LOCUS       NM_032892               5051 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens FERM domain containing 5 (FRMD5), transcript variant
            2, mRNA.
ACCESSION   NM_032892 NM_001031729
VERSION     NM_032892.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5051)
  AUTHORS   Keller Sarmiento,I.J., Bustos,B.I., Blackburn,J., Hac,N.E.F.,
            Ruzhnikov,M., Monroe,M., Levy,R.J., Kinsley,L., Li,M., Silani,V.,
            Lubbe,S.J., Krainc,D. and Mencacci,N.E.
  TITLE     De novo FRMD5 Missense Variants in Patients with Childhood-Onset
            Ataxia, Prominent Nystagmus, and Seizures
  JOURNAL   Mov Disord 39 (7), 1231-1236 (2024)
   PUBMED   38576116
  REMARK    GeneRIF: De novo FRMD5 Missense Variants in Patients with
            Childhood-Onset Ataxia, Prominent Nystagmus, and Seizures.
REFERENCE   2  (bases 1 to 5051)
  AUTHORS   Lu,S., Ma,M., Mao,X., Bacino,C.A., Jankovic,J., Sutton,V.R.,
            Bartley,J.A., Wang,X., Rosenfeld,J.A., Beleza-Meireles,A.,
            Chauhan,J., Pan,X., Li,M., Liu,P., Prescott,K., Amin,S., Davies,G.,
            Wangler,M.F., Dai,Y. and Bellen,H.J.
  TITLE     De novo variants in FRMD5 are associated with developmental delay,
            intellectual disability, ataxia, and abnormalities of eye movement
  JOURNAL   Am J Hum Genet 109 (10), 1932-1943 (2022)
   PUBMED   36206744
  REMARK    GeneRIF: De novo variants in FRMD5 are associated with
            developmental delay, intellectual disability, ataxia, and
            abnormalities of eye movement.
REFERENCE   3  (bases 1 to 5051)
  AUTHORS   Gawel,A.M., Ratajczak,M., Gajda,E., Grzanka,M., Paziewska,A.,
            Cieslicka,M., Kulecka,M., Oczko-Wojciechowska,M. and Godlewska,M.
  TITLE     Analysis of the Role of FRMD5 in the Biology of Papillary Thyroid
            Carcinoma
  JOURNAL   Int J Mol Sci 22 (13), 6726 (2021)
   PUBMED   34201607
  REMARK    GeneRIF: Analysis of the Role of FRMD5 in the Biology of Papillary
            Thyroid Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5051)
  AUTHORS   Mao,X., Tey,S.K., Ko,F.C.F., Kwong,E.M.L., Gao,Y., Ng,I.O.,
            Cheung,S.T., Guan,X.Y. and Yam,J.W.P.
  TITLE     C-terminal truncated HBx protein activates
            caveolin-1/LRP6/beta-catenin/FRMD5 axis in promoting
            hepatocarcinogenesis
  JOURNAL   Cancer Lett 444, 60-69 (2019)
   PUBMED   30583072
  REMARK    GeneRIF: High FRMD5 expression is associated with
            hepatocarcinogenesis.
REFERENCE   5  (bases 1 to 5051)
  AUTHORS   Zhu,C., Yamaguchi,K., Ohsugi,T., Terakado,Y., Noguchi,R.,
            Ikenoue,T. and Furukawa,Y.
  TITLE     Identification of FERM domain-containing protein 5 as a novel
            target of beta-catenin/TCF7L2 complex
  JOURNAL   Cancer Sci 108 (4), 612-619 (2017)
   PUBMED   28117551
  REMARK    GeneRIF: Data show that FERM domain-containing protein 5 (FRMD5) is
            regulated by both beta-catenin and transcription factor 7-Like 2
            protein (TCF7L2) in colon cancer cells.
REFERENCE   6  (bases 1 to 5051)
  AUTHORS   Guo,T., Yin,R.X., Pan,L., Yang,S., Miao,L. and Huang,F.
  TITLE     Integrative variants, haplotypes and diplotypes of the CAPN3 and
            FRMD5 genes and several environmental exposures associate with
            serum lipid variables
  JOURNAL   Sci Rep 7, 45119 (2017)
   PUBMED   28332615
  REMARK    GeneRIF: We conclude that integrative variants, haplotypes and
            diplotypes of the CAPN3 rs4344713 and FRMD5 rs524908, as well as
            DBP and BMI are associated with serum lipid variables in the Jing
            and Han populations.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5051)
  AUTHORS   Hu,J., Niu,M., Li,X., Lu,D., Cui,J., Xu,W., Li,G., Zhan,J. and
            Zhang,H.
