LOCUS       NM_015123               6283 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens FERM domain containing 4B (FRMD4B), mRNA.
ACCESSION   NM_015123 XM_001134464 XM_114303
VERSION     NM_015123.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6283)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 6283)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 6283)
  AUTHORS   Matkovich,S.J., Van Booven,D.J., Cappola,T.P. and Dorn,G.W. 2nd.
  TITLE     Association of an intronic, but not any exonic, FRMD4B sequence
            variant and heart failure
  JOURNAL   Clin Transl Sci 3 (4), 134-139 (2010)
   PUBMED   20718813
  REMARK    GeneRIF: association between the intronic rs6787362 FRMD4B SNP and
            ischemic cardiomyopathy in a European-derived population, but not
            FRMD4B variants as susceptibility factors in common heart failure
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 6283)
  AUTHORS   Dubois,P.C., Trynka,G., Franke,L., Hunt,K.A., Romanos,J.,
            Curtotti,A., Zhernakova,A., Heap,G.A., Adany,R., Aromaa,A.,
            Bardella,M.T., van den Berg,L.H., Bockett,N.A., de la Concha,E.G.,
            Dema,B., Fehrmann,R.S., Fernandez-Arquero,M., Fiatal,S.,
            Grandone,E., Green,P.M., Groen,H.J., Gwilliam,R., Houwen,R.H.,
            Hunt,S.E., Kaukinen,K., Kelleher,D., Korponay-Szabo,I., Kurppa,K.,
            MacMathuna,P., Maki,M., Mazzilli,M.C., McCann,O.T., Mearin,M.L.,
            Mein,C.A., Mirza,M.M., Mistry,V., Mora,B., Morley,K.I.,
            Mulder,C.J., Murray,J.A., Nunez,C., Oosterom,E., Ophoff,R.A.,
            Polanco,I., Peltonen,L., Platteel,M., Rybak,A., Salomaa,V.,
            Schweizer,J.J., Sperandeo,M.P., Tack,G.J., Turner,G., Veldink,J.H.,
            Verbeek,W.H., Weersma,R.K., Wolters,V.M., Urcelay,E., Cukrowska,B.,
            Greco,L., Neuhausen,S.L., McManus,R., Barisani,D., Deloukas,P.,
            Barrett,J.C., Saavalainen,P., Wijmenga,C. and van Heel,D.A.
  TITLE     Multiple common variants for celiac disease influencing immune gene
            expression
  JOURNAL   Nat Genet 42 (4), 295-302 (2010)
   PUBMED   20190752
  REMARK    Erratum:[Nat Genet.2010 May;42(5):465]
REFERENCE   5  (bases 1 to 6283)
  AUTHORS   Cappola,T.P., Li,M., He,J., Ky,B., Gilmore,J., Qu,L., Keating,B.,
            Reilly,M., Kim,C.E., Glessner,J., Frackelton,E., Hakonarson,H.,
            Syed,F., Hindes,A., Matkovich,S.J., Cresci,S. and Dorn,G.W. 2nd.
  TITLE     Common variants in HSPB7 and FRMD4B associated with advanced heart
            failure
  JOURNAL   Circ Cardiovasc Genet 3 (2), 147-154 (2010)
   PUBMED   20124441
  REMARK    GeneRIF: SNP is located in a 3' intronic region of the FRMD4B gene.
            FRMD4B as novel susceptibility loci for advanced heart failure.
REFERENCE   6  (bases 1 to 6283)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6283)
  AUTHORS   Kiel,D.P., Demissie,S., Dupuis,J., Lunetta,K.L., Murabito,J.M. and
            Karasik,D.
  TITLE     Genome-wide association with bone mass and geometry in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S14 (2007)
   PUBMED   17903296
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6283)
  AUTHORS   Klarlund,J.K., Holik,J., Chawla,A., Park,J.G., Buxton,J. and
            Czech,M.P.
