LOCUS       NM_174938               5260 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens FERM domain containing 3 (FRMD3), transcript variant
            1, mRNA.
ACCESSION   NM_174938
VERSION     NM_174938.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5260)
  AUTHORS   Shao,W., Li,J., Piao,Q., Yao,X., Li,M., Wang,S., Song,Z., Sun,Y.,
            Zheng,L., Wang,G., Liu,L., Yu,C., Huang,Y., Bao,Y. and Sun,L.
  TITLE     FRMD3 inhibits the growth and metastasis of breast cancer through
            the ubiquitination-mediated degradation of vimentin and subsequent
            impairment of focal adhesion
  JOURNAL   Cell Death Dis 14 (1), 13 (2023)
   PUBMED   36631457
  REMARK    GeneRIF: FRMD3 inhibits the growth and metastasis of breast cancer
            through the ubiquitination-mediated degradation of vimentin and
            subsequent impairment of focal adhesion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5260)
  AUTHORS   Zellinger,B., Bodenhofer,U., Englander,I.A., Kronberger,C.,
            Grambozov,B., Ruznic,E., Stana,M., Karner,J., Fastner,G.,
            Sotlar,K., Sedlmayer,F. and Zehentmayr,F.
  TITLE     Hsa-miR-3651 could serve as a novel predictor for in-breast
            recurrence via FRMD3
  JOURNAL   Breast Cancer 29 (2), 274-286 (2022)
   PUBMED   34865205
  REMARK    GeneRIF: Hsa-miR-3651 could serve as a novel predictor for
            in-breast recurrence via FRMD3.
REFERENCE   3  (bases 1 to 5260)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5260)
  AUTHORS   Al-waheeb,S., Alwohhaib,M., Abdelghani,A., Al-Sharrah,S.,
            Al-Shafey,E., Al-Sahow,A., Alyatama,N., Dashti,A.A. and Hussain,N.
  TITLE     Evaluation of associations between single nucleotide polymorphisms
            in the FRMD3 and CARS genes and diabetic nephropathy in a Kuwaiti
            population
  JOURNAL   Genet Mol Res 15 (1) (2016)
   PUBMED   26909942
  REMARK    GeneRIF: The risk (G and C) and non-risk (C and T) allele
            frequencies of the SNPs at the rs1888747 and rs739401 loci of FRMD3
            and CARS, respectively, did not differ significantly between the
            diabetics with (case) and without (control) nephropathy (P > 0.05).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5260)
  AUTHORS   Martini,S., Nair,V., Patel,S.R., Eichinger,F., Nelson,R.G.,
            Weil,E.J., Pezzolesi,M.G., Krolewski,A.S., Randolph,A.,
            Keller,B.J., Werner,T. and Kretzler,M.
  TITLE     From single nucleotide polymorphism to transcriptional mechanism: a
            model for FRMD3 in diabetic nephropathy
  JOURNAL   Diabetes 62 (7), 2605-2612 (2013)
   PUBMED   23434934
  REMARK    GeneRIF: model for FRMD3 in diabetic nephropathy proposes a
            possible transcriptional link through which the polymorphism in the
            FRMD3 promoter could influence transcriptional regulation within
            the bone morphogenetic protein (BMP)-signaling pathway
REFERENCE   6  (bases 1 to 5260)
  AUTHORS   Freedman,B.I., Langefeld,C.D., Lu,L., Divers,J., Comeau,M.E.,
            Kopp,J.B., Winkler,C.A., Nelson,G.W., Johnson,R.C., Palmer,N.D.,
            Hicks,P.J., Bostrom,M.A., Cooke,J.N., McDonough,C.W. and
            Bowden,D.W.
  TITLE     Differential effects of MYH9 and APOL1 risk variants on FRMD3
            Association with Diabetic ESRD in African Americans
  JOURNAL   PLoS Genet 7 (6), e1002150 (2011)
   PUBMED   21698141
  REMARK    GeneRIF: These analyses reveal a role for FRMD3 in AA T2DN
            susceptibility.
REFERENCE   7  (bases 1 to 5260)
  AUTHORS   Maeda,S., Araki,S., Babazono,T., Toyoda,M., Umezono,T., Kawai,K.,
            Imanishi,M., Uzu,T., Watada,H., Suzuki,D., Kashiwagi,A.,
            Iwamoto,Y., Kaku,K., Kawamori,R. and Nakamura,Y.