  TITLE     FERM domain-containing protein FRMD5 regulates cell motility via
            binding to integrin beta5 subunit and ROCK1
  JOURNAL   FEBS Lett 588 (23), 4348-4356 (2014)
   PUBMED   25448675
  REMARK    GeneRIF: FRMD5 regulates tumor cell motility via a dual pathway
            involving FRMD5 binding to integrin beta5 tail and to ROCK1
REFERENCE   8  (bases 1 to 5051)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   9  (bases 1 to 5051)
  AUTHORS   Wang,T., Pei,X., Zhan,J., Hu,J., Yu,Y. and Zhang,H.
  TITLE     FERM-containing protein FRMD5 is a p120-catenin interacting protein
            that regulates tumor progression
  JOURNAL   FEBS Lett 586 (19), 3044-3050 (2012)
   PUBMED   22846708
  REMARK    GeneRIF: FRMD5 may play a role in p120-catenin-based cell-cell
            contact and is involved in the regulation of tumor progression
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY049131.1, BC053647.1, DA276649.1 and AC023356.8.
            
            On Nov 23, 2018 this sequence version replaced NM_032892.4.
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.103366.1, BC053647.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417257.6/ ENSP00000403067.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                HY049131.1         24-63
            41-2283             BC053647.1         1-2243
            2284-2846           DA276649.1         11-573
            2847-5051           AC023356.8         72608-74812         c
FEATURES             Location/Qualifiers
     source          1..5051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..5051
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /note="FERM domain containing 5"
                     /db_xref="GeneID:84978"
                     /db_xref="HGNC:HGNC:28214"
                     /db_xref="MIM:616309"
     exon            1..319
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1930
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /note="isoform 2 is encoded by transcript variant 2; FERM
                     domain-containing protein 5"
                     /codon_start=1
                     /product="FERM domain-containing protein 5 isoform 2"
                     /protein_id="NP_116281.2"
                     /db_xref="CCDS:CCDS10107.2"
                     /db_xref="GeneID:84978"
                     /db_xref="HGNC:HGNC:28214"
                     /db_xref="MIM:616309"
                     /translation="MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFD
                     LLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPA
                     ALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSK
                     FQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGN
                     AAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPT
                     PEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKI
                     KREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPV
                     RSTSHGDTFLPHVRSSRTDSNERVAVIADEAYSPADSVLPTPVAEHSLELMLLSRQIN
                     GATCSIEEEKESEASTPTATEVEALGGELRALCQGHSGPEEEQVNKFVLSVLRLLLVT
                     MGLLFVLLLLLIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSL
                     LIDT"
     exon            320..424
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            425..467
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            468..546
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            547..644
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            645..768