  TITLE     Signaling complexes of the FERM domain-containing protein GRSP1
            bound to ARF exchange factor GRP1
  JOURNAL   J Biol Chem 276 (43), 40065-40070 (2001)
   PUBMED   11445584
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135851.1 and AC112221.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015123.2.
            
            Summary: This gene encodes a GRP1-binding protein which contains a
            FERM protein interaction domain as well as two coiled coil domains.
            This protein may play a role as a scaffolding protein. [provided by
            RefSeq, Mar 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.108962.1,
                                           SRR1803612.254213.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398540.8/ ENSP00000381549.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC135851.1         23240-23500
            262-327             AC135851.1         95811-95876
            328-422             AC135851.1         97971-98065
            423-515             AC135851.1         106893-106985
            516-600             AC135851.1         121492-121576
            601-657             AC112221.2         115310-115366       c
            658-680             AC112221.2         114493-114515       c
            681-764             AC112221.2         89874-89957         c
            765-830             AC112221.2         87125-87190         c
            831-888             AC112221.2         83589-83646         c
            889-975             AC112221.2         81530-81616         c
            976-1052            AC112221.2         63965-64041         c
            1053-1191           AC112221.2         62167-62305         c
            1192-1333           AC112221.2         61522-61663         c
            1334-1467           AC112221.2         60498-60631         c
            1468-1587           AC112221.2         60289-60408         c
            1588-1813           AC112221.2         58915-59140         c
            1814-1870           AC112221.2         55163-55219         c
            1871-2018           AC112221.2         53037-53184         c
            2019-2138           AC112221.2         47865-47984         c
            2139-2950           AC112221.2         46166-46977         c
            2951-3083           AC112221.2         41791-41923         c
            3084-6283           AC112221.2         34049-37248         c
FEATURES             Location/Qualifiers
     source          1..6283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.1"
     gene            1..6283
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="FERM domain containing 4B"
                     /db_xref="GeneID:23150"
                     /db_xref="HGNC:HGNC:24886"
                     /db_xref="MIM:617467"
     exon            1..261
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..3204
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="GRP1-binding protein GRSP1"
                     /codon_start=1
                     /product="FERM domain-containing protein 4B"
                     /protein_id="NP_055938.2"
                     /db_xref="CCDS:CCDS46863.1"
                     /db_xref="GeneID:23150"
                     /db_xref="HGNC:HGNC:24886"
                     /db_xref="MIM:617467"
                     /translation="MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLR
                     TWCGLQDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGI
                     TFIDDTGQQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLN
                     AKACVHKGQIEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPS
                     LAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISY
                     KGIGQYDIQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQ
                     TWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLV
                     TLETKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKK
                     ICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFL
                     IQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQK
                     ATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSLGIERIHF
                     RKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEPE
                     SSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRSSSTEILDDGSSYTSQSSTEY
                     YCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMPNLAQKDSLRNGVYSKSQE
                     PPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYRSSAHYGYERQRDYSRS
                     FHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLRGWYQRASGQKDQGH
                     SPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNWRTQLTIGLSDYE
                     TPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQRLFWHEDSKP
                     GTLV"
     exon            262..327
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..422
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..515
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..600
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..657
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..680
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..764
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..830
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..888
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..975
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1052
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1191
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1333
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1467
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1587
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1813
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1870
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2018
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2138
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2950
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3083
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..6283
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4779..4784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="hexamer: AACAAA"
     polyA_site      4801
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="major polyA site"
     regulatory      5049..5054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="hexamer: AATAAA"
     polyA_site      5070
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
     regulatory      5799..5804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="hexamer: ATTAAA"
     regulatory      5816..5821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="hexamer: ATTAAA"
     polyA_site      5829
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
     polyA_site      5841
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
     regulatory      6258..6263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
                     /note="hexamer: AATAAA"
     polyA_site      6283
                     /gene="FRMD4B"
                     /gene_synonym="6030440G05Rik; GRSP1"
ORIGIN      
        1 agcagaagcc ggcgtcggga gcccaggcgg gcaggccgct ggggtcgggg ctgcacgtac
       61 gagagccggg acgcccgggt tcagagcgaa ggaggaggca tggcttcggt gttcatgtgt
      121 ggcgtggagg acctgctgtt cagcggcagc cgcttcgtat ggaacttgac cgtgtccacg
      181 ctgcggagat ggtacacgga gaggctgcgg gcttgccacc aggtgctgcg gacgtggtgc
      241 gggctgcagg acgtgtacca gatgacagaa ggcaggcact gccaggtgca cctcctggat