  TITLE     Replication study for the association between four Loci identified
            by a genome-wide association study on European American subjects
            with type 1 diabetes and susceptibility to diabetic nephropathy in
            Japanese subjects with type 2 diabetes
  JOURNAL   Diabetes 59 (8), 2075-2079 (2010)
   PUBMED   20460425
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5260)
  AUTHORS   Pezzolesi,M.G., Poznik,G.D., Mychaleckyj,J.C., Paterson,A.D.,
            Barati,M.T., Klein,J.B., Ng,D.P., Placha,G., Canani,L.H.,
            Bochenski,J., Waggott,D., Merchant,M.L., Krolewski,B., Mirea,L.,
            Wanic,K., Katavetin,P., Kure,M., Wolkow,P., Dunn,J.S., Smiles,A.,
            Walker,W.H., Boright,A.P., Bull,S.B., Doria,A., Rogus,J.J.,
            Rich,S.S., Warram,J.H. and Krolewski,A.S.
  CONSRTM   DCCT/EDIC Research Group
  TITLE     Genome-wide association scan for diabetic nephropathy
            susceptibility genes in type 1 diabetes
  JOURNAL   Diabetes 58 (6), 1403-1410 (2009)
   PUBMED   19252134
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 5260)
  AUTHORS   Haase,D., Meister,M., Muley,T., Hess,J., Teurich,S., Schnabel,P.,
            Hartenstein,B. and Angel,P.
  TITLE     FRMD3, a novel putative tumour suppressor in NSCLC
  JOURNAL   Oncogene 26 (30), 4464-4468 (2007)
   PUBMED   17260017
  REMARK    GeneRIF: identify FRMD3 as a novel putative tumour suppressor gene
            suggesting an important role in the origin and progression of lung
            cancer.
REFERENCE   10 (bases 1 to 5260)
  AUTHORS   Ni,X., Ji,C., Cao,G., Cheng,H., Guo,L., Gu,S., Ying,K., Zhao,R.C.
            and Mao,Y.
  TITLE     Molecular cloning and characterization of the protein 4.1O gene, a
            novel member of the protein 4.1 family with focal expression in
            ovary
  JOURNAL   J Hum Genet 48 (2), 101-106 (2003)
   PUBMED   12601556
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041376.2, AK223597.1,
            AL137847.12 and BM873990.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174938.5.
            
            Summary: The protein encoded by this gene is a single pass membrane
            protein primarily found in ovaries. A similar protein in
            erythrocytes helps determine the shape of red blood cells, but the
            function of the encoded protein has not been determined. There is
            some evidence that this is a tumor suppressor gene, and there is
            also evidence linking defects in this gene to susceptibility to
            diabetic nephropathy in type 1 diabetes. Several transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3709842.1,
                                           SRR14038192.3026027.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304195.8/ ENSP00000303508.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BC041376.2         38-78
            42-2003             AK223597.1         1-1962
            2004-5122           AL137847.12        76650-79768         c
            5123-5260           BM873990.1         15-152              c
FEATURES             Location/Qualifiers
     source          1..5260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.32"
     gene            1..5260
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /note="FERM domain containing 3"
                     /db_xref="GeneID:257019"
                     /db_xref="HGNC:HGNC:24125"
                     /db_xref="MIM:607619"
     exon            1..317
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1964
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /note="isoform 1 is encoded by transcript variant 1; band
                     4.1-like protein 4; FERM domain-containing protein 3;
                     protein 4.1O; ovary type protein 4.1; band 4.1-like
                     protein 4O"
                     /codon_start=1
                     /product="FERM domain-containing protein 3 isoform 1"
                     /protein_id="NP_777598.3"
                     /db_xref="CCDS:CCDS43840.1"
                     /db_xref="GeneID:257019"
                     /db_xref="HGNC:HGNC:24125"
                     /db_xref="MIM:607619"
                     /translation="MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEI
                     SCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTHPP
                     YTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAEL
                     GDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLE
                     TYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGT
                     QKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYS
                     GKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEE
                     ELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNPS
                     ASLLPTPVDDDEIDMLFDCPSRLELEREDTDSFEDLEADENAFLIAEEEELKEARRAL
                     SWSYDILTGHIRVNPLVKSFSRLLVVGLGLLLFVFPLLLLLLESGIDLSFLCEIRQTP
                     EFEQFHYEYYCPLKEWVAGKVHLILYMLGCS"
     exon            318..422
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            423..465
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            466..544
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            545..642
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            643..766
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            767..854
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            855..943
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1007
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1096
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1171
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1240
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1365
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..5260
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5238..5243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /note="hexamer: AATAAA"
     polyA_site      5260
                     /gene="FRMD3"
                     /gene_synonym="4.1O; EPB41L4O; EPB41LO; P410"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgcccc ggccgctggg catgtgtgtc cgcaggcgcc cgacgctgcc gatgtcccgg
       61 ggctgagccg cgcccaggtg tcccggacag tgcgtgcgag cgtgtgtgtc cgcgcaggcg
      121 agcaccgcgc cggccctgag cctcccgctc gctccccacg gccgcggtgc atgttcgcct
      181 cctgccactg tgtgccgaga ggcaggagga ccatgaaaat gatccacttt cggagctcca
      241 gcgtcaaatc gctcagccag gagatgagat gcaccatccg gctgctggac gactcggaga
      301 tctcctgcca catccagagg gaaaccaaag ggcagtttct cattgaccac atctgcaact
      361 actacagcct gctggagaag gactactttg gcattcgcta tgtggaccca gagaagcaaa
      421 ggcactggct tgaacctaac aagtccatct tcaagcaaat gaaaactcat ccaccataca
      481 ccatgtgctt tagagtgaaa ttctacccac atgaaccctt gaagattaaa gaagagctca
      541 caagatacct tttatacctt cagattaaaa gggacatttt tcatggccgc ctgctgtgct
      601 ccttttctga tgctgcctac ctgggtgcct gtattgttca agctgagctt ggtgattacg
      661 atcctgatga gcatcctgag aattacatca gtgagtttga gattttcccc aagcagtcac
      721 agaagctgga aagaaaaata gtggaaattc ataaaaatga actcaggggg cagagcccac
      781 cagttgctga atttaacttg ctcctgaaag ctcacacttt ggaaacctac ggggtggatc
      841 ctcacccatg caaggattca acaggcacaa caacattttt aggattcaca gctgcaggct
      901 ttgtggtctt tcagggaaat aagagaatcc atttgataaa atggccagat gtctgcaaat
      961 tgaagtttga agggaagaca ttttatgtga ttggcaccca gaaggagaaa aaagccatgt
     1021 tggcattcca tacttcaaca ccagctgcct gcaaacatct ttggaagtgt ggagtggaaa
     1081 accaggcctt ttataagtat gcaaaatcca gtcagatcaa gactgtatca agcagcaaga
     1141 tattttttaa aggaagtaga tttcgatata gtgggaaagt tgccaaagag gtggtggagg
     1201 ccagttccaa gatccagagg gagcctcctg aggtgcacag agccaacatt actcagagcc
     1261 gcagttccca ctccttgaac aaacagctca tcattaacat ggaacccctg cagcccctgc
     1321 ttccttcccc cagcgagcaa gaagaagaac ttcctctggg tgagggtgtt ccattgccta
     1381 aagaggagaa catttctgct cccttgatct ccagctcccc agtgaaggca gcccgggagt
     1441 atgaagatcc ccctagtgaa gaggaagata aaataaaaga agaaccttta accatctctg
     1501 aactagtgta caacccaagt gccagcctgc tccccacccc tgtggatgac gatgagattg
     1561 acatgctctt tgactgtcct tctaggcttg agttggaaag agaagacaca gattcatttg
     1621 aggatctgga agcagatgaa aacgcctttt tgattgctga agaagaggag ctgaaggagg
     1681 ctcgccgtgc tttgtcgtgg agctatgaca ttctgactgg ccatattcgg gtgaacccac
     1741 tggtcaagag tttttccagg ctccttgtgg tgggcctggg actgctgctc tttgtatttc
     1801 ccctgctcct cctccttttg gagtcaggta ttgatctctc cttcttatgc gaaatccgcc