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            769..856
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            857..945
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1009
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1101
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1176
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1245
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1352
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..5051
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /note="hexamer: ATTAAA"
     polyA_site      2540
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /note="major polyA site"
     regulatory      5033..5038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /note="hexamer: AATAAA"
     polyA_site      5051
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /note="major polyA site"
ORIGIN      
        1 agagcccggc gcttgatctg ggctgggggg aggcggtggc ggctgaggga aggaggagga
       61 taaggaggag gaacgaggcc agcaggaggc aacggcagcg acggggccgg ggtgatggtg
      121 caggtgcctg gggtcggtgc ggagctgccg ggctgaggga cgcctggtcc agggtccgca
      181 gcgccgccgc gtcgctcccg ggcgggcggg cgggaagatg ctgagcaggt tgatgagcgg
      241 cagcagcagg agcctggagc gcgagtacag ctgcaccgtg cggctgctgg acgacagcga
      301 gtacacctgc accatccaga gagatgccaa aggccagtac ctgtttgacc ttctttgcca
      361 ccatctgaac ctacttgaga aagactattt tggtatccgc tttgtagacc cagataagca
      421 gcggcattgg ctggaattta caaagtctgt ggtgaaacaa ttgagatccc agcctccatt
      481 caccatgtgc ttccgtgtga agttttatcc tgcagaccct gctgctctga aagaagaaat
      541 aaccaggtat ttagtcttcc tgcagatcaa aagggatctc taccatggcc gactcctctg
      601 taaaacatcg gatgctgcct tgttagcagc ttacatcctt caagcggaga ttggggatta
      661 tgactcaggg aaacaccctg aaggctacag ctccaagttc cagtttttcc ctaaacattc
      721 agagaagctg gaaaggaaaa ttgctgagat tcacaagacg gaactgagtg gtcaaacacc
      781 agcaacatca gagctgaact tcttaagaaa agcacagaca ttggaaacat atggagtgga
      841 tcctcaccca tgtaaggacg tgtcaggaaa tgctgcattt ctggccttca ctccttttgg
      901 gtttgttgtt cttcaaggaa acaagagggt ccacttcatt aaatggaatg aggtgaccaa
      961 gctgaaattt gaaggaaaga ctttctattt atacgtaagt cagaaagagg aaaagaaaat
     1021 tattcttaca tattttgctc caactcctga agcgtgtaag cacctctgga aatgtggaat
     1081 cgagaaccaa gccttctaca agctggagaa gtcaagccaa gtccgcacag tgtccagcag
     1141 caatttattc tttaaaggga gccggttccg atacagtggc cgagttgcaa aggaagtcat
     1201 ggaatcaagt gctaagatca aacgggagcc accggaaata cacagagcag ggatggttcc
     1261 cagccggagc tgtccctcca taacccatgg cccaaggctg agcagcgtcc ccaggacccg
     1321 cagaagagct gttcacatct ccatcatgga aggcctagag tccttacggg acagtgccca
     1381 ttccacacca gtgcgttcca cttcccatgg ggacaccttc ctgcctcacg tgagaagcag
     1441 ccggacagat agcaatgagc gagtagctgt gattgcagac gaggcctaca gccctgcaga
     1501 cagcgtgctg cccacccctg tggctgagca cagcctggag ctgatgttgc tttcccggca
     1561 gatcaatgga gccacctgca gcattgagga ggagaaggaa tctgaagcca gcaccccaac
     1621 tgctacagag gtggaggccc ttgggggaga gctgagggcc ctgtgtcagg ggcacagcgg
     1681 gcccgaggag gaacaggtga ataagtttgt tctaagtgtc ctccgtttgc tccttgtgac
     1741 catgggactc ctctttgttt tgctcctcct cctgatcatc cttaccgagt ctgaccttga
     1801 cattgccttt ttccgtgata tccgccagac ccccgagttt gaacaattcc actatcaata
     1861 cttttgtccc ctcaggcgat ggtttgcctg caaaatccgc tcagtggtga gcctgctcat
     1921 tgacacctga gaaggcatga ctcctcccaa aaactagcca ggtggaccaa ggaacccggc
     1981 tacccattcc cagcaatggg acccatcgcg gaaccatcgg cacatatacc aagtcctcct
     2041 ctcatgactc aaagtccact gcagcctagg agggtgtttc ccagaagaag aaagggatag
     2101 gctcatgccc tgtctaaaca aactgggaaa actcattttc ttcagaagtt atttcaagaa
