LOCUS       NM_018027               6861 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens FERM domain containing 4A (FRMD4A), transcript variant
            1, mRNA.
ACCESSION   NM_018027
VERSION     NM_018027.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6861)
  AUTHORS   Diaz-Pena,R., Julia,R.F., Montes,J.F., Silva,R.S. and Olloquequi,J.
  TITLE     Polymorphisms in the FRMD4A Gene Are Associated With Chronic
            Obstructive Pulmonary Disease Susceptibility in a Latin American
            Population
  JOURNAL   Arch Bronconeumol 58 (5), 454-456 (2022)
   PUBMED   35312514
  REMARK    GeneRIF: Polymorphisms in the FRMD4A Gene Are Associated With
            Chronic Obstructive Pulmonary Disease Susceptibility in a Latin
            American Population.', trans 'Polimorfismos en el gen FRMD4A se
            asocian a riesgo de enfermedad pulmonar obstructiva cronica en
            poblacion latinoamericana.
REFERENCE   2  (bases 1 to 6861)
  AUTHORS   Zheng,X., Jia,B., Lin,X., Han,J., Qiu,X., Chu,H., Sun,X., Hu,W.,
            Pan,J., Chen,J. and Zhao,J.
  TITLE     FRMD4A: A potential therapeutic target for the treatment of tongue
            squamous cell carcinoma
  JOURNAL   Int J Mol Med 38 (5), 1443-1449 (2016)
   PUBMED   27666346
  REMARK    GeneRIF: Findings suggest that FRMD4A expression correlates with
            the development of tongue squamous cell carcinoma.
REFERENCE   3  (bases 1 to 6861)
  AUTHORS   Yan,X., Nykanen,N.P., Brunello,C.A., Haapasalo,A., Hiltunen,M.,
            Uronen,R.L. and Huttunen,H.J.
  TITLE     FRMD4A-cytohesin signaling modulates the cellular release of tau
  JOURNAL   J Cell Sci 129 (10), 2003-2015 (2016)
   PUBMED   27044754
  REMARK    GeneRIF: FRMD4A RNAi or inhibition of cytohesins strongly
            upregulated secretion of endogenous tau. These results suggest that
            FRMD4A, a genetic risk factor for late-onset Alzheimer's disease,
            regulates tau secretion by activating cytohesin-Arf6 signaling.
REFERENCE   4  (bases 1 to 6861)
  AUTHORS   Wang,M.M., Fang,M.X., Chen,L.G., Wang,H.Q., Liu,H.J. and Tang,H.L.
  TITLE     Differential expression of microRNA in endothelial cells incubated
            with serum of hypertension patients with blood-stasis syndrome
  JOURNAL   Chin J Integr Med 21 (11), 817-822 (2015)
   PUBMED   25864118
REFERENCE   5  (bases 1 to 6861)
  AUTHORS   Kupers,L.K., Xu,X., Jankipersadsing,S.A., Vaez,A., la Bastide-van
            Gemert,S., Scholtens,S., Nolte,I.M., Richmond,R.C., Relton,C.L.,
            Felix,J.F., Duijts,L., van Meurs,J.B., Tiemeier,H., Jaddoe,V.W.,
            Wang,X., Corpeleijn,E. and Snieder,H.