     1861 agacaccaga gtttgagcag tttcactatg aatactactg tcccctcaag gagtgggtgg
     1921 ctgggaaagt ccacctcatc ctctacatgc tgggttgctc atgaagttaa tctctcacgt
     1981 gactaagggc tatattcaat gctagtgatt tctttttttc agcaaatgcc tggttctgaa
     2041 gggtcacggg gctgtcaaca ggtgttcctt actcataatt gattattcaa acctttaagt
     2101 tagctttcca taattcactg cacttaaata agtttaaatc aaatacagtt attttagtta
     2161 caggttagga agatggtctt taaataacca aaaatatgtt tattttttat tatagtgtag
     2221 acataccctt catctattat atcataatac atgttacatt ggactgaatt agattttccc
     2281 atttctaata gttggcacca ttataagcta taaggttcag aatcagaatt ttagtaacaa
     2341 ctcaagagaa agttgttgaa tataatcctt agtgaaaaca gtgtcctcta accaatgcct
     2401 atacaactaa atttatgctg ggtttttggt tctgtttttt taaaaatatt tttatgtgtt
     2461 caaactattt tggtaaattt ttagcaaaaa aaaaaaagaa gcctcctgga gttatttaca
     2521 tgtacagatt gtaagactaa tgcacaaaag gtatatcaga atttttttaa tgttttggcg
     2581 ctactttgtt tttaaaaata tttttggctg aacaatacca taatttgtta tgatctgcat
     2641 aggagataga aaatgggtag aaagacacta tagtaagtaa gctgctaaaa cagaggatgg
     2701 aactggagga tgtagaaact gagagcatca agtggactca gggtggtcca tttttcaaag
     2761 tatttggaca agaggacttg ttattttcat ttgtattctg tccgtatatt ttggctggag
     2821 aagcagatgt tttaaaaaga aagtgagagt ttaaaggaaa aaaggtaaca gatgtgctag
     2881 tcagttgcat atcaatgtac attaacccaa gagtgaaggc agataggaac tggagaaatg
     2941 gaaagtggca aaaatgagtt ctggtgaggc tggcaggcaa atggtgacag gcgaatggtc
     3001 tattttatga aagtgatggt gatgccagcg ttcgatgatg tgaagagcag tgcagtcgct
     3061 gtctgagtta acatgaacat gtttaagtgg atctaaataa aagtggagaa actttaaggt
     3121 aaatattttg atccctcatg ccatttgttg tgattctgta gaagaaactt caaaaatgtg
     3181 tttgtatgtg agtgtgcgtg tgtgtgtgtg tgagagagag agagagagag agagagagaa
     3241 tatgaatggc tttttgatac atgtccatga tcatgttttg cggtggtcat tatactcctt
     3301 tcctttccca gttgttttaa aatttgactt ccatagagaa actggagagg cctcatgaga
     3361 tgacatacca gttcagcctg ggtaaagtag tgacatgacc ctaaccagac tgtagagggg
     3421 accagtgctc tagtaccttc cttgatacca ttaaatccat gatggaaagg atttaatcca
     3481 acaatttaat ggtatcaagg aaggtactag agcattgtac catcagcaac gtactgatgc
     3541 cttcccatgc agactacctg ctgatactgt gttatgtggg agaaagataa gagtctagaa
     3601 cttatgccat ggagcataga gcttctctgt ggattgaaaa cattccactg ccctaatgta
     3661 caaagttaca gggcccactt ggaatcgctc tctctagcta atgacattcc aaccctatca
     3721 ttagcatgat ttctaaattg ggcaatacat ttccactcac tcagtggagc tctgagtact
     3781 tcactggaca tttaattttg gaaatgagtt ttgaaactca gttcgtgaag cctgcagtcg
     3841 agcaaatgac tatatatttg ccattaagtt tgaggggttt cctttcctat atgctttcag
     3901 tgatttattt tgctttttaa ataaagattg tttgtttatt acctgaaagt tgatactgat
     3961 ttaggaatat attttctgtg attggaatcc tcaacaattt attttggaag cttgcagatg
     4021 gctaggtttg aaattgaaat ttgtgttttt ctccttcttt tctcatacga cttctaagtc
     4081 atcctttctg acataaggca actttagtgt agtctgcaca aaattagtcc ccttctgatc
     4141 atgcgtcata taattttctc taaagttctg actatgacaa atcatctggc cctcagtctt
     4201 tcaaaataat attatataat attttttaaa ttatggaact aatatatttt ccattgtaaa
     4261 atacttaaaa aatatgatag tataaatatc acatgtaatc caacgatgca gatttatctt
     4321 aaggagtaat aaatatatta ttttaacatt tccagctaac atctcttttc tcttaggtgg
     4381 aaacttcatt gttgaataga aatgttttta agtgaagaag ttgacagaat agggtctgct
     4441 gaatttaaac agccatcaaa agttaaactg gaatcttgaa atgccatttg ctcggcatag
     4501 aatcagagcc ttttagaaac atccatttaa gttttgttag aagatagtca ccagttgcct
     4561 gaatcgaatg aggaaaagcc tgcttccaga gatggacagt atattataga gtgagatata
     4621 gagtttaaag caagtgtgtg agtatatgta tattccatat tattggtata tgtgtgttta
     4681 tatatgaatc tgtatatatg tgtgtctttg aatagacaca acatatatgc ccctcatgca
     4741 taattgtgct tattttgccc taattgagga atttgagatg tattattggt tcttctccct
     4801 ctcagatact atggtgggta aaacccacag cctgaaaggg ttaaattttc cataaatgcc
     4861 actgagtgta catttgtgga tataaataaa tatatataat acacacacac atatggcaaa
     4921 tacatataca cacacaatat tgcctttagt gctaatgcaa gttggatcat gaaaacaatg
     4981 taggtaaagt aaagtatgta tttgtctgtg cttgaaaaat attgtaaaat gttatgtatt
     5041 tggaatatat tttgtggttt gtctaatatt tataaacaca actcggggtg aattcacaat
     5101 gagtttattt cattgaaata ctagagatat gggggccatg ttactgtgat tggagcctta
     5161 cctttgtata gtgaaatttg catttctatg tcaacatcca gattgtttta tatgttaata
     5221 tggtggcagg aatccctaat aaaaatactc tggggtaaaa
//
