagctgc gtccttagcg ggagcccgag tgcgggcggt ggcgggcttg
       61 gcggcggggc aggattccag gcaggagcct tgcctctcag gtggcgggct ctgcgaccct
      121 gcgagatgga cgggacagaa ggcagtgccg ggcagcccgg ccccgctgag cgatcccacc
      181 gaagcagcgt gtcctccgtg ggagcccgag cggctgacgt gctggtatac ctagcggatg
      241 acacggtggt gcccctggct gtggagaacc tgccctcgct cagtgcccat gagctgcacc
      301 gcgctgtccg cgaggtcctg cagcttccag acatcgccct ggatgtcttc gcgctctggc
      361 tggtctcccc tctgctggag gtgcagctga aacccaagca ccagccctac aagctgggac
      421 gccagtggcc ggagctgctg ctgcgcttca ccagtgcccc agacgatgac gtggccatgg
      481 atgagccttt cctgcagttc cgaaggaacg tgttcttccc aaagcggcgg gagctccaga
      541 tccatgacga ggaggtcctg cggctgctct atgaggaggc caagggcaac gtgctggctg
      601 cacggtaccc gtgcgacgtg gaggactgcg aggctctggg cgccctggtg tgccgcgtgc
      661 agcttgggcc ctaccagccc ggccggccgg cagcctgcga cctgagggag aagctggact
      721 ccttcctccc tgcccacctc tgtaagcggg gccagagtct ctttgctgcc ctccggggcc
      781 gtggggccag ggccgggccg ggcgagcagg gcctgctgaa cgcctaccgc caggtgcagg
      841 aggtcagcag cgacggcggg tgcgaggccg ccctgggcac ccactaccgc gcctatctcc
      901 tcaagtgcca cgagctgccg ttttatgggt gtgccttctt ccacggtgag gttgacaagc
      961 cggcccaagg ctttttgcac cggggtgggc gcaagccagt ttctgtggcc atcagtctgg
     1021 aaggcgtgca cgtcatcgat agcagagaga agcatgtcct gctgggcctg cgcttccagg
     1081 agctgtcgtg ggaccacacc tcccccgagg aggaggagcc catcttgtgg ctggagttcg
     1141 acggggacag cgagggcaca cctgtcaaca agctcctcaa gatctactcc aagcaggccg
     1201 aactgatgag cagtctcatt gagtactgca tcgaactgag ccaggcggcg gagcccgcag
     1261 gcccccagga cagtgcgact ggctcgccct cggaccccag ctcctcactg gctcctgttc
     1321 agcgccccaa gctgcggagg cagggcagtg tggtgtccag ccggatccag catctctcca
     1381 ccatcgacta cgtggaggac ggcaagggga tcaggcgagt gaagccgaag cgcaccacat
     1441 ccttcttcag ccggcagctg tccttgggcc aggggagcta caccgtggtg cagcccggcg
     1501 acagcctgga gcagggctga ggacgctgca cccggcagga ggagggcgac tgggggccct
     1561 ggcccggcac tgtcctcctg aggggcaggc gccggctgca acagtctcat gggtcaccac
     1621 gtggggaggg ctgcctcagc aggtttctca gaccacggag aagtgacttt tgggcccggg
     1681 gccatgcccg ggctgtgcaa agctggccag ggcctcctgt agggctcctc tgcagcctgc
     1741 cctcccttcc cccggatgct gggccctgct gctctctcag gaccatccga tcaagctgca
     1801 gctgccaccc tcacctagaa acatgccttt gtgcccacct caagatgggc agtgtccctg
     1861 ttctgaagtg cccagtggca gctccagtgg tagaggacca aggattgagg tttgggacct
     1921 gaagctccag tgtgtgcctt tggcctcttc cctggacttg ggtgaccagt ctccgtcttc
     1981 ctcctgctag tgctccaccc cccggacttg gatgaccagt ttcccacctt cctcctgctg
     2041 gtgctccatc ccccaatacc aggctgggcc accactctga ggagggtagg aggggcctcc
     2101 ctggattgaa ccgggacaga aacacggtga gggcccccac cacacctccc tggttgaatc
     2161 aggaatggag ggagccaggc agggccctac ctggggtcct gtgcccctcg ttctggtctc
     2221 ctttgcaggc acgagatacc agaaagagca tgcctttctg atagcctttg gtgatgtcac
     2281 tgctgggagg tggctatcct gtggaccacc tggcctccag acccacactc acagtctgtg
     2341 aaaaactgaa aatcccctgg tgggcactcc ctggagccca agcagctccc ctaggggact
     2401 gaccggacct gacctcccct ccctgtgtct gggtcttcag gttttagttt ggtctttgtt
     2461 catctgagtt gtgctggggc aacgccagga agtgccctgg gtacctctgc tgtgcgctcc
     2521 ttcccaggtg gcgccatgga ttcctctggg ggctggcgca tgcccaggaa agcctgggcc
     2581 acacgggaca ctctcttctt tatcgaggac acttggaaag gtgactgata tgggtgcttg
     2641 gcttctctgg tcccagcttg ccctccgggg agcaggggct ctgtcttgtc ccagatgagc
     2701 tgagagcccc tgagaggagg gctttcccag ccctgggacc ctccgaggtg ggtgtgcggg
     2761 tctcacaggt gcttcctggg acttcctgtg gctgcacagg gcttggcttt gtcttcgttc
     2821 ccggtggaaa accgtgggag aggaagcttg ggcctctact ccaagtatca gagcctgttc
     2881 accctcctcc ctttggtagc ttgtgaatgt gccaggtgtt tcgaggtagg cttgccttct
     2941 ggcagcatgg actttgttaa aataataggc ggaaagaaga ggcctgggaa gggcccccag
     3001 tcttttggaa tgtcctggtc acagggtcat gtcagctgcc agttctcgtc tcccgtcctg
     3061 gagttgctcg gtcttgcgga gctgcccgcc tgcctgttct ggcggctcca gcgcaggctg
     3121 tccctgctgc tttgattcca ggtgatttta ttttttttat ttttttattt tttttgagac
     3181 ggagtcttgc tctgttgccc aggcaggagt gcagtggcgc atctcggctc actgcaacct
     3241 ctgtctcaag cgattctcct gcctcagcct cctgagtagc tgggattaca ggtgcatgcc
     3301 accaggcccc gctgattttt gtatttttag tagagatagg gtttcaccat gttggtcagg
     3361 ctggtcgtga actcctgacc tcatgatctg cccgcctcaa cctcccaaag tgctgggatt
     3421 ataggcgtga gccaccgccc ccagctgatt ccaggcgaat tcttctctga tgggcgggcg
     3481 agggtgtgtt cgtgtgatgg gttggagtgt gtgtgtctga gtacacagat gatgtgtttt
     3541 cccttcagct tcttacgttt tctgagcatc cattgtgcct taacattttc tgcttgtcct
     3601 ttgggacaaa gcagtatttt actcattctt tgaatgttct cattcttttg tatcatgtga
     3661 cttattaaaa tcagtttcta acaaa
//