  TITLE     DNA methylation mediates the effect of maternal smoking during
            pregnancy on birthweight of the offspring
  JOURNAL   Int J Epidemiol 44 (4), 1224-1237 (2015)
   PUBMED   25862628
REFERENCE   6  (bases 1 to 6861)
  AUTHORS   Lambert,J.C., Grenier-Boley,B., Harold,D., Zelenika,D.,
            Chouraki,V., Kamatani,Y., Sleegers,K., Ikram,M.A., Hiltunen,M.,
            Reitz,C., Mateo,I., Feulner,T., Bullido,M., Galimberti,D.,
            Concari,L., Alvarez,V., Sims,R., Gerrish,A., Chapman,J.,
            Deniz-Naranjo,C., Solfrizzi,V., Sorbi,S., Arosio,B., Spalletta,G.,
            Siciliano,G., Epelbaum,J., Hannequin,D., Dartigues,J.F.,
            Tzourio,C., Berr,C., Schrijvers,E.M., Rogers,R., Tosto,G.,
            Pasquier,F., Bettens,K., Van Cauwenberghe,C., Fratiglioni,L.,
            Graff,C., Delepine,M., Ferri,R., Reynolds,C.A., Lannfelt,L.,
            Ingelsson,M., Prince,J.A., Chillotti,C., Pilotto,A., Seripa,D.,
            Boland,A., Mancuso,M., Bossu,P., Annoni,G., Nacmias,B., Bosco,P.,
            Panza,F., Sanchez-Garcia,F., Del Zompo,M., Coto,E., Owen,M.,
            O'Donovan,M., Valdivieso,F., Caffarra,P., Scarpini,E.,
            Combarros,O., Buee,L., Campion,D., Soininen,H., Breteler,M.,
            Riemenschneider,M., Van Broeckhoven,C., Alperovitch,A., Lathrop,M.,
            Tregouet,D.A., Williams,J. and Amouyel,P.
  TITLE     Genome-wide haplotype association study identifies the FRMD4A gene
            as a risk locus for Alzheimer's disease
  JOURNAL   Mol Psychiatry 18 (4), 461-470 (2013)
   PUBMED   22430674
  REMARK    GeneRIF: data suggest that FRMD4A could be a relevant candidate
            gene for AD risk.
            Erratum:[Mol Psychiatry. 2013 Apr;18(4):521. Caffara, P [corrected
            to Caffarra, P]]
REFERENCE   7  (bases 1 to 6861)
  AUTHORS   Goldie,S.J., Mulder,K.W., Tan,D.W., Lyons,S.K., Sims,A.H. and
            Watt,F.M.
  TITLE     FRMD4A upregulation in human squamous cell carcinoma promotes tumor
            growth and metastasis and is associated with poor prognosis
  JOURNAL   Cancer Res 72 (13), 3424-3436 (2012)
   PUBMED   22564525
  REMARK    GeneRIF: findings suggest FRMD4A as a novel candidate therapeutic
            target in HNSCC based on the key role in metastatic growth we have
            identified
REFERENCE   8  (bases 1 to 6861)
  AUTHORS   Yoon,D., Kim,Y.J., Cui,W.Y., Van der Vaart,A., Cho,Y.S., Lee,J.Y.,
            Ma,J.Z., Payne,T.J., Li,M.D. and Park,T.
  TITLE     Large-scale genome-wide association study of Asian population
            reveals genetic factors in FRMD4A and other loci influencing
            smoking initiation and nicotine dependence
  JOURNAL   Hum Genet 131 (6), 1009-1021 (2012)
   PUBMED   22006218
  REMARK    GeneRIF: A single nucleotide polymorphism in the FERM domain
            containing 4A protein is associated with nicotine dependence.
REFERENCE   9  (bases 1 to 6861)
  AUTHORS   Ikenouchi,J. and Umeda,M.
  TITLE     FRMD4A regulates epithelial polarity by connecting Arf6 activation
            with the PAR complex
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 748-753 (2010)
   PUBMED   20080746
REFERENCE   10 (bases 1 to 6861)
  AUTHORS   Matolweni,L.O., Bardien,S., Rebello,G., Oppon,E., Munclinger,M.,
            Ramesar,R., Watkins,H. and Mayosi,B.M.
  TITLE     Arrhythmogenic right ventricular cardiomyopathy type 6 (ARVC6):
            support for the locus assignment, narrowing of the critical region
            and mutation screening of three candidate genes
  JOURNAL   BMC Med Genet 7, 29 (2006)
   PUBMED   16569242
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069025.5, BC151244.1,
            AK289693.1, AL157392.18 and BU073361.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018027.4.