     2161 aggctcagcg actctgtttc tcatctttcc aatttgcagg ataatttttg gttttgaatt
     2221 ttgatttttc atagatgtat attattttga agtatcaaat aaaaataatt tattttacta
     2281 ttactgatta ttgcagtagt atcacctagc agaggggaca ctagttgaaa actagagagc
     2341 tgctgtcctc tgtattctgc aggagctttt cctgctggtg ccactgggtt ccagtagact
     2401 catcactgca gcctcagcag ggcaggccag ggatctggac aatggggact gtttagtttt
     2461 ttgtttgttt tttttgccag ccagaacttt taaaaaagta aacatccatg tagaatgatt
     2521 aaatggaaag ttgcttctta tgatggtctg agttggattt tcttttcctt ttgttttttc
     2581 aaatctgagc agagtgggca tctgaaggga ccaccgctac agcaacagca gcatcagggg
     2641 tggggtaagt ctgtcccctt agtctagagc ctagtgggca tcaccatagt tttgtataat
     2701 gaaactagac ttaacgtgat tttttttttc cgaagaacct caagactttt atagtgctcc
     2761 aggggcgtta aacgaattca gtggtaccag agatagatag ttctgtcaga aatgttggac
     2821 aaagtgtagt taagagaaag cagagttaag ttacctgaga gactgttgag atttggatag
     2881 cagtgcttat tttatataca cccccttgac ccaaagacta tttcaattta tattttaaca
     2941 acgaaatgtt attttcttaa caattcatat tttgttttta ctttatggat taagaaaata
     3001 gagcctgatg aactaaacga tgcaagaaag aaactgatcc tgagaatgaa aagcttcaga
     3061 aaatagaatt ccaagatcaa cagccttaga agggaccagg aaaagaatct tttaaaatag
     3121 atttctaaga gatgcctaca aaacacagaa tgtgaccgtg gcagagacca acacttagat
     3181 gtagaaatgc tgccccctag ggtcatcctc tgcataagtt ctaggaaagc atcaccatcc
     3241 ttgcagaggg aagtcctcga agcacgcagc acaggcatat gaagggcgag tgtgggatcc
     3301 taggcccaag ctcttcaact ctaaaaccaa tcacacacaa gatcctgttt tcatctcagg
     3361 gagagatttc taagtcatct ggggcttgag ggcttattta agggtggtca atggacatat
     3421 tcctggaccc acacaaaagt agagcagctg ctgataccct aattggacag ccccaaacgc
     3481 agaacagaac aagtcacttg tagacttgac ctcccctatt ttgtcccccg agatggtaga
     3541 accatgtcca tgtttacaat atgacaactg tggaataatt ggggttctta gggagagatt
     3601 tgcataattt taaagacatc ctttcatctg gaccagaggt caatcaactt atgtcaagtg
     3661 ctacacagta aatattttgg tttagcacgc catactgtgt cacaactgct caattctgcc
     3721 atcacagcac aaaaacagcc acagataatt tgtaaatgaa ggaacatggc tgtgttccaa
     3781 taaaacttta tgaaaacagt gagctgaatt tagcctacag gccataatac gccaatcctg
     3841 ctctagacaa taaaactgat ccttaccagt atgttagcag aagagggtca gtcagctctg
     3901 tttccatgcc tgacatgtat caaagatctg ggacctcttc ccagtggagg cactagggtt
     3961 gcttgtttaa agggtgcttg aacaactaac cagcaaagag atgtctgatg ccaaatgggc
     4021 aagatcaaat actggaatgc taaaacacag ctggaatcta agaagggaag agggcttctc
     4081 tgaccatttt cataccagca acaatttagg cagaattata aacatctatt tatcgagtga
     4141 caatacaaac cgaaggagat cctagtagag attaggggtc agttaaaatc aactagccac
     4201 tgccacttgt catctacata gcaaaggctt tatttagcac aggactaacg tgaaaagtag
     4261 acccagagat gaaaaggctg tcaggagaca gggggctggt gtccacctgg tatctactgt
     4321 cttatgcaac atagaagatt accttttagt gtagtgctcc tacctcagtt tgtagaatct
     4381 ggtgtttcta tgcagtgagt gatagcctca actctgacct ttcatattca cattagagac
     4441 agatgcagta ttccatatcc tagtatgttc cttgtgtcta gagttctaac agtacagtag
     4501 tctatgccat ttctaacagc taaattttgc tctgtaaaca gaaactttag ggttgttttt
     4561 ttccagggct catcccagaa aatatggata gaaaagtttc cttcagtttg cttttcaaat
     4621 agtgcttgaa taataaacct cctttgattg gtgactagtc ttttttggta tatctccacc
     4681 tttaaaaatt gttcaagttt ttaacctggt tatactgtgt tctaacatgt ctctcatttt
     4741 ctctcaaaat tagtttatct cattgtagaa aaagcaatgg ttttcatagc ttcatctatc
     4801 aggaaataaa actcttacta aagaatagca tactgcatct ttaagcagta gagggtaaac
     4861 tacctgcaaa tgtgaatttc ttagatacat ttaaaaatat atagttgtta accttctgtg
     4921 tgccaaaaac tcttaagtta cattttcctt caaagcaatg tacttttttc tacatatgca
     4981 gtatgtagtt agcataaaat cattggtgcc atgaagatta tttttaaact taaataaata
     5041 tttaaatatc a
//