      301 gataggagac tggagctgct ggttcagccc aaacttctag caagagagtt gctggaccta
      361 gtggcttcac atttcaacct gaaagaaaag gagtattttg gaataacatt catagatgac
      421 acaggtcagc agaactggct gcagttagat caccgagttc ttgaccacga tttgcccaag
      481 aaaccaggcc caaccatttt gcactttgct gtgaggtttt acattgagag catatcgttt
      541 ttaaaggata aaaccaccgt ggagctgttt ttcctgaatg caaaggcctg tgtgcacaag
      601 gggcaaatcg aagtagagag cgaaaccatc ttcaagttag cagcgtttat tttacaggaa
      661 gccaagggag attataccag tgatgaaaat gccaggaaag atttaaagac attaccagcc
      721 tttccaacca aaactcttca ggagcatcca tcccttgcct actgtgagga cagggtaatt
      781 gagcattatt tgaaaatcaa aggtctcact cgaggtcaag ctgtggttca gtatatgaaa
      841 atagtagaag ctctaccgac ttacggtgtc cattattatg cagtaaagga taagcaagga
      901 cttccttggt ggcttggaat aagctataag ggaattggcc aatatgatat acaagacaag
      961 gtgaagcctc ggaagttatt ccaatggaaa cagctggaga acttatattt ccgtgagaaa
     1021 aaatttgctg ttgaagttca tgatccacga aggatttcag tttcaagaag aacctttggg
     1081 caaagtggct tgtttgtgca aacatggtat gctaactctt ctctcatcaa gtccatttgg
     1141 gtaatggcaa ttagtcagca tcagttttac ttggaccgga agcaaagcaa agcaaaaatt
     1201 ccttcagcca ggagtttaga tgagattgca atggatttga cagagacagg aacacaaagg
     1261 gcctccaagc tggtgacact ggagacgaaa agtcagttca tcatggcaag taatggcagt
     1321 ttaatctcct caggttctca agactcagaa gttagtgaag agcaaaagag agaaaaaatc
     1381 cttgaactaa agaagaagga gaaactatta caagaaaaac ttctgaaaaa agttgaggag
     1441 cttaagaaga tctgtctgcg ggaggctgag ctcacaggca aaatgccaaa ggagtatccc
     1501 ctgaacatag gcgagaagcc tcctcaggtc agaagacgtg tgggtactgc gttcaaatta
     1561 gatgacaact tgctgccgag tgaagaagat cctgctttgc aagaactgga gagtaatttt
     1621 ctaatacaac aaaagctggt ggaagctgca aagaaacttg ccaatgagcc agacctttgt
     1681 aaaactgtga agaaaaagcg aaagcaagat tacacagatg cgatgaaaaa gcttcaggag
     1741 attgaaaatg caataaacga ataccgaatt aggtgtggaa agaaacccag ccagaaagca
     1801 acagtgttac cagaagacat aatcccctca gagagtagct ctttgtctga caccaccacc
     1861 tatgatgatc ccagtgatgc cttcactttt cctgggcagc gatcaagttc agtacctcat
     1921 tctccaagaa ttcttccccc caagtctctt ggtattgagc gaatccattt cagaaagtcg
     1981 tccatcaatg aacagtttgt ggataccagg cagtccagag aaatgctgtc cacacacagc
     2041 agcccttaca aaactctgga gaggcggccc cagggaggac gaagcatgcc caccacgcca
     2101 gttcttaccc gaaacgccta cagcagcagc cacttggaac ccgaatcttc atctcagcac
     2161 tgccgccagc ggagtggaag cctggagtcc cagtcccacc tgctctccga gatggacagc
     2221 gataagccat ttttctccct ctccaaatcc caaagaagca gcagcacaga aatcctcgat
     2281 gacgggtctt cttatacaag ccaatcaagc acagagtatt actgtgtgac accagttacc
     2341 ggcccctatt acaccaccca gaccctggac actcgcacca ggggtcggag gaggtcaaag
     2401 aaacagaatg tttctacttc aaattcagga agcatgccca acctagcaca aaaggatagt
     2461 ttgaggaatg gtgtttactc aaagagtcag gagccaccgt cttccagtta ctacattgcc
     2521 gggtacacac cctatgcaga gtgtgacttt tattacagtg gtggttatgt ctatgagaat
     2581 gacaccgagg gacagtatag tgtcaaccct tcctaccggt cctcagccca ctatggatat
     2641 gagcgccaga gggactacag cagatccttt cacgaagatg aggtcgaccg ggtaccccat
     2701 aacccatatg caactctccg gctgccaagg aaggctgctg caaaatcgga gcacatcacc
     2761 aaaaacatcc acaaggcctt agttgccgag cacttgcgtg gctggtacca gcgggcctct
     2821 gggcagaagg atcagggaca cagcccgcag accagctttg actcagacag gggatcacag
     2881 agatgcctgg ggtttgcggg gctgcaagta ccttgttctc caagcagtcg tgcatcctcg
     2941 tactcttcag tgtcttctac aaatgcttct gggaactgga ggacccagtt aaccataggg
     3001 ctgtcggatt acgagactcc agcacattct tcttacacca gctgctatgg caatgtctat
     3061 aatcctttac cctctccaag cagacaatac acagaaatca gtcaactgga tggtacagat
     3121 ggaaaccagc tggaagacaa cctggagagt agtgagcaga gactcttttg gcatgaagat
     3181 tcaaagcctg gaacattagt ctgaactgca gttggacctc ctgaccaagc actgcgttct
     3241 cacactagtg tgccttgcaa attgtatttg tcttccgaga ggatgttcgt tttagaaacc