            
            Summary: This gene encodes a FERM domain-containing protein that
            regulates epithelial cell polarity. It connects ADP ribosylation
            factor 6 (ARF6) with the Par protein complex, which regulates the
            remodeling of adherens junctions and linear actin cable formation
            during epithelial cell polarization. Polymorphisms in this gene are
            associated with Alzheimer's disease, and also with nicotine
            dependence. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151244.1, AB037715.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357447.7/ ENSP00000350032.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC069025.5         22573-22612
            41-2983             BC151244.1         12-2954
            2984-3531           AK289693.1         2869-3416
            3532-6303           AL157392.18        70622-73393         c
            6304-6861           BU073361.1         15-572              c
FEATURES             Location/Qualifiers
     source          1..6861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..6861
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /note="FERM domain containing 4A"
                     /db_xref="GeneID:55691"
                     /db_xref="HGNC:HGNC:25491"
                     /db_xref="MIM:616305"
     exon            1..328
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            329..454
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..3529
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /note="isoform a is encoded by transcript variant 1; FERM
                     domain-containing protein 4A; FERM domain containing 4"
                     /codon_start=1
                     /product="FERM domain-containing protein 4A isoform a"
                     /protein_id="NP_060497.3"
                     /db_xref="CCDS:CCDS7101.1"
                     /db_xref="GeneID:55691"
                     /db_xref="HGNC:HGNC:25491"
                     /db_xref="MIM:616305"
                     /translation="MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKE
                     LLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFY
                     IESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVR
                     SDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGV
                     HYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHD
                     PRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSL
                     SEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALK
                     SRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDE
                     QKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKKLQ
                     EIENAINENRIKSGKKPTQRASLIIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLH
                     SPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKPKMWSESSLDEPYEKVK
                     KRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIRGLPHWNSQSSMPSTPDLRVRSP
                     HYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNG
                     SDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKARQRQRQRQRAAGALGSASS
                     GSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLYIEGGATPVVVRSLESD
                     QEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSRSQILRTPSLGREGA
                     HDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFVAHSR
                     VTRMPQMCKATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGEATENSPILDGSE
                     SPPHQSTDE"
     exon            455..520
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            521..615
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            616..708
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            709..793
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..850
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            851..873
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            874..957
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1023
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1081
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1168
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1245
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1384
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1526
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1660
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1783
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..2012
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2069
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2307
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2475
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..3362
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3459
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3531
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..6861
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /note="hexamer: ATTAAA"
     polyA_site      4676
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /note="major polyA site"
     regulatory      6836..6841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
                     /note="hexamer: ATTAAA"
     polyA_site      6861
                     /gene="FRMD4A"
                     /gene_synonym="bA295P9.4; CCAFCA; FRMD4"
ORIGIN      
        1 gtctgtatgc ggcgtacatg tggtacagcc agggagatca gaacgctcac agaacaggca
       61 gtgcaattcc atgttcctct taagtatgtt agccctaccg ggagctgagc tggccagtct
      121 acttggagag gaaaagtaga tctggggaag gtggaagggt cagttcctaa gtgacttcct
      181 cctcggggat ggtaagggca tttgctgatc tccagtgact gcctggtgcc tcatggtcag
      241 actcggctgt ctcactccca gatatctgat tttgcaaaaa gggacacacc tatctgcagc
      301 aaagaagaca ctgaccagat tgcgagcggt gcttttggat gctctgtagc cacccggggc
      361 ccaggaggac tgactcggca gcaggattcg tgcatgggaa tcggagacca tggcagtgca
      421 gctggtgccc gactcagctc tcggcctgct gatgatgacg gagggccgcc gatgtcaagt
      481 acatcttctt gatgacagga agctggaact cctagtacag cccaagctgt tggccaagga
      541 gcttcttgac cttgtggctt ctcacttcaa tctgaaggaa aaggagtact ttggaatagc
      601 attcacagat gaaacgggac acttaaactg gcttcagcta gatcgaagag tattggaaca
      661 tgacttccct aaaaagtcag gacccgtggt tttatacttt tgtgtcaggt tctatataga
      721 aagcatttca tacctgaagg ataatgctac cattgagctt ttctttctga acgcgaagtc
      781 ctgcatctac aaggagctta ttgacgttga cagcgaagtg gtgtttgaat tagcttccta
      841 tattttacag gaggcaaagg gagatttttc tagcaatgaa gttgtgagga gtgacttgaa
      901 gaagctgcca gcccttccca cccaagccct gaaggagcac ccttccctgg cctactgtga
      961 agacagagtc attgagcact acaagaaact gaacggtcag acaagaggtc aagcaatcgt
     1021 aaactacatg agcatcgtgg agtctctccc aacctacggg gttcactatt atgcagtgaa
     1081 ggacaagcag ggcataccat ggtggctggg cctgagctac aaagggatct tccagtatga
     1141 ctaccatgat aaagtgaagc caagaaagat attccaatgg agacagttgg aaaacctgta
     1201 cttcagagaa aagaagtttt ccgtggaagt tcatgaccca cgcagggctt cagtgacaag
     1261 gaggacgttt gggcacagcg gcattgcagt gcacacgtgg tatgcatgtc cggcattgat
     1321 caagtccatc tgggctatgg ccataagcca acaccagttc tatctggaca gaaagcagag
     1381 taagtccaaa atccatgcag cacgcagcct gagtgagatc gccatcgacc tgaccgagac
     1441 ggggacgctg aagacctcga agctggccaa catgggtagc aaggggaaga tcatcagcgg
     1501 cagcagcggc agcctgctgt cttcaggttc tcaggaatca gatagctcgc agtcggccaa
     1561 gaaggacatg ctggctgcct tgaagtccag gcaggaagct ctggaggaaa ccctgcgtca
     1621 gaggctggag gaactgaaga agctgtgtct ccgagaagct gagctcacgg gcaagctgcc
     1681 agtagaatat cccctggatc caggggagga accacccatt gttcggagaa gaataggaac
     1741 agccttcaaa ctggatgaac agaaaatcct gcccaaagga gaggaagctg agctggaacg
     1801 cctggaacga gagtttgcca ttcagtccca gattacggag gccgcccgcc gcctagccag
     1861 tgaccccaac gtcagcaaaa aactgaagaa acaaaggaaa acctcgtatc tgaatgcact
     1921 gaagaaactg caggagattg aaaatgcaat caatgagaac cgcatcaagt ctgggaagaa
     1981 acccacccag agggcttcgc tgatcataga cgatggaaac attgccagtg aagacagctc
     2041 cctctcagat gcccttgttc ttgaggatga agactctcag gttaccagca caatatcccc
     2101 cctacattct cctcacaagg gactccctcc tcggccaccg tcgcacaaca ggcctcctcc
     2161 tccccagtcc ctggagggac tccgacagat gcactatcac cgcaacgact atgacaagtc
     2221 acccatcaag cccaaaatgt ggagtgagtc ctctttagat gaaccctatg agaaggtcaa
     2281 gaagcgctcc tctcacagcc attccagcag ccacaagcgc ttccccagca caggaagctg
     2341 tgcggaagcc ggcggaggaa gcaactcctt gcagaacagc cccatccgcg gcctcccgca
     2401 ctggaactcc cagtccagca tgccgtccac gccagacctg cgggtccgga gtccccacta
     2461 cgtccattcc acgaggtcgg tggacatcag ccccacccga ctgcacagcc tcgcactgca
     2521 ctttaggcac cggagctcca gcctggagtc ccagggcaag ctcctgggct cggaaaacga
     2581 caccgggagc cccgacttct acaccccgcg gactcgtagc agcaacggct cagaccccat
     2641 ggacgactgc tcgtcgtgca ccagccactc gagctcggag cactactacc cggcgcagat
     2701 gaacgccaac tactccacgc tggccgagga ctcgccgtcc aaggcgcgcc agaggcagag
     2761 gcagcggcag cgggcggcgg gcgcactggg ctcagccagc tcgggcagca tgcccaacct
     2821 ggcggcgcgc gggggtgcgg ggggcgcggg gggcgcgggg ggcggtgtgt acctgcacag
     2881 ccagagccag cccagctcgc agtaccgcat caaggagtac ccgctgtaca tcgagggcgg
     2941 cgccacgccc gtggtggtgc gcagcctgga gagcgaccag gagggccact acagcgtcaa
     3001 ggctcagttc aagacgtcca actcctacac ggcgggcggc ctgttcaagg agagctggcg
     3061 cggcggcggc ggcgacgagg gcgacacggg ccgcctgacg ccgtcgcgat cgcagatcct
     3121 gcggactccg tcgctgggcc gcgagggcgc ccacgacaag ggcgcgggcc gtgccgccgt
     3181 ctcagacgag ctgcgccagt ggtaccagcg ttccaccgcc tcgcacaagg agcacagccg
     3241 cctgtcgcac accagctcca cctcctcgga cagcggctcg cagtacagca cctcctccca
     3301 gagcaccttc gtggcgcaca gcagggtcac caggatgccc cagatgtgca aggccacgtc
     3361 agctgcctta cctcaaagcc agagaagctc gacaccgtca agtgaaattg gagccacccc
     3421 cccaagcagc ccccaccaca tcctaacctg gcagactgga gaagcaacag aaaactcacc
     3481 cattctggat gggtctgagt ctccacctca ccaaagtact gatgaataga ggagctacaa
     3541 tgatagctgt ttcctggatt cctccctcta tccagaacta gctgatgtcc agtggtacgg
     3601 gcaggaaaaa gccaagcccg ggaccctcgt gtgagccagc ccggcctaat ctgaccgcct
     3661 caacgccatt ctgagatcac ctcactgcct ctcatttgcc ttacccagac gcaccgtcac
     3721 cctgcaccag ctttggccct cagcactttt tttctcctgt ctccgcattc cctccccctt
     3781 gaaaacctga ctgaggagac attctggaag gttccggtcc cactgtgtgt cccctggcgc
     3841 tcttgcccat agagagccag acaccaatcc tcaatggcac cttggtggct tccctctgcc
     3901 atgacagccc ctaggccagg aaccatcagg ggggccagcc ggcatccaat tcctgcggat
     3961 aagtagcgtt gggagagaac gggaaagggg acttgagtta cagggtgacc cagaaagacg
     4021 attcagctgt gtccagcctg ccacccatac gtaggccaac caagcacttc atgaagagga