     3301 taaagacatc aaaggttgaa gagaagactt agttgccctg gaagtgaatc agtgaatcac
     3361 acaccaagcc ccacaaagcc cctaaaggag gatttggcct ttcaaactct aggcactaac
     3421 gtaactgtag ggtctgccca catgttgaag tattgccaag agaggactca gtgtgaagcc
     3481 ttcatcaata gcaagcactt tttaagggag taaaagttgt taaaggcaaa cctcaaaaac
     3541 atgaaagggc attcaggatg tcccatggca ataagaacag gggaaatctc agagcacaat
     3601 tcagcaggat gagagaaggg gaaccagaag ctccggagtc attgctcact tcagagtttg
     3661 aattcgtgag ctgacaaaga gtaacatgct ctttctacac agacatggac aatttagaca
     3721 gtattggaaa attacttgaa gctggatttt catgaagttc tgaatgagtg taaatgtttt
     3781 ttaggatact ataaagagtg atgtttttca taagcaccat aaaatgggtt ctggaaaaac
     3841 tgattacctt agcatcctgt aatataactt atggtagcag attggggaaa atgaagcagc
     3901 ccactgaata attgacaaag tctgcttgga gaacattcta aggtacaata tcatggagct
     3961 cctttttcct ttctccacta attgcgtgat gagctattgt tctggctgtt aattctccaa
     4021 ctcggctgtc atttgaagtg gcagacttaa tatggaaagt ttttataatt atgagtttga
     4081 aaaagcattt taagatgata cagaaagtat ccaaaacaac agaaaaaaaa agccacgtca
     4141 ttttagatga attgcgtgcc ttaaaatggt gaacgttaga aaattaaaca agtctggatt
     4201 ccacaagtag ttccaagtca ccaagtgaca aaaacaaggt taacattaaa aaagaaaaac
     4261 aacaacaacg acaaaaagct ccaagctgca gtggatttaa ttatgaggct aaaactacct
     4321 catactttcc ttggaagaac taattagcta tggtttattg tagggttttg tttgtttgtt
     4381 ttttaaagca aatgatttcc atattccaga ttgatctttt ttgtcatctt tgcttcaaaa
     4441 ttacataaaa ggtgctcctt tcccccttct tttatacaag tttcttgttc atattgtgaa
     4501 tagaaaagtt tctgaacaac ttttttggaa cattttctat ctatattcca aagcatgtaa
     4561 tatatacata aaaacgattt gttaaactgg tccttagtca tttgtataat tagaaatgaa
     4621 gtttgggaaa aaattttgga aaaaagacaa gcaaaaaaaa ataacttatt ccttttttgc
     4681 atatttgtat agccttctag aatcagaaat aacctttttg catattcttt tattgttctg
     4741 acttttcaag acctattatt tttttacata ggtcaataaa caaaaggtgt gctactgaaa
     4801 atgtttacgt tttcttccat ttatgtcagg ggttcatgtg aagcaggtcg cagtgctcta
     4861 cttcaagtaa tcatattggg caaggcttcg gatttttatt tatagtatta ccgtatttta
     4921 ttaattccgg gatgtacatt tttaaatatt tacattaaaa acatggttca tctttttatt
     4981 gatggcatat tctacttgaa ttggcagttt tttcttaata gtacattaaa aataatgctg
     5041 tgtcttacaa taaagttgcc ttagaattga tgaaatgcgg tagtttgtct cactgaggat
     5101 gactggtgag aacttttagg ttttttaatc ttgggaatgt tgtttatttg tagcaagtaa
     5161 tttatactaa tttcacagac tggcaaacag gtcttctaaa ttcaagaaat tagttctctg
     5221 acatccttta atcctacata atgtggagaa gggagtggaa atgaaatata tttccataca
     5281 tgtatcttgc ataaaataac atttttctgt tcctgaaata gtatggttac acttgcaagc
     5341 atgccttgaa agggcaaata taacttggct cccacagagg aaaagaaggt atagaaatgg
     5401 aagctcaggg ccaggcatag cggctcacac ctgtaatccc agcactttgg gaggccgaag
     5461 tgggaggatt gcttgagctc aggagttcaa gaccagcctg gacaacatgg tgaaacccca
     5521 tctctatgaa aatacaaaaa ttagccagtc atggtgatgt gtgcctgtaa tctcagctac
     5581 ttgggaggct gagttgggag gatatcttga gcccaggagg cggaggttgc agtgagccag
     5641 gatcgtgcca ctgcattcca gcctaggcaa taacagacct tgtctcaaga aaaaaaaaaa
     5701 aaaaaaaaaa agaaagaaat ggaagttcag caatcctact gcacggtttt cttcgtctct
     5761 tttgaaaaac atttctcaac cgcattggta ttaaaccaat taaactacgt tatttattaa
     5821 aagccaaaag tgacaaaagt acattattca acatgtacgt ttcctctttt ttattacaaa
     5881 ataccatggt taaatgcaaa accaaaatag tacataacaa aaacataatc gtgcccatta
     5941 gccgaacact ctcagatata atagttaatt tattgtatat ttgtttggat ttttttctat
     6001 gcatatagta atttttttaa agtccagcat attacaagta cagttttaca acattttttt
     6061 ttgtttgttt tgttttctgc ctaatatatc ttgggcctct gtatcaagac atactgatct
     6121 acctcataaa gatatatgtt taacaaggtg gatttttaaa attgcctcac cctactagat
     6181 gtttatctat ttttctatat ttgacaaaaa ttttcaaaat tcttccttgt actcacaaaa
     6241 gcttaaatat tacaagaaat aaagattccg gaattgtttt aaa
//