     4081 ggcctcgtgg catattcagt ttacacctga aatattcctt gatgggacag cttgtgggga
     4141 tggctatggg ggaaggggag gttgagaaag gaagttctcg acaccagaaa tgcatcggag
     4201 gaccacaatc agttctatgc tgccaaagat taaaaataaa taaaaacata aaaaattaag
     4261 aggggccaag aggaagacat tctttctgca aggaaatttc ttttaaattc tgaactgcta
     4321 ctacacacaa gtgaaagtca accctatgta aactggtgtc ctctctctag ccctctccct
     4381 tactggccca cttctctctc cgtagagagc ctgaaaaact gccccaatgc cacggtaaag
     4441 gcgaggaagt cttggctggc gttgctgact cacagtcgcc atccatctgg acacaaagag
     4501 agacctgtgg gagtcgtaga gggtactgtt agccccggtc catgcagggg gttcagccga
     4561 gcccaagact caaagctgct ttcctttcag gatttgtagt aacgtaaggt gataatggcc
     4621 aaaagtggtt ctctctcatt aaaccaacca gtaaaagcgt atcctatttt tttgcacaag
     4681 gtgtttcatt ttcgttttta tgggaaacca agggaaaagc acattgcgat ccattcagtg
     4741 tttaactgtc gtggctcatt ttctgttcgt tagcacttgt gtgacaaaag agctcagatc
     4801 cgacttctcc tatgtgtcac ttattccaag aacccaacta tgcccttagg tagaaagatt
     4861 tgactcgtgt gtctactagc caacaggcag agcagggttg aaaaaaatat cagctcccaa
     4921 agggcccatg tgtctacatc atcagttact gtcatgcacc acatttgtgt gcagatacca
     4981 aaagaggagg aaagaagaaa aaaattaatg tgtgggagct gcacgtttac atgttttgag
     5041 ctatgcttca aacacaactg gaaagccatc aatcttcaaa ggcctcaaaa atacttttat
     5101 agtaacaagt gcacgacttt agttgggtta ttcaagatgg cacaaaaagg tttccgcaga
     5161 ggtggtatgc tgtgcttttg gcgcaagtgg tggggggatg gggtgggggt ggaatttttt
     5221 tctcactcta atgacttcct attggaaagg cattgacagc cagggacagg agccagggtg
     5281 ggggtagttt tgtgggaaag cagaactgaa gttagcttaa gcataaaaac aaagaaaaat
     5341 cttcgctttt catgtatgtg gaatccaaga ataaccatag gctctaccag accagaaggg
     5401 taaggatgga cactaaaatg aaacaaatac caaggtattc cttctgctgc agcctggaga
     5461 ccaccgagag tcgagctggg gcacacacac acctggccgg gacccggcag ggacaaggcg
     5521 ggccgtggcc tcctccacca agtctctcta gacaattcag ggcctgcttt ccccagctcc
     5581 atgcatggct ggactggtga ttccagggtg cagaagggat tcatattccc agaacgcttt
     5641 aagtgtacac ctgcaggata aagagatacc ggttacatta ttaaatgatt ctagggattc
     5701 actgggggat atttttgttg cttttacttt catggttaga gctacaaaga acagtgattt
     5761 tttttttttc tcccttcccc attcagaaac attatacatt gggccatttt tctttctccc
     5821 aaagaagatt catggatagt cagactgaac tgtgtgcaac aggaaaagtc aaaagggaaa
     5881 aggtagctga tgaggttaca tggttacatg ttctacatca tgcatagtag cttgaaatct
     5941 agtctggaga aaactggatc aagattctag cccactggag ttgcaaggaa tgagaggcaa
     6001 aaattctaaa gatttgggtt atattttcaa cttgggggac agagagaaat ggagagcagg
     6061 aattacagtt ccaacaaaca tcatgatagt ctggtagtca agacagagat taagtaaaac
     6121 aggttttact gtttagctga gttcagttaa tacaaaatgt acataaaacg ttagtccttt
     6181 gagactgaca tgattaatga tcagtgtggt gggaaatgat gtagttattg tacacaagca
     6241 cttgcaaact ctttatccct atttctttaa aacaaaataa ggtgaaatac gaagtccttg
     6301 gtctgatata aagcccctat tggattcttc ggatgcgtaa aagaaattgc ctgtttcagc
     6361 cagaagactg gtgaaaacac atacatcaga ctatgttgtg agccaggttg attttttatt
     6421 ttattatatg caggtgagtg ttgaaactgt taaaattcca atttgttttc attcagtatt
     6481 agtttagttc taaatatagc aaaccccatc caggtgctat cagatgacca gttactgctt
     6541 agttaactag gtgtaaagtt ttacatatac attaatgtca atagtttatt acaagttgtg
     6601 taaaatggac tctagtttaa taatggggga aaaaagatta ggttgctcct gaaactgact
     6661 gtagagcatg taaaatgatt ttactggatt ctgttcaact gtaatcaatg aaaaagatgt
     6721 acgttgtaga caaagttgca gaattaaaaa aagaaatctg cttttaattt attctttttg
     6781 tattaagaat ttgtatagta cctttacatt ttgcaaaaca gtgttgtcaa cacttattaa
     6841 agcattttca aaatgaaaag a
//
